In this episode of Root of the Cause Radio, I’ll be covering the good, the bad and the ugly of estrogen metabolites: the more benign 2-Hydroxyestrone, the duality of the 16-Hydroxyestrone and the dreaded 4-Hydroxyestrone.1:53 - Phase 1 estrogen detoxification and estrogen metabolites2:47 - 16-Hydroxyestrone, the impact, risk and reasons for high levels and the possible downsides of very low levels4:06 - Can Estriol convert into anything harmful or helpful?5:40 - The bad and ugly of the 4-Hydroxyestrone and how methylation plays a critical role7:42 - Phosphatidylcholine and how it can indirectly help to neutralize the 4-Hydroxyestrone metabolite9:23 - What happens to the 4-Hydroxyestrones that don’t get methylated? Hint: DNA damage9:42 - How sulforaphane stimulates glutathione S transferase and quinone reductase to mop up DNA damaging quinones11:12 - Can you measure quinone levels? Can you measure DNA damage from oxidative stress (8-hydroxy-2-deoxyguanosine)?12:00 - How glutathione is made and the critical nutrients necessary13:49 - How glutathione and sulforaphane impact estrogen metabolites that don’t get methylated

In this episode of Root of the Cause Radio, I’ll be covering the good, the bad and the ugly of estrogen metabolites: the more benign 2-Hydroxyestrone, the duality of the 16-Hydroxyestrone and the dreaded 4-Hydroxyestrone.1:53 - Phase 1 estrogen detoxification and estrogen metabolites2:47 - 16-Hydroxyestrone, the impact, risk and reasons for high levels and the possible downsides of very low levels4:06 - Can Estriol convert into anything harmful or helpful?5:40 - The bad and ugly of the 4-Hydroxyestrone and how methylation plays a critical role7:42 - Phosphatidylcholine and how it can indirectly help to neutralize the 4-Hydroxyestrone metabolite9:23 - What happens to the 4-Hydroxyestrones that don’t get methylated? Hint: DNA damage9:42 - How sulforaphane stimulates glutathione S transferase and quinone reductase to mop up DNA damaging quinones11:12 - Can you measure quinone levels? Can you measure DNA damage from oxidative stress (8-hydroxy-2-deoxyguanosine)?12:00 - How glutathione is made and the critical nutrients necessary13:49 - How glutathione and sulforaphane impact estrogen metabolites that don’t get methylated

Estrogen Part 3 - Estrogen Metabolites (2-, 4-, 16-Hydroxyestrones) & Why They’re So Critical

Today’s episode is part 2 of my 3-part series on estrogen, where I’ll be covering the nuts and bolts of how we properly eliminate estrogen from the body, what’s needed to do so and some reasons for why that process may become suboptimal. I also discuss the timing of testing as well as how and why that detail can render greater value for some people.2:58 - Does the day of the month you test for estrogen matter? If so, when should you test and why4:52 - Mid-luteal phase of the menstrual cycle and its importance with estrogen testing6:24 - Estrogen clearance 1016:52 - The gallbladder’s, liver’s and bile’s impact on estrogen clearance7:53 - Bile production, bile flow, bile acids vs. bile salts and glycine/taurine and how they all impact estrogen clearance9:50 - Phosphatidylcholine, PEMT gene and their impact on bile and the gallbladder11:13 - Gut dysbiosis14:11 - Calcium D-glucarate15:29 - Some potential reasons for high estrogen in men

Today’s episode is part 2 of my 3-part series on estrogen, where I’ll be covering the nuts and bolts of how we properly eliminate estrogen from the body, what’s needed to do so and some reasons for why that process may become suboptimal. I also discuss the timing of testing as well as how and why that detail can render greater value for some people.2:58 - Does the day of the month you test for estrogen matter? If so, when should you test and why4:52 - Mid-luteal phase of the menstrual cycle and its importance with estrogen testing6:24 - Estrogen clearance 1016:52 - The gallbladder’s, liver’s and bile’s impact on estrogen clearance7:53 - Bile production, bile flow, bile acids vs. bile salts and glycine/taurine and how they all impact estrogen clearance9:50 - Phosphatidylcholine, PEMT gene and their impact on bile and the gallbladder11:13 - Gut dysbiosis14:11 - Calcium D-glucarate15:29 - Some potential reasons for high estrogen in men

Estrogen Part 2 – Estrogen Clearance and the Best Time to Test Estrogen Levels and Why

Today begins part 1 of my 3-part series on estrogen.I believe estrogen to be a very misunderstood hormone in the body, which is why I decided to use this platform to break down the finer points of estrogen, not only for women but for men as well.2:30 - Estrogen basics in women4:12 - Estrogen, bone density and PTH’s (parathyroid hormone’s) interplay5:05 - How estrogen is made in men6:18 - The aromatase gene (CYP19)7:07 - Effects of high and low estrogen in men10:16 - The 3 main estrogens and the pros, cons and limitations within the various testing methods14:35 - SHGB (sex hormone-binding globulin)19:42 - Estrogen metabolites (2-, 4-, and 16-Hydroxyestrones) and the value of knowing your levels

Today begins part 1 of my 3-part series on estrogen.I believe estrogen to be a very misunderstood hormone in the body, which is why I decided to use this platform to break down the finer points of estrogen, not only for women but for men as well.2:30 - Estrogen basics in women4:12 - Estrogen, bone density and PTH’s (parathyroid hormone’s) interplay5:05 - How estrogen is made in men6:18 - The aromatase gene (CYP19)7:07 - Effects of high and low estrogen in men10:16 - The 3 main estrogens and the pros, cons and limitations within the various testing methods14:35 - SHGB (sex hormone-binding globulin)19:42 - Estrogen metabolites (2-, 4-, and 16-Hydroxyestrones) and the value of knowing your levels

Estrogen Part 1 – Must-Know Elements of Estrogen for Both Woman and Men

Liposomal Colostrum

In this episode, we cover leaky gut, immune modulation, cancer, IGF1, growth hormone, pathogens and liposomal delivery systems, just to name a few.My guest today is Douglas Wyatt. Doug is the founder of Sovereign Laboratories, which provides the most efficacious bovine colostrum for immune resilience and maintaining homeostasis. Colostrum has been shown to help restore gastrointestinal damage caused by leaky gut, a primary cause of chronic disease. As Director of Research for the Vibrant Life Institute, Doug is the leading expert in colostrum and is credited with reintroducing bovine colostrum for human use.Mr. Wyatt is also a proponent of colostrum’s unique and powerful bioactive components that show incredible promise for turning the tide on the prevention and treatment of the world’s increasing chronic disease epidemic.2:10 - Doug’s story of his serendipitous discovery of colostrum and how he became a leading authority on the subject 12:08 - What is colostrum? What is its biological purpose and function for a newborn child? 17:05 - The effects on infants who do not receive colostrum and what can be done to remedy that19:33 - What else can colostrum do other than what it’s most known for – healing leaky gut? Contains lactoferrin (antimicrobial, inhibits viral replication, iron sequestrate), immunoglobulins (aids in fighting pathogens), polypeptides (immune modulatory)29:48 - Colostrum…immune “booster” or immune modulatory and what the difference is 35:20 - Liposomal turmeric and vitamin C 38:56 - What liposomal is and why liposomal colostrum is superior44:00 - Leaky gut. Is it real? If so, how to test for it? 48:59 - Secretory IgA (the gut’s immune system) in the context of colostrum51:33 - The IGF1/growth hormone with colostrum, cancer and if there are possible concerns

In this episode, we cover leaky gut, immune modulation, cancer, IGF1, growth hormone, pathogens and liposomal delivery systems, just to name a few.My guest today is Douglas Wyatt. Doug is the founder of Sovereign Laboratories, which provides the most efficacious bovine colostrum for immune resilience and maintaining homeostasis. Colostrum has been shown to help restore gastrointestinal damage caused by leaky gut, a primary cause of chronic disease. As Director of Research for the Vibrant Life Institute, Doug is the leading expert in colostrum and is credited with reintroducing bovine colostrum for human use.Mr. Wyatt is also a proponent of colostrum’s unique and powerful bioactive components that show incredible promise for turning the tide on the prevention and treatment of the world’s increasing chronic disease epidemic.2:10 - Doug’s story of his serendipitous discovery of colostrum and how he became a leading authority on the subject 12:08 - What is colostrum? What is its biological purpose and function for a newborn child? 17:05 - The effects on infants who do not receive colostrum and what can be done to remedy that19:33 - What else can colostrum do other than what it’s most known for – healing leaky gut? Contains lactoferrin (antimicrobial, inhibits viral replication, iron sequestrate), immunoglobulins (aids in fighting pathogens), polypeptides (immune modulatory)29:48 - Colostrum…immune “booster” or immune modulatory and what the difference is 35:20 - Liposomal turmeric and vitamin C 38:56 - What liposomal is and why liposomal colostrum is superior44:00 - Leaky gut. Is it real? If so, how to test for it? 48:59 - Secretory IgA (the gut’s immune system) in the context of colostrum51:33 - The IGF1/growth hormone with colostrum, cancer and if there are possible concerns

The Therapeutic Benefits of Liposomal Colostrum With Doug Wyatt

Albert Mensah

The final installment with Dr. Mensah, where we continue to take a deep dive into undermethylation.1:03 - Quantifying the severity of undermethylation using the whole blood histamine marker, and the thresholds that begin to hinder versus enhance performance8:35 - Calcium supplements for undermethylation, the mechanism and the potential down sides12:07 - Dr. Mensah's thoughts on the enzyme catecol-O-methyltransferase (COMT) and what, if anything, can be extrapolated from knowing your COMT status14:52 - Dr. Menshah feels undermethylating people are sensitive to folate. Should they then want to induce a mild deficiency?18:24 - SSRIs for someone with high histamine vs. SSRIs for someone with optimal histamine levels, or…is it copper overload?23:52 - Dr. Mensah's thoughts on genetic tests for pharmaceutical use Genesight.com 25:44 - Dr. Mensah’s thoughts on receptor down regulation concerns with SSRI medication28:00 - Zinc and its role in methylation, serotonin production and mental health29:13 - Dr. Mensah's thoughts on 5HTP supplementationMethylation Pathway Visual Aid SSRI 101 Visual AidMensahmedical.com﻿Listen to the Accompanying Episode Here: Methylation: A Primer to My interview with Dr. Albert MensahEmail ROTC@rootofthecause.net to ask a question or request a future episode. 

The final installment with Dr. Mensah, where we continue to take a deep dive into undermethylation.1:03 - Quantifying the severity of undermethylation using the whole blood histamine marker, and the thresholds that begin to hinder versus enhance performance8:35 - Calcium supplements for undermethylation, the mechanism and the potential down sides12:07 - Dr. Mensah's thoughts on the enzyme catecol-O-methyltransferase (COMT) and what, if anything, can be extrapolated from knowing your COMT status14:52 - Dr. Menshah feels undermethylating people are sensitive to folate. Should they then want to induce a mild deficiency?18:24 - SSRIs for someone with high histamine vs. SSRIs for someone with optimal histamine levels, or…is it copper overload?23:52 - Dr. Mensah's thoughts on genetic tests for pharmaceutical use <a href="http://www.genesight.com" rel="noopener noreferrer nofollow" target="_blank">Genesight.com</a> 25:44 - Dr. Mensah’s thoughts on receptor down regulation concerns with SSRI medication28:00 - Zinc and its role in methylation, serotonin production and mental health29:13 - Dr. Mensah's thoughts on 5HTP supplementation<h3> </h3><h3><a href="https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf" rel="noopener noreferrer nofollow" target="_blank">Methylation Pathway Visual Aid</a> </h3><h3><a href="https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046" rel="noopener noreferrer nofollow" target="_blank">SSRI 101 Visual Aid</a></h3><a href="http://Mensahmedical.com" rel="nofollow" target="_blank">Mensahmedical.com</a> ﻿Listen to the Accompanying Episode Here: <a href="https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939" rel="noopener noreferrer nofollow" target="_blank">Methylation: A Primer to My interview with Dr. Albert Mensah</a> Email <a href="mailto:ROTC@rootofthecause.net" rel="noopener noreferrer">ROTC@rootofthecause.net</a> to ask a question or request a future episode.

Part 3 – All Things Undermethylation With Methylation Expert Dr. Albert Mensah

Part two of my three-part series with methylation expert Dr. Albert Mensah.1:40 - Is it ever appropriate and/or helpful to combine pharmaceutical approaches with nutraceutical strategies for mental health in the context of methylation?4:13 - SAMe – a natural SSRI?7:35 - The SERT gene, SAMe, folate and various other ways one’s methyl status impacts serotonin10:20 - SAM to SAH ratio test: how and why this test can render actionable data Methylation profile/SAM to SAH ratio test17:50 - Ways the SAM to SAH ratio test can become skewed11:50 - What actually is homocysteine both in the context of methylation and in general? Do homocysteine levels correlate to methyl status?26:15 - Glycine: have this amino acid’s methyl-buffering effects been overstated?28:50 - Methionine: the concerns over excess methionine. Overstated and out of context?31:17 - Folate, folic acid and cancer32:40 - Folate pathway via MTHFR. Is it the main pathway, as most “experts" would have you believe, or is it the backup pathway to re-methylating homocysteine?Methylation Pathway Visual Aid SSRI 101 Visual AidMensahmedical.com﻿Listen to the Accompanying Episode Here: Methylation: A Primer to My interview with Dr. Albert Mensah﻿Email ROTC@rootofthecause.net with your questions, episode requests or feedback.

Part two of my three-part series with methylation expert Dr. Albert Mensah.1:40 - Is it ever appropriate and/or helpful to combine pharmaceutical approaches with nutraceutical strategies for mental health in the context of methylation?4:13 - SAMe – a natural SSRI?7:35 - The SERT gene, SAMe, folate and various other ways one’s methyl status impacts serotonin10:20 - SAM to SAH ratio test: how and why this test can render actionable data <a href="http://www.doctorsdata.com/Methyla5on-Pro%EF%AC%81le-plasma" rel="noopener noreferrer nofollow" target="_blank">Methylation profile/SAM to SAH ratio test</a>17:50 - Ways the SAM to SAH ratio test can become skewed11:50 - What actually is homocysteine both in the context of methylation and in general? Do homocysteine levels correlate to methyl status?26:15 - Glycine: have this amino acid’s methyl-buffering effects been overstated?28:50 - Methionine: the concerns over excess methionine. Overstated and out of context?31:17 - Folate, folic acid and cancer32:40 - Folate pathway via MTHFR. Is it the main pathway, as most “experts" would have you believe, or is it the backup pathway to re-methylating homocysteine? <h3><a href="https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf" rel="noopener noreferrer nofollow" target="_blank">Methylation Pathway Visual Aid</a> </h3><h3><a href="https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046" rel="noopener noreferrer nofollow" target="_blank">SSRI 101 Visual Aid</a></h3><a href="http://Mensahmedical.com" rel="nofollow" target="_blank">Mensahmedical.com</a> ﻿Listen to the Accompanying Episode Here: <a href="https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939" rel="noopener noreferrer nofollow" target="_blank">Methylation: A Primer to My interview with Dr. Albert Mensah</a>﻿Email <a href="mailto:ROTC@rootofthecause.net%20" rel="noopener noreferrer">ROTC@rootofthecause.net </a>with your questions, episode requests or feedback.

Part 2 – All Things Undermethylation With Methylation Expert Dr. Albert Mensah

Dr. Albert Mensah, MD, discusses cutting edge (and affordable) ways to test for undermethylation, plus its mental health implications, nutraceutical solutions, pharmaceutical options and much more.Dr. Mensah is the founder of Mensah Medical, an international biomedical clinic for patients diagnosed with autism, ADD, ADHD, OCD, Alzheimer’s disease, Parkinson’s disease, bipolar disorder, anxiety, depression and eating disorders. He treats patients with advanced nutrient therapy, an effective and natural alternative to prescription medication.Answering the need for specialists with backgrounds in both traditional and natural medicine, Dr. Mensah founded Mensah Medical after serving as a primary physician at the original Pfeiffer Treatment Center. While at Pfeiffer, he received extensive training from Dr. William J. Walsh, PhD, founder and former director of the Walsh Research Institute and a pioneer in methylation and mental health research. Dr. Mensah works closely with the Walsh Research Institute, updating therapies and protocols, initiating cutting-edge paradigms and serving as a clinical instructor for its International Doctor Training Program. 3:38 - What is methylation?7:00 - Serotonin production, activation, recycling and reprocessing9:03 - Whole blood histamine blood marker and its implication in methylation. The personality characteristic often seen in those with high whole blood histamine (undermethylators) and the advantages and struggles undermethylators are prone to12:26 - How and why there is an inverse relationship between methyl and histamine13:53 - How Dr. Mensha approaches a treatment plan for a high histamine individual15:56 - Can a genetic polymorphism (SNP) for histamine skew the whole blood histamine levels that would otherwise correlate to methylation?18:03 - Are whole blood histamine levels genetically determined or can they be altered if one “fixes” their undermethylation issues?19:06 - Why do many undermethylators do well on the supplement SAMe and don’t do as well when folate and/or folic acid is added to the SAMe?20:25 - Folate/folic acid – methylating agent or demethylating agent? Or both??22:30 - Selective serotonin reuptake inhibitor (SSRI) and the biochemical rationale behind this class of drugs25:53 - Why undermethylators tend to be hyper responders to SSRIs27:06 - Folate – select serotonin re-uptake enhancer? Folate contraindicated in undermethylators despite contrary popular belief? 29:45 - When and why to take and not take folate, irrespective of methyl status, particularly during pregnancy30:42 - The potential issues with haphazardly taking folate and/or folic acid during the entire pregnancy due to folate being a “double agent”31:35 - How the increased use of folic acid has contributed to global epigenetic changes32:03 - Dr. Mensah further explains how folate/folic acid is a “double agent”36:06 - Is methyl-folate as effective as it’s thought to be, and why?41:21 - Which type of B12 is best for undermethylators and balanced types? Methylcobalamin, Cyanocobalamin, Hydroxocobalamin?Methylation Pathway Visual Aid SSRI 101 Visual AidMensahmedical.com﻿Listen to the Accompanying Episode Here: Methylation: A Primer to My interview with Dr. Albert MensahFor questions or requests for future show topics, email ROTC@rootofthecause.net.

Dr. Albert Mensah, MD, discusses cutting edge (and affordable) ways to test for undermethylation, plus its mental health implications, nutraceutical solutions, pharmaceutical options and much more.Dr. Mensah is the founder of Mensah Medical, an international biomedical clinic for patients diagnosed with autism, ADD, ADHD, OCD, Alzheimer’s disease, Parkinson’s disease, bipolar disorder, anxiety, depression and eating disorders. He treats patients with advanced nutrient therapy, an effective and natural alternative to prescription medication.Answering the need for specialists with backgrounds in both traditional and natural medicine, Dr. Mensah founded Mensah Medical after serving as a primary physician at the original Pfeiffer Treatment Center. While at Pfeiffer, he received extensive training from Dr. William J. Walsh, PhD, founder and former director of the Walsh Research Institute and a pioneer in methylation and mental health research. Dr. Mensah works closely with the Walsh Research Institute, updating therapies and protocols, initiating cutting-edge paradigms and serving as a clinical instructor for its International Doctor Training Program. 3:38 - What is methylation?7:00 - Serotonin production, activation, recycling and reprocessing9:03 - Whole blood histamine blood marker and its implication in methylation. The personality characteristic often seen in those with high whole blood histamine (undermethylators) and the advantages and struggles undermethylators are prone to12:26 - How and why there is an inverse relationship between methyl and histamine13:53 - How Dr. Mensha approaches a treatment plan for a high histamine individual15:56 - Can a genetic polymorphism (SNP) for histamine skew the whole blood histamine levels that would otherwise correlate to methylation?18:03 - Are whole blood histamine levels genetically determined or can they be altered if one “fixes” their undermethylation issues?19:06 - Why do many undermethylators do well on the supplement SAMe and don’t do as well when folate and/or folic acid is added to the SAMe?20:25 - Folate/folic acid – methylating agent or demethylating agent? Or both??22:30 - Selective serotonin reuptake inhibitor (SSRI) and the biochemical rationale behind this class of drugs25:53 - Why undermethylators tend to be hyper responders to SSRIs27:06 - Folate – select serotonin re-uptake enhancer? Folate contraindicated in undermethylators despite contrary popular belief? 29:45 - When and why to take and not take folate, irrespective of methyl status, particularly during pregnancy30:42 - The potential issues with haphazardly taking folate and/or folic acid during the entire pregnancy due to folate being a “double agent”31:35 - How the increased use of folic acid has contributed to global epigenetic changes32:03 - Dr. Mensah further explains how folate/folic acid is a “double agent”36:06 - Is methyl-folate as effective as it’s thought to be, and why?41:21 - Which type of B12 is best for undermethylators and balanced types? Methylcobalamin, Cyanocobalamin, Hydroxocobalamin?<h3><a href="https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf" rel="noopener noreferrer nofollow" target="_blank">Methylation Pathway Visual Aid</a> </h3><h3><a href="https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046" rel="noopener noreferrer nofollow" target="_blank">SSRI 101 Visual Aid</a></h3><a href="http://Mensahmedical.com" rel="nofollow" target="_blank">Mensahmedical.com</a>﻿Listen to the Accompanying Episode Here: <a href="https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939" rel="noopener noreferrer nofollow" target="_blank">Methylation: A Primer to My interview with Dr. Albert Mensah</a>For questions or requests for future show topics, email <a rel="noopener noreferrer">ROTC@rootofthecause.net.</a>

Part 1 – All Things Undermethylation With Methylation Expert Dr. Albert Mensah

Today I’m doing a solo episode covering key concepts I discuss in my upcoming interview with one of the leading experts on methylation today, Dr. Albert Mensah. Dr. Mensah was in the game many years prior to the word methylation even becoming part of the functional medicine vernacular. He mentored under Dr. William Walsh, who started doing groundbreaking work on methylation in the mental health sphere decades before MTHFR became a trendy buzz term and years before methylation was at all talked about outside of academic circles. Dr. Mensah is part of this lineage of the great pioneers in the field of methylation research, and as such, you’ll see that his knowledge in this area knows no bounds. With that said, I felt that doing a solo episode to provide some background information and a better understanding of some of the advanced concepts we discuss would be of value. Look for my three-part interview series with Dr. Mensah, which will be released in the coming weeks. 2:16 - Selective serotonin re-uptake inhibitor SSRI physiology 1016:04 - How homocystein is biochemically made7:30 - Methionine converting to S-adenosyl-L-methione (SAM)8:03 - SAM converting to SAH9:02 - The SAM to SAH ratio9:55 - The methylation misconceptions of folate 12:14 - Selective serotonin reuptake enhancers 13:02 - gene polymorphism (SNP) 10113:41 - Glycine in the context of methylationMethylation Pathway Visual Aid SSRI 101 Visual AidEmail ROTC@rootofthecause.net with questions or requests for future episodes. 

Today I’m doing a solo episode covering key concepts I discuss in my upcoming interview with one of the leading experts on methylation today, Dr. Albert Mensah. Dr. Mensah was in the game many years prior to the word methylation even becoming part of the functional medicine vernacular. He mentored under Dr. William Walsh, who started doing groundbreaking work on methylation in the mental health sphere decades before MTHFR became a trendy buzz term and years before methylation was at all talked about outside of academic circles. Dr. Mensah is part of this lineage of the great pioneers in the field of methylation research, and as such, you’ll see that his knowledge in this area knows no bounds. With that said, I felt that doing a solo episode to provide some background information and a better understanding of some of the advanced concepts we discuss would be of value. Look for my three-part interview series with Dr. Mensah, which will be released in the coming weeks. 2:16 - Selective serotonin re-uptake inhibitor SSRI physiology 1016:04 - How homocystein is biochemically made7:30 - Methionine converting to S-adenosyl-L-methione (SAM)8:03 - SAM converting to SAH9:02 - The SAM to SAH ratio9:55 - The methylation misconceptions of folate 12:14 - Selective serotonin reuptake enhancers 13:02 - gene polymorphism (SNP) 10113:41 - Glycine in the context of methylation<h3><a href="https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf" rel="noopener noreferrer nofollow" target="_blank">Methylation Pathway Visual Aid</a> </h3><h3><a href="https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046" rel="noopener noreferrer nofollow" target="_blank">SSRI 101 Visual Aid</a></h3> Email <a href="mailto:ROTC@rootofthecause.net" rel="noopener noreferrer">ROTC@rootofthecause.net</a> with questions or requests for future episodes.

Methylation: A Primer to My Interview With Dr. Albert Mensah

Robby Besner

Today is part two of my two-part series with Robby Besner, where we continue to take a deep dive into all things sauna therapy, light therapy and detoxification.0:58 - Demystifying red light and the difference between actual red light wavelengths and red light bulbs5:19 - Therapeutic effects of the red Tri Light Panel9:11 - What is Low Level Laser Therapy (LLLT) and how does it differ from the light from an infrared sauna?14:53 - Electro Magnetic Frequencies (EMF) and Extremely Low Frequencies (ELF) regarding infrared saunas26:02 - Infrared sauna therapy for cancer. Testing to determine if a cancer is heat sensitive and radiation sensitive (reference page 2, section 4 titled “Radiotherapy/Hyperthermia Sensitivity” of the Heat Sensitive Cancer Test29:02 - Ozone therapy and its synergy with infrared sauna 32:52 - Mineral loss from sauna therapy and what to do about it38:50 - Detoxing organophosphates using infrared sauna therapy https://www.greatplainslaboratory.com/gpl-tox42:10 - The reason your head remains outside the sauna in Robby’s sauna design Therasage.comInstagram: @therasageinfraredEmail ROTC@rootofthecause.net with any questions or comments.

Today is part two of my two-part series with Robby Besner, where we continue to take a deep dive into all things sauna therapy, light therapy and detoxification.0:58 - Demystifying red light and the difference between actual red light wavelengths and red light bulbs5:19 - Therapeutic effects of the red Tri Light Panel9:11 - What is Low Level Laser Therapy (LLLT) and how does it differ from the light from an infrared sauna?14:53 - Electro Magnetic Frequencies (EMF) and Extremely Low Frequencies (ELF) regarding infrared saunas26:02 - Infrared sauna therapy for cancer. Testing to determine if a cancer is heat sensitive and radiation sensitive (reference page 2, section 4 titled “Radiotherapy/Hyperthermia Sensitivity” of the <a href="https://www.rgcc-group.com/wp-content/uploads/2019/06/Assessment-patients-name-1.pdf" rel="noopener noreferrer nofollow" target="_blank">Heat Sensitive Cancer Test</a>29:02 - Ozone therapy and its synergy with infrared sauna 32:52 - Mineral loss from sauna therapy and what to do about it38:50 - Detoxing organophosphates using infrared sauna therapy <a href="https://www.greatplainslaboratory.com/gpl-tox" rel="noopener noreferrer nofollow" target="_blank">https://www.greatplainslaboratory.com/gpl-tox</a>42:10 - The reason your head remains outside the sauna in Robby’s sauna design  <a href="http://Therasage.com" rel="nofollow" target="_blank">Therasage.com</a>Instagram: @therasageinfrared Email<a href="mailto:%20ROTC@rootofthecause.net%20" rel="noopener noreferrer"> ROTC@rootofthecause.net </a>with any questions or comments.

Part 2 – Infrared Sauna Therapy, Light Therapy & Advanced Therapeutic Detoxification With Robby Besner

Today is part one of my two-part series with guest Robby Besner. Robby is the founder of the company Therasage, through which he designs and sells full spectrum infrared saunas, among many other health optimization tools. He has an unusually unique and deep understanding of light therapy, heat therapy and detoxification in the form of sweating. Robby comes armed with the science behind all three of these powerful therapies.1:45 - What is infrared light and why is it so often associated with saunas?5:55 - The spectrum of the sun’s rays and the crossover to when it changes from non-ionizing (healing) radiation to ionizing (potentially harmful) radiation10:33 - Therapeutic benefits of the sun’s wavelengths vs. an infrared sauna14:02 - What is photobiomodulation? How do we get Vitamin D from the sun, and is that a form of photobiomodulation?21:43 - DMinder app26:48 - Hack to determine what Vitamin D level may be optimal for you29:46 - Benefits of nitric oxide and how infrared light affects it (stimulating cytochrome c oxidase)Therasage.comInstagram: @therasageinfraredReach out to ROTC@rootofthecause.net with any questions, comments or episode requests.

Today is part one of my two-part series with guest Robby Besner. Robby is the founder of the company Therasage, through which he designs and sells full spectrum infrared saunas, among many other health optimization tools. He has an unusually unique and deep understanding of light therapy, heat therapy and detoxification in the form of sweating. Robby comes armed with the science behind all three of these powerful therapies.1:45 - What is infrared light and why is it so often associated with saunas?5:55 - The spectrum of the sun’s rays and the crossover to when it changes from non-ionizing (healing) radiation to ionizing (potentially harmful) radiation10:33 - Therapeutic benefits of the sun’s wavelengths vs. an infrared sauna14:02 - What is photobiomodulation? How do we get Vitamin D from the sun, and is that a form of photobiomodulation?21:43 - DMinder app26:48 - Hack to determine what Vitamin D level may be optimal for you29:46 - Benefits of nitric oxide and how infrared light affects it (stimulating cytochrome c oxidase)<a href="https://therasage.com/" rel="noopener noreferrer nofollow" target="_blank">Therasage.com</a>Instagram: @therasageinfrared Reach out to ROTC<a href="mailto:rotc@rootofthecause.net" rel="noopener noreferrer">@rootofthecause.net </a>with any questions, comments or episode requests.

Part 1 – Infrared Sauna Therapy, Light Therapy & Advanced Therapeutic Detoxification With Robby Besner

Dive deeper into wellness than ever before. Host Dov joins leading experts and innovators in wellness, fitness and biohacking to discover the roots of the causes of modern health challenges. Join Dov as he explores innovative ways to optimize performance, address wellness issues and live your best life.

Patrick Theut

If you’re interested in reversing your coronary calcification and heart disease, today’s episode takes a deep dive into just that. Biochemist Patrick Theut put in over 16,000 hours of intense research to address and resolve his own heart disease, and that healing journey led him to create THE most effective Vitamin K supplement on the market today: Koncentrated K. The Root of the Cause podcast welcomes Patrick to educate us on exactly how he did it.3:14 - What is a coronary calcium score (CAC score)? 3:52 - Plaque vs. calcium4:14 - Determining severity of the CAC score 8:36 - Overview of Vitamin K12:14 - What is carboxylation and what is its role with Vitamin K dependent proteins? 12:58 - Does Vitamin K contribute to unwanted clotting? (Protein S, C, Z)17:02 - The body making the type of K it needs with any form of K as a substrate (K1, K2,   Mk-7, Mk-4)20:11 - Warfarin: contraindicated with K2?21:23 - Dabigatran: a work around to other Vitamin K blocking medications? 22:36 - Mk-4 vs. Mk-728:59 - Mechanism of action in calcium removal with Vitamin K235:00 - Foam cells, Autoschizis 38:26 - Vitamin K dosing for therapeutic purposes and for basic biological function 40:37 - Got a high coronary calcium score? What to do next43:44 - Testing for Vitamin K status 52:08 - High risk for stroke and taking K154:39 - Statins and coronary calcium score1:03:46 - Patrick’s Vitamin K formulation and how it came to be 1:10:59 - Astaxanthin and its role in the Koncentrated K formulationFor questions or requests of any kind, email ROTC@rootofthecause.net. 

If you’re interested in reversing your coronary calcification and heart disease, today’s episode takes a deep dive into just that. Biochemist Patrick Theut put in over 16,000 hours of intense research to address and resolve his own heart disease, and that healing journey led him to create THE most effective Vitamin K supplement on the market today: <a rel="noopener noreferrer">Koncentrated K</a>. The Root of the Cause podcast welcomes Patrick to educate us on exactly how he did it.3:14 - What is a coronary calcium score (CAC score)? 3:52 - Plaque vs. calcium4:14 - Determining severity of the CAC score 8:36 - Overview of Vitamin K12:14 - What is carboxylation and what is its role with Vitamin K dependent proteins? 12:58 - Does Vitamin K contribute to unwanted clotting? (Protein S, C, Z)17:02 - The body making the type of K it needs with any form of K as a substrate (K1, K2,   Mk-7, Mk-4)20:11 - Warfarin: contraindicated with K2?21:23 - <a href="https://en.wikipedia.org/wiki/Dabigatran" rel="noopener noreferrer nofollow" target="_blank">Dabigatran</a>: a work around to other Vitamin K blocking medications? 22:36 - Mk-4 vs. Mk-728:59 - Mechanism of action in calcium removal with Vitamin K235:00 - Foam cells, <a href="https://en.m.wikipedia.org/wiki/Autoschizis" rel="noopener noreferrer nofollow" target="_blank">Autoschizis</a> 38:26 - Vitamin K dosing for therapeutic purposes and for basic biological function 40:37 - Got a high coronary calcium score? What to do next43:44 - Testing for Vitamin K status 52:08 - High risk for stroke and taking K154:39 - Statins and coronary calcium score1:03:46 - Patrick’s Vitamin K formulation and how it came to be 1:10:59 - Astaxanthin and its role in the Koncentrated K formulationFor questions or requests of any kind, email <a href="mailto:ROTC@rootofthecause.net" rel="noopener noreferrer">ROTC@rootofthecause.net</a>.

Reversing Heart Disease & Calcification + All Things Vitamin K With Biochemist Patrick Theut

Dr. Brian Cornblatt joins me to unravel the unparalleled benefits of sulforaphane. Not only does he break down the science behind the detoxification capabilities of this potent phytochemical but he decodes the countless other profound uses of this remarkable compound as well.Dr. Cornblatt is a Johns Hopkins University School of Medicine graduate with a Ph.D. in Pharmacology and Molecular Sciences and a postdoctoral fellowship from the Johns Hopkins Bloomberg School of Public Health and Environmental Health Sciences Division of Toxicology. He is one of the leading experts on sulforaphane and THE leading expert on nutraceutical-based sulforaphane in the world today.Dr. Cornblatt is the creator of Avmacol, the most bioavailable glucoraphanin product that yields the highest amount of sulforaphane on the market. Avmacol is uniquely backed up by a robust supply of actual, verifiable clinical data, showcasing its broad range of powerfully therapeutic uses.2:15 - Sulforaphane 101: a primer4:22 - The story of how and why Dr. Cornblatt became so interested in the study of sulforaphane 10:00 - NRF2 and how sulforaphane affects it11:56 - How sulforaphane is made and the varying degrees to which glucoraphanin converts to sulforaphane from person to person16:13 - Glutathione, how it’s made in the body and how sulforaphane impacts it 19:53 - Potential pitfalls of taking exogenous glutathione21:50 - NAC with sulforaphane25:09 - Heat shock proteins and sulforaphanes impact 28:48 - Sulforaphane and H-Pylori31:49 - Innate vs. adaptive immune system 33:55 - Sulforaphane and autism44:33 - Avmocal vs. consuming broccoli sprouts 46:21 - Why Avmocal is not actually sulforaphane 48:36 - Bioavailability of sulforaphane and Avmacol52:47 - How much sulforaphane can one tablet of Avmacol render on average?56:38 - Taking Avmacol with a sulfur sensitivity58:50 - Avmacol vs. Prostaphane and the prostate1:03:53 - Avmocal...Goitrogenic?1:09:02 - Dr. Paul Saladino’s concern with sulforaphane 1:14:58 - DIM vs. sulforaphane1:19:14 - Sulforaphane, estrogen detoxification, quinone reductase1:21:56 - Heterocyclic amines and sulforaphane Avmacol Clinical Trials Avmacol.comFor questions or requests for future topics, email ROTC@rootofthecause.net

Dr. Brian Cornblatt joins me to unravel the unparalleled benefits of sulforaphane. Not only does he break down the science behind the detoxification capabilities of this potent phytochemical but he decodes the countless other profound uses of this remarkable compound as well.Dr. Cornblatt is a Johns Hopkins University School of Medicine graduate with a Ph.D. in Pharmacology and Molecular Sciences and a postdoctoral fellowship from the Johns Hopkins Bloomberg School of Public Health and Environmental Health Sciences Division of Toxicology. He is one of the leading experts on sulforaphane and THE leading expert on nutraceutical-based sulforaphane in the world today.Dr. Cornblatt is the creator of Avmacol, the most bioavailable glucoraphanin product that yields the highest amount of sulforaphane on the market. Avmacol is uniquely backed up by a robust supply of actual, verifiable clinical data, showcasing its broad range of powerfully therapeutic uses.2:15 - Sulforaphane 101: a primer4:22 - The story of how and why Dr. Cornblatt became so interested in the study of sulforaphane 10:00 - NRF2 and how sulforaphane affects it11:56 - How sulforaphane is made and the varying degrees to which glucoraphanin converts to sulforaphane from person to person16:13 - Glutathione, how it’s made in the body and how sulforaphane impacts it 19:53 - Potential pitfalls of taking exogenous glutathione21:50 - NAC with sulforaphane25:09 - Heat shock proteins and sulforaphanes impact 28:48 - Sulforaphane and H-Pylori31:49 - Innate vs. adaptive immune system 33:55 - Sulforaphane and autism44:33 - Avmocal vs. consuming broccoli sprouts 46:21 - Why Avmocal is not actually sulforaphane 48:36 - Bioavailability of sulforaphane and Avmacol52:47 - How much sulforaphane can one tablet of Avmacol render on average?56:38 - Taking Avmacol with a sulfur sensitivity58:50 - Avmacol vs. Prostaphane and the prostate1:03:53 - Avmocal...Goitrogenic?1:09:02 - Dr. Paul Saladino’s concern with sulforaphane 1:14:58 - DIM vs. sulforaphane1:19:14 - Sulforaphane, estrogen detoxification, quinone reductase1:21:56 - Heterocyclic amines and sulforaphane <a href="https://www.clinicaltrials.gov/ct2/results?term=avmacol&amp;Search=Search" rel="noopener noreferrer nofollow" target="_blank">Avmacol Clinical Trials</a> <h3><a href="http://Avmacol.com" rel="nofollow" target="_blank">Avmacol.com</a></h3>For questions or requests for future topics, email ROTC<a href="mailto:rotc@rootofthecause.net" rel="noopener noreferrer">@rootofthecause.net</a>

The Healing & Detox Potential of Sulforaphane With THE Leading Nutraceutical SFN expert, Dr. Brian Cornblatt

In today’s episode, I’ll be talking about the oral glucose tolerance test as well as sharing some biohacks you’ve never heard of before related to fasting, low carb diets and exercise hacks. I’ll also be mentioning some other blood sugar markers and how they relate and compare to the oral glucose tolerance test and discussing whether there is a cheaper, more efficient and, arguably, more accurate alternative test. Hint: the answer is yes!

In today’s episode, I’ll be talking about the oral glucose tolerance test as well as sharing some biohacks you’ve never heard of before related to fasting, low carb diets and exercise hacks. I’ll also be mentioning some other blood sugar markers and how they relate and compare to the oral glucose tolerance test and discussing whether there is a cheaper, more efficient and, arguably, more accurate alternative test. Hint: the answer is yes!

Blood Sugar Hacks, the Oral Glucose Tolerance Test and Biohacks You’ve Never Heard Of

In today’s episode, I’ll be talking about the blood sugar marker fructosamine. I’ll be comparing and contrasting it to the far more popular marker hemoglobin A1C.

In today’s episode, I’ll be talking about the blood sugar marker fructosamine. I’ll be comparing and contrasting it to the far more popular marker hemoglobin A1C.

Fructosamine: Underappreciated Yet Invaluable

In today’s episode, I’ll be discussing the good, the bad and the ugly of the blood sugar marker hemoglobin a1c. I’ll be breaking down how this marker works on a physiological level as well as how it’s used in the context of blood sugar regulation. I will elucidate some limitations and even potential pitfalls when using this marker.--- Send in a voice message: https://anchor.fm/rootcause/message

In today’s episode, I’ll be discussing the good, the bad and the ugly of the blood sugar marker hemoglobin a1c. I’ll be breaking down how this marker works on a physiological level as well as how it’s used in the context of blood sugar regulation. I will elucidate some limitations and even potential pitfalls when using this marker.--- Send in a voice message: <a href="https://anchor.fm/rootcause/message" rel="nofollow" target="_blank">https://anchor.fm/rootcause/message</a>

Hemoglobin A1c – a Good or Bad Marker?

In today’s episode, I’ll be getting into the blood chemistry marker fasting blood sugar. I’ll also discuss non-fasting blood sugar, some of the at-home biohacks you can do related to blood sugar as well as some of the various ways this test can be skewed and what to do about it.

In today’s episode, I’ll be getting into the blood chemistry marker fasting blood sugar. I’ll also discuss non-fasting blood sugar, some of the at-home biohacks you can do related to blood sugar as well as some of the various ways this test can be skewed and what to do about it.

Fasting Glucose and its Pitfalls

In this episode I’ll be giving an introductory primer to basic blood sugar physiology. What is glucose and how is it made? What is insulin and its role in blood sugar? What is glut 4 and its role? What role does GPL1 play? And much more.

In this episode I’ll be giving an introductory primer to basic blood sugar physiology. What is glucose and how is it made? What is insulin and its role in blood sugar? What is glut 4 and its role? What role does GPL1 play? And much more.

Blood Sugar Physiology 101

This podcast will focus on discussing matters of health, fitness, nutrition, biochemistry, human physiology and biohacking of all kinds. This show came out of my burning desire to connect you guys to world class experts that I personally have the great fortune of talking to regularly, from doctors to exercise scientists, nutritionists, leading researchers - and the list goes on. Basically any and all people who will help me and my audience reach a level of peak performance both physically and mentally. I consider myself a curator of information, and in these interviews, I’ll be teasing out all the complex scientific concepts and leaving you guys with actionable information to help you improve your quality of life. My goal is for these episodes to be fun and relaxed while still digging deep to obtain the answers to your burning questions.

This podcast will focus on discussing matters of health, fitness, nutrition, biochemistry, human physiology and biohacking of all kinds. This show came out of my burning desire to connect you guys to world class experts that I personally have the great fortune of talking to regularly, from doctors to exercise scientists, nutritionists, leading researchers - and the list goes on. Basically any and all people who will help me and my audience reach a level of peak performance both physically and mentally. I consider myself a curator of information, and in these interviews, I’ll be teasing out all the complex scientific concepts and leaving you guys with actionable information to help you improve your quality of life. My goal is for these episodes to be fun and relaxed while still digging deep to obtain the answers to your burning questions.

Intro

Root of the Cause Radio

The best podcast episodes of the most interesting stories and things. From skyping someone while they're in space, to tracking down and meeting a telephone scammer in person, to the story of a Galapagos. These episodes will keep you and all your friends entertained and captivated for hours. Learn something new in every episode! Add episodes you're interested into your queue below!

Best Episodes: Interesting Stories & Things

The Best Multi-Part Documentaries, with documentaries on Obama, Federer vs Nadal, the making of Star Wars, Netflix vs Blockbuster and more. Add episodes you're interested into your queue below!