The Filtrate:Joel TopfNayan AroraSophia AmbrusoWith Special Guest:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His Google Schoolar page is better than yours. And returning for her fourth time (why do we keep inviting her back?)Sadiya Khan @heartDocSadiya Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. LinkEditor:Priya YenebereShow Notes:Diuretic Therapy review by. Craig Brater NEJMThe manuscript in JAMA | NephJCMetoprolol vs Carvedilol: Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial (Lancet)EMPULSE: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (Nature Medicine)Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure The ASTRONAUT Randomized TrialEffects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure The EVEREST Outcome TrialSophia ended up placing fifth in NephMadness 2023. (Link)Joel finished 697thAfter winning in the opening round, Northwestern lost to UCLA,  in the second round of the March Madness tournament, 68-63.Torsemide to furosemide equivalents CardioMems positive trial: Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial (The Lancet)CardioMems negative trial: Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial (The Lancet)Estimation of the Absolute Risk of Cardiovascular Disease and Other Events: Issues With the Use of Multiple Fine-Gray Subdistribution Hazard Models (Circulation)Torasemide in chronic heart failure: results of the TORIC study (PubMed)Tubular SecretionsNayan: Louise Penny A World of Curiosities: A Novel (Amazon)Sadiya: Ted Lasso season threeSophia:The Last of Us on HBO and SNL skit Mario Cart as Prestige DramaBoback: Duolingo for Japanese

The Filtrate:Joel TopfNayan AroraSophia AmbrusoWith Special Guest:Boback Ziaeian <a href="https://twitter.com/boback" rel="nofollow" target="_blank">@boback</a> Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His <a href="https://scholar.google.com/citations?hl=en&amp;user=iTIF3ygAAAAJ" rel="nofollow" target="_blank">Google Schoolar page</a> is better than yours. And returning for her fourth time (why do we keep inviting her back?) Sadiya Khan <a href="https://twitter.com/HeartDocSadiya" rel="nofollow" target="_blank">@heartDocSadiya</a> Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. <a href="https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=25223" rel="nofollow" target="_blank">Link</a>Editor:Priya YenebereShow Notes:Diuretic Therapy review by. Craig Brater <a href="https://www.nejm.org/doi/full/10.1056/nejm199808063390607" rel="nofollow" target="_blank">NEJM</a>The manuscript in <a href="https://pubmed.ncbi.nlm.nih.gov/36648467/" rel="nofollow" target="_blank">JAMA</a> | <a href="http://www.nephjc.com/news/2023/2/7/transform-hf" rel="nofollow" target="_blank">NephJC</a>Metoprolol vs Carvedilol: Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial (<a href="https://pubmed.ncbi.nlm.nih.gov/12853193/" rel="nofollow" target="_blank">Lancet</a>)EMPULSE: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (<a href="https://www.nature.com/articles/s41591-021-01659-1" rel="nofollow" target="_blank">Nature Medicine</a>)Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure <a href="https://jamanetwork.com/journals/jama/fullarticle/1666394" rel="nofollow" target="_blank">The ASTRONAUT Randomized Trial</a>Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure <a href="https://jamanetwork.com/journals/jama/fullarticle/206251" rel="nofollow" target="_blank">The EVEREST Outcome Trial</a>Sophia ended up placing fifth in NephMadness 2023. (<a href="https://www.tourneytopia.com/AJKD/NephMadness/Pool/Standings.aspx" rel="nofollow" target="_blank">Link</a>)Joel finished 697thAfter winning in the opening round, Northwestern lost to UCLA, in the second round of the March Madness tournament, 68-63.<a href="https://www.drugs.com/medical-answers/equivalent-dosages-bumetanide-furosemide-torsemide-3572303/#:~:text=References%20differ%20in%20what%20they,furosemide%20(20mg%20IV%20furosemide)." rel="nofollow" target="_blank">Torsemide to furosemide</a> equivalents CardioMems positive trial: Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial (<a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00723-0/fulltext" rel="nofollow" target="_blank">The Lancet</a>)CardioMems negative trial: Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial (<a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01754-2/fulltext" rel="nofollow" target="_blank">The Lancet</a>)Estimation of the Absolute Risk of Cardiovascular Disease and Other Events: Issues With the Use of Multiple Fine-Gray Subdistribution Hazard Models (<a href="https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.121.008368" rel="nofollow" target="_blank">Circulation</a>)Torasemide in chronic heart failure: results of the TORIC study (<a href="https://pubmed.ncbi.nlm.nih.gov/12167392/" rel="nofollow" target="_blank">PubMed</a>)Tubular SecretionsNayan: Louise Penny A World of Curiosities: A Novel (<a href="https://www.amazon.com/Audible-World-Curiosities-Novel/dp/B09ZBM6MF3/ref=sr_1_1?hvadid=599491117618&amp;hvdev=c&amp;hvlocphy=9016789&amp;hvnetw=g&amp;hvqmt=e&amp;hvrand=17640373863851844484&amp;hvtargid=kwd-1659248410282&amp;hydadcr=13132_9741574&amp;keywords=a%20world%20of%20curiosities%20louise%20penny&amp;qid=1688354054&amp;sr=8-1" rel="nofollow" target="_blank">Amazon</a>)Sadiya: Ted Lasso <a href="https://variety.com/2023/tv/news/ted-lasso-season-3-review-final-season-1235629420/" rel="nofollow" target="_blank">season three</a>Sophia:<a href="https://www.hbo.com/the-last-of-us" rel="nofollow" target="_blank">The Last of Us</a> on HBO and <a href="https://www.youtube.com/watch?v=UiIRlg4Xr5w" rel="nofollow" target="_blank">SNL skit Mario Cart as Prestige Drama</a>Boback: <a href="https://www.duolingo.com" rel="nofollow" target="_blank">Duolingo</a> for Japanese

Freely Filtered 059: Furosemide v Torsemide

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanNayan AroraSophia AmbrusoWith Special Guest:Megan Prochaska Assistant professor of medicine at University of Chicago John Asplin Medical Director Consultant LithoLink (Twitter)Editor:Joel TopfShow Notes:The LithoLink websiteStone Camp tweetPrevention of Repeated Episodes of Kidney Stones in Adults: A Clinical Practice Guideline From the American College of Physicians (link)NOSTONE in the NEJM and NephJCFred Coe Google Scholar | YouTube | BlogHypercalcuria.  Curhan et al. 24-h uric acid excretion and the risk of kidney stones PubMedEQUIL2 software to evaluate urinary super saturation Anna Zisman Racial Differences in Risk Factors for Kidney Stone Formation (CJASN)Potassium Citrate on GoodRxMoonstone NutritionPotassium and citrate by Fred Coe (blog)Thiazide Diuretics and Fracture Risk: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials (PubMed)Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria by Coe et al (PubMed)NHANES 24-hour urine Na (Abstract) Kidney Stone risk is reduced with empagliflozin (PubMed)Prospective trial to determine the effect of SGLT2i on urinary supersaturation (BMJ Open)GLP agonists and kidney stone risk  Tubular SecretionsSwap: Star Wars: Thrawn Series by Timothy Zahn (Penguin Random House)Josh: Little League  Megan: Renal related podcastsSophia Renal Stone Camp and ABCKidney.comNayan: Ted Lasso Robert Galbraithand The Comoran Strike Novels (home page)John: Fred Coe’s BlogJoel: Spiderman across the Spider-Verse (Wikipedia)

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanNayan AroraSophia AmbrusoWith Special Guest:Megan Prochaska Assistant professor of medicine at University of Chicago John Asplin Medical Director Consultant LithoLink (<a href="https://twitter.com/ravineja" rel="nofollow" target="_blank">Twitter</a>)Editor:Joel TopfShow Notes:The LithoLink <a href="https://litholink.labcorp.com" rel="nofollow" target="_blank">website</a>Stone Camp <a href="https://twitter.com/MSemins/status/993331724594630656?s=20" rel="nofollow" target="_blank">tweet</a>Prevention of Repeated Episodes of Kidney Stones in Adults: A Clinical Practice Guideline From the American College of Physicians (<a>link</a>)NOSTONE in the <a href="https://www.nejm.org/doi/10.1056/NEJMoa2209275" rel="nofollow" target="_blank">NEJM</a> and <a href="http://www.nephjc.com/news/no-stone" rel="nofollow" target="_blank">NephJC</a>Fred Coe <a href="https://scholar.google.com/citations?hl=en&amp;user=X6vdtYAAAAAJ" rel="nofollow" target="_blank">Google Scholar</a> | <a href="https://www.youtube.com/channel/UCnFxApRWMyc6B1H_v4gJRUA" rel="nofollow" target="_blank">YouTube</a> | <a href="https://kidneystones.uchicago.edu/author/flcoe/" rel="nofollow" target="_blank">Blog</a>Hypercalcuria. Curhan et al. 24-h uric acid excretion and the risk of kidney stones <a href="https://pubmed.ncbi.nlm.nih.gov/18059457/" rel="nofollow" target="_blank">PubMed</a><a href="https://www.auajournals.org/doi/10.1016/S0022-5347%2817%2947703-2" rel="nofollow" target="_blank">EQUIL2</a> software to evaluate urinary super saturation Anna Zisman Racial Differences in Risk Factors for Kidney Stone Formation (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409744/" rel="nofollow" target="_blank">CJASN</a>)Potassium Citrate on <a href="https://www.goodrx.com/potassium-citrate-citric-acid" rel="nofollow" target="_blank">GoodRx</a><a href="https://moonstonenutrition.com" rel="nofollow" target="_blank">Moonstone Nutrition</a>Potassium and citrate by Fred Coe (<a href="https://kidneystones.uchicago.edu/how-citrate-gets-into-the-urine/" rel="nofollow" target="_blank">blog</a>)Thiazide Diuretics and Fracture Risk: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664541/" rel="nofollow" target="_blank">PubMed</a>)Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria by Coe et al (<a href="https://pubmed.ncbi.nlm.nih.gov/3404813/" rel="nofollow" target="_blank">PubMed</a>)NHANES 24-hour urine Na (<a href="https://www.ahajournals.org/doi/10.1161/circ.134.suppl_1.16878" rel="nofollow" target="_blank">Abstract</a>) Kidney Stone risk is reduced with empagliflozin (<a href="https://pubmed.ncbi.nlm.nih.gov/35290464/" rel="nofollow" target="_blank">PubMed</a>)Prospective trial to determine the effect of SGLT2i on urinary supersaturation (<a href="https://bmjopen.bmj.com/content/12/3/e059073#:~:text=Due%20to%20their%20unique%20mode,measure%20to%20reduce%20stone%20recurrence." rel="nofollow" target="_blank">BMJ Open</a>)GLP agonists and kidney stone risk Tubular SecretionsSwap: Star Wars: Thrawn Series by Timothy Zahn (<a href="https://www.penguinrandomhouse.com/series/D34/star-wars-thrawn" rel="nofollow" target="_blank">Penguin Random House</a>)Josh: Little League Megan: Renal related podcastsSophia Renal Stone Camp and <a href="http://abckidney.com" rel="nofollow" target="_blank">ABCKidney.com</a>Nayan: Ted Lasso Robert Galbraithand The Comoran Strike Novels (<a href="https://robert-galbraith.com/stories/" rel="nofollow" target="_blank">home page</a>)John: <a href="https://kidneystones.uchicago.edu/author/flcoe/" rel="nofollow" target="_blank">Fred Coe’s Blog</a>Joel: Spiderman across the Spider-Verse (<a href="https://en.wikipedia.org/wiki/Spider-Man:_Across_the_Spider-Verse" rel="nofollow" target="_blank">Wikipedia</a>)

Freely Filtered 060: HCTZ v Kidney Stones, The NOSTONE trial 

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanJordy CohenWith Special Guest:Areef ishani lead author and Chief of Medicine VA MinneapolisEditor:Nayan AroraShow Notes:MRFIT switches diuretics and finds better outcomes. Swapnil shows how many studies he is familiar with by spewing out a string of them.Chlorthalidone wins: ALLHAT, MRFIT, SPRINT, HYVET, CLICK (not mentioned by Swap but by Jordy later)HCTZ loses: HOPE3, ACCOMPLISHDiuretic half-lifes NEJM reviewEdarbyclor: Azilsartan and Chlorthalidone $240/month as per GoodRxNice mention of late study originator Frank Lederle. Please see his article in Annals about his diagnosis of pancreatic cancer. Moving. Network analysis of HCTZ vs chlorthalidoneAntihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil by George BakrisSynopsis of the 2020 U.S. Department of Veterans Affairs/U.S. Department of Defense Clinical Practice Guideline: The Diagnosis and Management of Hypertension in the Primary Care Setting (Annals of Internal Medicine)Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study by Jordy CohenStudy showing better risk reward ratio of low dose than high dose thiazide diuretics. Treatment of hypertension in the elderly: I. Blood pressure and clinical changes. Results of a Department of Veterans Affairs Cooperative Study.Tubular SecretionsSwapnil Louise Penny author of book upon which the Amazon Prime series, Three Pines is based on.Jordy Last of Us series on HBOJosh Channel Your Enthusiasm A Very Special Episode: Meet the GlaucomfleckensAreef The Body: A Guide for OccupantsJoel NephMadness (this did not age well)

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanJordy CohenWith Special Guest:<a href="https://twitter.com/Areefishani" rel="nofollow" target="_blank">Areef ishani</a> lead author and Chief of Medicine <a href="https://twitter.com/VAMinneapolis" rel="nofollow" target="_blank">VA Minneapolis</a>Editor:Nayan AroraShow Notes:<a href="https://pubmed.ncbi.nlm.nih.gov/2225366/" rel="nofollow" target="_blank">MRFIT switches diuretics</a> and finds better outcomes. Swapnil shows how many studies he is familiar with by spewing out a string of them.Chlorthalidone wins: <a href="https://jamanetwork.com/journals/jama/fullarticle/195626" rel="nofollow" target="_blank">ALLHAT</a>, MRFIT, <a href="https://www.nejm.org/doi/full/10.1056/nejmoa1511939" rel="nofollow" target="_blank">SPRINT</a>, <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa0801369" rel="nofollow" target="_blank">HYVET</a>, <a href="https://www.nejm.org/doi/full/10.1056/nejmoa2110730" rel="nofollow" target="_blank">CLICK</a> (not mentioned by Swap but by Jordy later)HCTZ loses: <a href="https://www.nejm.org/doi/full/10.1056/nejmoa1600175" rel="nofollow" target="_blank">HOPE3</a>, <a href="https://www.nejm.org/doi/full/10.1056/nejmoa0806182#:~:text=The%20ACCOMPLISH%20study%20was%20a,risk%20for%20a%20cardiovascular%20event." rel="nofollow" target="_blank">ACCOMPLISH</a>Diuretic half-lifes <a href="https://www.nejm.org/doi/full/10.1056/nejm199808063390607" rel="nofollow" target="_blank">NEJM review</a>Edarbyclor: Azilsartan and Chlorthalidone $240/month as per <a href="https://www.goodrx.com/edarbyclor/" rel="nofollow" target="_blank">GoodRx</a>Nice mention of late study originator Frank Lederle. Please see his <a href="https://www.acpjournals.org/doi/10.7326/M17-2788" rel="nofollow" target="_blank">article in Annals</a> about his diagnosis of pancreatic cancer. Moving. <a href="https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.112.191106" rel="nofollow" target="_blank">Network analysis</a> of HCTZ vs chlorthalidone<a href="https://pubmed.ncbi.nlm.nih.gov/22939358/" rel="nofollow" target="_blank">Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil</a> by George BakrisSynopsis of the 2020 U.S. Department of Veterans Affairs/U.S. Department of Defense Clinical Practice Guideline: The Diagnosis and Management of Hypertension in the Primary Care Setting (<a href="https://www.acpjournals.org/doi/10.7326/M20-3798" rel="nofollow" target="_blank">Annals of Internal Medicine</a>)<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965294/" rel="nofollow" target="_blank">Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study</a> by Jordy CohenStudy showing better risk reward ratio of low dose than high dose thiazide diuretics. <a href="https://www.ahajournals.org/doi/10.1161/01.hyp.15.4.348" rel="nofollow" target="_blank">Treatment of hypertension in the elderly: I. Blood pressure and clinical changes. Results of a Department of Veterans Affairs Cooperative Study.</a>Tubular SecretionsSwapnil <a href="https://en.wikipedia.org/wiki/Louise_Penny" rel="nofollow" target="_blank">Louise Penny</a> author of book upon which the Amazon Prime series, <a href="https://www.primevideo.com/detail/Three-Pines/0H8O66YGZTDEH7RBGSXG1O3CDD" rel="nofollow" target="_blank">Three Pines</a> is based on.Jordy <a href="https://www.imdb.com/title/tt3581920/" rel="nofollow" target="_blank">Last of Us series on HBO</a>Josh Channel Your Enthusiasm <a href="http://www.rosebook.club/episodes/2023/3/4/glaucomflecken" rel="nofollow" target="_blank">A Very Special Episode: Meet the Glaucomfleckens</a>Areef <a href="https://www.amazon.com/The-Body-Bill-Bryson-audiobook/dp/B07RB2C1LV/ref=sr_1_1?hvadid=433869804407&amp;hvdev=c&amp;hvlocint=9016826&amp;hvlocphy=1007808&amp;hvnetw=g&amp;hvqmt=e&amp;hvrand=12645357682093088592&amp;hvtargid=kwd-848861931734&amp;hydadcr=7635_9903235&amp;keywords=the%20body%20-%20a%20guide%20for%20occupants&amp;qid=1682995180&amp;sr=8-1" rel="nofollow" target="_blank">The Body: A Guide for Occupants</a>Joel <a href="https://ajkdblog.org/category/nephmadness/" rel="nofollow" target="_blank">NephMadness</a> (this did not age well)

Freely Filtered 058: HCTZ v Chlorthalidone, The Diuretic Comparison Project

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoWith Special Guest:Anna Vinakova Associate Professor of Medicine at Virginia Commonwealth University. NephMadness Executive. Vanuja Java is a transplant nephrologist at Washington University in St. Louis, MO. Her research involves functional characterization of genetic variants in complement-mediated diseases. She co-chairs the ClinGen complement gene curation expert panel.Editor:Sophia AmbrusoShow Notes:#NephMadness 2023: Thrombotic Microangiopathy RegionTMA Review article in the NEJM from 2014: Syndromes of Thrombotic MicroangiopathyDr. Anuja Java Co-chairs Working Group in an International Committee for Revising aHUS NomenclatureNephrology Secrets 4th Edition at AmazonUniversity of Iowa Genetic testing for aHUSEarly Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study. KI reports. This is the Netherlands study. They used home urine dipsticks to monitor for relapses. Clinical promise of next-generation complement therapeutics Nature reviews. Drug DiscoveryNephMadness PodcrawlTubular SecretionsSwap: Neuromancer and the works of William Gibson (@GreatDismal)Sophia: The Magicians on NetflixAnna: Recommends nephrology. Says it is awesome. Anuja: Dope Sick on Hulu and Women in Nephrology mentor programJosh: Mobituaries with Mo Rocca. Specifically “Death of a Banana”Joel: Ivory by TapBot

The Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoWith Special Guest:Anna Vinakova Associate Professor of Medicine at Virginia Commonwealth University. NephMadness Executive. Vanuja Java is a transplant nephrologist at Washington University in St. Louis, MO. Her research involves functional characterization of genetic variants in complement-mediated diseases. She co-chairs the ClinGen complement gene curation expert panel.Editor:Sophia AmbrusoShow Notes:#NephMadness 2023: <a href="https://ajkdblog.org/2023/03/01/nephmadness-2023-thrombotic-microangiopathy-region/" rel="nofollow" target="_blank">Thrombotic Microangiopathy Region</a>TMA Review article in the NEJM from 2014: <a href="https://www.nejm.org/doi/10.1056/NEJMra1312353" rel="nofollow" target="_blank">Syndromes of Thrombotic Microangiopathy</a>Dr. Anuja Java Co-chairs <a href="https://nephrology.wustl.edu/dr-anuja-java-co-chairs-working-group-for-revising-ahus-nomenclature/" rel="nofollow" target="_blank">Working Group in an International Committee for Revising aHUS Nomenclature</a>Nephrology Secrets 4th Edition at <a href="https://www.amazon.com/Nephrology-Secrets-Edgar-Lerma-FACP/dp/0323478719" rel="nofollow" target="_blank">Amazon</a>University of Iowa <a href="https://morl.lab.uiowa.edu/clinical-diagnostic-services/clinical-renal-diagnostic-division/genetic-renal-panel-testing" rel="nofollow" target="_blank">Genetic testing for aHUS</a>Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study. <a href="https://www.sciencedirect.com/science/article/pii/S2468024922018265" rel="nofollow" target="_blank">KI reports</a>. This is the Netherlands study. They used home urine dipsticks to monitor for relapses. Clinical promise of next-generation complement therapeutics <a href="https://europepmc.org/article/med/31324874#free-full-text" rel="nofollow" target="_blank">Nature reviews. Drug Discovery</a><a href="http://nephmadness.com/podcrawl" rel="nofollow" target="_blank">NephMadness Podcrawl</a>Tubular SecretionsSwap: <a href="https://www.amazon.com/Neuromancer-William-Gibson/dp/0441569595" rel="nofollow" target="_blank">Neuromancer</a> and the works of William Gibson (<a href="https://twitter.com/GreatDismal" rel="nofollow" target="_blank">@GreatDismal</a>)Sophia: <a href="https://en.wikipedia.org/wiki/The_Magicians_(American_TV_series)" rel="nofollow" target="_blank">The Magicians</a> on NetflixAnna: Recommends nephrology. Says it is awesome. Anuja: <a href="https://en.wikipedia.org/wiki/Dopesick_(miniseries)" rel="nofollow" target="_blank">Dope Sick</a> on Hulu and <a href="https://www.womeninnephrology.org" rel="nofollow" target="_blank">Women in Nephrology</a> mentor programJosh: <a href="https://podcasts.apple.com/us/podcast/mobituaries-with-mo-rocca/id1449045549" rel="nofollow" target="_blank">Mobituaries with Mo Rocca</a>. Specifically “<a href="https://podcasts.apple.com/us/podcast/mobituaries-with-mo-rocca/id1449045549" rel="nofollow" target="_blank">Death of a Banana</a>”Joel: <a href="https://tapbots.com/ivory/" rel="nofollow" target="_blank">Ivory by TapBot</a>

Freely Filtered 057: NephMadness 2023 TMA

Welcome to the NephMadness PodCrawlThe idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of the first goals behind NephMadness was to build a community and in the early years of Twitter, NephMadness was central to the formation of #NephTwitter and defining the ethos that makes our online community kind, intelligent, vibrant, and interesting. The NephMadness Podcrawl hopes to inspire and grow the nephrology podcast community in the same way. For 2023, our second year,  the PodCrawl has assembled the Avengers of Medical Pods!Go to NephMadness.com/podcrawl for more information and links to all of the podcasts!The Curbsiders gets the skinny on mineralcorticoid receptor antagonistsCore IM will be covering Kidney Transplant in their classic Five Pearl formatThe CardioNerds will be covering the effect of Heart Failure Devices on Kidney HealthFreely Filtered will try to understand thrombotic microangiopathyISN Global Kidney Care goes deep on IgA nephropathyThe Cribsiders look at transitions, first the Peditrics to Adult nephrology transition and then from living to death with palliative nephrology Fellow on Call will be covering OnconephrologyAnd finally, The Nephron Segment looks at Transgender Health and CKD

Welcome to the NephMadness PodCrawlThe idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of the first goals behind NephMadness was to build a community and in the early years of Twitter, NephMadness was central to the formation of #NephTwitter and defining the ethos that makes our online community kind, intelligent, vibrant, and interesting. The NephMadness Podcrawl hopes to inspire and grow the nephrology podcast community in the same way. For 2023, our second year,  the PodCrawl has assembled the Avengers of Medical Pods!Go to <a href="https://NephMadness.com/podcrawl" rel="nofollow" target="_blank">NephMadness.com/podcrawl</a> for more information and links to all of the podcasts! The Curbsiders gets the skinny on mineralcorticoid receptor antagonistsCore IM will be covering Kidney Transplant in their classic Five Pearl formatThe CardioNerds will be covering the effect of Heart Failure Devices on Kidney HealthFreely Filtered will try to understand thrombotic microangiopathyISN Global Kidney Care goes deep on IgA nephropathyThe Cribsiders look at transitions, first the Peditrics to Adult nephrology transition and then from living to death with palliative nephrology Fellow on Call will be covering OnconephrologyAnd finally, The Nephron Segment looks at Transgender Health and CKD

Say "Hi" to the #NephMadness PodCrawl

The Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoWith Special Guest:Amit Garg @AmitXGarg, Nephrologist at Western University, London, and lead PI of the MYTEMP trial. Editor:Joel TopfShow Notes:MyTEMP in pubmed: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trialMyTEMP Summary on NephJC It’s really cold in OntarioThe NephTrials blog summary on Pragmatic TrialsThe pragmatic TiME trial on longer time on dialysis (ahem, sabotaged by site investigators like Joel who cut dialysate time) Dember et al in JASNPoor quality of trial data preceding MyTEMP, a systematic review from Mustafa et al in JASN The 2007 European Best Practice Guideline (EBPG) from 2007, recommending “Cool dialysate temperature dialysis (35–36°C) or isothermic treatments by blood temperature controlled feedback should be prescribed in patients with frequent episodes of IDH (Evidence level I).” in NDT47% of centres from a DOPPS study of 273 centers routinely use of lower dialysate temperature, Dasgupta et al in JASNHow do you convert from C to F? Almanac.com (35.5 C is 96.9 F; 37 C is 98.6 F)More on the rationale and design of MyTEMP: Al-Jaishi et al in CJKHDHow big is 4.3 million (the number of hemodialysis treatments in MyTEMP)? Very big indeed.NephJC discussion of another cluster RCT and granular data only on a subset SSASS Participants in dialysis clinical trials are not representative of the real world dialysis cohorts, Smyth et al in JAMA Int MedPeritoneal dialysis numbers in Ontario are high, Blake et al in PDI, though with ~ 60% CVC rates, Blake et al in Kidney360Dialysate Magnesium #DreamRCT from Swap, NephTrials discussion of DialMagStatistical analysis plan of MyTEMP, Dixon et al in CJKHDTubular SecretionsSwap: Watch Everything, Everywhere All At Once on PrimeNayan: Read The Midnight Ride from Ben Mezrich (brother of Josh Mezrich from the NephJC Summer Book Club 2021)Sophia: Making nephrology education fun at the UC DenverAmit: The wrestling team at Western U from 1990-91Joel: House of the Dragon on HBO Max

The Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoWith Special Guest:Amit Garg <a href="https://twitter.com/AmitXGarg" rel="nofollow" target="_blank">@AmitXGarg</a>, Nephrologist at Western University, London, and lead PI of the MYTEMP trial. Editor:Joel TopfShow Notes:MyTEMP in pubmed: <a href="https://pubmed.ncbi.nlm.nih.gov/36343653/" rel="nofollow" target="_blank">Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial</a>MyTEMP Summary on <a href="http://www.nephjc.com/news/mytemp" rel="nofollow" target="_blank">NephJC</a> It’s really <a href="https://www.theweathernetwork.com/en/news/weather/forecasts/polar-vortexs-return-will-mean-dangerous-50-wind-chill-in-ontario" rel="nofollow" target="_blank">cold</a> in OntarioThe NephTrials blog summary on <a href="http://www.nephjc.com/news/2021/2/15/pragmatictrials" rel="nofollow" target="_blank">Pragmatic Trials</a>The pragmatic TiME trial on longer time on dialysis (ahem, sabotaged by site investigators like Joel who cut dialysate time) <a href="https://pubmed.ncbi.nlm.nih.gov/31000566/" rel="nofollow" target="_blank">Dember et al in JASN</a>Poor quality of trial data preceding MyTEMP, a systematic review from <a href="https://pubmed.ncbi.nlm.nih.gov/26712807/" rel="nofollow" target="_blank">Mustafa et al in JASN </a>The 2007 European Best Practice Guideline (EBPG) from 2007, recommending “Cool dialysate temperature dialysis (35–36°C) or isothermic treatments by blood temperature controlled feedback should be prescribed in patients with frequent episodes of IDH (Evidence level I).” in <a href="https://academic.oup.com/ndt/article/22/suppl_2/ii22/1871231?login=false" rel="nofollow" target="_blank">NDT</a>47% of centres from a DOPPS study of 273 centers routinely use of lower dialysate temperature, <a href="https://pubmed.ncbi.nlm.nih.gov/30723164/" rel="nofollow" target="_blank">Dasgupta et al in JASN</a>How do you convert from C to F? <a href="https://www.almanac.com/temperature-conversion-celsius-fahrenheit" rel="nofollow" target="_blank">Almanac.com</a> (35.5 C is 96.9 F; 37 C is 98.6 F)More on the rationale and design of MyTEMP:<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003172/" rel="nofollow" target="_blank"> Al-Jaishi et al in CJKHD</a>How big is 4.3 million (the number of hemodialysis treatments in MyTEMP)? <a href="https://howmanyzeros.com/zeros-in-4-3-million" rel="nofollow" target="_blank">Very big indeed</a>.NephJC discussion of another cluster RCT and granular data only on a subset <a href="http://www.nephjc.com/news/salt-substitute" rel="nofollow" target="_blank">SSASS </a>Participants in dialysis clinical trials are not representative of the real world dialysis cohorts, <a href="https://pubmed.ncbi.nlm.nih.gov/31282924/" rel="nofollow" target="_blank">Smyth et al in JAMA Int Med</a>Peritoneal dialysis numbers in <a href="https://www.ontariorenalnetwork.ca/en/renal-network-data/performance-data/dialysis-performance-data" rel="nofollow" target="_blank">Ontario</a> are high, <a href="https://pubmed.ncbi.nlm.nih.gov/33969759/" rel="nofollow" target="_blank">Blake et al in PDI</a>, though with ~ 60% CVC rates, <a href="https://journals.lww.com/kidney360/pages/articleviewer.aspx?year=2020&amp;issue=02000&amp;article=00005&amp;type=Fulltext" rel="nofollow" target="_blank">Blake et al in Kidney360</a>Dialysate Magnesium <a href="https://www.medpagetoday.com/nephrology/dreamrct/53870" rel="nofollow" target="_blank">#DreamRCT</a> from Swap, NephTrials <a href="http://www.nephjc.com/news/clusterct" rel="nofollow" target="_blank">discussion</a> of DialMagStatistical analysis plan of MyTEMP, <a href="https://pubmed.ncbi.nlm.nih.gov/34471542/" rel="nofollow" target="_blank">Dixon et al in CJKHD</a>Tubular SecretionsSwap: Watch <a href="https://www.imdb.com/title/tt6710474/" rel="nofollow" target="_blank">Everything, Everywhere All At Once</a> on PrimeNayan: Read <a href="https://www.goodreads.com/en/book/show/58340975" rel="nofollow" target="_blank">The Midnight Ride</a> from Ben Mezrich (brother of Josh Mezrich from the <a href="http://www.nephjc.com/news/2021/8/2/nephjc-summer-book-club" rel="nofollow" target="_blank">NephJC Summer Book Club 2021</a>)Sophia: Making nephrology education fun at the <a href="https://medschool.cuanschutz.edu/renal" rel="nofollow" target="_blank">UC Denver</a>Amit: The <a href="https://i0.wp.com/metrasmuseum.ca/wp-content/uploads/2015/06/1990-91-Mens-Wrestling-Senior-Preseason-MC.jpg" rel="nofollow" target="_blank">wrestling team</a> at Western U from 1990-91Joel: <a href="https://www.imdb.com/title/tt11198330/" rel="nofollow" target="_blank">House of the Dragon</a> on HBO Max

Freely Filtered 056: MyTEMP

The Filtrate:Joel TopfSwapnil HiremathJordy Cohen With Special Guest:Laurie Tomlinson. @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy. Editor: Priya Yenebere Show Notes:STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney DiseaseSTOP-ACE Summary in NephJC Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney diseaseEfficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: NEJMDr. Tomlinson’s article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study NephJC | PubMed Accuracy of eGFR at low GFR: A new equation to estimate glomerular filtration rateStrong opinions, loosely held. “Permissive AKI” with treatment of heart failure. Editorial by Chirag Parish and Steven CocaThe rational for NICE avoiding RASi in black patients: Hypertension and ethnic groupAASK trial showing superiority of RASi in African Americans. JAMAALLHAT post-hoc analysis of outcomes by self-reported race. JAMA | PubMedSophisticated Swedish observational study that Swap loved. Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide StudyTarget Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, YouTubeTarget Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in JAMATubular SecretionsJordy: Third season of His Dark Materials on HBOSwap: Movies by Wes Anderson on Disney PlusLaurie: The Book, “Nearly All the Men in Lagos are Mad”Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | AmazonJoel EO | NYT Review

The Filtrate:Joel TopfSwapnil HiremathJordy Cohen With Special Guest:Laurie Tomlinson. <a href="https://twitter.com/Roxytonin" rel="nofollow" target="_blank">@Roxytonin</a> Nephrologist at University Hospitals Sussex and research hero of Jordy. Editor: Priya Yenebere Show Notes:STOP-ACE in pubmed: <a href="https://pubmed.ncbi.nlm.nih.gov/36326117/" rel="nofollow" target="_blank">Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease</a>STOP-ACE Summary in <a href="http://www.nephjc.com/news/stopacei" rel="nofollow" target="_blank">NephJC</a> Prior data showing preservation of renal function by stopping ACEi: <a href="https://pubmed.ncbi.nlm.nih.gov/19820248/" rel="nofollow" target="_blank">The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease</a>Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa053107" rel="nofollow" target="_blank">NEJM</a>Dr. Tomlinson’s article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study <a href="http://www.nephjc.com/news/2017/4/24/riseandfall" rel="nofollow" target="_blank">NephJC</a> | <a href="https://pubmed.ncbi.nlm.nih.gov/28279964/" rel="nofollow" target="_blank">PubMed</a> Accuracy of eGFR at low GFR: <a href="https://pubmed.ncbi.nlm.nih.gov/19414839/" rel="nofollow" target="_blank">A new equation to estimate glomerular filtration rate</a><a href="https://daringfireball.net/linked/2018/01/29/bongiorno-jobs" rel="nofollow" target="_blank">Strong opinions, loosely held.</a> <a href="https://www.kidney-international.org/article/S0085-2538(19)30708-2/pdf" rel="nofollow" target="_blank">“Permissive AKI” with treatment of heart failure</a>. Editorial by Chirag Parish and Steven CocaThe rational for NICE avoiding RASi in black patients: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1432176/" rel="nofollow" target="_blank">Hypertension and ethnic group</a>AASK trial showing superiority of RASi in African Americans. <a href="https://jamanetwork.com/journals/jama/fullarticle/195530" rel="nofollow" target="_blank">JAMA</a>ALLHAT post-hoc analysis of outcomes by self-reported race. <a href="https://jamanetwork.com/journals/jama/fullarticle/200638" rel="nofollow" target="_blank">JAMA</a> | <a href="https://pubmed.ncbi.nlm.nih.gov/15811979/" rel="nofollow" target="_blank">PubMed</a>Sophisticated Swedish observational study that Swap loved. <a href="https://journals.lww.com/JASN/pages/articleviewer.aspx?article=00017&amp;issue=02000&amp;type=Fulltext&amp;year=2021" rel="nofollow" target="_blank">Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study</a>Target Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, <a href="https://www.youtube.com/watch?t=6s&amp;v=6L3-0I1EEGM" rel="nofollow" target="_blank">YouTube</a>Target Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in <a href="https://jamanetwork.com/journals/jama/article-abstract/2799678" rel="nofollow" target="_blank">JAMA</a>Tubular SecretionsJordy: Third season of <a href="https://www.hbo.com/his-dark-materials" rel="nofollow" target="_blank">His Dark Materials</a> on HBOSwap: Movies by <a href="https://www.imdb.com/name/nm0027572/" rel="nofollow" target="_blank">Wes Anderson</a> on Disney PlusLaurie: The Book, “<a href="https://en.wikipedia.org/wiki/Nearly_All_the_Men_in_Lagos_are_Mad" rel="nofollow" target="_blank">Nearly All the Men in Lagos are Mad</a>”Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | <a href="https://www.amazon.com/How-Medicine-Works-When-Doesnt/dp/1538723603" rel="nofollow" target="_blank">Amazon</a>Joel EO | <a href="https://www.nytimes.com/2022/11/17/movies/eo-review-donkey.html?action=click&amp;module=RelatedLinks&amp;pgtype=Article" rel="nofollow" target="_blank">NYT Review</a>

Freely Filtered 055: STOP ACE!

The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso Priya Yenebere  With Special Guest: Brendon Neuen, Secretariat of the SGLT2 Trialists Consortium and cool guy on Twitter.  Editor:  Sophia Ambruso  Show Notes: Joel’s Conflict of Interest Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space. Joel starts off with a history of SGLT2i EMPA-REG Outcomes. First! CANVAS. OMG this signal is reproducible! CREDENCE (🎧). It works in a dedicated population at high risk of kidney disease. And in a study designed for renal end-points. DAPA-CKD (🎧). It’s not just for diabetics! EMPA-Kidney. It works at really low GFR. And without albuminuria. And again in non-diabetics. SGLT Inhibitors for Type 1 Diabetes: Proceed With Extreme Caution Click to find the supplement (requires a subscription)Differences in definition in the decreased renal function component of the composite primary outcomes. EMPA-Kidney 40% DAPA-Kidney 50% CREDENCE doubling of serum Cr Usability Testing of a Sick-Day Protocol in CKD (Pubmed) New Guidelines for Statistical Reporting in the Journal (link, commentary on said guidelines by Frank Harrell) CKD outcomes and the FDA: Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency The Peripheral on Amazon Prime Unsealed the Tylenol Murders Podcast Project Hail Mary by Andrew Weir Lizzy McAlpine Singer Song Writer Rachel Maddow Presents: Ultra Twitter chaos continues. Get your Med-Mastodon handle

The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso Priya Yenebere With Special Guest: Brendon Neuen, Secretariat of the SGLT2 Trialists Consortium and cool guy on <a href="https://twitter.com/brendonneuen" rel="nofollow" target="_blank">Twitter</a>. Editor: Sophia Ambruso Show Notes: Joel’s <a href="https://pbfluids.com/about/" rel="nofollow" target="_blank">Conflict of Interest</a> Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space. Joel starts off with a history of SGLT2i <a href="http://www.nephjc.com/news/2016/6/23/empa-reg-renal-results" rel="nofollow" target="_blank">EMPA-REG Outcomes</a>. First! <a href="http://www.nephjc.com/news/canvas" rel="nofollow" target="_blank">CANVAS</a>. OMG this signal is reproducible! <a href="http://www.nephjc.com/news/credence" rel="nofollow" target="_blank">CREDENCE</a> (<a href="http://www.nephjc.com/freelyfiltered/2019/4/28/freely-filtered-003-credence" rel="nofollow" target="_blank">🎧</a>). It works in a dedicated population at high risk of kidney disease. And in a study designed for renal end-points. <a href="http://www.nephjc.com/news/dapa-ckd" rel="nofollow" target="_blank">DAPA-CKD</a> (<a href="http://www.nephjc.com/freelyfiltered/2021/dapa-ckd" rel="nofollow" target="_blank">🎧</a>). It’s not just for diabetics! EMPA-Kidney. It works at really low GFR. And without albuminuria. And again in non-diabetics. <a href="https://diabetesjournals.org/care/article/42/6/991/36067/SGLT-Inhibitors-for-Type-1-Diabetes-Proceed-With" rel="nofollow" target="_blank">SGLT Inhibitors for Type 1 Diabetes: Proceed With Extreme Caution</a> <a href="https://www.nejm.org/doi/suppl/10.1056/NEJMoa2204233/suppl_file/nejmoa2204233_appendix.pdf" rel="nofollow" target="_blank">Click</a> to find the supplement (requires a subscription) Differences in definition in the decreased renal function component of the composite primary outcomes. EMPA-Kidney 40% DAPA-Kidney 50% CREDENCE doubling of serum Cr Usability Testing of a Sick-Day Protocol in CKD (<a href="https://pubmed.ncbi.nlm.nih.gov/30867156/" rel="nofollow" target="_blank">Pubmed</a>) New Guidelines for Statistical Reporting in the Journal (<a href="https://www.nejm.org/doi/full/10.1056/NEJMe1906559" rel="nofollow" target="_blank">link</a>, <a href="https://discourse.datamethods.org/t/updates-to-nejm-statistical-guidelines-for-authors/1888" rel="nofollow" target="_blank">commentary</a> on said guidelines by Frank Harrell) CKD outcomes and the FDA: <a href="https://www.ajkd.org/article/S0272-6386(19)30883-2/fulltext" rel="nofollow" target="_blank">Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency</a> <a href="https://www.amazon.com/The-Peripheral-Season-1/dp/B0B8TFMYXZ/?gclid=CjwKCAiAhqCdBhB0EiwAH8M_Gmf3PNtS-PFhrHovm-QkARdU_HIDeT7g6IntqkrSPid_RPcgOeI7yBoCUzgQAvD_BwE&amp;mrntrk=pcrid_629460942132_slid__pgrid_145634038547_pgeo_9016837_x__ptid_kwd-303010509061&amp;ref=DVM_US_DL_SL_GO_AST_PERIS1_mkw_swTKkHyT1-dc" rel="nofollow" target="_blank">The Peripheral</a> on Amazon Prime <a href="https://www.chicagotribune.com/tylenolmurders/ct-chicago-tylenol-murders-podcast-episode-1-20220922-kqde23s4bnebxhak23z5enobhu-htmlstory.html" rel="nofollow" target="_blank">Unsealed the Tylenol Murders</a> Podcast <a href="https://www.amazon.com/Project-Hail-Mary-Andy-Weir/dp/0593135202" rel="nofollow" target="_blank">Project Hail Mary</a> by Andrew Weir <a href="https://en.wikipedia.org/wiki/Lizzy_McAlpine" rel="nofollow" target="_blank">Lizzy McAlpine</a> Singer Song Writer Rachel Maddow Presents: <a href="https://www.msnbc.com/rachel-maddow-presents-ultra" rel="nofollow" target="_blank">Ultra</a> Twitter chaos continues. Get your <a href="https://med-mastodon.com/invite/y4pz9sM8" rel="nofollow" target="_blank">Med-Mastodon handle</a>

Freely Filtered 054: EMPA Kidney!

The Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoEditor: Nayan AroraShow Notes:Joel’s Conflict of Interest StatementThe Draft Board EMPA-Kidney is “off the board”Lunch Symposium on Current and Future Approaches to the Diagnostic Assessment and Management of AKI in Patients with Cirrhosis provided by an educational grant from Mallinckrodt PharmaceuticalsThe CONFIRM Trial Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome in NephJCClinical Practice Session Leveraging Social Media to Create, Learn, Teach, Advocate, and Dispel MisinformationThe BEST-Fluids Trial: A Randomized Controlled Trial of Balanced Crystalloid Solution vs. Saline to Prevent Delayed Graft Function in Deceased Donor Kidney Transplantation - Michael G. Collins, Magid Fahim, Elaine Pascoe, Carmel Hawley, David W. Johnson, Philip A. Clayton, Steven J. Chadban (ClinicalTrials.gov)The Late Breaking and High Impact Trials Session line upStop ACEiCLARITY Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trialEffects of Pantoprazole on Kidney Outcomes: Post Hoc Analyses From the COMPASS Randomized Controlled Trial by Lonnie Pyne, et alNo Stone: Hydrochlorothiazide for the Prevention of Kidney Stone Recurrence by Daniel Foster, et alMyTEMP: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trialClinical Practice Session Best of NephJC“We'd Now Like To Open The Floor To Shorter speeches disguised as questions.”ASN Task Force on the Future of NephrologyAttracting Osteopathic Medical Students Into NephrologyHasan Minhaj’s joke at the expense of DOsTRANSFORM-HF: Torsemide vs. Furosemide in Treating Patients With HFPoint-of-Care Ultrasound in Nephrology specifically VExUS

The Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoEditor: Nayan AroraShow Notes:Joel’s <a href="https://pbfluids.com/about/" rel="nofollow" target="_blank">Conflict of Interest</a> Statement<a href="https://docs.google.com/document/d/1oCPdH2KT799RQ1wUyBhq3fvLyMVs8RcwrT1So6CsGB8/edit?usp=sharing" rel="nofollow" target="_blank">The Draft Board</a> EMPA-Kidney is “off the board”Lunch Symposium on <a href="https://www.asn-online.org/education/kidneyweek/2022/program-session-details.aspx?sessId=438058" rel="nofollow" target="_blank">Current and Future Approaches to the Diagnostic Assessment and Management of AKI in Patients with Cirrhosis</a> provided by an educational grant from Mallinckrodt PharmaceuticalsThe CONFIRM Trial <a href="http://www.nephjc.com/news/terlipressinrct" rel="nofollow" target="_blank">Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome</a> in NephJCClinical Practice Session <a href="https://www.asn-online.org/education/kidneyweek/2022/program-session-details.aspx?sessId=422712" rel="nofollow" target="_blank">Leveraging Social Media to Create, Learn, Teach, Advocate, and Dispel Misinformation</a>The BEST-Fluids Trial: A Randomized Controlled Trial of Balanced Crystalloid Solution vs. Saline to Prevent Delayed Graft Function in Deceased Donor Kidney Transplantation - Michael G. Collins, Magid Fahim, Elaine Pascoe, Carmel Hawley, David W. Johnson, Philip A. Clayton, Steven J. Chadban (<a href="https://clinicaltrials.gov/ct2/show/NCT03829488" rel="nofollow" target="_blank">ClinicalTrials.gov</a>)The Late Breaking and High Impact Trials Session <a href="https://www.asn-online.org/education/kidneyweek/2022/KW22_LBCTs.pdf" rel="nofollow" target="_blank">line up</a>Stop ACEiCLARITY <a href="https://www.bmj.com/content/379/bmj-2022-072175" rel="nofollow" target="_blank">Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial</a>Effects of Pantoprazole on Kidney Outcomes: Post Hoc Analyses From the COMPASS Randomized Controlled Trial by Lonnie Pyne, et alNo Stone: Hydrochlorothiazide for the Prevention of Kidney Stone Recurrence by Daniel Foster, et alMyTEMP: <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01805-0/fulltext" rel="nofollow" target="_blank">Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial</a>Clinical Practice Session <a href="https://www.asn-online.org/education/kidneyweek/2022/program-session-details.aspx?sessId=419348" rel="nofollow" target="_blank">Best of NephJC</a>“We'd Now Like To Open The Floor To Shorter speeches disguised as questions.”<a href="https://www.asn-online.org/FutureOfNephrology" rel="nofollow" target="_blank">ASN Task Force on the Future of Nephrology</a><a href="https://www.kidneynews.org/view/journals/kidney-news/13/4/article-p20_5.xml" rel="nofollow" target="_blank">Attracting Osteopathic Medical Students Into Nephrology</a><a href="https://www.kevinmd.com/2022/01/hasan-minhajs-joke-at-the-expense-of-dos.html" rel="nofollow" target="_blank">Hasan Minhaj’s joke at the expense of DOs</a>TRANSFORM-HF: <a href="https://www.acc.org/Latest-in-Cardiology/Articles/2022/11/01/22/00/sat-1130am-transform-hf-aha-2022" rel="nofollow" target="_blank">Torsemide vs. Furosemide in Treating Patients With HF</a><a href="https://www.asn-online.org/education/kidneyweek/2022/program-session-details.aspx?sessId=432718&amp;sessPar=432543" rel="nofollow" target="_blank">Point-of-Care Ultrasound in Nephrology</a> specifically VExUS

Freely Filtered 053: The Kidney Week Draft

The Filtrate:Joel TopfJordy CohenNayan AroraSophia AmbrusoSpecial Guests:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (SODIUM-HF). His Google Schoolar page is better than yours. David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical &amp; Translational Institute. Show Notes:Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (The CARESS Trial)Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure (The UNLOAD trial)Diuretic Strategies in Patients with Acute Decompensated Heart Failure (The DOSE Trial)Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure (The 3T Trial)Sequential nephron blockade with a thiazide diuretic has a 1 B-NR (non-radomized) grade in the AHA/ACC Heart Failure Guidelines (7.2)Three important acute decompensated heart failure with SGLT2i:1. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure (SOLOIST-WHF Trial)2. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (The EMPULSE Trial)3. Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art ReviewCardiologist Sues Epic Over Copyright InfringementOutcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: a propensity analysis.Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance (PubMed)Efficacy and Safety of Spironolactone in Acute Heart Failure (ATHENA Trial)Joel with a video on acetazolamide for altitude sickness. The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine(Amazon)

The Filtrate:Joel TopfJordy CohenNayan AroraSophia AmbrusoSpecial Guests:Boback Ziaeian <a href="https://twitter.com/boback" rel="nofollow" target="_blank">@boback</a> Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (<a href="http://www.nephjc.com/freelyfiltered/49/sodium-hf" rel="nofollow" target="_blank">SODIUM-HF</a>). His <a href="https://scholar.google.com/citations?hl=en&amp;user=iTIF3ygAAAAJ" rel="nofollow" target="_blank">Google Schoolar page</a> is better than yours. <a href="https://www.ohsu.edu/school-of-medicine/ellison-lab/david-h-ellison" rel="nofollow" target="_blank">David Ellison</a> <a href="https://twitter.com/dhekidney" rel="nofollow" target="_blank">@dhekidney</a> is professor of medicine at Oregon Health Science University and head of the Oregon Clinical &amp; Translational Institute. Show Notes:Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1210357" rel="nofollow" target="_blank">The CARESS Trial</a>)Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure (<a href="https://pubmed.ncbi.nlm.nih.gov/17291932/" rel="nofollow" target="_blank">The UNLOAD trial</a>)Diuretic Strategies in Patients with Acute Decompensated Heart Failure (<a href="https://www.nejm.org/doi/full/10.1056/nejmoa1005419" rel="nofollow" target="_blank">The DOSE Trial</a>)Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure (<a href="https://pubmed.ncbi.nlm.nih.gov/31838029/" rel="nofollow" target="_blank">The 3T Trial</a>)Sequential nephron blockade with a thiazide diuretic has a 1 B-NR (non-radomized) grade in the <a href="https://www.ahajournals.org/doi/10.1161/CIR.0000000000001063" rel="nofollow" target="_blank">AHA/ACC Heart Failure Guidelines</a> (7.2)Three important acute decompensated heart failure with SGLT2i:1. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure (<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2030183" rel="nofollow" target="_blank">SOLOIST-WHF Trial</a>)2. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (<a href="https://www.nature.com/articles/s41591-021-01659-1" rel="nofollow" target="_blank">The EMPULSE Trial</a>)3. Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (<a href="https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.059038" rel="nofollow" target="_blank">EMPAG-HF</a>)<a href="https://pubmed.ncbi.nlm.nih.gov/33183512/" rel="nofollow" target="_blank">Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review</a><a href="https://www.medpagetoday.com/special-reports/exclusives/97977" rel="nofollow" target="_blank">Cardiologist Sues Epic Over Copyright Infringement</a>Outcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: <a href="https://www.ahajournals.org/doi/10.1161/JAHA.118.009149" rel="nofollow" target="_blank">a propensity analysis</a>.Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance (<a href="https://pubmed.ncbi.nlm.nih.gov/31074184/" rel="nofollow" target="_blank">PubMed</a>)Efficacy and Safety of Spironolactone in Acute Heart Failure (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675712/" rel="nofollow" target="_blank">ATHENA Trial</a>)Joel with a <a href="https://m.facebook.com/medmastery/videos/acetazolamide-and-the-potassium-sparing-diuretics/1132237163630250/" rel="nofollow" target="_blank">video on acetazolamide for altitude sickness</a>. The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine(Amazon)

Freely Filtered 052: Acetazolamide for Acute Decompensated Heart Failure (ADVOR)

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

great way to stay up to date on all things kidney. hosts are delightful and incredibly knowledgeable. I turned this on to put myself to sleep one night but they managed to keep me awake and wanting more so I had to switch to a lesser podcast.  will definitely be a regular part of my rotation. thank you!!! 

Gerald @ GrepMed

podcast i didn’t realize was missing from my life...

Thankful for a place to hear all their brilliance at once place

Excellent!

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

Freely Filtered, a NephJC Podcast

Joel TopfJennie LinMatt SparksSamira FaroukThe strange story of Jennifer Strange.https://insiderexclusive.com/radios-deadly-stunts-the-jennifer-strange-story/Water Pokerhttps://www.thelocal.se/20120706/41878Nintendo Game Consoleshttps://en.wikipedia.org/wiki/Nintendo_video_game_consoles2019 Narins winner, Mitchel Rosner on MDMA induced hyponatremiahttps://www.ncbi.nlm.nih.gov/pubmed/18684895And Rosner again on exercise induced hyponatremia.https://cjasn.asnjournals.org/content/2/1/151The Arieff article on the dangers of severe hyponatremia: Hyponatremia, Convulsions, Respiratory Arrest, and Permanent Brain Damage after Elective Surgery in Healthy Womenhttps://www.nejm.org/doi/full/10.1056/NEJM198606123142401The Richard Sterns article on the dangers of rapid correction of hyponatremia: Osmotic Demyelination Syndrome Following Correction of Hyponatremiahttps://www.nejm.org/doi/10.1056/NEJM198606123142402The editorial by the man himself, Robert Narins: Therapy of Hyponatremiahttps://www.nejm.org/doi/full/10.1056/NEJM198606123142409The infant study showing seizures associated with rapid correction of hypernatremia.https://www.ncbi.nlm.nih.gov/pubmed/35558?dopt=AbstractFollow up study with oral rehydration.https://www.ncbi.nlm.nih.gov/pubmed/3958850?dopt=AbstractThe Linder study of adults admitted to the ICUhttps://www.ncbi.nlm.nih.gov/pubmed/18037096French study on patients presenting to the ER with hypernatremia.https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-37Study on US veterans showing poorer outcomes with slow correction of hypernatremia.https://www.ncbi.nlm.nih.gov/pubmed/21358313Cerebral edema during the treatment of DKA.https://emj.bmj.com/content/21/2/141The MIMIC 3 Database. MIMIC is an openly available dataset developed by the MIT Lab for Computational Physiology, comprising deidentified health data associated with ~40,000 critical care patients. It includes demographics, vital signs, laboratory tests, medications, and more.https://mimic.physionet.orgChalrson Comorbidity Indexhttps://www.mdcalc.com/charlson-comorbidity-index-cci#creator-insightsThe paper: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.https://www.ncbi.nlm.nih.gov/pubmed/3558716JCI article on organic brain osmnoles in response to hypernatremiahttps://www.ncbi.nlm.nih.gov/pubmed/2332498?dopt=AbstractJohn Booth on the value of MIMIC 3https://twitter.com/ThePeanutKidney/status/1128742219471642624Sri Lekha on checking labs in hypernatremiahttps://twitter.com/LTummalapalli/status/1128479041634226176Steve Coca on chunky water administrationhttps://twitter.com/scoca1/status/1128744643422769152Steve Coca musing the Cersei’s sodium levelhttps://twitter.com/scoca1/status/1128698514026975232Steve Coca swearing in High Valarlian:https://twitter.com/scoca1/status/1128629713826721792Steve Coca proving the non-existence of hypernatremia therapy being associated with brain damage through the inability of trial lawyers to find and sue doctors for this issue:https://twitter.com/scoca1/status/1128652586612080642The original paper on the Kardashian Indexhttps://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0424-0Kardashian Index Calculatorhttp://theinformationalturn.net/kardashian-index/Facebook CEO Mark Zuckerberg says the ‘future is private’https://www.theverge.com/2019/4/30/18524188/facebook-f8-keynote-mark-zuckerberg-privacy-future-2019Khenar Jhaveri et al on ‘WhatsApp’ening in nephrology traininghttps://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfz045/5482109Mike Morrison’s video on how to rebuild the scientific posterhttps://www.youtube.com/watch?v=1RwJbhkCA58Mike’s Twitter: https://twitter.com/mikemorrison?lang=en with lot’s of examples of his design in the wild.Make your own QR code: https://www.qr-code-generator.comGoodRx: https://www.goodrx.comTen Worst Drugs for your Kidney: https://www.goodrx.com/blog/10-worst-medications-for-your-kidneys/Drugs that can falsely elevate your creatinine levels: https://www.goodrx.com/blog/drugs-cause-false-high-creatinine-levels-blood-test/Dr Orrange, not wishing to engage on Twitter in a meaningful way: https://twitter.com/Orrangemd/status/1129165083194511361

Joel TopfJennie LinMatt SparksSamira FaroukThe strange story of Jennifer Strange.<a href="https://insiderexclusive.com/radios-deadly-stunts-the-jennifer-strange-story/" rel="nofollow" target="_blank">https://insiderexclusive.com/radios-deadly-stunts-the-jennifer-strange-story/</a> Water Poker<a href="https://www.thelocal.se/20120706/41878" rel="nofollow" target="_blank">https://www.thelocal.se/20120706/41878</a> Nintendo Game Consoles<a href="https://en.wikipedia.org/wiki/Nintendo_video_game_consoles" rel="nofollow" target="_blank">https://en.wikipedia.org/wiki/Nintendo_video_game_consoles</a> 2019 Narins winner, Mitchel Rosner on MDMA induced hyponatremia<a href="https://www.ncbi.nlm.nih.gov/pubmed/18684895" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/18684895</a> And Rosner again on exercise induced hyponatremia.<a href="https://cjasn.asnjournals.org/content/2/1/151" rel="nofollow" target="_blank">https://cjasn.asnjournals.org/content/2/1/151</a> The Arieff article on the dangers of severe hyponatremia: Hyponatremia, Convulsions, Respiratory Arrest, and Permanent Brain Damage after Elective Surgery in Healthy Women<a href="https://www.nejm.org/doi/full/10.1056/NEJM198606123142401" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJM198606123142401</a> The Richard Sterns article on the dangers of rapid correction of hyponatremia: Osmotic Demyelination Syndrome Following Correction of Hyponatremia<a href="https://www.nejm.org/doi/10.1056/NEJM198606123142402" rel="nofollow" target="_blank">https://www.nejm.org/doi/10.1056/NEJM198606123142402</a> The editorial by the man himself, Robert Narins: Therapy of Hyponatremia<a href="https://www.nejm.org/doi/full/10.1056/NEJM198606123142409" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJM198606123142409</a> The infant study showing seizures associated with rapid correction of hypernatremia.<a href="https://www.ncbi.nlm.nih.gov/pubmed/35558?dopt=Abstract" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/35558?dopt=Abstract</a> Follow up study with oral rehydration.<a href="https://www.ncbi.nlm.nih.gov/pubmed/3958850?dopt=Abstract" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/3958850?dopt=Abstract</a> The Linder study of adults admitted to the ICU<a href="https://www.ncbi.nlm.nih.gov/pubmed/18037096" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/18037096</a> French study on patients presenting to the ER with hypernatremia.<a href="https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-37" rel="nofollow" target="_blank">https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-37</a> Study on US veterans showing poorer outcomes with slow correction of hypernatremia.<a href="https://www.ncbi.nlm.nih.gov/pubmed/21358313" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/21358313</a> Cerebral edema during the treatment of DKA.<a href="https://emj.bmj.com/content/21/2/141" rel="nofollow" target="_blank">https://emj.bmj.com/content/21/2/141</a> The MIMIC 3 Database. MIMIC is an openly available dataset developed by the MIT Lab for Computational Physiology, comprising deidentified health data associated with ~40,000 critical care patients. It includes demographics, vital signs, laboratory tests, medications, and more.<a href="https://mimic.physionet.org" rel="nofollow" target="_blank">https://mimic.physionet.org</a> Chalrson Comorbidity Index<a href="https://www.mdcalc.com/charlson-comorbidity-index-cci#creator-insights" rel="nofollow" target="_blank">https://www.mdcalc.com/charlson-comorbidity-index-cci#creator-insights</a>The paper: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.<a href="https://www.ncbi.nlm.nih.gov/pubmed/3558716" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/3558716</a> JCI article on organic brain osmnoles in response to hypernatremia<a href="https://www.ncbi.nlm.nih.gov/pubmed/2332498?dopt=Abstract" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/2332498?dopt=Abstract</a> John Booth on the value of MIMIC 3<a href="https://twitter.com/ThePeanutKidney/status/1128742219471642624" rel="nofollow" target="_blank">https://twitter.com/ThePeanutKidney/status/1128742219471642624</a>Sri Lekha on checking labs in hypernatremia<a href="https://twitter.com/LTummalapalli/status/1128479041634226176" rel="nofollow" target="_blank">https://twitter.com/LTummalapalli/status/1128479041634226176</a>Steve Coca on chunky water administration<a href="https://twitter.com/scoca1/status/1128744643422769152" rel="nofollow" target="_blank">https://twitter.com/scoca1/status/1128744643422769152</a>Steve Coca musing the Cersei’s sodium level<a href="https://twitter.com/scoca1/status/1128698514026975232" rel="nofollow" target="_blank">https://twitter.com/scoca1/status/1128698514026975232</a>Steve Coca swearing in High Valarlian:<a href="https://twitter.com/scoca1/status/1128629713826721792" rel="nofollow" target="_blank">https://twitter.com/scoca1/status/1128629713826721792</a> Steve Coca proving the non-existence of hypernatremia therapy being associated with brain damage through the inability of trial lawyers to find and sue doctors for this issue:<a href="https://twitter.com/scoca1/status/1128652586612080642" rel="nofollow" target="_blank">https://twitter.com/scoca1/status/1128652586612080642</a> The original paper on the Kardashian Index<a href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0424-0" rel="nofollow" target="_blank">https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0424-0</a>Kardashian Index Calculator<a href="http://theinformationalturn.net/kardashian-index/" rel="nofollow" target="_blank">http://theinformationalturn.net/kardashian-index/</a> Facebook CEO Mark Zuckerberg says the ‘future is private’<a href="https://www.theverge.com/2019/4/30/18524188/facebook-f8-keynote-mark-zuckerberg-privacy-future-2019" rel="nofollow" target="_blank">https://www.theverge.com/2019/4/30/18524188/facebook-f8-keynote-mark-zuckerberg-privacy-future-2019</a> Khenar Jhaveri et al on ‘WhatsApp’ening in nephrology training<a href="https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfz045/5482109" rel="nofollow" target="_blank">https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfz045/5482109</a> Mike Morrison’s video on how to rebuild the scientific poster<a href="https://www.youtube.com/watch?v=1RwJbhkCA58" rel="nofollow" target="_blank">https://www.youtube.com/watch?v=1RwJbhkCA58</a>Mike’s Twitter: <a href="https://twitter.com/mikemorrison?lang=en" rel="nofollow" target="_blank">https://twitter.com/mikemorrison?lang=en</a> with lot’s of examples of his design in the wild.Make your own QR code: <a href="https://www.qr-code-generator.com" rel="nofollow" target="_blank">https://www.qr-code-generator.com</a> GoodRx: <a href="https://www.goodrx.com" rel="nofollow" target="_blank">https://www.goodrx.com</a>Ten Worst Drugs for your Kidney: <a href="https://www.goodrx.com/blog/10-worst-medications-for-your-kidneys/" rel="nofollow" target="_blank">https://www.goodrx.com/blog/10-worst-medications-for-your-kidneys/</a>Drugs that can falsely elevate your creatinine levels: <a href="https://www.goodrx.com/blog/drugs-cause-false-high-creatinine-levels-blood-test/" rel="nofollow" target="_blank">https://www.goodrx.com/blog/drugs-cause-false-high-creatinine-levels-blood-test/</a>Dr Orrange, not wishing to engage on Twitter in a meaningful way: <a href="https://twitter.com/Orrangemd/status/1129165083194511361" rel="nofollow" target="_blank">https://twitter.com/Orrangemd/status/1129165083194511361</a>

Freely Filtered 004 Hypernatremia

Cast:Joel TopfSamira FaroukJennie LinSwapnil Hiremathand special guest, Perry WilsonA clinically applicable approach to continuous prediction of future acute kidney injury. https://www.ncbi.nlm.nih.gov/pubmed/?term=A+clinically+applicable+approach+to+continuous+prediction+of+future+acute+kidney+injury#Deep Mind National Health services scandal https://www.telegraph.co.uk/technology/2017/07/03/googles-deepmind-nhs-misused-patient-data-trial-watchdog-says/KDIGO AKI guidelines (PDF) https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdfFrank Harrell on the value of continuous variables http://biostat.mc.vanderbilt.edu/wiki/Main/CatContinuoushttps://twitter.com/f2harrell/status/1176908371464794113?s=20Wilson’s AKI Alert trial published in The Lancet, Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. http://www.nephjc.com/aki-alertThe NINJA trial http://www.nephjc.com/news/2016/8/3/ninja-using-technology-to-prevent-acute-kidney-injury?rq=ninjaThe end of EPICparodyEMR: https://twitter.com/EPICEMRparody/status/1178788488881299457?s=20EPICparodyEMR on Explore the Space: https://www.explorethespaceshow.com/podcasting/epicparodyemr-on-electronic-medical-records/Tweet where Nassim Nicholas Taleb calls Swap an imbecile: https://twitter.com/nntaleb/status/1178252052453089281?s=20Blood Pressure Medicines for Five Years to Prevent Death, Heart Attacks, and Strokes. https://www.thennt.com/nnt/anti-hypertensives-to-prevent-death-heart-attacks-and-strokes/NNT is SPRINT: In participants assigned to intensive BP lowering, major adverse cardiovascular events were reduced by 25% (5.2% v. 6.8%; hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.64–0.89; number needed to treat [NNT] of 62 over 3 yr) and all-cause mortality was reduced by 27% (3.3% v. 4.5%; HR 0.73, 95% CI 0.60–0.90; NNT of 90 over 3 yr).NNT is highly misleading when assessing chronic disease prevention. https://www.ncbi.nlm.nih.gov/pubmed/25027390Washington University School of Medicine establishes Division of Physician-Scientists https://medicine.wustl.edu/news/school-of-medicine-establishes-division-of-physician-scientists/Physician scientists in the NEJM https://www.nejm.org/doi/full/10.1056/NEJMp1904482NYT article on Physician Scientists: https://www.nytimes.com/2019/09/23/opinion/doctor-scientist-medical-research.htmlbrussels.sprout on Instagram https://www.instagram.com/brussels.sprout/?hl=enSuperintelligence by Nick Bostrom https://www.amazon.com/Superintelligence-Dangers-Strategies-Nick-Bostrom/dp/1501227742Amazon bulk powdered cheese: https://www.amazon.com/s?k=powdered+cheese&amp;ref=nb_sb_noss

Cast:Joel TopfSamira FaroukJennie LinSwapnil Hiremathand special guest, Perry Wilson A clinically applicable approach to continuous prediction of future acute kidney injury. <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=A+clinically+applicable+approach+to+continuous+prediction+of+future+acute+kidney+injury#" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/?term=A+clinically+applicable+approach+to+continuous+prediction+of+future+acute+kidney+injury#</a>Deep Mind National Health services scandal <a href="https://www.telegraph.co.uk/technology/2017/07/03/googles-deepmind-nhs-misused-patient-data-trial-watchdog-says/" rel="nofollow" target="_blank">https://www.telegraph.co.uk/technology/2017/07/03/googles-deepmind-nhs-misused-patient-data-trial-watchdog-says/</a>KDIGO AKI guidelines (PDF) <a href="https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf" rel="nofollow" target="_blank">https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf</a>Frank Harrell on the value of continuous variables <a href="http://biostat.mc.vanderbilt.edu/wiki/Main/CatContinuous" rel="nofollow" target="_blank">http://biostat.mc.vanderbilt.edu/wiki/Main/CatContinuous</a><a href="https://twitter.com/f2harrell/status/1176908371464794113?s=20" rel="nofollow" target="_blank">https://twitter.com/f2harrell/status/1176908371464794113?s=20</a>Wilson’s AKI Alert trial published in The Lancet, Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. <a href="http://www.nephjc.com/aki-alert" rel="nofollow" target="_blank">http://www.nephjc.com/aki-alert</a>The NINJA trial <a href="http://www.nephjc.com/news/2016/8/3/ninja-using-technology-to-prevent-acute-kidney-injury?rq=ninja" rel="nofollow" target="_blank">http://www.nephjc.com/news/2016/8/3/ninja-using-technology-to-prevent-acute-kidney-injury?rq=ninja</a>The end of EPICparodyEMR: <a href="https://twitter.com/EPICEMRparody/status/1178788488881299457?s=20" rel="nofollow" target="_blank">https://twitter.com/EPICEMRparody/status/1178788488881299457?s=20</a>EPICparodyEMR on Explore the Space: <a href="https://www.explorethespaceshow.com/podcasting/epicparodyemr-on-electronic-medical-records/" rel="nofollow" target="_blank">https://www.explorethespaceshow.com/podcasting/epicparodyemr-on-electronic-medical-records/</a>Tweet where Nassim Nicholas Taleb calls Swap an imbecile: <a href="https://twitter.com/nntaleb/status/1178252052453089281?s=20" rel="nofollow" target="_blank">https://twitter.com/nntaleb/status/1178252052453089281?s=20</a>Blood Pressure Medicines for Five Years to Prevent Death, Heart Attacks, and Strokes. <a href="https://www.thennt.com/nnt/anti-hypertensives-to-prevent-death-heart-attacks-and-strokes/" rel="nofollow" target="_blank">https://www.thennt.com/nnt/anti-hypertensives-to-prevent-death-heart-attacks-and-strokes/</a>NNT is SPRINT: In participants assigned to intensive BP lowering, major adverse cardiovascular events were reduced by 25% (5.2% v. 6.8%; hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.64–0.89; number needed to treat [NNT] of 62 over 3 yr) and all-cause mortality was reduced by 27% (3.3% v. 4.5%; HR 0.73, 95% CI 0.60–0.90; NNT of 90 over 3 yr).NNT is highly misleading when assessing chronic disease prevention. <a href="https://www.ncbi.nlm.nih.gov/pubmed/25027390" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/25027390</a>Washington University School of Medicine establishes Division of Physician-Scientists <a href="https://medicine.wustl.edu/news/school-of-medicine-establishes-division-of-physician-scientists/" rel="nofollow" target="_blank">https://medicine.wustl.edu/news/school-of-medicine-establishes-division-of-physician-scientists/</a> Physician scientists in the NEJM <a href="https://www.nejm.org/doi/full/10.1056/NEJMp1904482" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMp1904482</a>NYT article on Physician Scientists: <a href="https://www.nytimes.com/2019/09/23/opinion/doctor-scientist-medical-research.html" rel="nofollow" target="_blank">https://www.nytimes.com/2019/09/23/opinion/doctor-scientist-medical-research.html</a>brussels.sprout on Instagram <a href="https://www.instagram.com/brussels.sprout/?hl=en" rel="nofollow" target="_blank">https://www.instagram.com/brussels.sprout/?hl=en</a>Superintelligence by Nick Bostrom <a href="https://www.amazon.com/Superintelligence-Dangers-Strategies-Nick-Bostrom/dp/1501227742" rel="nofollow" target="_blank">https://www.amazon.com/Superintelligence-Dangers-Strategies-Nick-Bostrom/dp/1501227742</a>Amazon bulk powdered cheese: <a href="https://www.amazon.com/s?k=powdered+cheese&amp;ref=nb_sb_noss" rel="nofollow" target="_blank">https://www.amazon.com/s?k=powdered+cheese&amp;ref=nb_sb_noss</a>

Freely Filtered 008 Deep Mind

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksSamira FaroukShow Notes:Pathway 2 Trialhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00257-3/fulltextNephJC discussion of Pathway2http://www.nephjc.com/pathwayThe DIAMOND Trial. Much more ambitious than I described in the podcast.https://clinicaltrials.gov/ct2/show/NCT03888066SPRINThttps://www.nejm.org/doi/full/10.1056/NEJMoa1511939Omron 907 BP cuffonly $678 from Amazon: https://www.amazon.com/Omron-HEM-907XL-IntelliSense-Professional/dp/B000FENZPSEvaluation of the Potential for Drug Interactions With Patiromer in Healthy Volunteers:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555446/The TOPCAT Trial story: A Clinical Trial Torpedoed By Fraud and Incompetencehttps://blogs.sciencemag.org/pipeline/archives/2017/04/27/a-clinical-trial-torpedoed-by-fraud-and-incompetenceCJSAN article looking at 24-hour urine for calcium and phos with patiromerhttps://cjasn.asnjournals.org/content/14/1/103Swap’s best tweeters of #Kidney Wkaldorodrigo https://twitter.com/aldorodrigoAlex Meraz https://twitter.com/nephroguyJoshua Waitzman https://twitter.com/JwaitzKIDNEYconkidneycon.org

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksSamira FaroukShow Notes:Pathway 2 Trial<a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00257-3/fulltext" rel="nofollow" target="_blank">https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00257-3/fulltext</a>NephJC discussion of Pathway2<a href="http://www.nephjc.com/pathway" rel="nofollow" target="_blank">http://www.nephjc.com/pathway</a>The DIAMOND Trial. Much more ambitious than I described in the podcast.<a href="https://clinicaltrials.gov/ct2/show/NCT03888066" rel="nofollow" target="_blank">https://clinicaltrials.gov/ct2/show/NCT03888066</a>SPRINT<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1511939" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa1511939</a>Omron 907 BP cuffonly $678 from Amazon: <a href="https://www.amazon.com/Omron-HEM-907XL-IntelliSense-Professional/dp/B000FENZPS" rel="nofollow" target="_blank">https://www.amazon.com/Omron-HEM-907XL-IntelliSense-Professional/dp/B000FENZPS</a>Evaluation of the Potential for Drug Interactions With Patiromer in Healthy Volunteers:<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555446/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555446/</a>The TOPCAT Trial story: A Clinical Trial Torpedoed By Fraud and Incompetence<a href="https://blogs.sciencemag.org/pipeline/archives/2017/04/27/a-clinical-trial-torpedoed-by-fraud-and-incompetence" rel="nofollow" target="_blank">https://blogs.sciencemag.org/pipeline/archives/2017/04/27/a-clinical-trial-torpedoed-by-fraud-and-incompetence</a>CJSAN article looking at 24-hour urine for calcium and phos with patiromer<a href="https://cjasn.asnjournals.org/content/14/1/103" rel="nofollow" target="_blank">https://cjasn.asnjournals.org/content/14/1/103</a>Swap’s best tweeters of #Kidney Wkaldorodrigo <a href="https://twitter.com/aldorodrigo" rel="nofollow" target="_blank">https://twitter.com/aldorodrigo</a>Alex Meraz <a href="https://twitter.com/nephroguy" rel="nofollow" target="_blank">https://twitter.com/nephroguy</a>Joshua Waitzman <a href="https://twitter.com/Jwaitz" rel="nofollow" target="_blank">https://twitter.com/Jwaitz</a>KIDNEYcon<a href="https://kidneycon.org/" rel="nofollow" target="_blank">kidneycon.org</a>

Freely Filtered 009 AMBER

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksShow Notes:NephJC Coverage of MENTOR: http://www.nephjc.com/news/mentorMENTOR: https://www.nejm.org/doi/full/10.1056/NEJMoa1814427KDIGO Membranous recommendations: https://kdigo.org/wp-content/uploads/2017/02/KDIGO-2012-GN-Guideline-English.pdf2017 Kidney Week Abstract: https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2831149PEXIVAS: http://www.nephjc.com/news/pexivasearlyHeymann Nephritis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042693/Susan Quaggin: https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=26269Manasi Bapat on non-inferiority trials: http://www.nephjc.com/news/2019/7/8/understanding-the-vortex-of-non-inferiority-trialsPrognosis and risk factors for idiopathic membranous nephropathy with nephrotic syndrome in Japan: https://www.sciencedirect.com/science/article/pii/S0085253815498503Nice review of Membranous by Alfaadhel and Cattrran that purports to say than CNI are the standard therapy for idiopathic membranous. (It doesn’t) https://www.ncbi.nlm.nih.gov/pubmed/27536673?dopt=AbstractPablo Garcia saves the day: https://twitter.com/PabloGarciaMD/status/1148767319323099136?s=20Larry beck’s land mark study demonstrating antiPLA2r as the antigen in idiopathic membranous. https://www.nejm.org/doi/full/10.1056/NEJMoa0810457GEMRITUX Study: https://www.ncbi.nlm.nih.gov/pubmed/27352623Jennie Lin’s How to Be a Nephrology Fellow, Choose Your Own Adventure: https://twitter.com/jenniejlin/status/1156329711057981442?s=20CJASN How to Review a Paper Podcast: https://www.asn-online.org/media/podcast/CJASN/2019_07_23_How_to_Write_a_Cons.mp3

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksShow Notes:NephJC Coverage of MENTOR: <a href="http://www.nephjc.com/news/mentor" rel="nofollow" target="_blank">http://www.nephjc.com/news/mentor</a> MENTOR: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1814427" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa1814427</a>KDIGO Membranous recommendations: <a href="https://kdigo.org/wp-content/uploads/2017/02/KDIGO-2012-GN-Guideline-English.pdf" rel="nofollow" target="_blank">https://kdigo.org/wp-content/uploads/2017/02/KDIGO-2012-GN-Guideline-English.pdf</a>2017 Kidney Week Abstract: <a href="https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2831149" rel="nofollow" target="_blank">https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2831149</a> PEXIVAS: <a href="http://www.nephjc.com/news/pexivasearly" rel="nofollow" target="_blank">http://www.nephjc.com/news/pexivasearly</a>Heymann Nephritis: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042693/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042693/</a>Susan Quaggin: <a href="https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=26269" rel="nofollow" target="_blank">https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=26269</a>Manasi Bapat on non-inferiority trials: <a href="http://www.nephjc.com/news/2019/7/8/understanding-the-vortex-of-non-inferiority-trials" rel="nofollow" target="_blank">http://www.nephjc.com/news/2019/7/8/understanding-the-vortex-of-non-inferiority-trials</a>Prognosis and risk factors for idiopathic membranous nephropathy with nephrotic syndrome in Japan: <a href="https://www.sciencedirect.com/science/article/pii/S0085253815498503" rel="nofollow" target="_blank">https://www.sciencedirect.com/science/article/pii/S0085253815498503</a> Nice review of Membranous by Alfaadhel and Cattrran that purports to say than CNI are the standard therapy for idiopathic membranous. (It doesn’t) <a href="https://www.ncbi.nlm.nih.gov/pubmed/27536673?dopt=Abstract" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/27536673?dopt=Abstract</a>Pablo Garcia saves the day: <a href="https://twitter.com/PabloGarciaMD/status/1148767319323099136?s=20" rel="nofollow" target="_blank">https://twitter.com/PabloGarciaMD/status/1148767319323099136?s=20</a>Larry beck’s land mark study demonstrating antiPLA2r as the antigen in idiopathic membranous. <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa0810457" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa0810457</a> GEMRITUX Study: <a href="https://www.ncbi.nlm.nih.gov/pubmed/27352623" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/27352623</a>Jennie Lin’s How to Be a Nephrology Fellow, Choose Your Own Adventure: <a href="https://twitter.com/jenniejlin/status/1156329711057981442?s=20" rel="nofollow" target="_blank">https://twitter.com/jenniejlin/status/1156329711057981442?s=20</a> CJASN How to Review a Paper Podcast: <a href="https://www.asn-online.org/media/podcast/CJASN/2019_07_23_How_to_Write_a_Cons.mp3" rel="nofollow" target="_blank">https://www.asn-online.org/media/podcast/CJASN/2019_07_23_How_to_Write_a_Cons.mp3</a>

Freely Filtered 007 MENTOR

Just the dudes gathered to talk about the JAMA Internal Medicine Meta Analysis on Gadolinium in CKD stage 4 and 5.Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast AgentA Systematic Review and Meta-analysis.Summary on NephJCCast:Joel TopfSwapnil HiremathMatt SparksShow Notes:Swap has a disclosure!He was an author on the Canadian Association of Radiology guidelines on use of Gad in CKD.Grobner’s original paper reporting the association between gadolinium and NSF.Matt’s article on alternatives to gadolinium in MRI:Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overviewUsing Ferumoxytol as an MRI contrast agent.Saurabh Jha’s editorial (@RogueRad) for NephMadness when Gadolinium in CKD 4 was a team in 2018.PEXIVAS was an abstract in 2018 and was not published until 2020.A Cultural History of Rock-Paper-ScissorsMichelle’s recent case of NSF in a child (in case you thought this disease was gone)Removing Gad with dialysis.Matt’s tubular secretion: Biorender.comJohn Mandrola Expert or not an expert?JACC Case Reports on the Kardashian IndexRobert Cardiff’s editorial on the Kardashian Index in JACC Case Reports.Bryan Vartabedian blog post on Robert Cardiff’s editorialAnd NephMadness is coming! Friday March 13, 2020!

Just the dudes gathered to talk about the JAMA Internal Medicine Meta Analysis on Gadolinium in CKD stage 4 and 5.<a href="https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2757311" rel="nofollow" target="_blank">Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast AgentA Systematic Review and Meta-analysis.</a><a href="http://www.nephjc.com/news/gad-not-so-bad" rel="nofollow" target="_blank">Summary on NephJC</a>Cast:Joel TopfSwapnil HiremathMatt SparksShow Notes:Swap has a disclosure!He was an author on the Canadian Association of Radiology guidelines on use of Gad in CKD.<a href="https://www.ncbi.nlm.nih.gov/pubmed/16431890" rel="nofollow" target="_blank">Grobner’s original paper reporting the association between gadolinium and NSF</a>.Matt’s article on alternatives to gadolinium in MRI:<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708018/" rel="nofollow" target="_blank">Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overview</a><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854636/" rel="nofollow" target="_blank">Using Ferumoxytol as an MRI contrast agent.</a><a href="https://ajkdblog.org/2018/03/22/gadolinium-are-we-overregulating-or-overprescribing/" rel="nofollow" target="_blank">Saurabh Jha’s editorial</a> (<a href="https://twitter.com/RogueRad" rel="nofollow" target="_blank">@RogueRad</a>) for NephMadness when <a href="https://ajkdblog.org/2018/03/15/nephmadness-2018-contrast-region/" rel="nofollow" target="_blank">Gadolinium in CKD 4</a> was a team in 2018.<a href="http://www.nephjc.com/news/pexivasearly" rel="nofollow" target="_blank">PEXIVAS</a> was an abstract in 2018 and was not published until 2020.<a href="https://www.theatlantic.com/entertainment/archive/2015/12/how-rock-paper-scissors-went-viral/418455/" rel="nofollow" target="_blank">A Cultural History of Rock-Paper-Scissors</a><a href="https://twitter.com/rheault_m/status/1222209442990739456?s=20" rel="nofollow" target="_blank">Michelle’s recent case of NSF in a child</a> (in case you thought this disease was gone)<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmri.21981" rel="nofollow" target="_blank">Removing Gad with dialysis</a>.Matt’s tubular secretion: <a href="https://biorender.com/" rel="nofollow" target="_blank">Biorender.com</a><a href="https://twitter.com/drjohnm" rel="nofollow" target="_blank">John Mandrola</a> Expert or not an expert?<a href="https://casereports.onlinejacc.org/content/2/2/330?_ga=2.246661888.58839767.1583814024-1795490018.1583814024" rel="nofollow" target="_blank">JACC Case Reports on the Kardashian Index</a>Robert Cardiff’s <a href="https://casereports.onlinejacc.org/content/2/2/335" rel="nofollow" target="_blank">editorial</a> on the Kardashian Index in JACC Case Reports.<a href="https://33charts.com/robert-califf-peanut-gallery/" rel="nofollow" target="_blank">Bryan Vartabedian blog post</a> on Robert Cardiff’s editorialAnd <a href="https://ajkdblog.org/category/nephmadness/" rel="nofollow" target="_blank">NephMadness</a> is coming! Friday March 13, 2020!

Freely Filtered 011 Gadolinium Meta-analysis

Joel TopfJennie LinMatt SparksSwapnil HiremathShow Notes: IgA Nephropathy ScoreLevi Strauss: https://www.biography.com/fashion-designer/levi-straussLevey MDRD study: https://www.ncbi.nlm.nih.gov/pubmed/10075613ADPKD Total Kidney Volume: https://www.nejm.org/doi/10.1056/NEJMoa054341Halt PKD: https://www.nejm.org/doi/full/10.1056/nejmoa1402685Tempo 3:4 Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1205511Description description of IgA nephropathy by Berger and Hiunglais: https://www.ncbi.nlm.nih.gov/pubmed/4180586The reprint in JASN in 2000 with commentary as part of the Milestones in Nephrology series: https://jasn.asnjournals.org/content/jnephrol/11/10/1957.full.pdf JASN supplies an English translation from the original French.Nice reference from JASN backing up Matt’s assertion that preeclampsia and not IgA nephropathy is the most common glomerular disease in the world: https://jasn.asnjournals.org/content/18/8/2281Description of the Singapore Army screening recruits from the Oxford Textbook of Clinical Nephrology: https://books.google.com/books?id=fVItBQAAQBAJ&amp;lpg=PA485&amp;ots=JRoOnUnleT&amp;dq=singapore%20kidney%20biopsy%20army&amp;pg=PA485#v=onepage&amp;q&amp;f=falseDescription of the Japanese glomerulonephritis screening program: https://cjasn.asnjournals.org/content/2/6/1360Swapnil’s studies on autopsy studies:Finland: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC501386/Japan: https://www.ncbi.nlm.nih.gov/pubmed/12753320/Nephrology Secrets, either one of the best or the best nephrology textbooks ever: https://www.amazon.com/Nephrology-Secrets-Book-Edgar-Lerma-ebook/dp/B079TSYNQW/ref=sr_1_1TESTING Trial on NephJC: http://www.nephjc.com/news/2017/8/28/testingStop-Iga Trial on NephJC: http://www.nephjc.com/iga-nephropathyTesting Trial two: Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study Low Dose Study: https://clinicaltrials.gov/ct2/show/NCT01560052MEST Score versus MEST-C in NephJC: http://www.nephjc.com/news/2016/10/16/do-crescents-matter-for-iga-nephropathyNice discussion of the statistical tests during the Tweet Chat by people who know their stats (I.e. not Joel): https://twitter.com/NephJC/status/1133546750814367746Tweet-length description of IDI: https://twitter.com/kiwiskiNZ/status/1133595698929098752Assessing the performance of prediction models: a framework for traditional and novel measures. https://www.ncbi.nlm.nih.gov/pubmed/20010215/Net Reclassification Indices for Evaluating Risk-Prediction Instruments: A Critical Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918180/Predicting Progression in CKD: Perspectives and Precautions https://www.ajkd.org/article/S0272-6386(15)01413-4/abstractThe Article by Nancy Cook in Circulation that Jennie was talking about: Use and misuse of the receiver operating characteristic curve in risk prediction. https://www.ncbi.nlm.nih.gov/pubmed/17309939Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens https://www.nature.com/articles/ng.3118Genome-wide polygenic risk predictors for kidney disease https://www.nature.com/articles/s41581-018-0067-6Where does Matt find minutia like the grams of IgA produced a day? Here: https://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130216Animal models of IgA nephropathy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337240/Matt’s Book Originals: https://www.amazon.com/gp/product/014312885X/ref=dbs_a_def_rwt_bibl_vppi_i1Eric Neilson, Dean of Northwestern University https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=23239Brussels sprout Insta-famous dog and future dean of the medical school: https://www.instagram.com/brussels.sprout/?hl=enJosh Farkas Rantorial about Contrast Nephropathy: https://twitter.com/PulmCrit/status/1134922050794139648Swapnil’s Tweetorial about Contrast Nephropathy: https://twitter.com/hswapnil/status/1133906398096609280Tukaram’s pic of NEJM’s progression from Contrast Induced Nephropathy to Contrast Associated Nephropathy: https://twitter.com/tukaramj/status/1135214980985266178Zero sodium dialysate for heart failure? https://twitter.com/i/moments/1134811009217155072

Joel TopfJennie LinMatt SparksSwapnil HiremathShow Notes: IgA Nephropathy ScoreLevi Strauss: <a href="https://www.biography.com/fashion-designer/levi-strauss" rel="nofollow" target="_blank">https://www.biography.com/fashion-designer/levi-strauss</a> Levey MDRD study: <a href="https://www.ncbi.nlm.nih.gov/pubmed/10075613" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/10075613</a> ADPKD Total Kidney Volume: <a href="https://www.nejm.org/doi/10.1056/NEJMoa054341" rel="nofollow" target="_blank">https://www.nejm.org/doi/10.1056/NEJMoa054341</a> Halt PKD: <a href="https://www.nejm.org/doi/full/10.1056/nejmoa1402685" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/nejmoa1402685</a> Tempo 3:4 Trial: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1205511" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa1205511</a> Description description of IgA nephropathy by Berger and Hiunglais: <a href="https://www.ncbi.nlm.nih.gov/pubmed/4180586" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/4180586</a>The reprint in JASN in 2000 with commentary as part of the Milestones in Nephrology series: <a href="https://jasn.asnjournals.org/content/jnephrol/11/10/1957.full.pdf" rel="nofollow" target="_blank">https://jasn.asnjournals.org/content/jnephrol/11/10/1957.full.pdf</a> JASN supplies an English translation from the original French.Nice reference from JASN backing up Matt’s assertion that preeclampsia and not IgA nephropathy is the most common glomerular disease in the world: <a href="https://jasn.asnjournals.org/content/18/8/2281" rel="nofollow" target="_blank">https://jasn.asnjournals.org/content/18/8/2281</a>Description of the Singapore Army screening recruits from the Oxford Textbook of Clinical Nephrology: <a href="https://books.google.com/books?id=fVItBQAAQBAJ&amp;lpg=PA485&amp;ots=JRoOnUnleT&amp;dq=singapore%20kidney%20biopsy%20army&amp;pg=PA485#v=onepage&amp;q&amp;f=false" rel="nofollow" target="_blank">https://books.google.com/books?id=fVItBQAAQBAJ&amp;lpg=PA485&amp;ots=JRoOnUnleT&amp;dq=singapore%20kidney%20biopsy%20army&amp;pg=PA485#v=onepage&amp;q&amp;f=false</a>Description of the Japanese glomerulonephritis screening program: <a href="https://cjasn.asnjournals.org/content/2/6/1360" rel="nofollow" target="_blank">https://cjasn.asnjournals.org/content/2/6/1360</a>Swapnil’s studies on autopsy studies:Finland: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC501386/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC501386/</a>Japan: <a href="https://www.ncbi.nlm.nih.gov/pubmed/12753320/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/12753320/</a> Nephrology Secrets, either one of the best or the best nephrology textbooks ever: <a href="https://www.amazon.com/Nephrology-Secrets-Book-Edgar-Lerma-ebook/dp/B079TSYNQW/ref=sr_1_1" rel="nofollow" target="_blank">https://www.amazon.com/Nephrology-Secrets-Book-Edgar-Lerma-ebook/dp/B079TSYNQW/ref=sr_1_1</a>TESTING Trial on NephJC: <a href="http://www.nephjc.com/news/2017/8/28/testing" rel="nofollow" target="_blank">http://www.nephjc.com/news/2017/8/28/testing</a> Stop-Iga Trial on NephJC: <a href="http://www.nephjc.com/iga-nephropathy" rel="nofollow" target="_blank">http://www.nephjc.com/iga-nephropathy</a> Testing Trial two: Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study Low Dose Study: <a href="https://clinicaltrials.gov/ct2/show/NCT01560052" rel="nofollow" target="_blank">https://clinicaltrials.gov/ct2/show/NCT01560052</a> MEST Score versus MEST-C in NephJC: <a href="http://www.nephjc.com/news/2016/10/16/do-crescents-matter-for-iga-nephropathy" rel="nofollow" target="_blank">http://www.nephjc.com/news/2016/10/16/do-crescents-matter-for-iga-nephropathy</a> Nice discussion of the statistical tests during the Tweet Chat by people who know their stats (I.e. not Joel): <a href="https://twitter.com/NephJC/status/1133546750814367746" rel="nofollow" target="_blank">https://twitter.com/NephJC/status/1133546750814367746</a> Tweet-length description of IDI: <a href="https://twitter.com/kiwiskiNZ/status/1133595698929098752" rel="nofollow" target="_blank">https://twitter.com/kiwiskiNZ/status/1133595698929098752</a> Assessing the performance of prediction models: a framework for traditional and novel measures. <a href="https://www.ncbi.nlm.nih.gov/pubmed/20010215/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/20010215/</a> Net Reclassification Indices for Evaluating Risk-Prediction Instruments: A Critical Review <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918180/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918180/</a> Predicting Progression in CKD: Perspectives and Precautions <a href="https://www.ajkd.org/article/S0272-6386(15)01413-4/abstract" rel="nofollow" target="_blank">https://www.ajkd.org/article/S0272-6386(15)01413-4/abstract</a> The Article by Nancy Cook in Circulation that Jennie was talking about: Use and misuse of the receiver operating characteristic curve in risk prediction. <a href="https://www.ncbi.nlm.nih.gov/pubmed/17309939" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/17309939</a>Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens <a href="https://www.nature.com/articles/ng.3118" rel="nofollow" target="_blank">https://www.nature.com/articles/ng.3118</a>Genome-wide polygenic risk predictors for kidney disease <a href="https://www.nature.com/articles/s41581-018-0067-6" rel="nofollow" target="_blank">https://www.nature.com/articles/s41581-018-0067-6</a> Where does Matt find minutia like the grams of IgA produced a day? Here: <a href="https://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130216" rel="nofollow" target="_blank">https://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130216</a>Animal models of IgA nephropathy: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337240/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337240/</a>Matt’s Book Originals: <a href="https://www.amazon.com/gp/product/014312885X/ref=dbs_a_def_rwt_bibl_vppi_i1" rel="nofollow" target="_blank">https://www.amazon.com/gp/product/014312885X/ref=dbs_a_def_rwt_bibl_vppi_i1</a>Eric Neilson, Dean of Northwestern University <a href="https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=23239" rel="nofollow" target="_blank">https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=23239</a>Brussels sprout Insta-famous dog and future dean of the medical school: <a href="https://www.instagram.com/brussels.sprout/?hl=en" rel="nofollow" target="_blank">https://www.instagram.com/brussels.sprout/?hl=en</a>Josh Farkas Rantorial about Contrast Nephropathy: <a href="https://twitter.com/PulmCrit/status/1134922050794139648" rel="nofollow" target="_blank">https://twitter.com/PulmCrit/status/1134922050794139648</a>Swapnil’s Tweetorial about Contrast Nephropathy: <a href="https://twitter.com/hswapnil/status/1133906398096609280" rel="nofollow" target="_blank">https://twitter.com/hswapnil/status/1133906398096609280</a>Tukaram’s pic of NEJM’s progression from Contrast Induced Nephropathy to Contrast Associated Nephropathy: <a href="https://twitter.com/tukaramj/status/1135214980985266178" rel="nofollow" target="_blank">https://twitter.com/tukaramj/status/1135214980985266178</a>Zero sodium dialysate for heart failure? <a href="https://twitter.com/i/moments/1134811009217155072" rel="nofollow" target="_blank">https://twitter.com/i/moments/1134811009217155072</a>

Freely Filtered 005 IgA Nephropathy

Cast:Joel TopfJennie LinSamira FaroukSwapnil HiremathShow Notes:NephJC coverage of SONAR: http://www.nephjc.com/news/sonarSONAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30995972Avosentan for overt diabetic nephropathy, the ASCEND trial: https://www.ncbi.nlm.nih.gov/pubmed/20167702RADAR coverage at NephJC, May 2014: http://www.nephjc.com/atrasentanRADAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24722445/Google Hangout on RADAR: https://www.youtube.com/watch?v=pkkQbb-isog&amp;feature=youtu.beVlado Perkovic: https://twitter.com/VladoPerkovicSONAR: https://en.wikipedia.org/wiki/SonarNephmadness adaptive trial: https://ajkdblog.org/2016/03/10/nephmadness-2016-statistics-in-nephrology-region/#adaptiveKIDNEYcon adaptive trial tweet thread: https://twitter.com/hswapnil/status/1117194018331471873?s=21Excellent NEJM review on adaptive trials: https://www.nejm.org/doi/10.1056/NEJMra1510061Potential role of Adaptive trials in AKI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869991/BNP levels in CKD: https://cjasn.asnjournals.org/content/3/6/1644Generalizability from Wikipedia: https://en.wikipedia.org/wiki/Generalizability_theoryAnemia (and other adverse effects) of Endothelin antagonists: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210319/Data safety monitoring boards: https://www.nidcr.nih.gov/research/human-subjects-research/interventional-studies/data-and-safety-monitoring-board-guidelinesAbbVie Allergen Merger: https://www.barrons.com/articles/abbvie-allergan-merger-pharma-deals-takeda-celgene-bristol-myers-squibb-51563890831Tangri Kidney Failure Risk Equation: https://qxmd.com/calculate/calculator_308/kidney-failure-risk-equation-4-variableFragility index paper: https://www.ncbi.nlm.nih.gov/m/pubmed/24508144/LITFL write up: https://litfl.com/fragility-index/Calculator:  https://clincalc.com/Stats/FragilityIndex.aspxCANVAS Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1811744Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study by David Juurlink et al.: https://www.nejm.org/doi/full/10.1056/NEJMoa040135Vinay Prasad: https://en.wikipedia.org/wiki/Vinay_PrasadClassic mouse studies looking at endothelin: https://www.jci.org/articles/view/119297/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/8377387/https://diabetes.diabetesjournals.org/content/65/8/2429Nice reviews:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698004/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216619/Review of vascular effects:https://www.ncbi.nlm.nih.gov/pubmed/28223322

Cast:Joel TopfJennie LinSamira FaroukSwapnil HiremathShow Notes:NephJC coverage of SONAR: <a href="http://www.nephjc.com/news/sonar" rel="nofollow" target="_blank">http://www.nephjc.com/news/sonar</a>SONAR in PubMed: <a href="https://www.ncbi.nlm.nih.gov/pubmed/30995972" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/30995972</a>Avosentan for overt diabetic nephropathy, the ASCEND trial: <a href="https://www.ncbi.nlm.nih.gov/pubmed/20167702" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/20167702</a>RADAR coverage at NephJC, May 2014: <a href="http://www.nephjc.com/atrasentan" rel="nofollow" target="_blank">http://www.nephjc.com/atrasentan</a>RADAR in PubMed: <a href="https://www.ncbi.nlm.nih.gov/pubmed/24722445/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/24722445/</a>Google Hangout on RADAR: <a href="https://www.youtube.com/watch?v=pkkQbb-isog&amp;feature=youtu.be" rel="nofollow" target="_blank">https://www.youtube.com/watch?v=pkkQbb-isog&amp;feature=youtu.be</a>Vlado Perkovic: <a href="https://twitter.com/VladoPerkovic" rel="nofollow" target="_blank">https://twitter.com/VladoPerkovic</a>SONAR: <a href="https://en.wikipedia.org/wiki/Sonar" rel="nofollow" target="_blank">https://en.wikipedia.org/wiki/Sonar</a>Nephmadness adaptive trial: <a href="https://ajkdblog.org/2016/03/10/nephmadness-2016-statistics-in-nephrology-region/#adaptive" rel="nofollow" target="_blank">https://ajkdblog.org/2016/03/10/nephmadness-2016-statistics-in-nephrology-region/#adaptive</a>KIDNEYcon adaptive trial tweet thread: <a href="https://twitter.com/hswapnil/status/1117194018331471873?s=21" rel="nofollow" target="_blank">https://twitter.com/hswapnil/status/1117194018331471873?s=21</a>Excellent NEJM review on adaptive trials: <a href="https://www.nejm.org/doi/10.1056/NEJMra1510061" rel="nofollow" target="_blank">https://www.nejm.org/doi/10.1056/NEJMra1510061</a>Potential role of Adaptive trials in AKI: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869991/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869991/</a>BNP levels in CKD: <a href="https://cjasn.asnjournals.org/content/3/6/1644" rel="nofollow" target="_blank">https://cjasn.asnjournals.org/content/3/6/1644</a>Generalizability from Wikipedia: <a href="https://en.wikipedia.org/wiki/Generalizability_theory" rel="nofollow" target="_blank">https://en.wikipedia.org/wiki/Generalizability_theory</a>Anemia (and other adverse effects) of Endothelin antagonists: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210319/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210319/</a>Data safety monitoring boards: <a href="https://www.nidcr.nih.gov/research/human-subjects-research/interventional-studies/data-and-safety-monitoring-board-guidelines" rel="nofollow" target="_blank">https://www.nidcr.nih.gov/research/human-subjects-research/interventional-studies/data-and-safety-monitoring-board-guidelines</a>AbbVie Allergen Merger: <a href="https://www.barrons.com/articles/abbvie-allergan-merger-pharma-deals-takeda-celgene-bristol-myers-squibb-51563890831" rel="nofollow" target="_blank">https://www.barrons.com/articles/abbvie-allergan-merger-pharma-deals-takeda-celgene-bristol-myers-squibb-51563890831</a>Tangri Kidney Failure Risk Equation: <a href="https://qxmd.com/calculate/calculator_308/kidney-failure-risk-equation-4-variable" rel="nofollow" target="_blank">https://qxmd.com/calculate/calculator_308/kidney-failure-risk-equation-4-variable</a>Fragility index paper: <a href="https://www.ncbi.nlm.nih.gov/m/pubmed/24508144/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/m/pubmed/24508144/</a>LITFL write up: <a href="https://litfl.com/fragility-index/" rel="nofollow" target="_blank">https://litfl.com/fragility-index/</a>Calculator: <a href="https://clincalc.com/Stats/FragilityIndex.aspx" rel="nofollow" target="_blank">https://clincalc.com/Stats/FragilityIndex.aspx</a>CANVAS Trial: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1811744" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa1811744</a>Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study by <a href="https://twitter.com/DavidJuurlink" rel="nofollow" target="_blank">David Juurlink</a> et al.: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa040135" rel="nofollow" target="_blank">https://www.nejm.org/doi/full/10.1056/NEJMoa040135</a>Vinay Prasad: <a href="https://en.wikipedia.org/wiki/Vinay_Prasad" rel="nofollow" target="_blank">https://en.wikipedia.org/wiki/Vinay_Prasad</a>Classic mouse studies looking at endothelin: <a href="https://www.jci.org/articles/view/119297/pdf" rel="nofollow" target="_blank">https://www.jci.org/articles/view/119297/pdf</a> <a href="https://www.ncbi.nlm.nih.gov/pubmed/8377387/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/8377387/</a> <a href="https://diabetes.diabetesjournals.org/content/65/8/2429" rel="nofollow" target="_blank">https://diabetes.diabetesjournals.org/content/65/8/2429</a>Nice reviews: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698004/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698004/</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216619/" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216619/</a>Review of vascular effects: <a href="https://www.ncbi.nlm.nih.gov/pubmed/28223322" rel="nofollow" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/28223322</a>

Freely Filtered 006 SONAR

This week we discussed the CREDENCE trial published in the NEJM, on the effect of Canaglifozin on diabetic nephropathy. There was lots to discuss so it may be a long podcast.The article is available here.The NephJC summary can be read here, with links to the visual abstract, and the wrapup.Links from the show:Swapnil’s first post at AJKDblog on SGLT2i in 2014! SGLT-2 Inhibitors: Can They Prevent Diabetic Nephropathy?Lonnie Pyne’s brilliant tweetorial on proteinuria as a proposed end-point in CKD trials.Combined RAAS blockade (don’t do it)Combining ACEI and direct renin inhibitorsCombining ACEi and ARBWe repeatedly compare CREDENCE to IDNT by Ed Lewis and RENAAL by Barry BrennerYou will need to be familiar with EMPA-REG and CANVAS (links to summaries on NephJC)Why run-in periods are bad for clinical trials: Run-in Periods in Randomized TrialsImplications for the Application of Results in Clinical PracticeHispanics in the study: https://twitter.com/VladoPerkovic/status/1121078118029103105Lot of discussion on mechanisms: • The original description of phlorizin by Josef von Mering in 1800• Podocyte effects in JCI• Effect on Hyperfiltration by SGlT2i in humans• Emerging role of proximal tubule in CKD via GWAS studies• SGLT2i effect on Na/H exchangers in heart and kidney• SGLT2i interact with heart NHE1 (mouse model)• SGLT2i as the ‘betablockers’ of the kidney?Jordan Weinstein on the clinical scientists’ mechanism of SHGLT2i:https://twitter.com/drjjw/status/1121577808164159491Why subgroups should be interpreted very carefullyHost: Joel TopfDiscussants: Samira Farouk, Swapnil Hiremath, Jennie Lin and Matt Sparks.

This week we discussed the CREDENCE trial published in the NEJM, on the effect of Canaglifozin on diabetic nephropathy. There was lots to discuss so it may be a long podcast.The article is available <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=30990260" rel="nofollow" target="_blank">here</a>.The NephJC summary can be read <a href="http://www.nephjc.com/news/credence" rel="nofollow" target="_blank">here</a>, with links to the visual abstract, and the wrapup. Links from the show:Swapnil’s first post at AJKDblog on SGLT2i in 2014! <a href="https://ajkdblog.org/2014/05/12/sglt-2-inhibitors-can-they-prevent-diabetic-nephropathy/" rel="nofollow" target="_blank">SGLT-2 Inhibitors: Can They Prevent Diabetic Nephropathy?</a>Lonnie Pyne’s <a href="https://twitter.com/lp7777777/status/1083897727749099520" rel="nofollow" target="_blank">brilliant tweetorial</a> on proteinuria as a proposed end-point in CKD trials.Combined RAAS blockade (don’t do it)<a href="https://www.bmj.com/content/344/bmj.e42" rel="nofollow" target="_blank">Combining ACEI and direct renin inhibitors</a><a href="https://www.nejm.org/doi/full/10.1056/nejmoa1303154" rel="nofollow" target="_blank">Combining ACEi and ARB</a>We repeatedly compare CREDENCE to <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa011303" rel="nofollow" target="_blank">IDNT by Ed Lewis</a> and <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa011161" rel="nofollow" target="_blank">RENAAL by Barry Brenner</a>You will need to be familiar with <a href="http://www.nephjc.com/news/2016/6/23/empa-reg-renal-results" rel="nofollow" target="_blank">EMPA-REG</a> and <a href="http://www.nephjc.com/news/canvas" rel="nofollow" target="_blank">CANVAS</a> (links to summaries on NephJC)Why run-in periods are bad for clinical trials: <a href="https://jamanetwork.com/journals/jama/fullarticle/187167" rel="nofollow" target="_blank">Run-in Periods in Randomized Trials</a><a href="https://jamanetwork.com/journals/jama/fullarticle/187167" rel="nofollow" target="_blank">Implications for the Application of Results in Clinical Practice</a>Hispanics in the study: <a href="https://twitter.com/VladoPerkovic/status/1121078118029103105" rel="nofollow" target="_blank">https://twitter.com/VladoPerkovic/status/1121078118029103105</a>Lot of discussion on mechanisms: • The original description of <a href="https://twitter.com/Charbel_Khoury/status/1120858590640836610?s=20" rel="nofollow" target="_blank">phlorizin</a> by Josef von Mering in 1800• Podocyte effects in <a href="https://insight.jci.org/articles/view/98720" rel="nofollow" target="_blank">JCI</a>• Effect on <a href="https://link.springer.com/article/10.1007%2Fs00125-014-3396-4" rel="nofollow" target="_blank">Hyperfiltration</a> by SGlT2i in humans• Emerging role of proximal tubule in CKD via <a href="https://t.co/BwNOeUqoTp?amp=1" rel="nofollow" target="_blank">GWAS</a> studies• SGLT2i effect on <a href="https://t.co/DhnvoCUhF2?amp=1" rel="nofollow" target="_blank">Na/H exchangers</a> in heart and kidney• SGLT2i interact with <a href="https://www.ncbi.nlm.nih.gov/m/pubmed/29197997/" rel="nofollow" target="_blank">heart NHE1</a> (mouse model)• SGLT2i as the ‘<a href="https://t.co/Eh9xNtpbys?amp=1" rel="nofollow" target="_blank">betablockers</a>’ of the kidney? Jordan Weinstein on the clinical scientists’ mechanism of SHGLT2i:<a href="https://twitter.com/drjjw/status/1121577808164159491" rel="nofollow" target="_blank">https://twitter.com/drjjw/status/1121577808164159491</a> Why <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140673605177095/fulltext" rel="nofollow" target="_blank">subgroups</a> should be interpreted very carefully Host: Joel TopfDiscussants: Samira Farouk, Swapnil Hiremath, Jennie Lin and Matt Sparks.

Freely Filtered 003 CREDENCE

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksShow Notes:The NephJC discussion can be found here.The study was published in the NEJM.NephJC summary of the AJKD systematic review of uremic pruritusAtul Gawande on itching.Pinnacle MountainComprehensive review on toxicodendron dermatitis: poison ivy, oak, and sumac.KIDNEYconTom Oates 12 days of Poems on Twitter

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksShow Notes:The NephJC discussion can be found <a href="http://www.nephjc.com/news/difelikefalin" rel="nofollow" target="_blank">here</a>.The study was published in the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1912770" rel="nofollow" target="_blank">NEJM</a>.<a href="http://www.nephjc.com/news/pruritis" rel="nofollow" target="_blank">NephJC summary</a> of the AJKD systematic review of uremic pruritus<a href="https://www.newyorker.com/magazine/2008/06/30/the-itch" rel="nofollow" target="_blank">Atul Gawande</a> on itching.<a href="https://en.wikipedia.org/wiki/Pinnacle_Mountain_(Arkansas)" rel="nofollow" target="_blank">Pinnacle Mountain</a><a href="https://www.ncbi.nlm.nih.gov/pubmed/16805148" rel="nofollow" target="_blank">Comprehensive review on toxicodendron dermatitis: poison ivy, oak, and sumac</a>.<a href="http://kidneycon.org/" rel="nofollow" target="_blank">KIDNEYcon</a>Tom Oates <a href="https://twitter.com/i/events/1214295206406819840" rel="nofollow" target="_blank">12 days of Poems on Twitter</a>

Freely Filtered 010 Difelakefalin

The Filtrate:Matt SparksJoel TopfSwapnil Hiremath COI: he was a sub-investigator on STARRTJennie LinAnd two special guests:Dr. Jay Koyner of the University of Chicago and #NephBBQ fame.Anitha Vijayan, professor of medicine at Wash U in St LouisShow Notes:The STARRT-AKI trial acronym is: Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney InjuryMatt suggests STAKRT-AKI Standard versus Accelerated Initiation of Kikdney-Replacement Therapy in Acute Kidney InjuryCoverage at NephJC: Time to Stop Starting RRT Early in AKIHouse of God by Samuel Shem. Contemporary Review in the New Yorker. AmazonRonco’s legendary dose of CRRT study. Lancet 2000.AJKD Meta analysis on initiation of dialysis in AKI by VF Seabra.Lead time biasTiming of Initiation of Dialysis in Critically Ill Patients with Acute Kidney Injury Initiation of dialysis by BUN in the Picard trial by Dr. Kathleen Liu.Jean-Luc PicardImmortal time biasAKIKI and ELAIN trials as covered by NephJCIssues surrounding informed consent in the ICUThe Chicago WayDr Palevsky’s ATN Study, AKA Intensity of Renal Support in Critically Ill Patients with Acute Kidney InjuryIs Irregardless A Word?Debate at Kidney Week: Intensivist vs Nephrologist for Renal Replacement Therapy (RRT) in the ICUInternal and External Validation of a Machine Learning Risk Score for Acute Kidney InjuryThat sweet sweet NephJC pot of goldFurosemide Stress Test and Biomarkers for the Prediction of AKI SeverityThai study that used FST to randomize patients for early versus late start KRT: Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial)AKIKI 2 at clinical trials.govSwapnil’s Tubular secretion, the Twitter timeline of Oded RechaviMatt’s Tubular Secretion: #kidneydietchallengeAnitha comes from the land of coconuts. Lots of potassium in coconut water.The Skeleton Key Group on The Renal Fellow Network

The Filtrate:Matt SparksJoel TopfSwapnil Hiremath COI: he was a sub-investigator on STARRTJennie LinAnd two special guests:<a href="https://twitter.com/jaykoyner" rel="nofollow" target="_blank">Dr. Jay Koyner</a> of the University of Chicago and <a href="https://twitter.com/hashtag/nephbbq?src=hashtag_click" rel="nofollow" target="_blank">#NephBBQ</a> fame.<a href="https://twitter.com/VijayanMD" rel="nofollow" target="_blank">Anitha Vijayan</a>, professor of medicine at Wash U in St LouisShow Notes:<a href="https://www.nejm.org/doi/10.1056/NEJMoa2000741" rel="nofollow" target="_blank">The STARRT-AKI trial</a> acronym is: Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney InjuryMatt suggests STAKRT-AKI Standard versus Accelerated Initiation of Kikdney-Replacement Therapy in Acute Kidney InjuryCoverage at NephJC: <a href="http://www.nephjc.com/news/starrt-aki" rel="nofollow" target="_blank">Time to Stop Starting RRT Early in AKI</a>House of God by Samuel Shem. <a href="https://www.newyorker.com/books/under-review/the-house-of-god-a-book-as-sexist-as-it-was-influential-gets-a-sequel" rel="nofollow" target="_blank">Contemporary Review in the New Yorker</a>. <a href="https://www.amazon.com/House-God-Samuel-Shem/dp/0425238091" rel="nofollow" target="_blank">Amazon</a>Ronco’s legendary dose of CRRT study. <a href="https://pubmed.ncbi.nlm.nih.gov/10892761/" rel="nofollow" target="_blank">Lancet 2000</a>.<a href="https://www.ajkd.org/article/S0272-6386(08)00829-9/abstract" rel="nofollow" target="_blank">AJKD Meta analysis</a> on initiation of dialysis in AKI by VF Seabra.<a href="https://first10em.com/ebm/lead-time-bias/" rel="nofollow" target="_blank">Lead time bias</a><a href="https://cjasn.asnjournals.org/content/1/5/915" rel="nofollow" target="_blank">Timing of Initiation of Dialysis in Critically Ill Patients with Acute Kidney Injury</a> Initiation of dialysis by BUN in the Picard trial by Dr. Kathleen Liu.<a href="https://en.wikipedia.org/wiki/Jean-Luc_Picard" rel="nofollow" target="_blank">Jean-Luc Picard</a><a href="https://www.bmj.com/content/340/bmj.b5087" rel="nofollow" target="_blank">Immortal time bias</a><a href="http://www.nephjc.com/news/2016/5/26/acute-kidney-injury-when-to-dialyze?rq=akiki" rel="nofollow" target="_blank">AKIKI and ELAIN trials</a> as covered by NephJC<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137230/" rel="nofollow" target="_blank">Issues surrounding informed consent in the ICU</a><a href="https://www.youtube.com/watch?v=GRz_kyT9Yyc" rel="nofollow" target="_blank">The Chicago Way</a>Dr Palevsky’s ATN Study, AKA <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa0802639" rel="nofollow" target="_blank">Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury</a><a href="https://www.dictionary.com/e/is-irregardless-a-word/" rel="nofollow" target="_blank">Is Irregardless A Word?</a><a href="https://www.kidneynews.org/kidney-week/on-site/debate-kidney-week-intensivist-vs-nephrologist-for-renal-replacement-therapy-rrt-in-the-icu" rel="nofollow" target="_blank">Debate at Kidney Week: Intensivist vs Nephrologist for Renal Replacement Therapy (RRT) in the ICU</a><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7420241/" rel="nofollow" target="_blank">Internal and External Validation of a Machine Learning Risk Score for Acute Kidney Injury</a><a href="https://www.nicepng.com/ourpic/u2e6t4q8i1r5w7i1_image-of-pot-gold-google-search-st-patricks/" rel="nofollow" target="_blank">That sweet sweet NephJC pot of gold</a><a href="https://jasn.asnjournals.org/content/26/8/2023" rel="nofollow" target="_blank">Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity</a>Thai study that used FST to randomize patients for early versus late start KRT: <a href="https://pubmed.ncbi.nlm.nih.gov/29673370/" rel="nofollow" target="_blank">Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial)</a><a href="https://clinicaltrials.gov/ct2/show/NCT03396757" rel="nofollow" target="_blank">AKIKI 2 at clinical trials.gov</a>Swapnil’s Tubular secretion, the Twitter timeline of <a href="https://twitter.com/OdedRechavi" rel="nofollow" target="_blank">Oded Rechavi</a>Matt’s Tubular Secretion: <a href="https://twitter.com/hashtag/kidneydietchallenge?src=hashtag_click" rel="nofollow" target="_blank">#kidneydietchallenge</a><a href="https://twitter.com/VijayanMD/status/975869174617661440?s=20" rel="nofollow" target="_blank">Anitha comes from the land of coconuts</a>. <a href="https://twitter.com/VijayanMD/status/1294380738910072832" rel="nofollow" target="_blank">Lots of potassium in coconut water</a>.<a href="https://www.renalfellow.org/category/the-skeleton-key-group/" rel="nofollow" target="_blank">The Skeleton Key Group</a> on The Renal Fellow Network

Freely Filtered 024: STARRT me up!

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