34. Acids and Acid Derivatives
34. Acids and Acid Derivatives
Reactions of carboxylic acids and their salts include nucleophilic substitution and decarboxylation to leave enols, free... Read more
2 Apr 2012
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50mins
27. Triphenylmethyl and an Introduction to Carbonyl Chemistry
27. Triphenylmethyl and an Introduction to Carbonyl Chemistry
Painstaking studies of his “hexaphenylethane” and its reactivity convinced Gomberg that he had prepared the first trival... Read more
2 Apr 2012
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45mins
6. Brønsted Acidity and the Generality of Nucleophilic Substitution
6. Brønsted Acidity and the Generality of Nucleophilic Substitution
The coincidentally substantial extent of ionic dissociation of water provides an example of Brønsted acidity, or nucleop... Read more
2 Apr 2012
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46mins
38. Review: Synthesis of Cortisone
38. Review: Synthesis of Cortisone
Discoverers of the structure and biological activity of steroid hormones won seven Nobel Prizes between 1927 and 1975. ... Read more
2 Apr 2012
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52mins
37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products
37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products
Modern spectroscopic tools show not only the constitution, configuration, and conformation of glucose but also how it in... Read more
2 Apr 2012
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54mins
36. [gr]α-Reactivity and Condensation Reactions
36. [gr]α-Reactivity and Condensation Reactions
As in many synthetic procedures, an important challenge in ketone alkylation is choosing reagents and conditions that al... Read more
2 Apr 2012
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53mins
33. Green Chemistry. Acids and Acid Derivatives
33. Green Chemistry. Acids and Acid Derivatives
Green chemistry needs new asymmetric reactions and safer, more environmental Mitsunobu reactions. The Mitsunobu mechanis... Read more
2 Apr 2012
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49mins
35. Acyl Insertions and [gr]α-Reactivity
35. Acyl Insertions and [gr]α-Reactivity
When a nucleophilic atom bearing a good leaving group attacks a carbonyl group, an adjacent R group can migrate to the n... Read more
2 Apr 2012
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48mins
32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison
32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison
Spectroscopic determination of bond dissociation energies is relatively straightforward for many diatomic molecules, but... Read more
2 Apr 2012
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47mins
30. Oxidation States and Mechanisms
30. Oxidation States and Mechanisms
A difficult exam question shows how visible and NMR spectroscopy related to long-term misassignment of the structure for... Read more
2 Apr 2012
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46mins