Cover image of Freshman Organic Chemistry 2

Freshman Organic Chemistry 2

Freshman Organic Chemistry 2

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34. Acids and Acid Derivatives

34. Acids and Acid Derivatives

Reactions of carboxylic acids and their salts include nucleophilic substitution and decarboxylation to leave enols, free... Read more

2 Apr 2012

50mins

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27. Triphenylmethyl and an Introduction to Carbonyl Chemistry

27. Triphenylmethyl and an Introduction to Carbonyl Chemistry

Painstaking studies of his “hexaphenylethane” and its reactivity convinced Gomberg that he had prepared the first trival... Read more

2 Apr 2012

45mins

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6. Brønsted Acidity and the Generality of Nucleophilic Substitution

6. Brønsted Acidity and the Generality of Nucleophilic Substitution

The coincidentally substantial extent of ionic dissociation of water provides an example of Brønsted acidity, or nucleop... Read more

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38. Review: Synthesis of Cortisone

38. Review: Synthesis of Cortisone

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37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products

37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products

Modern spectroscopic tools show not only the constitution, configuration, and conformation of glucose but also how it in... Read more

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36. [gr]α-Reactivity and Condensation Reactions

36. [gr]α-Reactivity and Condensation Reactions

As in many synthetic procedures, an important challenge in ketone alkylation is choosing reagents and conditions that al... Read more

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33. Green Chemistry. Acids and Acid Derivatives

33. Green Chemistry. Acids and Acid Derivatives

Green chemistry needs new asymmetric reactions and safer, more environmental Mitsunobu reactions. The Mitsunobu mechanis... Read more

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35. Acyl Insertions and [gr]α-Reactivity

35. Acyl Insertions and [gr]α-Reactivity

When a nucleophilic atom bearing a good leaving group attacks a carbonyl group, an adjacent R group can migrate to the n... Read more

2 Apr 2012

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32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison

32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison

Spectroscopic determination of bond dissociation energies is relatively straightforward for many diatomic molecules, but... Read more

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30. Oxidation States and Mechanisms

30. Oxidation States and Mechanisms

A difficult exam question shows how visible and NMR spectroscopy related to long-term misassignment of the structure for... Read more

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