Host: Todd Mahr, MD     Guest: Warner Carr, MD  What phases does the FDA use to approve a new medication, and why does this process take several years? Why must the active and excipient components of the medication, as well as the device, complete all of the testing phases? Dr. Warner Carr, allergist at Allergy and Asthma Associates in Mission Viejo, California, shares insight from his role as a new drug reviewer at the FDA. How do physicians play a vital role in the drug-approval process by providing clinical feedback to the FDA? Dr. Todd Mahr hosts.

Host: Todd Mahr, MD Guest: Warner Carr, MD What phases does the FDA use to approve a new medication, and why does this process take several years? Why must the active and excipient components of the medication, as well as the device, complete all of the testing phases? Dr. Warner Carr, allergist at Allergy and Asthma Associates in Mission Viejo, California, shares insight from his role as a new drug reviewer at the FDA. How do physicians play a vital role in the drug-approval process by providing clinical feedback to the FDA? Dr. Todd Mahr hosts.

The FDA Drug-Approval Process for Allergy Products


Host: Ketan Sheth, MD, MBA     Guest: Carlos Camargo, MD, DrPH, MPH  What's the best strategy for managing patients with chronic asthma, and how can physicians create an action plan with their patients to treat an asthma exacerbation? Host Dr. Ketan Sheth reviews recent guideline recommendations for preventing asthma exacerbations with Dr. Carlos Camargo, associate professor of medicine and epidemiology at Harvard Medical School. How are acute and chronic management of asthma different?

Host: Ketan Sheth, MD, MBA Guest: Carlos Camargo, MD, DrPH, MPH What's the best strategy for managing patients with chronic asthma, and how can physicians create an action plan with their patients to treat an asthma exacerbation? Host Dr. Ketan Sheth reviews recent guideline recommendations for preventing asthma exacerbations with Dr. Carlos Camargo, associate professor of medicine and epidemiology at Harvard Medical School. How are acute and chronic management of asthma different?

Preventing Asthma Exacerbations


Host: Ketan Sheth, MD, MBA     Guest: William Lumry, MD  Hereditary angioedema is relatively rare and is often misdiagnosed as an allergic reaction to medication or food. What symptoms are helpful differentiating points for making an accurate hereditary angioedema diagnosis? Dr. William Lumry, clinical professor of internal medicine at the University of Texas Southwestern Medical School, outlines the types of hereditary angioedema, factors which can contribute to an acute attack, and therapies to prevent or treat patients with this condition. Dr. Ketan Sheth hosts.

Host: Ketan Sheth, MD, MBA Guest: William Lumry, MD Hereditary angioedema is relatively rare and is often misdiagnosed as an allergic reaction to medication or food. What symptoms are helpful differentiating points for making an accurate hereditary angioedema diagnosis? Dr. William Lumry, clinical professor of internal medicine at the University of Texas Southwestern Medical School, outlines the types of hereditary angioedema, factors which can contribute to an acute attack, and therapies to prevent or treat patients with this condition. Dr. Ketan Sheth hosts.

Hereditary Angioedema


Host: Todd Mahr, MD     Guest: Sidney Braman, MD, FACP, FCCP  Chronic obstructive pulmonary disease, or COPD, is often diagnosed in late stages, as it is a slowly progressing condition. How can physicians diagnose patients with this deadly disease in its earlier stages, to increase the success of reversing some of its symptoms? Dr. Sidney Braman, professor of medicine at the Warren Alpert Medical School of Brown University, describes who is affected by COPD, and how physicians can best treat these patients. Dr. Todd Mahr hosts.

Host: Todd Mahr, MD Guest: Sidney Braman, MD, FACP, FCCP Chronic obstructive pulmonary disease, or COPD, is often diagnosed in late stages, as it is a slowly progressing condition. How can physicians diagnose patients with this deadly disease in its earlier stages, to increase the success of reversing some of its symptoms? Dr. Sidney Braman, professor of medicine at the Warren Alpert Medical School of Brown University, describes who is affected by COPD, and how physicians can best treat these patients. Dr. Todd Mahr hosts.

The COPD Spectrum


Host: Ketan Sheth, MD, MBA     Guest: William Silvers, MD  Are the symptoms of exercise-induced asthma always apparent, and if not, how can physicians diagnose the condition? Can exercise-induced asthma exist independently, or does it always signify an underlying asthmatic condition? Host Dr. Ketan Sheth discusses the pathogenesis of and treatments for exercise-induced asthma with Dr. William Silvers, clinical professor of medicine at the University of Colorado School of Medicine. Dr. Silvers will explain the phenomenon that the seemily innocuous food celery can specifically cause exercise-induced allergic reactions.

Host: Ketan Sheth, MD, MBA Guest: William Silvers, MD Are the symptoms of exercise-induced asthma always apparent, and if not, how can physicians diagnose the condition? Can exercise-induced asthma exist independently, or does it always signify an underlying asthmatic condition? Host Dr. Ketan Sheth discusses the pathogenesis of and treatments for exercise-induced asthma with Dr. William Silvers, clinical professor of medicine at the University of Colorado School of Medicine. Dr. Silvers will explain the phenomenon that the seemily innocuous food celery can specifically cause exercise-induced allergic reactions.

Management for Exercise-Induced Asthma


Host: Todd Mahr, MD     Guest: Steven Weinstein, MD  Clinical trials are essential to the safe development of medications. How are clinical trials structured, and what are the features of the various clinical trial stages? Dr. Steven Weinstein, clinical professor in the department of pediatrics at the University of California at Irvine, provides an overview of clinical trials with host Dr. Todd Mahr. What are the ethical considerations taken into account during clinical trials?

Host: Todd Mahr, MD Guest: Steven Weinstein, MD Clinical trials are essential to the safe development of medications. How are clinical trials structured, and what are the features of the various clinical trial stages? Dr. Steven Weinstein, clinical professor in the department of pediatrics at the University of California at Irvine, provides an overview of clinical trials with host Dr. Todd Mahr. What are the ethical considerations taken into account during clinical trials?

The Importance of Clinical Trials in Allergy Research


Host: Todd Mahr, MD     Guest: Bradley E. Chipps, MD, FAAP, FACAAI, FAAAAI, FCCP  What criteria are included in the modified asthma predictive index, and how does this index help physicians diagnose young patients with wheezing and coughing? When is bronchoscopy recommended as an important diagnostic tool for evaluating pediatric lower respiratory symptoms? Dr. Bradley Chipps, medical director of respiratory therapy at Sutter Medical Center, reviews how physicians might work up a young patient with these respiratory symptoms, and suggests the most effective treatments. Dr. Todd Mahr hosts.

Host: Todd Mahr, MD Guest: Bradley E. Chipps, MD, FAAP, FACAAI, FAAAAI, FCCP What criteria are included in the modified asthma predictive index, and how does this index help physicians diagnose young patients with wheezing and coughing? When is bronchoscopy recommended as an important diagnostic tool for evaluating pediatric lower respiratory symptoms? Dr. Bradley Chipps, medical director of respiratory therapy at Sutter Medical Center, reviews how physicians might work up a young patient with these respiratory symptoms, and suggests the most effective treatments. Dr. Todd Mahr hosts.

Managing Lower Respiratory Symptoms in Infants and Children


Host: Todd Mahr, MD     Guest: Jason Knuffman, MD  A cough that continues for more than a couple of months is considered chronic. What are the most likely causes of chronic cough in non-smoking adults, other than asthma? Dr. Jason Knuffman, allergist in the department of allergy at Gunderson Lutheran Health System in LaCrosse, Wisconsin, discusses how to avoid some common pitfalls that are often encountered when evaluating and treating adults with chronic cough. Dr. Todd Mahr hosts.

Host: Todd Mahr, MD Guest: Jason Knuffman, MD A cough that continues for more than a couple of months is considered chronic. What are the most likely causes of chronic cough in non-smoking adults, other than asthma? Dr. Jason Knuffman, allergist in the department of allergy at Gunderson Lutheran Health System in LaCrosse, Wisconsin, discusses how to avoid some common pitfalls that are often encountered when evaluating and treating adults with chronic cough. Dr. Todd Mahr hosts.

Evaluating and Treating Adult Chronic Cough


Host: Ketan Sheth, MD, MBA     Guest: Santiago Martinez, MD  What is the relationship between immunity and autism? Do the immune systems of those with autism function differently than the rest of the population? Dr. Santiago Martinez, clinical assistant professor at Florida State University College of Medicine, joins host Dr. Ketan Sheth to discuss the immune systems of autism patients. Is there any evidence that might suggest that autoimmune disorders in mothers can somehow contribute to the development of autism in their children?

Host: Ketan Sheth, MD, MBA Guest: Santiago Martinez, MD What is the relationship between immunity and autism? Do the immune systems of those with autism function differently than the rest of the population? Dr. Santiago Martinez, clinical assistant professor at Florida State University College of Medicine, joins host Dr. Ketan Sheth to discuss the immune systems of autism patients. Is there any evidence that might suggest that autoimmune disorders in mothers can somehow contribute to the development of autism in their children?

Probing the Connection Between Autism and Immunity


Host: Ketan Sheth, MD, MBA     Guest: J. Allen Meadows, MD  How are Medicare and health insurance companies affecting physicians and their patients' access to care? What can physicians do to influence policy at the local level? Dr. J. Allen Meadows, clinical instructor in the Montgomery Internal Medicine Residency Program at the University of Alabama at Birmingham, suggests ways allergists and other physicians can get involved with their communities and shape policies affecting how physicians care for their patients. Dr. Ketan Sheth hosts.

Host: Ketan Sheth, MD, MBA Guest: J. Allen Meadows, MD How are Medicare and health insurance companies affecting physicians and their patients' access to care? What can physicians do to influence policy at the local level? Dr. J. Allen Meadows, clinical instructor in the Montgomery Internal Medicine Residency Program at the University of Alabama at Birmingham, suggests ways allergists and other physicians can get involved with their communities and shape policies affecting how physicians care for their patients. Dr. Ketan Sheth hosts.

The Role of Allergists at the Grassroots of Medicine and Public Health


This series highlights expert perspectives, key studies, and breaking news from a diverse portfolio of allergy, asthma, and immunology topics. Hosted by clinical allergists Dr. Todd Mahr and Dr. Ketan Sheth, and produced in partnership with the American College of Asthma, Allergy, and Immunology, Hot Topics in Allergy is America's go-to resource for accurate and timely AAI education.

Hot Topics in Allergy

Host: Ketan Sheth, MD, MBA     Guest: Jay Portnoy, MD  Molds are unique organisms that surround us, yet there is growing concern about how molds can impact our health. What sorts of bodily reactions are linked to molds? Should we be worried about adverse health effects from all molds or are some generally safe? Dr. Jay Portnoy, chief of allergy, asthma and immunology at Children's Mercy Hospitals and Clinics and professor of pediatrics at the University of Missouri-Kansas City School of Medicine, discusses the realities of ever-present molds with host Dr. Ketan Sheth.

Host: Ketan Sheth, MD, MBA Guest: Jay Portnoy, MD Molds are unique organisms that surround us, yet there is growing concern about how molds can impact our health. What sorts of bodily reactions are linked to molds? Should we be worried about adverse health effects from all molds or are some generally safe? Dr. Jay Portnoy, chief of allergy, asthma and immunology at Children's Mercy Hospitals and Clinics and professor of pediatrics at the University of Missouri-Kansas City School of Medicine, discusses the realities of ever-present molds with host Dr. Ketan Sheth.

The Facts on Mold's Health Effects


Host: Ketan Sheth, MD, MBA     Guest: Stuart Stoloff, MD  For the first time in 10 years, the guidelines for allergy management have been significantly updated. With the goal of optimizing asthma control for every patient, how were the new guidelines created, and how should they be applied? Dr. Stuart Stoloff, a family practitioner from Carson City, Nevada, and member of the National Asthma Education and Prevention Program’s Expert Panel 3, speaks with your host, Dr. Ketan Sheth on the creation of the new guidelines and their application in the exam room.

Host: Ketan Sheth, MD, MBA Guest: Stuart Stoloff, MD For the first time in 10 years, the guidelines for allergy management have been significantly updated. With the goal of optimizing asthma control for every patient, how were the new guidelines created, and how should they be applied? Dr. Stuart Stoloff, a family practitioner from Carson City, Nevada, and member of the National Asthma Education and Prevention Program’s Expert Panel 3, speaks with your host, Dr. Ketan Sheth on the creation of the new guidelines and their application in the exam room.

Bringing Allergy Guidelines into the Patient Exam Room


Host: Todd Mahr, MD     Guest: Stephen Tilles, MD  Aspirin is something widely used in everyday practice, and generally well-tolerated. Yet, potentially serious adverse effects - sometimes leading to hospitalization - exist. Who's at risk? What are the symptoms, and can Aspirin desensitization work for all patients? Join Dr. Todd A. Mahr as he speaks with Dr. Stephen Tilles, clinical assistant professor at the University of Washington School of Medicine, in a discussion of aspirin intolerance.

Host: Todd Mahr, MD Guest: Stephen Tilles, MD Aspirin is something widely used in everyday practice, and generally well-tolerated. Yet, potentially serious adverse effects - sometimes leading to hospitalization - exist. Who's at risk? What are the symptoms, and can Aspirin desensitization work for all patients? Join Dr. Todd A. Mahr as he speaks with Dr. Stephen Tilles, clinical assistant professor at the University of Washington School of Medicine, in a discussion of aspirin intolerance.

Aspirin Intolerance: Testing & Desensitization


Host: Ketan Sheth, MD, MBA     Guest: John Oppenheimer, MD  Although asthma is chronic, it is treatable. The new asthma guidelines demonstrate a shift in attitudes. Whereas we used to assess the severity of the condition, now we ask how well it is controlled. Dr. John Oppenheimer, director of clinical research at Pulmonary and Allergy Associates as well as clinical associate professor of medicine at the New Jersey Medical School in Newark, New Jersey, explores the best ways to follow asthma control with host Dr. Ketan Sheth.

Host: Ketan Sheth, MD, MBA Guest: John Oppenheimer, MD Although asthma is chronic, it is treatable. The new asthma guidelines demonstrate a shift in attitudes. Whereas we used to assess the severity of the condition, now we ask how well it is controlled. Dr. John Oppenheimer, director of clinical research at Pulmonary and Allergy Associates as well as clinical associate professor of medicine at the New Jersey Medical School in Newark, New Jersey, explores the best ways to follow asthma control with host Dr. Ketan Sheth.

Best Ways to Follow Asthma Control


Host: Todd Mahr, MD     Guest: William Berger, MD     Guest: Bradley E. Chipps, MD, FAAP, FACAAI, FAAAAI, FCCP  Recent research confirms adolescent asthma and obesity directly correlates with significant risk of adult asthma. Does obesity impact the therapy response rate? Which current devices confer precise delivery of medication? Host Dr. Todd Mahr guides a dialogue with Dr. Bradley Chipps, medical director of the Capital Allergy &amp; Respiratory Disease Center in Sacramento, Calif., and Dr. William Berger, medical director of the Allergy and Asthma Associates of Southern California.

Host: Todd Mahr, MD Guest: William Berger, MD Guest: Bradley E. Chipps, MD, FAAP, FACAAI, FAAAAI, FCCP Recent research confirms adolescent asthma and obesity directly correlates with significant risk of adult asthma. Does obesity impact the therapy response rate? Which current devices confer precise delivery of medication? Host Dr. Todd Mahr guides a dialogue with Dr. Bradley Chipps, medical director of the Capital Allergy &amp; Respiratory Disease Center in Sacramento, Calif., and Dr. William Berger, medical director of the Allergy and Asthma Associates of Southern California.

Obesity and Asthma: Tracking Health Outcomes from Childhood through Adulthood


Host: Todd Mahr, MD     Guest: Ketan Sheth, MD, MBA  Dr Ketan Sheth was one of the advisors on the Pediatric Allergies in America survey. This was the largest and most comprehensive national survey of parents of allergy sufferers, allergy sufferers under age 18, and health provider perspectives concerning allergic rhinitis. The survey was designed using the same methods and many of the same measures as Allergies in America (2006). A number of important conclusions about the current state of nasal allergies among American children are:  Nasal congestion was the most frequent and bothersome symptom for children with allergies; Children suffer considerable discomfort during allergy attacks, such that one third of parents reported their child’s discomfort was not tolerable without relief; Impact of nasal allergies to a child’s productivity is considerable with an average loss of 29% among children with allergies on days when their allergies are at their worst; Patient non-compliance with prescribed treatment for the condition is driven more by dissatisfaction with product effectiveness and duration, than side effects, cost or ease of administration; Doctors and parents agreed that better education of parents about their child’s condition and treatment of allergic rhinitis is important.  The findings from the Pediatrics Allergies in America survey identify important challenges …

Host: Todd Mahr, MD Guest: Ketan Sheth, MD, MBA Dr Ketan Sheth was one of the advisors on the Pediatric Allergies in America survey. This was the largest and most comprehensive national survey of parents of allergy sufferers, allergy sufferers under age 18, and health provider perspectives concerning allergic rhinitis. The survey was designed using the same methods and many of the same measures as Allergies in America (2006). A number of important conclusions about the current state of nasal allergies among American children are: <ul> <li>Nasal congestion was the most frequent and bothersome symptom for children with allergies;</li> <li>Children suffer considerable discomfort during allergy attacks, such that one third of parents reported their child’s discomfort was not tolerable without relief;</li> <li>Impact of nasal allergies to a child’s productivity is considerable with an average loss of 29% among children with allergies on days when their allergies are at their worst;</li> <li>Patient non-compliance with prescribed treatment for the condition is driven more by dissatisfaction with product effectiveness and duration, than side effects, cost or ease of administration;</li> <li>Doctors and parents agreed that better education of parents about their child’s condition and treatment of allergic rhinitis is important.</li> </ul> The findings from the Pediatrics Allergies in America survey identify important challenges …

Highlights from the 'Pediatric Allergies in America' Survey


Host: Todd Mahr, MD     Guest: Stephen Tilles, MD  How common is Aspirin Intolerance? When was it first discovered, and what are the clinical manifestations? Dr. Stephen Tilles, clinical assistant professor at the University of Washington School of Medicine, joins Dr. Todd A. Mahr to discuss aspirin intolerance, highlighting symptoms and provocative testing.

Host: Todd Mahr, MD Guest: Stephen Tilles, MD How common is Aspirin Intolerance? When was it first discovered, and what are the clinical manifestations? Dr. Stephen Tilles, clinical assistant professor at the University of Washington School of Medicine, joins Dr. Todd A. Mahr to discuss aspirin intolerance, highlighting symptoms and provocative testing.

Aspirin Intolerance: Prevalence & Diagnosis


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