original episode notes and transcript here: https://future.a16z.com/podcasts/malaria-vaccine-tech-science-news/ Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. As with all of the episodes on this show about tech &amp; science trends in the news, and where they are on the long arc of innovation -- this one is actually a story of human ingenuity over 100 years in the making, with the ultimate breakthrough in a malaria vaccine just last year that we discuss here. (And while we were one of the very first to cover the coronavirus pandemic back in Jan 2020, and several episodes all about vaccines, this is an unusual one: fighting a parasite vs a virus, what that means, how, and why it matters.)It is also one of Chokshi's signature “2x explainers”, where we quickly cover the headlines and tech trends, but also offer evergreen explainers, analysis, frameworks, and more to understand those trends -- whether it was TikTok’s algorithm, GPT-3, the opioid crisis, or the anatomy of a hack. Thank you to you all for listening, sharing, engaging and coming along with us on this journey! Thank you as well to our brilliant audio editors, expert guests, and several others. The team will be putting this feed on hiatus temporarily, and in the meantime, you can follow my other work here at a16z as well as other projects on Twitter @smc90. Stay tuned for more! 

original episode notes and transcript here: <a href="" rel="nofollow" target="_blank">https://future.a16z.com/podcasts/malaria-vaccine-tech-science-news/ </a>Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she <a href="https://twitter.com/smc90/status/1489713548699701248" rel="nofollow" target="_blank">shifts</a> gears and the show goes on hiatus until relaunched with a new host. As with all of the episodes on this show about tech &amp; science trends in the news, and where they are on the long arc of innovation -- this one is actually a story of human ingenuity over 100 years in the making, with the ultimate breakthrough in a malaria vaccine just last year that we discuss here. (And while we were one of the very first to cover the coronavirus pandemic back in Jan 2020, and several episodes all about vaccines, this is an unusual one: fighting a parasite vs a virus, what that means, how, and why it matters.)It is also one of Chokshi's signature “2x explainers”, where we quickly cover the headlines and tech trends, but also offer evergreen explainers, analysis, frameworks, and more to understand those trends -- whether it was <a href="https://future.a16z.com/podcasts/tiktok-seeing-like-algorithm/" rel="nofollow" target="_blank">TikTok’s algorithm</a>, <a href="https://future.a16z.com/podcasts/natural-language-deep-learning/" rel="nofollow" target="_blank">GPT-3</a>, <a href="https://future.a16z.com/podcasts/opioid-crisis-dea-database/" rel="nofollow" target="_blank">the opioid crisis</a>, or the <a href="https://future.a16z.com/podcasts/solarwinds-hack-explained/" rel="nofollow" target="_blank">anatomy of a hack</a>.  Thank you to you all for listening, sharing, engaging and coming along with us on this journey! Thank you as well to our brilliant audio editors, expert guests, and several others. The team will be putting this feed on hiatus temporarily, and in the meantime, you can follow my other work here at a16z as well as other projects on Twitter <a href="https://twitter.com/smc90" rel="nofollow" target="_blank">@smc90</a>. Stay tuned for more!

Parasite, the Malaria (Tech & Science) Edition

Watershed

Welcome to 16 Minutes, our podcast where we discuss tech trends in the news and their impact on the long arc of innovation. Today’s topic is crypto regulation, and specifically, two recent federal government hearings in the news that were focused on crypto and therefore the related trend of web3. In contrast to the model of web2 — typified by very broadly used but also very centralized platforms run by corporations — web3 refers to the idea of a new internet enabled by crypto that is owned by builders and users.The first hearing that took place was at the House Committee on Financial Services, featuring six crypto company CEOs and resulting in a five-hour session that prompted headlines like “Congress Gets a Crash Course on Cryptocurrency.” Then, just last week, the U.S. Senate’s Banking, Housing, and Urban Affairs Committee held its own hearing, this time focused on stablecoins, which are privately issued cryptocurrencies that are pegged to a stable asset such as the U.S. dollar, and are used in decentralized financial services. We’ve covered crypto regulatory issues on 16 Minutes before with a16z experts, including an episode with former federal prosecutor  Katie Haun and former New York Stock Exchange regulatory chief Anthony Albanese. That discussion, which you can find in this feed under episode #50, was about a proposal by the Treasury Department’s financial crimes enforcement arm that included provisions for digital asset reporting. (As a reminder, none of the following should be taken as investment advice, please see a16z.com/disclosures for more important information.) All of these hearings are also connected to the broader question of innovation, and keeping the U.S. competitive on a global stage.So with that context, our guest today is a16z global head of policy Tomicah Tillemann, who before joining a16z served as senior advisor to two secretaries of state. He reports on the hearings and their significance, and gives a quick pulse-check on where we are with crypto regulation right now.

Welcome to 16 Minutes, our podcast where we discuss tech trends in the news and their impact on the long arc of innovation. Today’s topic is crypto regulation, and specifically, two recent federal government hearings in the news that were focused on crypto and therefore the related trend of web3. In contrast to the model of web2 — typified by very broadly used but also very centralized platforms run by corporations — web3 refers to the idea of a new internet enabled by crypto that is owned by builders and users.The first hearing that took place was at the House Committee on Financial Services, featuring six crypto company CEOs and resulting in a five-hour session that prompted <a href="https://www.nytimes.com/2021/12/08/business/house-financial-services-crypto.html" rel="nofollow" target="_blank">headlines</a> like “Congress Gets a Crash Course on Cryptocurrency.” Then, just last week, the U.S. Senate’s Banking, Housing, and Urban Affairs Committee held its own <a href="https://www.banking.senate.gov/hearings/stablecoins-how-do-they-work-how-are-they-used-and-what-are-their-risks" rel="nofollow" target="_blank">hearing</a>, this time focused on stablecoins, which are privately issued cryptocurrencies that are pegged to a stable asset such as the U.S. dollar, and are used in decentralized financial services. We’ve covered crypto regulatory issues on 16 Minutes before with a16z experts, including an episode with former federal prosecutor  Katie Haun and former New York Stock Exchange regulatory chief Anthony Albanese. That discussion, which you can find in this feed under episode #50, was about a proposal by the Treasury Department’s financial crimes enforcement arm that included provisions for digital asset reporting. (As a reminder, none of the following should be taken as investment advice, please see <a href="http://a16z.com/disclosures" rel="nofollow" target="_blank">a16z.com/disclosures</a> for more important information.) All of these hearings are also connected to the broader question of innovation, and keeping the U.S. competitive on a global stage.So with that context, our guest today is a16z global head of policy <a href="https://a16z.com/author/tomicah-tillemann/" rel="nofollow" target="_blank">Tomicah Tillemann</a>, who before joining a16z served as senior advisor to two secretaries of state. He reports on the hearings and their significance, and gives a quick pulse-check on where we are with crypto regulation right now.

Crypto at Congress: 'Watershed' Moment for Regulation and Web3

Welcome to 16 Minutes, our show on the a16z podcast network where we talk about tech trends that are dominating news headlines, industry buzz, and where we are on the long arc of innovation. Today’s episode actually features a look back at the GameStop saga — the stock market drama that some headlines described as a “David-and-Goliath battle” that quote “upended Wall Street.” For quick basic context, here’s what happened: A group of Reddit users mass-purchased and drove up prices of stock in the video game retailer GameStop, forcing short sellers including hedge funds and institutional investors to back out in a short squeeze, pushing prices even higher. But beyond the news, this also portended other, broader trends including redefining the power of retail investors, the phenomenon of meme stocks, and more.  So in this episode — which is from a conversation that originally took place live on Clubhouse  (and which, by the way, can also be found on the a16z Live feed) —  a16z co-founder Marc Andreessen talks to Ken Griffin, founder and CEO of the hedge fund Citadel, which was a key player in GameStop as both a market maker and investor. You’ll also hear a16z general partner and fintech expert Alex Rampell join later in the conversation.Griffin also just purchased (in a Sotheby’s auction a little over two weeks ago) one of the original copies of the U.S. Constitution, an auction in which a decentralized autonomous organization called ConstitutionDAO also bid on buying it. Marc and Ken touch briefly on this at the very end. 

Welcome to 16 Minutes, our show on the a16z podcast network where we talk about tech trends that are dominating news headlines, industry buzz, and where we are on the long arc of innovation. Today’s episode actually features a look back at the GameStop saga — the stock market drama that some headlines described as a “David-and-Goliath battle” that quote “<a href="https://abcnews.go.com/Business/gamestop-timeline-closer-saga-upended-wall-street/story?id=75617315" rel="nofollow" target="_blank">upended Wall Street.</a>” For quick basic context, here’s what happened: A group of Reddit users mass-purchased and drove up prices of stock in the video game retailer GameStop, forcing short sellers including hedge funds and institutional investors to back out in a short squeeze, pushing prices even higher. But beyond the news, this also portended other, broader trends including redefining the power of retail investors, the phenomenon of meme stocks, and more.  So in this episode — which is from a conversation that originally took place live on Clubhouse  (and which, by the way, can also be found on the a16z Live feed) —  a16z co-founder Marc Andreessen talks to Ken Griffin, founder and CEO of the hedge fund Citadel, which was a key player in GameStop as both a market maker and investor. You’ll also hear a16z general partner and fintech expert Alex Rampell join later in the conversation.Griffin also just purchased (in a Sotheby’s auction a little over two weeks ago) one of the original copies of the U.S. Constitution, an auction in which a decentralized autonomous organization called ConstitutionDAO also bid on buying it. Marc and Ken touch briefly on this at the very end.

Inside the GameStop Drama; The U.S. Constitution, Auctioned

Welcome to 16 Minutes, our show where we talk about tech trends in the news. We have two segments today: 1) The announcement recently that Valve Software, which operates the massive gaming platform Steam, added a rule against games that use blockchain technologies or that allow users to exchange cryptocurrencies or NFTs – this rule appeared on its “What you shouldn’t publish on Steam” onboarding list for developers. We go beyond the players to the trends at play here, putting the news in context — as is the premise of this show — because it not only immediately impacts gaming developers and gamers using the platform, but has implications for gaming business models and the arc of innovation in gaming as part of the web3 movement. Our expert guests are a16z partner Jonathan Lai and a16z partner Eddy Lazzarin. 2) The FDA’s announcement last month that it authorized marketing of the “first artificial intelligence (AI)-based software designed to identify an area of interest on the prostate biopsy image with the highest likelihood of harboring cancer so it can be reviewed further by the pathologist if the area of concern has not been identified on initial review.” The FDA reviewed the technology from Paige Prostate through its De Novo regulatory pathway. We have three expert guests: Eli Van Allen, associate professor of Medicine at Harvard Medical School and chief of the Division of Population Sciences at the Dana-Farber Cancer Institute; a16z bio general partner Vineeta  Agarwala; and a16z bio partner Jay Rughani.

Welcome to 16 Minutes, our show where we talk about tech trends in the news. We have two segments today: 1) The announcement recently that Valve Software, which operates the massive gaming platform Steam, added a rule against games that use blockchain technologies or that allow users to exchange cryptocurrencies or NFTs – this rule appeared on its “What you shouldn’t publish on Steam” onboarding list for developers. We go beyond the players to the trends at play here, putting the news in context — as is the premise of this show — because it not only immediately impacts gaming developers and gamers using the platform, but has implications for gaming business models and the arc of innovation in gaming as part of the web3 movement. Our expert guests are a16z partner Jonathan Lai and a16z partner Eddy Lazzarin. 2) The FDA’s announcement last month that it authorized marketing of the “first artificial intelligence (AI)-based software designed to identify an area of interest on the prostate biopsy image with the highest likelihood of harboring cancer so it can be reviewed further by the pathologist if the area of concern has not been identified on initial review.” The FDA reviewed the technology from Paige Prostate through its De Novo regulatory pathway. We have three expert guests: Eli Van Allen, associate professor of Medicine at Harvard Medical School and chief of the Division of Population Sciences at the Dana-Farber Cancer Institute; a16z bio general partner Vineeta Agarwala; and a16z bio partner Jay Rughani.

Steam Halts Web3 Games; FDA Approves Prostate Cancer AI

In today’s episode we have two short segments, both on bioscience topics:[0:00] Moderna has started clinical trials for a flu vaccine, called mRNA-1010, that is based on the same mRNA technology that Moderna and Pfizer used for their COVID vaccines, and that several other companies including Sanofi and Glaxo all are actively working on for the influenza use case. Our experts are general partners Vineeta Agarwala and Jorge Conde of the a16z bio team, who have joined us on many of our vaccine-related episodes, which you can find at a16z.com/vaccines. They discuss what comes next for the clinical trials of this mRNA-based flu vaccines, why companies aren't planning to use the faster and more-targeted mRNA technology for COVID's Delta variant, and how mRNA vaccines will change not only our approach to flu shots but to other respiratory viruses. [9:53] Google’s DeepMind AlphaFold, in partnership with the European Molecular Biology Laboratory, is publicly sharing its entire protein structure database -- with predicted protein structure models for  ~20,000 proteins expressed by the human genome -- meaning that all its data will be freely and openly available to the scientific community. (We previously discussed DeepMind's AlphaFold protein-folding AI on this show in episode #48.) General partner Vijay Pande of the a16z bio team helps us answer the question: Why does it matter that a huge database of very accurate predicted protein structures is now freely available?

In today’s episode we have two short segments, both on bioscience topics: [0:00] Moderna has started clinical trials for a flu vaccine, called mRNA-1010, that is based on the same mRNA technology that Moderna and Pfizer used for their COVID vaccines, and that several other companies including Sanofi and Glaxo all are actively working on for the influenza use case. Our experts are general partners Vineeta Agarwala and Jorge Conde of the a16z bio team, who have joined us on many of our vaccine-related episodes, which you can find at <a href="http://a16z.com/vaccines" rel="nofollow" target="_blank">a16z.com/vaccines</a>. They discuss what comes next for the clinical trials of this mRNA-based flu vaccines, why companies aren't planning to use the faster and more-targeted mRNA technology for COVID's Delta variant, and how mRNA vaccines will change not only our approach to flu shots but to other respiratory viruses. [9:53] Google’s DeepMind AlphaFold, in partnership with the European Molecular Biology Laboratory, is publicly sharing its entire protein structure database -- with predicted protein structure models for ~20,000 proteins expressed by the human genome -- meaning that all its data will be freely and openly available to the scientific community. (We previously discussed DeepMind's AlphaFold protein-folding AI on this show in episode #48.) General partner Vijay Pande of the a16z bio team helps us answer the question: Why does it matter that a huge database of very accurate predicted protein structures is now freely available?

mRNA for Flu Vaccine? AI Protein-Folding Goes Open Source

Given recent news of drug company settlements, calls to action, policy moves, and more, this episode is a rerun of one of our very early explainers (episode #4 of 16 Minutes, 2019) on the opioid crisis. Bio experts and a16z general partners Jorge Conde and Vijay Pande discuss on 16 Minutes (our shortform show where we discuss the headlines, tease apart what's hype' what's real, and where we are on the long arc of innovation) with host Sonal Chokshi: how opioids work;the questions around who's to blame;and other directions for managing pain.Where could tech come in, even with the broader social, cultural, and structural context involved here?original episode:https://a16z.com/2019/08/04/16mins-news-opioid-crisis-dea-database/

Given recent news of drug company settlements, <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01653-6/fulltext" rel="nofollow" target="_blank">calls</a> to action, policy moves, and more, this episode is a rerun of one of our very early explainers (episode #4 of 16 Minutes, 2019) on the opioid crisis. Bio experts and a16z general partners Jorge Conde and Vijay Pande discuss on 16 Minutes (our shortform show where we discuss the headlines, tease apart what's hype' what's real, and where we are on the long arc of innovation) with host Sonal Chokshi: <ul><li>how opioids work;</li><li>the questions around who's to blame;</li><li>and other directions for managing pain.</li></ul>Where could tech come in, even with the broader social, cultural, and structural context involved here?original episode: <a href="https://a16z.com/2019/08/04/16mins-news-opioid-crisis-dea-database/" rel="nofollow" target="_blank">https://a16z.com/2019/08/04/16mins-news-opioid-crisis-dea-database/</a>

Opioid Crisis - How, Who, and Tech

Welcome to 16 Minutes, the a16z show where we talk about tech trends in the news, what’s hype and what’s real, and the long arc of innovation.In today's episode we’re talking about the latest developments and trends in cybercrime – including the trends of ransomware, and, attacks on physical infrastructure.First (0:00 - 6:07), we have the recent attack on the meat processing plant JBS, the largest meat processor in the world; just last week it had to temporarily shut down some operations in the U.S., Canada, and Australia due to an attack on its servers, with the hackers demanding payment from the company. These types of “ransomware" attacks are increasing – recently hackers hit the Colonial Pipeline, the largest refined oil pipeline in the U.S., and disrupted fuel distribution on the East Coast. In that attack, hackers demanded and received millions in ransom, though the Justice Department announced on Monday it had recovered much of that ransom, paid in bitcoin. Hackers have also recently hit health care organizations, school systems, and even ferry services.In the second segment (6:08 - 12:13), we’ll briefly talk about the breach of home and enterprise wireless network management technology provider Ubiquiti. Security researcher Brian Krebs reported allegations from a whistleblower, and more recently, lawsuits have been filed. Here we’ll focus on the questions it raises for security.  Both segments feature a16z operating partner for security (and former Box CSO) Joel de la Garza. Martin Casado, a16z general partner and co-founder of networking company Nicira, joins us for the second segment.###The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Welcome to 16 Minutes, the a16z show where we talk about tech trends in the news, what’s hype and what’s real, and the long arc of innovation.In today's episode we’re talking about the latest developments and trends in cybercrime – including the trends of ransomware, and, attacks on physical infrastructure.First (0:00 - 6:07), we have the recent attack on the meat processing plant JBS, the largest meat processor in the world; just last week it had to temporarily shut down some operations in the U.S., Canada, and Australia due to an attack on its servers, with the hackers demanding payment from the company. These types of “ransomware" attacks are increasing – recently hackers hit the Colonial Pipeline, the largest refined oil pipeline in the U.S., and disrupted fuel distribution on the East Coast. In that attack, hackers demanded and received millions in ransom, though the Justice Department announced on Monday it had recovered much of that ransom, paid in bitcoin. Hackers have also recently hit health care organizations, school systems, and even ferry services.In the second segment (6:08 - 12:13), we’ll briefly talk about the breach of home and enterprise wireless network management technology provider Ubiquiti. Security researcher Brian Krebs reported allegations from a whistleblower, and more recently, lawsuits have been filed. Here we’ll focus on the questions it raises for security.  Both segments feature a16z operating partner for security (and former Box CSO) Joel de la Garza. Martin Casado, a16z general partner and co-founder of networking company Nicira, joins us for the second segment.###The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Ransomware Attacks on the Rise; Hackers Target IoT

Given recent buzz and ongoing debates around the Endless Frontiers Act -- which some have described as “the most important piece of legislation no one's heard of” -- this episode is a rerun of an episode from last year, recorded after said act was initially unveiled. The short discussion covers the broader topic and theme of funding science and innovation, and R&amp;D in general -- not just in government agencies, but corporations, and the overall landscape there as well. Notably, the name of the Endless Frontiers act was inspired by the famous memo, “Science, the Endless Frontier”, which was a report to the then U.S.-President by Vannevar Bush, Director of the Office of Scientific Research and Development in July 1945 -- and that led to the creation of the independent government agency the National Science Foundation (NSF).For quick context (without covering current discussions/ updates in the news right now) -- the bipartisan proposal had proposed giving NSF over $100B over 5 years in funding.  It had also proposed rebranding the National Science Foundation into the National "Science and Technology" Foundation, which a16z general partner Martin Casado (who has worked the full spectrum from academia to research lab to startup to big company) discusses with Sonal Chokshi in this episode.  You can also find their conversation  with former Stanford president John Hennessy and Marc Andreessen on the changing relationship between academia and industry at a16z.com/researchtostartup. original episode: https://a16z.com/2020/07/09/16mins-nsf-funding-science-corporate-innovation-remote-work-new-normal-future/ 

Given recent buzz and ongoing debates around the Endless Frontiers Act -- which some have described as “the most important piece of legislation no one's heard of” -- this episode is a rerun of an episode from last year, recorded after said act was initially unveiled. The short discussion covers the broader topic and theme of funding science and innovation, and R&amp;D in general -- not just in government agencies, but corporations, and the overall landscape there as well. Notably, the name of the Endless Frontiers act was inspired by the famous memo, “<a href="https://www.nsf.gov/od/lpa/nsf50/vbush1945.htm" rel="nofollow" target="_blank">Science, the Endless Frontier</a>”, which was a report to the then U.S.-President by Vannevar Bush, Director of the Office of Scientific Research and Development in July 1945 -- and that led to the creation of the independent government agency the National Science Foundation (NSF).For quick context (without covering current discussions/ updates in the news right now) -- the bipartisan proposal had proposed giving NSF over $100B over 5 years in funding.  It had also proposed rebranding the National Science Foundation into the National "Science and Technology" Foundation, which a16z general partner Martin Casado (who has worked the full spectrum from academia to research lab to startup to big company) discusses with Sonal Chokshi in this episode.  You can also find their conversation  with former Stanford president John Hennessy and Marc Andreessen on the changing relationship between academia and industry at <a href="http://a16z.com/researchtostartup" rel="nofollow" target="_blank">a16z.com/researchtostartup</a>. original episode: <a href="" rel="nofollow" target="_blank">https://a16z.com/2020/07/09/16mins-nsf-funding-science-corporate-innovation-remote-work-new-normal-future/</a>

Science (and Tech), the Endless Frontier

Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five.So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- Rajeev Venkayya of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and what's left to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease?Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been nearly a century in the making. 

Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the <a href="https://www.ox.ac.uk/news/2021-04-23-malaria-vaccine-becomes-first-achieve-who-specified-75-efficacy-goal" rel="nofollow" target="_blank">news that came out</a> a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in <a href="https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3830681" rel="nofollow" target="_blank">preprint</a> with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five.So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- <a href="https://www.takeda.com/who-we-are/company-information/executive-leadership/rajeev-venkayya/" rel="nofollow" target="_blank">Rajeev Venkayya</a> of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and <a href="https://www.nature.com/articles/d41586-021-01096-7" rel="nofollow" target="_blank">what's left</a> to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease?Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been <a href="https://academic.oup.com/cid/article/60/6/930/497479" rel="nofollow" target="_blank">nearly a century</a> in the making.

Malaria Vaccine Breakthrough, Beyond the Buzz

In this week’s episode of 16 Minutes, our show where we cover tech trends in the news — and also cover themes from company developer and innovation events! — we focus on the latest coming out of Apple’s event this week. The company announced a bunch of things, ranging from new device colors and form factors to podcast services, but in this episode we asked regular guest Steven Sinofsky (an a16z board partner and former Microsoft Windows president who has appeared on past event episodes including covering CES and Apple’s M1 chip) to weigh in. He shares what he thinks all these moves say about the evergreen “consumer vs. professional” question, to what the company’s new devices (namely tablets, personal computers, and TVs) tell us about the long arc of innovation.

In this week’s episode of 16 Minutes, our show where we cover tech trends in the news — and also cover themes from company developer and innovation events! — we focus on the latest coming out of Apple’s event this week. The company announced a bunch of things, ranging from new device colors and form factors to podcast services, but in this episode we asked regular guest Steven Sinofsky (an a16z board partner and former Microsoft Windows president who has appeared on past event episodes including covering CES and Apple’s M1 chip) to weigh in. He shares what he thinks all these moves say about the evergreen “consumer vs. professional” question, to what the company’s new devices (namely tablets, personal computers, and TVs) tell us about the long arc of innovation.

Apple Event: Desktop-Tablet Convergence, Cord-Cutting, "Find Anything," & More

16 Minutes on the News is a short news podcast where we cover the top headlines of the week, the a16z podcast way -- why are these topics in the news; what's real, what's hype from our vantage point; and what are our experts' quick takes on these trends?About the a16z Podcast: Discusses tech and culture trends, news, and the future -- especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes -- and now shows -- are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

Please keep it up! Excellent way to keep up with news. Great achievement.  Sonol is a total QUEEN!

Fantastic news resource // smart and deep

Outside of the mainstream, good production

16 Minutes on the News is a short news podcast where we cover the top headlines of the week, the a16z podcast way -- why are these topics in the news; what's real, what's hype from our vantage point; and what are our experts' quick takes on these trends? About the a16z Podcast: Discusses tech and culture trends, news, and the future -- especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes -- and now shows -- are released every week; visit <a href="http://a16z.com" rel="nofollow" target="_blank">a16z.com</a> for more details and to sign up for our newsletters and other content as well!

16 Minutes News by a16z

This is the 14th episode of 16 Minutes, our weekly-ish news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts general partner Julie Yoo and market dev partner Venkat Mocherla from the bio team, and former CSO/ a16z security operating partner Joel de la Garza -- in conversation with Sonal Chokshi:UPS drones deliver prescriptions -- For the first time ever, drones delivered prescription medication directly to residential homes and retirement homes in North Carolina this month; but why don't we already get drugs by delivery? And what's the significance of pharma as a node in the healthcare system?Apple opens health records to vets -- Apple and the Department of Veterans Affairs announced recently that veterans can now access their health information on their iPhones; why is (or isn't) this significant, and wherefore the promise of EHRs (electronic health records)?!hackers can use lasers to command voice devices -- Security researchers were able to send laser-powered “light commands” to smart assistants (including products like Amazon’s Alexa, Apple’s Siri, Facebook’s Portal, and Google Assistant) to take full control over them at specific distances; how worried should we be, and how does this affect the future of a voice-enabled world?Relevant/ related links:on healthcare delivery and the pharma industry:software eats care delivery by Julie Yooscience, business, and innovation in pharma with Vas Narasimhan, Jorge Conde, Vijay Pande, and Sonal Chokshion hacks of all kinds:https://a16z.com/tag/hacked/

This is the 14th episode of 16 Minutes, our weekly-ish news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts general partner Julie Yoo and market dev partner Venkat Mocherla from the bio team, and former CSO/ a16z security operating partner Joel de la Garza -- in conversation with Sonal Chokshi:<ol><li>UPS drones deliver prescriptions -- For <a href="https://www.theverge.com/2019/11/6/20951213/ups-drone-delivery-prescription-medication-north-carolina-pharmacy-matternet" rel="nofollow" target="_blank">the first time</a> ever, drones delivered prescription medication directly to residential homes and retirement homes in North Carolina this month; but why don't we already get drugs by delivery? And what's the significance of pharma as a node in the healthcare system?</li><li>Apple opens health records to vets -- Apple and the Department of Veterans Affairs <a href="https://www.cnbc.com/amp/2019/11/06/apple-opens-up-its-health-records-service-to-veterans-with-iphones.html" rel="nofollow" target="_blank">announced recently</a> that veterans can now access their health information on their iPhones; why is (or isn't) this significant, and wherefore the promise of EHRs (electronic health records)?!</li><li>hackers can use lasers to command voice devices -- Security researchers <a href="https://www.wired.com/story/lasers-hack-amazon-echo-google-home/" rel="nofollow" target="_blank">were able to send</a> laser-powered “<a href="https://lightcommands.com/20191104-Light-Commands.pdf" rel="nofollow" target="_blank">light commands</a>” to smart assistants (including products like Amazon’s Alexa, Apple’s Siri, Facebook’s Portal, and Google Assistant) to take full control over them at specific distances; how worried should we be, and how does this affect the future of a voice-enabled world?</li></ol><h3>Relevant/ related links:</h3><ul><li>on healthcare delivery and the pharma industry:<ul><li><a href="https://a16z.com/2019/07/31/video-software-eats-care-delivery/" rel="nofollow" target="_blank">software eats care delivery by Julie Yoo</a></li><li><a href="https://a16z.com/author/vas-narasimhan/" rel="nofollow" target="_blank">science, business, and innovation in pharma with Vas Narasimhan, Jorge Conde, Vijay Pande, and Sonal Chokshi</a></li></ul></li><li>on hacks of all kinds:<ul><li><a href="https://a16z.com/tag/hacked/" rel="nofollow" target="_blank">https://a16z.com/tag/hacked/</a></li></ul></li></ul>

Pharma Drones; Veteran Health Records; Light to Voice Hacks (#14)

This is the 11th episode of 16 Minutes, our weekly news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts managing partner Scott Kupor and general partner in fintech Angela Strange, respectively, in conversation with Sonal Chokshi:crypto &amp; regulation/policy updates from the SEC and IRS -- including the SEC releasing an announcement that it settled charges for an unregistered ICO, and the IRS' issuing guidance (in the form of a revenue ruling and answers to FAQs) on tax treatment for hard forks and air drops;ATM fees at record highs -- where it was reported that it now costs ~$4.72 (vs. $1.97 in 1998, as tracked by Bankrate.com) to withdraw money from ATMs not owned by one's bank, which disproportionately falls on low-income people in neighborhoods banks tend to avoidFor relevant background/ related links:on crypto &amp; regulation:"Kik and the SEC: What's Going on and What Does It Mean for Crypto?" by Katie Haun"Analogies, the Big Picture, and Considerations for Regulating Crypto" by Scott Kupor &amp; Sonal Chokshion ATM fees and "banking the unbanked":"The Next 3 Billion in Financial Services" by Angela Strange---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

This is the 11th episode of 16 Minutes, our weekly news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts managing partner Scott Kupor and general partner in fintech Angela Strange, respectively, in conversation with Sonal Chokshi:<ol><li>crypto &amp; regulation/policy updates from the SEC and IRS -- including the SEC releasing an announcement that it <a href="https://www.sec.gov/news/press-release/2019-202" rel="nofollow" target="_blank">settled charges</a> for an unregistered ICO, and the IRS' <a href="https://www.irs.gov/newsroom/virtual-currency-irs-issues-additional-guidance-on-tax-treatment-and-reminds-taxpayers-of-reporting-obligations" rel="nofollow" target="_blank">issuing</a> guidance (in the form of a <a href="https://www.irs.gov/pub/irs-drop/rr-19-24.pdf" rel="nofollow" target="_blank">revenue ruling</a> and answers to <a href="https://www.irs.gov/individuals/international-taxpayers/frequently-asked-questions-on-virtual-currency-transactions" rel="nofollow" target="_blank">FAQs</a>) on tax treatment for hard forks and air drops;</li><li>ATM fees at record highs -- where it was <a href="https://www.axios.com/atm-fees-record-banks-checking-accounts-50265354-2e61-45ce-9569-209577c8f1fb.html" rel="nofollow" target="_blank">reported</a> that it now costs ~$4.72 (vs. $1.97 in 1998, as tracked by <a href="http://Bankrate.com" rel="nofollow" target="_blank">Bankrate.com</a>) to withdraw money from ATMs not owned by one's bank, which disproportionately falls on low-income people in neighborhoods banks tend to avoid</li></ol><h3>For relevant background/ related links:</h3><ul><li>on crypto &amp; regulation:<ul><li><a href="https://a16z.com/2019/05/15/kik-and-the-sec-whats-going-on-and-what-does-it-mean-for-crypto/" rel="nofollow" target="_blank">"Kik and the SEC: What's Going on and What Does It Mean for Crypto?" by Katie Haun</a></li><li><a href="https://a16z.com/2018/05/04/considerations-for-regulating-cryptonetworks/" rel="nofollow" target="_blank">"Analogies, the Big Picture, and Considerations for Regulating Crypto" by Scott Kupor &amp; Sonal Chokshi</a></li></ul></li><li>on ATM fees and "banking the unbanked":<ul><li><a href="https://a16z.com/2018/01/21/next-3billion-financial-services-summit/" rel="nofollow" target="_blank">"The Next 3 Billion in Financial Services" by Angela Strange</a></li></ul></li></ul>---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Crypto Regulations; ATM Fees (#12)

For our first episode of 2020 -- #18 of our show 16 Minutes, where we cover recent headlines, the a16z way, from our vantage point in tech, and especially what's hype/ what's real -- we do one of our special deep-dive episodes on a single topic: personal genomics.It’s a turn of the decade — and January-appropriate! — look backward/ look forward given recent and past retrospective and prospective pieces in the media on the promise, and perils, of the ability to sequence one’s DNA and what it means for personalized medicine, criminal investigations, privacy, and so on.Our a16z expert for this episode is general partner Jorge Conde, who has a long history in the space, in conversation with host Sonal Chokshi. They cover everything from where genealogy databases and large datasets come in to fetal testing, multi-omics, and much more spanning past, present, and future.

For our first episode of 2020 -- #18 of our show <a href="https://a16z.com/tag/16-minutes/" rel="nofollow" target="_blank">16 Minutes</a>, where we cover recent headlines, the a16z way, from our vantage point in tech, and especially what's hype/ what's real -- we do one of our special deep-dive episodes on a single topic: personal genomics.It’s a turn of the decade — and January-appropriate! — look backward/ look forward given <a href="https://www.buzzfeednews.com/article/peteraldhous/10-years-ago-dna-tests-were-the-future-of-medicine-now" rel="nofollow" target="_blank">recent</a> and <a href="https://www.gq.com/story/richard-powers-genome-sequence" rel="nofollow" target="_blank">past</a> retrospective and prospective pieces in the media on the promise, and perils, of the ability to sequence one’s DNA and what it means for personalized medicine, criminal investigations, privacy, and so on.Our a16z expert for this episode is general partner <a href="https://a16z.com/author/jorge-conde/" rel="nofollow" target="_blank">Jorge Conde</a>, who has a long history in the space, in conversation with host Sonal Chokshi. They cover everything from where genealogy databases and large datasets come in to fetal testing, multi-omics, and much more spanning past, present, and future.

Personal Genomics - Hype vs Reality (#18)

This is the 11th episode of 16 Minutes, a weekly show where we quickly cover the top headlines of the week, the a16z Podcast way: why are these topics in the news; what’s real, what’s hype -- from our vantage point in tech.This week, we do a 20-ish minute deep-dive on CRISPR, to tease apart the FUD from the facts given a bunch of recent news (not research!) around the gene-editing platform. The news implications range from policy to practice:At the end of July, one of the first laws to directly regulate CRISPR was signed in the state of California by Governor Gavin Newsom, making it illegal for "gene therapy" kits to be sold, unless they have a clear warning label that the kit is "not for self-administration” -- this policy may affect future "biohacking"... but also, such kits don't really exist yet!At the end of August, the Alliance for Regenerative Medicine (ARM, an TKTK) released a Therapeutic Developers’ Statement of Principles for the use of gene editing in therapeutic applications -- endorsed by 13 of the most active companies in the field -- while it supports somatic cell editing, it also asserts that germline gene editing "is currently inappropriate in human clinical settings".The above news is also relevant given news of/ the scandal from earlier this year (first revealed by MIT Technology Review) around "CRISPR babies" with germline edits born in China;Meanwhile, clinical trials for CRISPR are coming of age, with the first publicly identified CRISPR patient (treating sickle cell disease) and the first CRISPR study inside the body (for LCA, the most common cause of inherited childhood blindness); how do these show pacing and containment of risks (somatic cell, monogenetic phenotypes, ex vivo, etc.)?Finally, how does all this news affect innovation in gene therapies and other applications? When it comes to engineering the genome -- including tech challenges and startup opportunities -- what might we  borrow from the history of innovation here? If CRISPR is not a single tool or set of proteins but a platform, what becomes possible? General partner Jorge Conde and partner Andy Tran, both of the a16z bio team, share their thoughts on all this and more with host Sonal Chokshi in this episode of 16 Minutes.

This is the 11th episode of 16 Minutes, a weekly show where we quickly cover the top headlines of the week, the a16z Podcast way: why are these topics in the news; what’s real, what’s hype -- from our vantage point in tech.This week, we do a 20-ish minute deep-dive on CRISPR, to tease apart the FUD from the facts given a bunch of recent news (not research!) around the gene-editing platform. The news implications range from policy to practice:<ul><li>At the end of July, one of the first laws <a href="https://www.technologyreview.com/s/614100/dont-change-your-dna-at-home-says-americas-first-crispr-law/" rel="nofollow" target="_blank">to directly</a> regulate CRISPR was signed in the state of California by Governor Gavin Newsom, making it illegal for "gene therapy" kits to be sold, unless they have a clear warning label that the kit is "not for self-administration” -- this policy may affect future "<a href="https://www.vox.com/future-perfect/2019/8/13/20802059/california-crispr-biohacking-illegal-josiah-zayner" rel="nofollow" target="_blank">biohacking</a>"... but also, such kits don't really exist yet!</li><li>At the end of August, the Alliance for Regenerative Medicine (ARM, an TKTK) <a href="https://alliancerm.org/press-release/the-alliance-for-regenerative-medicine-releases-statement-of-principles-on-genome-editing/" rel="nofollow" target="_blank">released</a> a Therapeutic Developers’ Statement of Principles for the use of gene editing in therapeutic applications -- <a href="https://www.ft.com/content/c0e217ac-c5ce-11e9-a8e9-296ca66511c9" rel="nofollow" target="_blank">endorsed by</a> 13 of the most active companies in the field -- while it supports somatic cell editing, it also asserts that germline gene editing "is currently inappropriate in human clinical settings".</li><li>The above news is also relevant given news of/ the scandal from <a href="https://www.nature.com/articles/d41586-019-00673-1" rel="nofollow" target="_blank">earlier this year</a> (first <a href="https://www.technologyreview.com/s/612458/exclusive-chinese-scientists-are-creating-crispr-babies/" rel="nofollow" target="_blank">revealed by</a> MIT Technology Review) around "CRISPR babies" with germline edits born in China;</li><li>Meanwhile, clinical trials for CRISPR are coming of age, with the <a href="https://www.npr.org/sections/health-shots/2019/07/29/744826505/sickle-cell-patient-reveals-why-she-is-volunteering-for-landmark-gene-editing-st" rel="nofollow" target="_blank">first publicly identified CRISPR patient</a> (treating sickle cell disease) and the <a href="https://www.apnews.com/132d29e760834699b12c0c5b0a77e4c0" rel="nofollow" target="_blank">first CRISPR study inside the body</a> (for LCA, the most common cause of inherited childhood blindness); how do these show pacing and containment of risks (somatic cell, monogenetic phenotypes, ex vivo, etc.)?</li></ul>Finally, how does all this news affect innovation in gene therapies and other applications? When it comes to engineering the genome -- including <a href="https://a16z.com/2019/10/05/engineering-the-genome-challenges-and-opportunities-in-the-next-wave-of-medicine/?utm_source=a16z-main-show&amp;utm_medium=podcast&amp;utm_campaign=CRISPR" rel="nofollow" target="_blank">tech challenges and startup opportunities</a> -- what might we  borrow from <a href="https://a16z.com/2019/02/26/george-church-genome-sequencing-conversation-jorge-conde//?utm_source=a16z-main-show&amp;utm_medium=podcast&amp;utm_campaign=CRISPR" rel="nofollow" target="_blank">the history of innovation here</a>? If CRISPR is not a single tool or set of proteins but a platform, what becomes possible? General partner Jorge Conde and partner Andy Tran, both of the a16z bio team, share their thoughts on all this and more with host Sonal Chokshi in this episode of 16 Minutes.

CRISPR: Policy, Platform, Trials (#11)

Our news podcast, 16 Minutes -- where we quickly cover the top headlines of the week, the a16z way (why are these topics in the news; what's real, what's hype from our vantage point of tech trends) -- is now only available as its own show feed, separately from the main a16z Podcast... so be sure to subscribe wherever you get your podcasts if you want our weekly news &amp; tech take!This is the tenth episode of the show, and this week we cover a variety of topics with the following a16z experts:Amazon Care healthcare news this week that they're now providing a virtual medical clinic for employees, initially in Seattle, using telemedicine and in-home visits; what does their delivering healthcare actually mean for both incumbents and startups... and the future of medicine? -- with Julie Yoo and Jorge CondeOculus Connect 6, Facebook's annual developer event, where there were a number of announcements about devices, content, and more that could be key to the evolution of virtual reality (VR) and augmented reality (AR) -- with Chris DixonGoogle quantum supremacy claim, as shared in a paper with/via NASA; what's fact, what's fiction about it; what does it actually mean (or not mean) for cryptography and other applications; and where are we, really, in quantum computing? -- with Vijay Pande...hosted by Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Our news podcast, 16 Minutes -- where we quickly cover the top headlines of the week, the a16z way (why are these topics in the news; what's real, what's hype from our vantage point of tech trends) -- is now only available as its own show feed, separately from the main a16z Podcast... so be sure to <a href="https://16minutes.simplecast.com/" rel="nofollow" target="_blank">subscribe</a> wherever you get your podcasts if you want our weekly news &amp; tech take!This is the tenth episode of the show, and this week we cover a variety of topics with the following a16z experts:<ul><li>Amazon Care healthcare news this week that they're now providing <a href="https://www.cnbc.com/2019/09/24/amazon-launches-employee-health-clinic-amazon-care.html" rel="nofollow" target="_blank">a virtual medical clinic</a> for employees, initially in Seattle, using telemedicine and in-home visits; what does their <a href="https://a16z.com/2019/07/31/how-software-is-eating-care-delivery-in-healthcare/" rel="nofollow" target="_blank">delivering</a> healthcare actually mean for both incumbents and startups... and the future of medicine? -- with Julie Yoo and Jorge Conde</li><li>Oculus Connect 6, Facebook's annual developer event, where there were a number of announcements <a href="https://www.oculus.com/blog/oculus-connect-6-introducing-hand-tracking-on-oculus-quest-facebook-horizon-and-more/" rel="nofollow" target="_blank">about devices, content, and more</a> that could be key to the evolution of <a href="https://a16z.com/category/virtual-reality/" rel="nofollow" target="_blank">virtual reality</a> (VR) and augmented reality (AR) -- with Chris Dixon</li><li>Google quantum supremacy claim, as shared in a paper <a href="https://drive.google.com/file/d/19lv8p1fB47z1pEZVlfDXhop082Lc-kdD/view" rel="nofollow" target="_blank">with/via NASA</a>; what's fact, what's fiction about it; what does it actually mean (or not mean) <a href="https://a16z.com/2015/09/04/dan-boneh-a16z-professor-in-residence/" rel="nofollow" target="_blank">for cryptography</a> and other applications; and where are we, really, <a href="https://a16z.com/category/quantum-computing/" rel="nofollow" target="_blank">in quantum computing</a>? -- with Vijay Pande</li></ul>...hosted by Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Amazon Healthcare, Oculus & VR/AR, Google Quantum Supremacy? (#10)

In this 19th episode of our news show, where we cover recent headlines from our vantage point in tech, we cover the following news items (in conversation with Sonal Chokshi):recent moves to regulate artificial intelligence (AI) software including the White House's recent guidance (and op-ed from the U.S. CTO) on AI in general, as well as limits to exports of specific AI software that went into effect this week -- with operating partner Frank Chen (whose talk was cited in an earlier White House report);recent activity on the topic of negative interest rates as well as quantitative easing, given recent remarks (and paper) from former chairman of the Federal Reserve Ben Bernanke -- with general partner Alex Rampell, who covers all things fintech.

In this 19th episode of our news show, where we cover recent headlines from our vantage point in tech, we cover the following news items (in conversation with Sonal Chokshi):<ul><li>recent moves to regulate artificial intelligence (AI) software including the White House's recent <a href="https://www.whitehouse.gov/wp-content/uploads/2020/01/Draft-OMB-Memo-on-Regulation-of-AI-1-7-19.pdf" rel="nofollow" target="_blank">guidance</a> (and <a href="https://www.bloomberg.com/opinion/articles/2020-01-07/ai-that-reflects-american-values" rel="nofollow" target="_blank">op-ed</a> from the U.S. CTO) on AI in general, as well as <a href="https://www.reuters.com/article/us-usa-artificial-intelligence/u-s-government-limits-exports-of-artificial-intelligence-software-idUSKBN1Z21PT" rel="nofollow" target="_blank">limits to exports</a> of specific AI software that went into effect this week -- with operating partner Frank Chen (whose <a href="https://a16z.com/2016/06/10/ai-deep-learning-machines/" rel="nofollow" target="_blank">talk</a> was cited in an earlier White House report);</li><li>recent activity on the topic of negative interest rates as well as quantitative easing, given recent <a href="https://www.brookings.edu/blog/ben-bernanke/2020/01/04/the-new-tools-of-monetary-policy/" rel="nofollow" target="_blank">remarks</a> (and <a href="https://www.brookings.edu/wp-content/uploads/2019/12/Bernanke_ASSA_lecture.pdf" rel="nofollow" target="_blank">paper</a>) from former chairman of the Federal Reserve Ben Bernanke -- with general partner Alex Rampell, who covers all things fintech.</li></ul>

Regulating AI; Negative Interest Rates (#19)

This episode of our news show teases apart what was just a concept, what's near from the annual Consumer Electronics Show (CES 2020). Board partner Steven Sinofsky (in conversation with Sonal Chokshi) takes us on a quick tour of the based on his annual field trip report from the floor.Topics covered include:folding screens and 8K displays5G, wi-fi 6, new millimeter wave 5Gtransportation: cars, voice, micromobilitysmart home automation and securitybatteries and USB-CArticles/ headlines in this episode:CES 2020: The Primordial Soup of Innovation by Steven Sinofsky, Learning by ShippingEight big takeways from CES 2020 by Dieter Bohn, The Verge

This episode of our news show teases apart what was just a concept, what's near from the annual Consumer Electronics Show (CES 2020). Board partner Steven Sinofsky (in conversation with Sonal Chokshi) takes us on a quick tour of the based on his annual field trip <a href="https://medium.learningbyshipping.com/ces2020-primordial-soup-of-innovation-208571f15c94" rel="nofollow" target="_blank">report</a> from the floor.Topics covered include:<ul><li>folding screens and 8K displays</li><li>5G, wi-fi 6, new millimeter wave 5G</li><li>transportation: cars, voice, micromobility</li><li>smart home automation and security</li><li>batteries and USB-C</li></ul>Articles/ headlines in this episode:<ul><li><a href="https://medium.learningbyshipping.com/ces2020-primordial-soup-of-innovation-208571f15c94" rel="nofollow" target="_blank">CES 2020: The Primordial Soup of Innovation</a> by Steven Sinofsky, Learning by Shipping</li><li><a href="https://www.theverge.com/platform/amp/2020/1/10/21059230/ces-2020-biggest-trends" rel="nofollow" target="_blank">Eight big takeways from CES 2020</a> by Dieter Bohn, The Verge</li></ul>

CES 2020 - Screens, 8K, 5G, Cars, Micromobility, Smart Home

This is episode #9 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they’re in the news; why they matter from our vantage point in tech -- and share our experts’ views on the trends involved.This week we do a short but deep dive to tease apart the FUD from the facts on all the phone hacks of late (also, arguably, one of the worst years on record for certain device manufacturers) -- given the following news:Just this week, the FBI’s Cyber Division released a notification to private industry on “Cyber Criminals Use Social Engineering and Technical Attacks to Circumvent Multi-Factor Authentication”;Last week, a telecom security firm reported a vulnerability called “Simjacker” where SMS containing spyware-like code "takes over" a phone's SIM card in order to retrieve and perform sensitive commands, regardless of platform or device;Over the past month, Google and Apple have been going back and forth over a post the former released, “A very deep dive into iOS Exploit chains found in the wild”, where a small collection of hacked websites were using iPhone zero-day vulnerabilities to target China's Uyghur Muslim community (though Google is not the one who revealed the specific websites, Apple did confirm it in their response a week later) -- what do we make of this exchange; of the fact that zero-day hacks are now more expensive on Android than on Apple; and of Apple's ethos when it comes to a third-party ecosystem for security?Finally, how should we think about phone authentication overall when it comes to security, and what can we do to secure ourselves? Our a16z experts -- general partner Martin Casado and former chief security officer/ operating partner for security Joel de la Garza -- share their thoughts on all this and more with host Sonal Chokshi, in this episode of 16 Minutes.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at a16z.com/investments.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see a16z.com/disclosures for additional important information.

This is episode #9 of our <a href="https://a16z.com/2019/07/21/16mins-news-neuralink-bcis-tiktok-faceapp-iheartradio/" rel="nofollow" target="_blank">news show</a>, <a href="https://a16z.com/tag/16-minutes/" rel="nofollow" target="_blank">16 Minutes</a>, where we quickly cover recent headlines of the week, the a16z way -- why they’re in the news; why they matter from our vantage point in tech -- and share our experts’ views on the trends involved.This week we do a short but deep dive to tease apart the FUD from the facts on all the phone hacks of late (also, arguably, one of the <a href="https://www.vice.com/en_us/article/mbmgqp/this-is-worst-year-for-iphone-security-yet-2019" rel="nofollow" target="_blank">worst</a> years on record for certain device manufacturers) -- given the following news:<ul><li>Just this week, the FBI’s Cyber Division <a href="https://www.sc.edu/study/colleges_schools/law/centers/cybersecurity/_docs/fbi_cyber_pin/2019/fbi_pin-20190917_multi-factor_authentication.pdf" rel="nofollow" target="_blank">released a notification</a> to private industry on “Cyber Criminals Use Social Engineering and Technical Attacks to Circumvent Multi-Factor Authentication”;</li><li>Last week, a telecom security firm <a href="https://www.adaptivemobile.com/blog/simjacker-next-generation-spying-over-mobile" rel="nofollow" target="_blank">reported</a> a vulnerability called “Simjacker” where SMS containing spyware-like code "takes over" a phone's SIM card in order to retrieve and perform sensitive commands, <a href="https://arstechnica.com/information-technology/2019/09/hackers-are-exploiting-a-platform-agnostic-flaw-to-track-mobile-phone-locations/" rel="nofollow" target="_blank">regardless of platform or device</a>;</li><li>Over the past month, Google and Apple have been going back and forth over <a href="https://googleprojectzero.blogspot.com/2019/08/a-very-deep-dive-into-ios-exploit.html" rel="nofollow" target="_blank">a post the former released</a>, “A very deep dive into iOS Exploit chains found in the wild”, where a small collection of hacked websites were using iPhone zero-day vulnerabilities to target China's Uyghur Muslim community (though Google is not the one <a href="https://techcrunch.com/2019/08/31/china-google-iphone-uyghur/" rel="nofollow" target="_blank">who revealed</a> the specific websites, Apple <a href="https://www.wired.com/story/ios-hacks-apple-response/" rel="nofollow" target="_blank">did confirm it</a> in <a href="https://www.apple.com/newsroom/2019/09/a-message-about-ios-security/" rel="nofollow" target="_blank">their response</a> a week later) -- what do we make of this exchange; of the fact that zero-day hacks are <a href="https://www.wired.com/story/android-zero-day-more-than-ios-zerodium/" rel="nofollow" target="_blank">now more expensive</a> on Android than on Apple; and of Apple's ethos when it comes to a <a href="https://mobileidworld.com/apples-nfc-update-enables-yubikey-authentication/" rel="nofollow" target="_blank">third-party</a> ecosystem for security?</li></ul>Finally, how should we think about phone authentication overall when it comes to security, and what can we do to secure ourselves? Our a16z experts -- general partner Martin Casado and former chief security officer/ operating partner for security Joel de la Garza -- share their thoughts on all this and more with host Sonal Chokshi, in this episode of 16 Minutes.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="http://a16z.com/investments" rel="nofollow" target="_blank">a16z.com/investments</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="http://a16z.com/disclosures" rel="nofollow" target="_blank">a16z.com/disclosures</a> for additional important information.

All the Recent Phone Hacks (#9)

This episode of 16 Minutes on the news covers:FICO credit score changes, what are they, do they matter? -- with a16z fintech general partners Angela Strange and Anish Acharya;electronic health record provider Epic's letter urging hospitals to oppose government regulations that would make it easier for patients and companies to access medical information, and where is the Plaid of healthcare? -- at 10:19 with a16z bio general partner Julie Yoo;...in conversation with Sonal Chokshi.Background links / pieces mentioned in this episode:Changes are coming to your credit score, Anna Bahney, CNN BusinessFICO changes could lower your credit score, AnnaMaria Andriotis, Wall Street JournalEpic’s CEO is urging hospital customers to oppose rules that would make it easier to share medical info &amp; Epic and about 60 hospital chains come out against rules that would make it easier to share medical info, Chrissy Farr, CNBCHealth care data-sharing rules touch off intense lobbying fight, Darius Tahir, Politico ---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

This episode of 16 Minutes on the news covers:<ul><li>FICO credit score changes, what are they, do they matter? -- with a16z fintech general partners Angela Strange and Anish Acharya;</li><li>electronic health record provider Epic's letter urging hospitals to oppose government regulations that would make it easier for patients and companies to access medical information, and where is the Plaid of healthcare? -- at 10:19 with a16z bio general partner Julie Yoo;</li></ul>...in conversation with Sonal Chokshi.<h3>Background links / pieces mentioned in this episode:</h3><ul><li><a href="https://www.cnn.com/2020/01/24/success/fico-score-changes/index.html" rel="nofollow" target="_blank">Changes are coming to your credit score</a>, Anna Bahney, CNN Business</li><li><a href="https://www.wsj.com/articles/fico-changes-could-lower-your-credit-score-11579780800" rel="nofollow" target="_blank">FICO changes could lower your credit score</a>, AnnaMaria Andriotis, Wall Street Journal</li><li><a href="https://www.cnbc.com/2020/01/22/epic-ceo-sends-letter-urging-hospitals-to-oppose-hhs-data-sharing-rule.html" rel="nofollow" target="_blank">Epic’s CEO is urging hospital customers to oppose rules that would make it easier to share medical info</a> &amp; <a href="https://www.cnbc.com/2020/02/05/epic-about-60-hospitals-sign-letter-opposing-hhs-proposed-data-rules.html" rel="nofollow" target="_blank">Epic and about 60 hospital chains come out against rules that would make it easier to share medical info</a>, Chrissy Farr, CNBC</li><li><a href="https://www.politico.com/news/2020/01/15/health-care-data-sharing-rules-touch-off-intense-lobbying-fight-099289" rel="nofollow" target="_blank">Health care data-sharing rules touch off intense lobbying fight</a>, Darius Tahir, Politico</li></ul> ---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Epic Battles in Healthcare, FICO Changes

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it's an ongoing and fast-developing news cycle, we take a quick snapshot for where we are, what we know, and what we don't know, and discuss the vantage point of where tech comes in. Topics covered include:definition of a virus, categories of coronavirusesorigins and spreadhow this stacks up so far against SARS and MERSspeed of sequencing, implications of genomic infospeed of information sharingR0 ("r-naught"/"nought") and what it measuresdifferent ways to think about how bad a given epidemic iscurrent moves and treatmentsOur a16z guest is Judy Savitskaya on the bio team, in conversation with Sonal Chokshi.Link sources or background readings for this episode:Centers for Disease Control and Prevention (in the U.S. Department of Health and Human Services) + typesWorld Health Organization (in the United Nations) -- situation report #6, January 26Other background readings / pieces mentioned in this episode: "Scientists are moving at record speed to create new coronavirus vaccines--but they may come too late", Jon Cohen, Science (AAAS), January 27"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", The Lancet, January 24"Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin", bioRxiv, January 2 *note - preprint, NOT peer reviewed*"The deceptively simple number sparking coronavirus fears", Ed Yong, The Atlantic, January 28 *this appeared AFTER this episode was recorded, so sharing here as additional reading only*

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it's an ongoing and fast-developing news cycle, we take a quick snapshot for where we are, what we know, and what we don't know, and discuss the vantage point of where tech comes in. Topics covered include:<ul><li>definition of a virus, categories of coronaviruses</li><li>origins and spread</li><li>how this stacks up so far against SARS and MERS</li><li>speed of sequencing, implications of genomic info</li><li>speed of information sharing</li><li>R0 ("r-naught"/"nought") and what it measures</li><li>different ways to think about how bad a given epidemic is</li><li>current moves and treatments</li></ul>Our a16z guest is Judy Savitskaya on the bio team, in conversation with Sonal Chokshi.<h3>Link sources or background readings for this episode:</h3><ul><li><a href="https://www.cdc.gov/coronavirus/" rel="nofollow" target="_blank">Centers for Disease Control and Prevention</a> (in the U.S. Department of Health and Human Services) + <a href="https://www.cdc.gov/coronavirus/types.html" rel="nofollow" target="_blank">types</a></li><li><a href="https://www.who.int/health-topics/coronavirus" rel="nofollow" target="_blank">World Health Organizatio</a>n (in the United Nations) -- situation report #6, <a href="https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200126-sitrep-6-2019--ncov.pdf?sfvrsn=beaeee0c_4" rel="nofollow" target="_blank">January 26</a></li></ul><h3>Other background readings / pieces mentioned in this episode: </h3><ul><li>"Scientists are moving at record speed to create new coronavirus vaccines--but they may come too late", Jon Cohen, Science (AAAS), <a href="https://www.sciencemag.org/news/2020/01/scientists-are-moving-record-speed-create-new-coronavirus-vaccines-they-may-come-too" rel="nofollow" target="_blank">January 27</a></li><li>"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", The Lancet, <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext" rel="nofollow" target="_blank">January 24</a></li><li>"Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin", bioRxiv, <a href="https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2" rel="nofollow" target="_blank">January 2</a> *note - preprint, NOT peer reviewed*</li><li>"The deceptively simple number sparking coronavirus fears", Ed Yong, The Atlantic, <a href="https://www.theatlantic.com/science/archive/2020/01/how-fast-and-far-will-new-coronavirus-spread/605632/" rel="nofollow" target="_blank">January 28</a> *this appeared AFTER this episode was recorded, so sharing here as additional reading only*</li></ul>

Coronavirus Outbreak

This episode covers the latest updates since our previous deep-dive on the novel coronavirus outbreak. We cover the latest developments -- new name, new declarations, new numbers, new definitions -- as well as:practical implications for the U.S. healthcare system given how it works today, and where we might go in the future -- with a16z general partner Julie Yoo, given our vantage point in tech; andhow the rt-PCR test works, and other updates about what the data do and don't tell us, and whether and what terms are useful or not -- with a16z bio partner Judy Savitskaya;...in conversation with Sonal Chokshi.Sources for this episode and/or other background links:latest numbers: cases in the U.S. (CDC, as of February 17, 2020); global cases (WHO situation report #25, February 14, 2020); spike in diagnosing cases as reported in China (SCMP, Scott Gottlieb)situation &amp; policy statements/reports: CDC summary (as of February 14, 2020); "Annual report on global preparedness for health emergencies", WHO (Global Preparedness Monitoring Board, 2019)on definitions (of pandemics, endemics), other terms, and various naming conventions: "Understanding pandemics: What they mean, what they don't mean, and what comes next with the coronavirus", Helen Branswell, StatNews (February 12, 2020); on disease occurrence and levels (CDC); "misinfodemic"; best practices on naming new human infectious diseases (WHO); qPCR (Keith Robison)image: 2019 Novel Coronavirus (2019-nCoV), CDC, via Wikimedia Commons

This episode covers the latest updates since our <a href="https://a16z.com/2020/01/29/16mins-news-coronavirus-outbreak-2019ncov-r0-genomics-epidemics/" rel="nofollow" target="_blank">previous deep-dive</a> on the novel coronavirus outbreak. We cover the latest developments -- new name, new declarations, new numbers, new definitions -- as well as:<ol><li>practical implications for the U.S. healthcare system given how it works today, and where we might go in the future -- with a16z general partner <a href="https://a16z.com/author/julie-yoo/" rel="nofollow" target="_blank">Julie Yoo</a>, given our vantage point in tech; and</li><li>how the rt-PCR test works, and other updates about what the data do and don't tell us, and whether and what terms are useful or not -- with a16z bio partner Judy Savitskaya;</li></ol>...in conversation with Sonal Chokshi.<h3>Sources for this episode and/or other background links:</h3><ul><li>latest numbers: cases in the U.S. (<a href="https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html" rel="nofollow" target="_blank">CDC, as of February 17, 2020</a>); global cases (<a href="https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200214-sitrep-25-covid-19.pdf?sfvrsn=61dda7d_2" rel="nofollow" target="_blank">WHO situation report #25, February 14, 2020</a>); spike in diagnosing cases as reported in China (<a href="https://www.scmp.com/news/china/society/article/3050354/coronavirus-hubei-province-reports-sharp-spike-new-confirmed" rel="nofollow" target="_blank">SCMP</a>, <a href="https://twitter.com/ScottGottliebMD/status/1227768644291170306" rel="nofollow" target="_blank">Scott Gottlieb</a>)</li><li>situation &amp; policy statements/reports: CDC summary (<a href="https://www.cdc.gov/coronavirus/2019-ncov/summary.html" rel="nofollow" target="_blank">as of February 14, 2020</a>); "Annual report on global preparedness for health emergencies", WHO (<a href="https://apps.who.int/gpmb/assets/annual_report/GPMB_annualreport_2019.pdf" rel="nofollow" target="_blank">Global Preparedness Monitoring Board, 2019</a>)</li><li>on definitions (of pandemics, endemics), other terms, and various naming conventions: "Understanding pandemics: What they mean, what they don't mean, and what comes next with the coronavirus", Helen Branswell, StatNews (<a href="https://www.statnews.com/2020/02/12/understanding-pandemics-what-they-mean-coronavirus/" rel="nofollow" target="_blank">February 12, 2020</a>); on disease occurrence and levels (<a href="https://www.cdc.gov/csels/dsepd/ss1978/lesson1/section11.html" rel="nofollow" target="_blank">CDC</a>); "<a href="https://twitter.com/maiamajumder/status/1227847272823771136" rel="nofollow" target="_blank">misinfodemic</a>"; best practices on naming new human infectious diseases (<a href="https://apps.who.int/iris/bitstream/handle/10665/163636/WHO_HSE_FOS_15.1_eng.pdf;jsessionid=A50FD2F63D1F69F2DCEAE78F35801734?sequence=1" rel="nofollow" target="_blank">WHO</a>); qPCR (<a href="http://omicsomics.blogspot.com/2020/02/a-qpcr-explainer.html" rel="nofollow" target="_blank">Keith Robison</a>)</li></ul>image: 2019 Novel Coronavirus (2019-nCoV), CDC, via <a href="https://commons.wikimedia.org/wiki/File:2019-nCoV-CDC-23311.png" rel="nofollow" target="_blank">Wikimedia Commons</a>

Coronavirus Updates

This episode of 16 Minutes on the news covers:Google could bring Steam support to Chrome OS, according to an earlier unconfirmed report, and what that could mean for the broader gaming ecosystem, developers as well as devices -- with a16z general partner Andrew Chen and Jonathan Lai on the consumer team;New York restaurants and retail establishments can no longer reject cash payments under legislation that was passed by the City Council there; what this says about the banking system more broadly, why it's a regressive tax on the poor and therefore a progressive move -- at 8:57 with a16z general partner Alex Rampell on the fintech team;updates on COVID-19 disease -- at 16:44 based on latest reports from WHO and CDC as of Friday March 6....with Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

This episode of 16 Minutes on the news covers:<ul><li>Google could bring Steam support to Chrome OS, according to an earlier unconfirmed <a href="https://www.androidpolice.com/2020/01/17/exclusive-google-is-working-to-bring-steam-to-chrome-os/" rel="nofollow" target="_blank">report</a>, and what that could mean for the broader gaming ecosystem, developers as well as devices -- with a16z general partner Andrew Chen and Jonathan Lai on the consumer team;</li><li>New York restaurants and retail establishments can no longer reject cash payments under legislation that <a href="https://nypost.com/2020/01/24/cashless-businesses-are-now-banned-in-nyc/" rel="nofollow" target="_blank">was passed</a> by the City Council there; what this says about the banking system more broadly, why it's a regressive tax on the poor and therefore a progressive move -- at 8:57 with a16z general partner Alex Rampell on the fintech team;</li><li>updates on COVID-19 disease -- at 16:44 based on latest reports from <a href="https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200305-sitrep-45-covid-19.pdf?sfvrsn=ed2ba78b_4" rel="nofollow" target="_blank">WHO</a> and <a href="https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html" rel="nofollow" target="_blank">CDC</a> as of Friday March 6.</li></ul>...with Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Gaming & Chrome OS/Steam; Going Cashless; Coronavirus Latest

This episode of 16 Minutes on the news covers:all the recent fintech acquisitions! from Intuit announcing it's acquiring Credit Karma this week to Morgan Stanley announcing it's acquiring E-trade last week to Visa acquiring Plaid last month, and so on -- what’s going on, why, and why now? -- with a16z general partner Anish Acharya;recent hearing on SEC's complaint against Telegram, which turns out not to be about cryptocurrency at large, a particular subset of cryptocurrencies, or whether a cryptocurrencly is inherently a security -- but may have broader implications for policy and policy making -- at 7:57 with a16z managing partner Scott Kupor;...in conversation with Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

This episode of 16 Minutes on the news covers:<ul><li>all the recent fintech acquisitions! from Intuit <a href="https://investors.intuit.com/news/news-details/2020/Intuit-to-Acquire-Credit-Karma/default.aspx" rel="nofollow" target="_blank">announcing</a> it's acquiring Credit Karma this week to Morgan Stanley <a href="https://www.morganstanley.com/press-releases/morgan-stanley-to-acquire-e-trade" rel="nofollow" target="_blank">announcing</a> it's acquiring E-trade last week to Visa <a href="https://usa.visa.com/about-visa/newsroom/press-releases.releaseId.16856.html" rel="nofollow" target="_blank">acquiring</a> Plaid last month, and so on -- what’s going on, why, and why now? -- with a16z general partner Anish Acharya;</li><li>recent hearing on SEC's complaint against Telegram, which turns out not to be about cryptocurrency at large, a particular subset of cryptocurrencies, or whether a cryptocurrencly is inherently a security -- but may have broader implications for policy and policy making -- at 7:57 with a16z managing partner Scott Kupor;</li></ul>...in conversation with Sonal Chokshi.---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

What's Up With All These Fintech Acquisitions; SEC Rules

This is episode #3 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we do a short but deep dive on esports, given recent news of the inaugural Fortnite World Cup champion, and how this all fits into the broader trends in gaming, social networks, and the future of entertainment. Our a16z experts in this episode are general partner Andrew Chen and investing team partner D'Arcy Coolican, both of the consumer vertical, in conversation with host Sonal Chokshi.

This is episode #3 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we do a short but deep dive on esports, given recent news of the inaugural Fortnite World Cup champion, and how this all fits into the broader trends in gaming, social networks, and the future of entertainment. Our a16z experts in this episode are general partner Andrew Chen and investing team partner D'Arcy Coolican, both of the consumer vertical, in conversation with host Sonal Chokshi.

Fortnite, Esports, Gaming, and Entertainment (#3)

This is episode #6 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts:  health claims, insurance &amp; big tech, and healthcare data liquidity -- with a16z bio partner Julie Yoo; Capital One data breach, cloud security, and corporate hacks -- with a16z operating partner for security Joel de la Garza;  ...hosted by Sonal Chokshi.

This is episode #6 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts: <ul> <li>health claims, insurance &amp; big tech, and healthcare data liquidity -- with a16z bio partner Julie Yoo;</li> <li>Capital One data breach, cloud security, and corporate hacks -- with a16z operating partner for security Joel de la Garza;</li> </ul> ...hosted by Sonal Chokshi.

Health Claims Data, Corporate Breaches (#6)

with @astrange @jeff_jordan and @smc90 This is episode #5 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts:  Federal Reserve real-time payment and settlement service FedNow, the U.S. payments rail, and fintech -- with a16z general partner Angela Strange; Barney's bankruptcy, the "death of retail", and ecommerce -- with a16z general partner Jeff Jordan;  ...hosted by Sonal Chokshi.

with @astrange @jeff_jordan and @smc90 This is episode #5 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we cover, with the following a16z experts: <ul> <li>Federal Reserve real-time payment and settlement service FedNow, the U.S. payments rail, and fintech -- with a16z general partner Angela Strange;</li> <li>Barney's bankruptcy, the "death of retail", and ecommerce -- with a16z general partner Jeff Jordan;</li> </ul> ...hosted by Sonal Chokshi.

Fed Real-time Payments, Death of Retail (#5)

This is episode #4 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we do a short but deep dive on the opioid crisis, given recent data around where and who was behind the manufacturing and distribution of specific opioids:  How do opioids work, why these drugs? Who's to blame? What are other directions for managing pain -- and where could tech come in, even with the broader social, cultural, and structural context involved?  Our a16z experts in this episode are a16z bio general partners Jorge Conde and Vijay Pande, in conversation with host Sonal Chokshi.

This is episode #4 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well. This week we do a short but deep dive on the opioid crisis, given recent data around where and who was behind the manufacturing and distribution of specific opioids: <ul> <li>How do opioids work, why these drugs?</li> <li>Who's to blame?</li> <li>What are other directions for managing pain -- and where could tech come in, even with the broader social, cultural, and structural context involved?</li> </ul> Our a16z experts in this episode are a16z bio general partners Jorge Conde and Vijay Pande, in conversation with host Sonal Chokshi.

The Opioid Crisis (#4)

On this show, we cover recent headlines, the a16z Podcast way -- what’s hype, what’s real; why they matter from our vantage point in tech -- and this week, we cover the following news (in conversation with Sonal Chokshi):Star War trailer premieres in... Fortnite? What's the significance of the latest Star Wars trailer debuting inside a video game over a movie theater or TV or even YouTube and Facebook? It has to do with the bigger picture of games, social networks, and virtual worlds; so what are the implications for marketers, game developers, and how we will live/work/play? -- with Jonathan Lai, consumer teamCongress warns tech companies to take action on encryption... or else! Concerned about protecting the most vulnerable Americans and devices "going dark" to law enforcement (especially given "several serious cases where we can't access the device in the time period where it is most important for us to access it"), Congress recently sent a warning to tech companies to get their "act together" on encryption... or else "we will impose our will on you", by this time next year. But what if we're having the wrong conversation to break the deadlock, and what conversation could we be having? -- with Martin Casado, general partner, and operating partner for security Joel de la GarzaRelevant/ related links:on gaming State of play: Six trends revolutionizing gaming by Jonathan Lai and Andrew ChenNew business models for gaming [podcast] with Kevin Chou, Chris Dixon, and Sonal ChokshiCome for the games, stay for the party [podcast] with Andrew Chen, Jonathan Lai, and Lauren MurrowTech trends changing gaming [podcast] with Tim Shafer, Justin Bailey, Herman Narula, and Sonal Chokshion security16 steps to securing your data (and life) by Joel de la Garza

On this show, we cover recent headlines, the a16z Podcast way -- what’s hype, what’s real; why they matter from our vantage point in tech -- and this week, we cover the following news (in conversation with Sonal Chokshi):<ol><li>Star War trailer premieres in... Fortnite? What's the significance of the latest Star Wars trailer debuting inside a video game over a movie theater or TV or even YouTube and Facebook? It has to do with the bigger picture of games, social networks, and virtual worlds; so what are the implications for marketers, game developers, and how we will live/work/play? -- with Jonathan Lai, consumer team</li><li>Congress warns tech companies to take action on encryption... or else! Concerned about protecting the most vulnerable Americans and devices "<a href="https://www.fbi.gov/services/operational-technology/going-dark" rel="nofollow" target="_blank">going dark</a>" to law enforcement (especially given "several serious cases where we can't access the device in the time period where it is most important for us to access it"), Congress <a href="https://www.cnet.com/news/congress-warns-tech-companies-take-action-on-encryption-or-we-will/" rel="nofollow" target="_blank">recently sent a warning to tech companies</a> to get their "act together" on encryption... or else "we will impose our will on you", by this time next year. But what if we're having the wrong conversation to break the deadlock, and what conversation could we be having? -- with Martin Casado, general partner, and operating partner for security Joel de la Garza</li></ol><h3>Relevant/ related links:</h3><ul><li>on gaming <ul><li><a href="https://a16z.com/2019/10/16/trends-revolutionizing-games/" rel="nofollow" target="_blank">State of play: Six trends revolutionizing gaming</a> by Jonathan Lai and Andrew Chen</li><li><a href="https://a16z.com/2019/09/28/business-models-gaming-platform-shifts-blockchain-crypto-collaboration-creativity/" rel="nofollow" target="_blank">New business models for gaming [podcast]</a> with Kevin Chou, Chris Dixon, and Sonal Chokshi</li><li><a href="https://a16z.com/2019/11/02/come-for-the-games-stay-for-the-party/" rel="nofollow" target="_blank">Come for the games, stay for the party [podcast]</a> with Andrew Chen, Jonathan Lai, and Lauren Murrow</li><li><a href="https://a16z.com/2015/06/03/a16z-podcast-tech-trends-changing-gaming/" rel="nofollow" target="_blank">Tech trends changing gaming [podcast]</a> with Tim Shafer, Justin Bailey, Herman Narula, and Sonal Chokshi</li></ul></li><li>on security<ul><li><a href="https://a16z.com/2019/11/12/16-steps-secure-you/" rel="nofollow" target="_blank">16 steps to securing your data (and life)</a> by Joel de la Garza</li></ul></li></ul>

Star Wars in Fortnite; Encryption Ultimatum (#17)

This is the 16th episode of 16 Minutes, our news show where we cover the top headlines, the a16z Podcast way: what’s real / what’s hype; why they matter from our vantage point in tech.This week, we cover the following news (in conversation with Sonal Chokshi):NYSE &amp; SEC back and forth over direct listings -- The NYSE recently proposed allowing companies to raise capital during direct listings (currently, they're different than IPOs in that there is no offering); the SEC rejected it; and they just filed a new proposal... but beyond this news and these artifacts, what's the bigger picture when it comes to other structural factors involved here? -- with Scott Kupor.vaping apps &amp; Apple; FDA &amp; CBD-- two recent moves: Apple banning 181 vaping apps from its app store, FDA issuing warning letters against 15 companies with products that have CBD in them; what's our quick take on the blurring lines between these two seemingly different bits of news? -- with Vijay Pande.Relevant/ related links:IPOs, direct listings, more:beyond the opening bell: what do (and don't) IPOs tell us about companies? by Scott Kupordirect listings, the myths and the facts [podcast] with Stacey Cunningham, Barry McCarthy, and Sonal Chokshiall about direct listings with Jamie McGurkthe curious case (and the behind-the-scenes story of) the OpenTable IPO [podcast] with Jeff Jordan, J.D. Moriarty, and Sonal Chokshion capital formation, smaller companies, and IPOs [testimony] by Scott Kupor---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

This is the 16th episode of 16 Minutes, our news show where we cover the top headlines, the a16z Podcast way: what’s real / what’s hype; why they matter from our vantage point in tech.This week, we cover the following news (in conversation with Sonal Chokshi):<ol><li>NYSE &amp; SEC back and forth over direct listings -- The NYSE recently <a href="https://www.axios.com/wall-street-nyse-direct-listings-a5552c89-0aa1-4204-904a-2746fe50e773.html" rel="nofollow" target="_blank">proposed</a> allowing companies to raise capital during direct listings (currently, they're different than IPOs in that there is no offering); the SEC <a href="https://www.axios.com/sec-reject-nyse-direct-listings-cf5d795f-e651-4c51-be1c-8110dbbe5d27.html" rel="nofollow" target="_blank">rejected</a> it; and they just <a href="https://amp.axios.com/new-york-stock-exchange-direct-listing-e7e37a29-1b81-451d-9a7b-7f04983b74a6.html" rel="nofollow" target="_blank">filed</a> a new proposal... but beyond this news and these artifacts, what's the bigger picture when it comes to other structural factors involved here? -- with Scott Kupor.</li><li>vaping apps &amp; Apple; FDA &amp; CBD-- two recent moves: Apple <a href="https://amp.axios.com/exclusive-apple-to-remove-vaping-apps-from-store-8669fd94-e92a-4ce4-a9e2-ce5afa598b67.html" rel="nofollow" target="_blank">banning</a> 181 vaping apps from its app store, FDA <a href="https://www.fda.gov/news-events/press-announcements/fda-warns-15-companies-illegally-selling-various-products-containing-cannabidiol-agency-details" rel="nofollow" target="_blank">issuing</a> warning letters against 15 companies with products that have CBD in them; what's our quick take on the blurring lines between these two seemingly different bits of news? -- with Vijay Pande.</li></ol><h3>Relevant/ related links:</h3><ul><li>IPOs, direct listings, more:<ul><li><a href="https://a16z.com/2019/07/09/ipo-process-prices-behind-scenes-companies/" rel="nofollow" target="_blank">beyond the opening bell: what do (and don't) IPOs tell us about companies? by Scott Kupor</a></li><li><a href="https://a16z.com/2019/12/10/direct-listings-myths-process/" rel="nofollow" target="_blank">direct listings, the myths and the facts [podcast] with Stacey Cunningham, Barry McCarthy, and Sonal Chokshi</a></li><li><a href="https://a16z.com/2019/07/02/direct-listings/" rel="nofollow" target="_blank">all about direct listings with Jamie McGurk</a></li><li><a href="https://a16z.com/2017/07/24/opentable-ipo-story/" rel="nofollow" target="_blank">the curious case (and the behind-the-scenes story of) the OpenTable IPO [podcast] with Jeff Jordan, J.D. Moriarty, and Sonal Chokshi</a></li><li><a href="https://a16z.com/2019/06/20/capital-formation-smaller-companies-ipos-policy-testimony-june-2017/" rel="nofollow" target="_blank">on capital formation, smaller companies, and IPOs [testimony] by Scott Kupor</a></li></ul></li></ul>---The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Direct Listings NYSE SEC; Vaping Apps & Apple, CBD & FDA (#16)

This is episode #8 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends.This week we cover, with the following a16z experts:Apple's latest event announcing new products and services across mobile, TV, and gaming; where is (and isn't) innovation happening, and what's next -- with a16z's Benedict Evans;wearables and health trackers such as Fitbit supplying services to the government of Singapore, and what it means for the hype vs. reality of the current trends of wearables (and "the quantified self"); going beyond counting steps to clinical applications and detecting comorbid conditions; strong vs. weak technologies and how to pay beyond fee-for-service to fee-for-value; and where does this all fit in a sensor-ified future? -- with a16z bio general partner Vijay Pande;...hosted by Sonal Chokshi. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

This is episode #8 of our <a href="https://a16z.com/2019/07/21/16mins-news-neuralink-bcis-tiktok-faceapp-iheartradio/" rel="nofollow" target="_blank">news show</a>, <a href="https://a16z.com/tag/16-minutes/" rel="nofollow" target="_blank">16 Minutes</a>, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends.This week we cover, with the following a16z experts:<ul><li>Apple's latest event announcing new products <a href="https://www.ben-evans.com/benedictevans/2019/9/13/Apple-services-moats" rel="nofollow" target="_blank">and services</a> across mobile, TV, and gaming; where is (and isn't) innovation happening, and what's next -- with a16z's <a href="https://www.ben-evans.com/" rel="nofollow" target="_blank">Benedict Evans</a>;</li><li>wearables and health trackers such as Fitbit <a href="https://www.cnbc.com/2019/08/21/fitbit-to-supply-trackers-to-hundreds-of-thousands-in-singapore.html" rel="nofollow" target="_blank">supplying</a> services to the government of Singapore, and what it means for the hype vs. reality of the current trends of wearables (and "<a href="https://a16z.com/2017/05/08/wearables-quantifiedself-biohacking/" rel="nofollow" target="_blank">the quantified self</a>"); going beyond counting steps to <a href="https://cardiogram.com/research/" rel="nofollow" target="_blank">clinical applications and detecting comorbid conditions</a>; strong vs. weak technologies and how to pay <a href="https://a16z.com/2019/09/08/value-based-healthcare-outcomes-conway/" rel="nofollow" target="_blank">beyond fee-for-service to fee-for-value</a>; and where does this all fit in a sensor-ified future? -- with a16z bio general partner <a href="https://a16z.com/author/vijay-pande/" rel="nofollow" target="_blank">Vijay Pande</a>;</li></ul>...hosted by Sonal Chokshi. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at <a href="https://a16z.com/investments/" rel="nofollow" target="_blank">https://a16z.com/investments/</a>.Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see <a href="https://a16z.com/disclosures" rel="nofollow" target="_blank">https://a16z.com/disclosures</a> for additional important information.

Apple Camera, Services; Wearables - Where are We (#8)

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