 Is a rigid HPV vaccination schedule really necessary? Story by Bruce Jancin, reporting from the annual meeting of the European Society for Pediatric Infectious Diseases. Delayed administration of the second dose of an HPV vaccine had no negative impact on the magnitude of the immune response. Other top stories:   Women are underrepresented as lead authors in oncology trialsThe proportion has been increasing but still lags behind the proportion of female oncologists in the United States.   Dupilumab found effective for adolescents with moderate to severe ADRates of skin infections were higher in the placebo group, compared with the treatment groups.   Exposure to outdoor air pollutants linked to increased emphysema  Being exposed to outdoor air pollutants was associated with increases in emphysema as assessed via CT imaging.   Favorable Ebola results lead to drug trial termination, new focus  Two of four therapeutics showed greater survival, prompting termination of the initial trial and randomization of new patients to these two drugs.   You can contact the MDedge Daily Medical News team by emailing us at podcasts@mdedge.com or by following us on Twitter @MDedgeTweets.

<a href="https://www.mdedge.com/internalmedicine/article/206364/vaccines/are-rigid-hpv-vaccination-schedules-really-necessary" rel="nofollow" target="_blank"> Is a rigid HPV vaccination schedule really necessary?</a> Story by Bruce Jancin, reporting from the annual meeting of the European Society for Pediatric Infectious Diseases. Delayed administration of the second dose of an HPV vaccine had no negative impact on the magnitude of the immune response. Other top stories: <ol> <li><a href="https://www.mdedge.com/hematology-oncology/article/206298/practice-management/women-underrepresented-oncology-trial" rel="nofollow" target="_blank"> Women are underrepresented as lead authors in oncology trials</a>The proportion has been increasing but still lags behind the proportion of female oncologists in the United States. </li> <li><a href="https://www.mdedge.com/dermatology/article/206313/atopic-dermatitis/dupilumab-found-effective-adolescents-moderate-severe" rel="nofollow" target="_blank"> Dupilumab found effective for adolescents with moderate to severe AD</a>Rates of skin infections were higher in the placebo group, compared with the treatment groups. </li> <li><a href="https://www.mdedge.com/internalmedicine/article/206356/pulmonology/exposure-outdoor-air-pollutants-linked-increased" rel="nofollow" target="_blank"> Exposure to outdoor air pollutants linked to increased emphysema </a> Being exposed to outdoor air pollutants was associated with increases in emphysema as assessed via CT imaging. </li> <li><a href="https://www.mdedge.com/infectiousdisease/article/206301/emerging-infections/favorable-ebola-results-lead-drug-trial" rel="nofollow" target="_blank"> Favorable Ebola results lead to drug trial termination, new focus </a> Two of four therapeutics showed greater survival, prompting termination of the initial trial and randomization of new patients to these two drugs. </li> </ol> You can contact the MDedge Daily Medical News team by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or by following us on Twitter @<a href="https://twitter.com/mdedgetweets" rel="nofollow" target="_blank">MDedgeTweets</a>.

Too few women oncology investigators; is a rigid HPV vaccination schedule needed?

David Henry

SPECIAL Crossover with Blood &amp; Cancer, the official podcast of MDedge HematologyOncology.  You can learn more about Blood &amp; Cancer at http://www.mdedge.com/podcasts/blood-cancer   SHOW NOTES:  Alan P. Lyss, MD, a medical oncologist in community practice at Missouri Baptist Medical Center in St. Louis, joins Blood &amp; Cancer host David H. Henry, MD, of the University of Pennsylvania, Philadelphia, to break down the most interesting and practice-changing studies at the recent 2019 annual meeting of the American Society of Clinical Oncology. Complete show notes by Ronak H. Mistry, DO, resident in the department of internal medicine, University of Pennsylvania, Philadelphia, are available online here. For more MDedge podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @mdedgehemonc David Henry on Twitter: @DavidHenryMD     Relevant links:  Big Data  Abstract LBA1 Abstract LBA5563 Abstract 110 CancerLinQ Database   Colorectal Cancer  Abstract 3500 Abstract 3501   Pancreatic Cancer  Abstract 4000 Abstract LBA4   Prostate Cancer  Abstract LBA2   Lung Cancer  Abstract 8504   Breast Cancer  Abstract 500 Abstract 502 TAILORx Abstract 503   Health Informatics  Abstract 6509 Abstract 6510   Multiple Myeloma  Multiple Myeloma Abstracts Smoldering Myeloma  Abstract 8000   Myeloma  Abstract 8002 Abstract 8007     

SPECIAL Crossover with Blood &amp; Cancer, the official podcast of MDedge HematologyOncology.  You can learn more about Blood &amp; Cancer at <a href="http://www.mdedge.com/podcasts/blood-cancer" rel="nofollow" target="_blank">http://www.mdedge.com/podcasts/blood-cancer</a> SHOW NOTES: <a href="https://doctors.bjc.org/wlp2/doctors/info/AKT00423/Alan-P-Lyss-MD" rel="nofollow" target="_blank"> Alan P. Lyss, MD</a>, a medical oncologist in community practice at Missouri Baptist Medical Center in St. Louis, joins Blood &amp; Cancer host <a href="https://www.pennmedicine.org/providers/profile/david-henry" rel="nofollow" target="_blank">David H. Henry, MD</a>, of the University of Pennsylvania, Philadelphia, to break down the most interesting and practice-changing studies at the recent 2019 annual meeting of the American Society of Clinical Oncology. Complete show notes by Ronak H. Mistry, DO, resident in the department of internal medicine, University of Pennsylvania, Philadelphia, are available online <a href="https://www.mdedge.com/podcasts/blood-cancer/all" rel="nofollow" target="_blank">here</a>. For more MDedge podcasts, go to <a href="https://www.mdedge.com/podcasts" rel="nofollow" target="_blank">mdedge.com/podcasts</a> Email the show: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Interact with us on Twitter: <a href="https://twitter.com/MDedgeHemOnc" rel="nofollow" target="_blank">@mdedgehemonc</a> David Henry on Twitter: <a href="http://bit.ly/2HXI6Lw" rel="nofollow" target="_blank">@DavidHenryMD</a> Relevant links: <ul> <li>Big Data <ul> <li><a href="http://bit.ly/2FqGnN7" rel="nofollow" target="_blank">Abstract LBA1</a></li> <li><a href="http://bit.ly/2L650Ch" rel="nofollow" target="_blank">Abstract LBA5563</a></li> <li><a href="http://bit.ly/2J3pyZP" rel="nofollow" target="_blank">Abstract 110</a></li> <li><a href="http://bit.ly/2WSCqGN" rel="nofollow" target="_blank">CancerLinQ Database</a></li> </ul> </li> <li>Colorectal Cancer <ul> <li><a href="http://bit.ly/2WYefff" rel="nofollow" target="_blank">Abstract 3500</a></li> <li><a href="http://bit.ly/2WV9vSD" rel="nofollow" target="_blank">Abstract 3501</a></li> </ul> </li> <li>Pancreatic Cancer <ul> <li><a href="http://bit.ly/2ISbDp2" rel="nofollow" target="_blank">Abstract 4000</a></li> <li><a href="http://bit.ly/2Iuc8Xn" rel="nofollow" target="_blank">Abstract LBA4</a></li> </ul> </li> <li>Prostate Cancer <ul> <li><a href="http://bit.ly/2RBkkIF" rel="nofollow" target="_blank">Abstract LBA2</a></li> </ul> </li> <li>Lung Cancer <ul> <li><a href="http://bit.ly/2ZLHoHx" rel="nofollow" target="_blank">Abstract 8504</a></li> </ul> </li> <li>Breast Cancer <ul> <li><a href="http://bit.ly/2x9xQK0" rel="nofollow" target="_blank">Abstract 500</a></li> <li><a href="http://bit.ly/2WUZmVW" rel="nofollow" target="_blank">Abstract 502</a></li> <li><a href="http://bit.ly/2IX9yby" rel="nofollow" target="_blank">TAILORx</a></li> <li><a href="http://bit.ly/2Kv37Qm" rel="nofollow" target="_blank">Abstract 503</a></li> </ul> </li> <li>Health Informatics <ul> <li><a href="http://bit.ly/2J2r8ec" rel="nofollow" target="_blank">Abstract 6509</a></li> <li><a href="http://bit.ly/2WYMlzF" rel="nofollow" target="_blank">Abstract 6510</a></li> </ul> </li> <li>Multiple Myeloma <ul> <li><a href="http://bit.ly/2XuXKq8" rel="nofollow" target="_blank">Multiple Myeloma Abstracts</a></li> <li>Smoldering Myeloma <ul> <li><a href="http://bit.ly/2XuXYgY" rel="nofollow" target="_blank">Abstract 8000</a></li> </ul> </li> <li>Myeloma <ul> <li><a href="http://bit.ly/2Jcgbaj" rel="nofollow" target="_blank">Abstract 8002</a></li> <li><a href="http://bit.ly/2Iucn4J" rel="nofollow" target="_blank">Abstract 8007</a></li> </ul> </li> </ul> </li> </ul>

SPECIAL: ASCO Journal Club with Blood & Cancer host David Henry, MD

Today's top stories in clinical medicine.    Medical cannabis laws appear no longer tied to drop in opioid overdose mortality  EULAR revises its RA management recommendations  Aggressive lowering of LDL cholesterol: Is it a good thing?  Residents are drowning in job offers -- and debt   You can contact the MDedge Daily Medical News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets

Today's top stories in clinical medicine.  <ol> <li><a href="https://www.mdedge.com/familymedicine/article/203337/addiction-medicine/medical-cannabis-laws-appear-no-longer-tied-drop" rel="nofollow" target="_blank"> Medical cannabis laws appear no longer tied to drop in opioid overdose mortality</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/203346/rheumatoid-arthritis/eular-revises-its-ra-management-recommendations" rel="nofollow" target="_blank"> EULAR revises its RA management recommendations</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/203319/lipid-disorders/aggressive-lowering-ldl-cholesterol-it-good-idea" rel="nofollow" target="_blank"> Aggressive lowering of LDL cholesterol: Is it a good thing?</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/203300/business-medicine/residents-are-drowning-job-offers-and-debt" rel="nofollow" target="_blank"> Residents are drowning in job offers -- and debt</a></li> </ol> You can contact the MDedge Daily Medical News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>

Do cannabis laws cut opioid deaths? Plus, residents swamped by debt, job offers

Today's top stories in clinical medicine.    Treat insomnia as a full-fledged disorder.  Illinois law expands abortion rights.  Consider iatrogenesis in patients with new psychiatric symptoms.  Foot osteoarthritis: forgotten no longer.   You can contact the MDedge Daily Medical News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

Today's top stories in clinical medicine.  <ol> <li><a href="https://www.mdedge.com/familymedicine/article/203160/sleep-medicine/treat-insomnia-full-fledged-disorder" rel="nofollow" target="_blank"> Treat insomnia as a full-fledged disorder.</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/203153/business-medicine/illinois-law-expands-abortion-rights-women" rel="nofollow" target="_blank"> Illinois law expands abortion rights.</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/203170/depression/consider-iatrogenesis-patients-new-psychiatric-symptoms" rel="nofollow" target="_blank"> Consider iatrogenesis in patients with new psychiatric symptoms.</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/203183/osteoarthritis/foot-oa-forgotten-no-longer" rel="nofollow" target="_blank"> Foot osteoarthritis: forgotten no longer.</a></li> </ol> You can contact the MDedge Daily Medical News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Treat insomnia like a disorder; what's causing new psychiatric symptoms?

Today's top stories in clinical medicine:   Modest changes deemed inherent in 'normal' aging  COPD exacerbations associated with poor sleep quality  Genetic analysis links PCSK9 inhibition and CV mortality  Obesity and overweight declined among lower-income kids   You can contact the MDedge Daily Medical News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

Today's top stories in clinical medicine: <ol> <li><a href="https://www.mdedge.com/psychiatry/article/203072/geriatrics/modest-cognitive-changes-deemed-inherent-normal-aging" rel="nofollow" target="_blank"> Modest changes deemed inherent in 'normal' aging</a></li> <li><a href="https://www.mdedge.com/familypracticenews/article/203056/copd/copd-exacerbations-associated-poor-sleep-quality" rel="nofollow" target="_blank"> COPD exacerbations associated with poor sleep quality</a></li> <li><a href="https://www.mdedge.com/familypracticenews/article/203030/lipid-disorders/genetic-analysis-links-pcsk9-inhibition-and-cv" rel="nofollow" target="_blank"> Genetic analysis links PCSK9 inhibition and CV mortality</a></li> <li><a href="https://www.mdedge.com/pediatrics/article/203075/obesity/obesity-and-overweight-declined-among-lower-income-kids" rel="nofollow" target="_blank"> Obesity and overweight declined among lower-income kids</a></li> </ol> You can contact the MDedge Daily Medical News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Some cognitive changes 'normal' with aging; obesity declined among lower-income children

Today's top stories:   Chronic opioid use may be common in patients with ankylosing spondylitis  Reducing pediatric RSV burden is top priority  Less reactogenic acellular pertusses vaccine has waning immunity  Nearly two-thirds of gynecologic oncology respondents experienced sexual harassment   You can contact the MDedge Daily Medical News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

Today's top stories: <ol> <li><a href="https://www.mdedge.com/internalmedicine/article/202752/ankylosing-spondylitis/chronic-opioid-use-may-be-common-patients" rel="nofollow" target="_blank"> Chronic opioid use may be common in patients with ankylosing spondylitis</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/202754/pediatrics/reducing-pediatric-rsv-burden-top-priority" rel="nofollow" target="_blank"> Reducing pediatric RSV burden is top priority</a></li> <li><a href="https://www.mdedge.com/familymedicine/article/202709/vaccines/less-reactogenic-acellular-pertussis-vaccine-has-waning" rel="nofollow" target="_blank"> Less reactogenic acellular pertusses vaccine has waning immunity</a></li> <li><a href="https://www.mdedge.com/obgyn/article/202742/gynecologic-cancer/nearly-two-thirds-gynecologic-oncology-respondents" rel="nofollow" target="_blank"> Nearly two-thirds of gynecologic oncology respondents experienced sexual harassment</a></li> </ol> You can contact the MDedge Daily Medical News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Chronic opioids and ankylosing spondylitis; 2/3 of gyn-oncs experienced sexual harassment

You can find more of our podcasts at http://www.mdedge.com/podcasts. Today's top stories in clinical medicine:  Updated systematic review of aspirin for primary prevention shows benefits, risks.  Estimated prevalence of OSA in the Americas stands at 170 million.  How to reverse type 2 diabetes with a crash diet the DiRECT approach. Zeroing in on a key issue: SGLT2s or GLP-1s for elderly T2D?  You can contact the MDedge Daily Medical News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

You can find more of our podcasts at <a href="http://www.mdedge.com/podcasts" rel="nofollow" target="_blank">http://www.mdedge.com/podcasts</a>. Today's top stories in clinical medicine: <ol> <li>Updated systematic review of aspirin for primary prevention shows benefits, risks.</li> <li><a href="https://www.mdedge.com/internalmedicine/article/202195/sleep-medicine/estimated-prevalence-osa-americas-stands-170-million" rel="nofollow" target="_blank"> Estimated prevalence of OSA in the Americas stands at 170 million.</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/202554/diabetes/how-reverse-type-2-diabetes-crash-diet-direct-approach" rel="nofollow" target="_blank"> How to reverse type 2 diabetes with a crash diet the DiRECT approach.</a></li> <li>Zeroing in on a key issue: SGLT2s or GLP-1s for elderly T2D?</li> </ol> You can contact the MDedge Daily Medical News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Does aspirin prevent anything? And how to pick the right diabetes drug 

You can find more of our podcasts on our website: http://www.mdedge.com/podcasts Today's top stories in clinical medicine:   Coffee, tea, and soda all up GERD risk  Warfarin boosts OS risk in Rotterdam Study  mTORC1 inhibitor protects elderly asthmatics from viral respiratory infections  NJ law, EMR alerts appear effective at reducing opioid prescriptions   You can contact the MDedge Daily Medical News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

You can find more of our podcasts on our website: <a href="http://www.mdedge.com/podcasts" rel="nofollow" target="_blank">http://www.mdedge.com/podcasts</a> Today's top stories in clinical medicine: <ol> <li><a href="https://www.mdedge.com/internalmedicine/article/201598/gastroenterology/coffee-tea-and-soda-all-gerd-risk" rel="nofollow" target="_blank"> Coffee, tea, and soda all up GERD risk</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/201586/osteoarthritis/warfarin-boosts-oa-risk-rotterdam-study" rel="nofollow" target="_blank"> Warfarin boosts OS risk in Rotterdam Study</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/201600/asthma/mtorc1-inhibitor-protects-elderly-asthmatics-viral" rel="nofollow" target="_blank"> mTORC1 inhibitor protects elderly asthmatics from viral respiratory infections</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/201566/pain/nj-law-emr-alerts-appear-effective-reducing-opioid" rel="nofollow" target="_blank"> NJ law, EMR alerts appear effective at reducing opioid prescriptions</a></li> </ol> You can contact the MDedge Daily Medical News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Coffee, tea, and soda increase GERD risk

Today in clinical medicine:   Most measles cases in 25 years prompts government pleas to vaccinate  Positive psoriatic arthritis screens occur often in psoriasis patients  Sleep apnea is linked with tau accumulation in the brain  Patients say primary care video visits are convenient, high quality   You can contact the MDedge Daily News by emailing us at podcasts@mdedge.com or following us on Twitter at @MDedgeTweets.

Today in clinical medicine: <ol> <li><a href="https://www.mdedge.com/internalmedicine/article/199790/infectious-diseases/most-measles-cases-25-years-prompts-government" rel="nofollow" target="_blank"> Most measles cases in 25 years prompts government pleas to vaccinate</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/199840/psoriatic-arthritis/positive-psoriatic-arthritis-screens-occur-often" rel="nofollow" target="_blank"> Positive psoriatic arthritis screens occur often in psoriasis patients</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/199835/sleep-medicine/sleep-apnea-linked-tau-accumulation-brain" rel="nofollow" target="_blank"> Sleep apnea is linked with tau accumulation in the brain</a></li> <li><a href="https://www.mdedge.com/internalmedicine/article/199800/business-medicine/patients-say-primary-care-video-visits-are" rel="nofollow" target="_blank"> Patients say primary care video visits are convenient, high quality</a></li> </ol> You can contact the MDedge Daily News by emailing us at <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

Government pleas for measles vaccination

The 2019 annual Internal Medicine meeting of the American College of Physicians took place beginning April 10 in Philadelphia. MDedge Podcast host and producer Nick Andrews joined Internal Medicine News editor Katie Lennon to discuss a few of the biggest topics.  ACP 2019 highlights:  Telemedicine update. Neuropathic pain update. Negotiating a strong contract. ACP launches quality improvement tools.  You can contact the MDedge Daily news by emailing podcasts@mdedge.com or by following us on Twitter at @MDedgeTweets.

The 2019 annual Internal Medicine meeting of the American College of Physicians took place beginning April 10 in Philadelphia. MDedge Podcast host and producer Nick Andrews joined Internal Medicine News editor Katie Lennon to discuss a few of the biggest topics.  ACP 2019 highlights: <ol> <li><a href="http://bit.ly/2DevwF0" rel="nofollow" target="_blank">Telemedicine update.</a></li> <li><a href="http://bit.ly/2Xb7DFS" rel="nofollow" target="_blank">Neuropathic pain update.</a></li> <li><a href="http://bit.ly/2Xcwx7T" rel="nofollow" target="_blank">Negotiating a strong contract.</a></li> <li><a href="http://bit.ly/2Ik3Qmm" rel="nofollow" target="_blank">ACP launches quality improvement tools.</a></li> </ol> You can contact the MDedge Daily news by emailing <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> or by following us on Twitter at <a href="http://bit.ly/2TN5AKO" rel="nofollow" target="_blank">@MDedgeTweets</a>.

ACP Internal Medicine Meeting 2019

The latest clinical medicine and health policy news for healthcare professionals, delivered each weekday by host Nick Andrews and MDedge editors. The information in this podcast is provided for informational and educational purposes only.

This podcast is a fast and convenient way to stay up to date on the news in medicine. Was better when it came out in the morning. Can you go back to that?

Great daily update

It’s tough to deliver a 7 to 9 minute daily podcast covering the most significant advances in medicine. This one delivers and is as much a part of my daily podcast as is the NYT podcast  The Daily. Congrats to the MDEdge team that puts this together.

Excellent, Fast Medical Updates for Clinicians & Advanced Consumers

Daily Medical News

Sexual assault and harassment and the impact they have on women’s health. Also today, experts recommend anti-TNFs to for severe psoriasis in pregnancy, the FDA approves first-of-its-kind lung disease treatment, and do you know what the rive ontological emergencies are?

Sexual assault and harassment and the impact they have on women’s health. Also today, experts recommend anti-TNFs to for severe psoriasis in pregnancy, the FDA approves first-of-its-kind lung disease treatment, and do you know what the rive ontological emergencies are?

Sexual assault, harassment linked to depression

Patients with non-alcoholic fatty liver disease who consumed modest quantities of alcohol had significantly less improvement in NASH. Also today, new AGA guidelines on opioid-induced constipation, a self-management intervention for epilepsy improves quality of life, and fewer enrollees reach the Medicare drug donut hole.

Patients with non-alcoholic fatty liver disease who consumed <a href="https://www.mdedge.com/internalmedicinenews/article/173684/ibd-intestinal-disorders/aga-guideline-treatment-opioid-induced" rel="noopener nofollow" target="_blank">modest quantities of alcohol</a> had significantly less improvement in NASH. Also today, new <a href="https://www.mdedge.com/internalmedicinenews/article/171669/hepatology/even-modest-alcohol-use-may-worsen-nafld" rel="noopener nofollow" target="_blank">AGA guidelines on opioid-induced</a> constipation, a self-management <a href="https://www.mdedge.com/internalmedicinenews/article/173788/epilepsy-seizures/self-management-intervention-epilepsy-achieves" rel="noopener nofollow" target="_blank">intervention for epilepsy</a> improves quality of life, and fewer enrollees reach the <a href="https://www.mdedge.com/internalmedicinenews/article/173446/practice-management/medicare-donut-hole-fewer-enrollees-more" rel="noopener nofollow" target="_blank">Medicare drug donut hole</a>.

Modest alcohol and NAFLD

Around one-half of women and, one-third of men will eventually develop dementia, stroke, or parkinsonism during their lifetime (http://bit.ly/2OxI0yh0). Also today, trivalent adjuvant influenza vaccine aIIV3 is safe in elderly adults (http://bit.ly/2P6MWqY) , pill burden affects the ability to reach systolic BP control (http://bit.ly/2P5LOUy), and breast cancer risk in type 2 diabetes related to adiposity (http://bit.ly/2NiOsVf).

Around one-half of women and, one-third of men will eventually develop dementia, stroke, or parkinsonism during their lifetime (<a href="http://bit.ly/2OxI0yh0" rel="nofollow" target="_blank">http://bit.ly/2OxI0yh0</a>). Also today, trivalent adjuvant influenza vaccine aIIV3 is safe in elderly adults (<a href="http://bit.ly/2P6MWqY" rel="nofollow" target="_blank">http://bit.ly/2P6MWqY</a>) , pill burden affects the ability to reach systolic BP control (<a href="http://bit.ly/2P5LOUy" rel="nofollow" target="_blank">http://bit.ly/2P5LOUy</a>), and breast cancer risk in type 2 diabetes related to adiposity <a href="http://bit.ly/2NiOsVf" rel="nofollow" target="_blank">(http://bit.ly/2NiOsVf</a>).

Neurological disease and aging

Hayden Bosworth, PhD has advice on how to get on top of home BP monitoring and how it can be clinically relevant (http://bit.ly/2QkMllQ). Also today, opioid use in osteoarthritis may mean more activity-limiting pain (http://bit.ly/2QlQqWN), sulfasalazine is pinpointed as the reason for high triple-therapy discontinuation (http://bit.ly/2DIyqoc), and point-of-care test for respiratory viruses lowers antibiotic use (http://bit.ly/2xRiLNM).

Hayden Bosworth, PhD has advice on how to get on top of home BP monitoring and how it can be clinically relevant (<a href="http://bit.ly/2QkMllQ" rel="nofollow" target="_blank">http://bit.ly/2QkMllQ</a>). Also today, opioid use in osteoarthritis may mean more activity-limiting pain (<a href="http://bit.ly/2QlQqWN" rel="nofollow" target="_blank">http://bit.ly/2QlQqWN</a>), sulfasalazine is pinpointed as the reason for high triple-therapy discontinuation (<a href="http://bit.ly/2DIyqoc" rel="nofollow" target="_blank">http://bit.ly/2DIyqoc</a>), and point-of-care test for respiratory viruses lowers antibiotic use (<a href="http://bit.ly/2xRiLNM" rel="nofollow" target="_blank">http://bit.ly/2xRiLNM</a>).

Get on top of home BP monitoring

Ketamine may be helpful in central sensitization pain syndromes (http://bit.ly/2O5TN6F). Also today, trifarotene cream for acne meats all endpoints in twin phase 3 trials (http://bit.ly/2xJ5GGz), the pros and cons of gastric bypass surgery for patients with type 2 diabetes (http://bit.ly/2OOam4m), and it looks like obesity plays a role in sleep-disordered breathing for pregnant women (http://bit.ly/2px9yWr).

Ketamine may be helpful in central sensitization pain syndromes (<a href="http://bit.ly/2O5TN6F" rel="nofollow" target="_blank">http://bit.ly/2O5TN6F</a>). Also today, trifarotene cream for acne meats all endpoints in twin phase 3 trials (<a href="http://bit.ly/2xJ5GGz" rel="nofollow" target="_blank">http://bit.ly/2xJ5GGz</a>), the pros and cons of gastric bypass surgery for patients with type 2 diabetes (<a href="http://bit.ly/2OOam4m" rel="nofollow" target="_blank">http://bit.ly/2OOam4m</a>), and it looks like obesity plays a role in sleep-disordered breathing for pregnant women (<a href="http://bit.ly/2px9yWr" rel="nofollow" target="_blank">http://bit.ly/2px9yWr</a>).

Ketamine for pain syndromes

Most patients with type 2 diabetes stop taking their medication within a year, and nearly one-third stop within the first 3 months (http://bit.ly/2QD0U4U). Also today, the FDA approves Ajovy for migraine prevention(http://bit.ly/2Nhbxwq), some teens are using cannabis in their vapor devices (http://bit.ly/2pekqs7), and alpha-blocker use is still common and still risky (http://bit.ly/2No2QAE).

Most patients with type 2 diabetes stop taking their medication within a year, and nearly one-third stop within the first 3 months (<a href="http://bit.ly/2QD0U4U" rel="nofollow" target="_blank">http://bit.ly/2QD0U4U</a>). Also today, the FDA approves Ajovy for migraine prevention(<a href="http://bit.ly/2Nhbxwq" rel="nofollow" target="_blank">http://bit.ly/2Nhbxwq</a>), some teens are using cannabis in their vapor devices (<a href="http://bit.ly/2pekqs7" rel="nofollow" target="_blank">http://bit.ly/2pekqs7</a>), and alpha-blocker use is still common and still risky (<a href="http://bit.ly/2No2QAE" rel="nofollow" target="_blank">http://bit.ly/2No2QAE</a>).

Alarming rate of diabetes medication discontinuations

Successful phase 3 data for new headache medications (rimegepant, ubrogepant, lasmiditan) are finally raining in after a lengthy drought. Also today, interferon status and family history predict autoimmune connective tissue disease, steroid injection before rotator cuff repair predicts revision, and the CMS resumes risk adjustment payments for 2017.

Successful phase 3 data <a href="http://bit.ly/2mYo8F2" rel="noopener nofollow" target="_blank">for new headache medications</a> (rimegepant, ubrogepant, lasmiditan) are finally raining in after a lengthy drought. Also today, interferon status and family history <a href="http://bit.ly/2vqsTeo" rel="noopener nofollow" target="_blank">predict autoimmune connective tissue</a> disease, steroid <a href="http://bit.ly/2M2JX19" rel="noopener nofollow" target="_blank">injection before rotator cuff</a> repair predicts revision, and the CMS <a href="http://bit.ly/2v4giOz" rel="noopener nofollow" target="_blank">resumes risk adjustment payments</a> for 2017.

Finally, New migraine drugs

Single-dose influenza drug baloxavirhas similar efficacy to oseltamivir, according to new data in the New England Journal of Medicine. Also today, the relationship between obstructive sleep apnea and gout, community-based therapy for asthma in African American teens, and the importance of hospital settings for pneumonia.

Single-dose <a href="http://bit.ly/2oMTTlo" rel="noopener nofollow" target="_blank">influenza drug baloxavir</a>has similar efficacy to oseltamivir, according to new data in the <a href="http://bit.ly/2MRVK7d" rel="noopener nofollow" target="_blank">New England Journal of Medicine</a>. Also today, the relationship between <a href="http://bit.ly/2NkVPzy" rel="noopener nofollow" target="_blank">obstructive sleep apnea and gout</a>, community-based therapy for <a href="http://bit.ly/2NkXxRu" rel="noopener nofollow" target="_blank">asthma in African American teens</a>, and the <a href="http://bit.ly/2CpKSs3" rel="noopener nofollow" target="_blank">importance of hospital settings for pneumonia</a>.

Baloxavir, oseltamivir similar for influenza

Multiple studies based on phase 3 clinical trials of the investigational drug solriamfetol have found that it may be effective for improving next-day wakefulness and work productivity in people with narcolepsy and obstructive sleep apnea, and that the drug can maintain its effect throughout the day as well as for up to 6 months. Also today, ankylosing spondylitis progression slowed when NSAIDs were added to TNFi, chronic kidney disease more common among patients with type 2 diabetes, laws that promote drug price transparency gain ground.

Multiple studies based on <a href="https://www.mdedge.com/internalmedicinenews/article/169655/pulmonology/investigational-solriamfetol-may-improve-multiple" rel="noopener nofollow" target="_blank">phase 3 clinical trials of the investigational drug</a> solriamfetol have found that it may be effective for improving next-day wakefulness and work productivity in people with narcolepsy and obstructive sleep apnea, and that the drug can maintain its effect throughout the day as well as for up to 6 months. Also today, ankylosing spondylitis <a href="https://www.mdedge.com/internalmedicinenews/article/169617/spondyloarthropathies/ankylosing-spondylitis-progression-slowed" rel="noopener nofollow" target="_blank">progression slowed when NSAIDs were added</a> to TNFi, chronic kidney disease <a href="https://www.mdedge.com/internalmedicinenews/article/169646/diabetes/chronic-kidney-disease-40-more-common-t2dm-t1dm" rel="noopener nofollow" target="_blank">more common among patients with type 2 diabetes</a>, laws that promote <a href="https://www.mdedge.com/internalmedicinenews/article/169674/business-medicine/drug-price-transparency-laws-gain-ground" rel="noopener nofollow" target="_blank">drug price transparency</a> gain ground.

Solriamfetol could improve sleep measures

Contact us: podcasts@mdedge.com  FDA panels back intranasal esketamine for refractory depression. http://bit.ly/2TOKrfp ONC aims to help doctors, patients with information sharing in proposed rule. http://bit.ly/2X3SVkP Survey: Health care costs unlikely to improve in 2019. http://bit.ly/2SwSIYJ Vaccination and antiviral treatment don't lower stroke risk after shingles. http://bit.ly/2tjYQVa 

Contact us: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> <ol> <li>FDA panels back intranasal esketamine for refractory depression. <a href="http://bit.ly/2TOKrfp" rel="nofollow" target="_blank">http://bit.ly/2TOKrfp</a></li> <li>ONC aims to help doctors, patients with information sharing in proposed rule. <a href="http://bit.ly/2X3SVkP" rel="nofollow" target="_blank">http://bit.ly/2X3SVkP</a></li> <li>Survey: Health care costs unlikely to improve in 2019. <a href="http://bit.ly/2SwSIYJ" rel="nofollow" target="_blank">http://bit.ly/2SwSIYJ</a></li> <li>Vaccination and antiviral treatment don't lower stroke risk after shingles. <a href="http://bit.ly/2tjYQVa" rel="nofollow" target="_blank">http://bit.ly/2tjYQVa</a></li> </ol>

FDA weighs esketamine for depression

Contact us: podcasts@mdedge.com Follow MDedge on Twitter: @MDedgeTweets In this special edition of the MDedge Daily News, Nick Andrews and Terry Rudd report the latest news from the 2018 annual San Antonio Breast Cancer Symposium. Stories include: using low-dose tamoxifen, the latest findings fro KATHERINE trial, results of a meta-analysis of neoadjuvant chemotherapy, and capecitabine in early stage triple negative breast cancer

Contact us: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a> Follow MDedge on Twitter: @MDedgeTweets In this special edition of the MDedge Daily News, Nick Andrews and Terry Rudd report the latest news from the 2018 annual San Antonio Breast Cancer Symposium. Stories include: using low-dose tamoxifen, the latest findings fro KATHERINE trial, results of a meta-analysis of neoadjuvant chemotherapy, and capecitabine in early stage triple negative breast cancer

Special Report: SABCS

Over the last decade, opioid use has not significantly declined, despite efforts to educate physicians about the risk of abuse. Also today, the Fitbit Flex is feasible and provides nuanced step-count data in patients with MS, even moderate alcohol use could worsen outcomes in nonalcoholic fatty liver disease, and a new study supports meningococcal B vaccine in children with rare diseases.

Over the last decade, <a href="https://www.mdedge.com/internalmedicinenews/article/171660/addiction-medicine/opioid-use-has-not-declined-meaningfully" rel="noopener nofollow" target="_blank">opioid use has not significantly declined</a>, despite efforts to educate physicians about the risk of abuse. Also today, the Fitbit Flex <a href="https://www.mdedge.com/internalmedicinenews/article/171696/multiple-sclerosis/fitbit-flex-feasible-provides-nuanced-step" rel="noopener nofollow" target="_blank">is feasible and provides nuanced step-count</a> data in patients with MS, even <a href="https://www.mdedge.com/internalmedicinenews/article/171669/hepatology/even-modest-alcohol-use-may-worsen-nafld" rel="noopener nofollow" target="_blank">moderate alcohol use could worsen outcomes</a> in nonalcoholic fatty liver disease, and a new study supports <a href="https://www.mdedge.com/familypracticenews/article/171638/vaccines/study-supports-meningococcal-b-vaccine-children-rare" rel="noopener nofollow" target="_blank">meningococcal B vaccine in children</a> with rare diseases.

No meaningful decline in opioid use

New research debunks three migraine trigger myths. Also today, the relationship between migraines and menopause, the FDA recommends pooled Zika testing of blood donations, and ICD use drops in hospitals named in a federal lawsuit.

New research debunks <a href="https://www.mdedge.com/familypracticenews/article/169582/pain/study-busts-three-migraine-trigger-myths/page/0/1" rel="noopener nofollow" target="_blank">three migraine trigger</a> myths. Also today, the relationship <a href="https://www.mdedge.com/internalmedicinenews/article/169564/pain/migraine-and-menopause-longitudinal-study-shows-what-expect" rel="noopener nofollow" target="_blank">between migraines and menopause</a>, the FDA recommends <a href="https://www.mdedge.com/internalmedicinenews/article/169645/transfusion-medicine/fda-recommends-pooled-zika-testing-blood" rel="noopener nofollow" target="_blank">pooled Zika testing</a> of blood donations, and <a href="https://www.mdedge.com/internalmedicinenews/article/169556/heart-failure/icd-use-curbed-hospitals-named-federal-lawsuit" rel="noopener nofollow" target="_blank">ICD use drops in hospitals</a> named in a federal lawsuit.

Migraine trigger myths

Fluoroquinolones are recommended for adults with cancer-related immunosuppression. Also today, statins are not preventative in the elderly unless they have diabetes, children born from ART have risk for arterial hypertension, and Supreme Court nominee Judge Kavanaugh testifies on Roe v. Wade.

Fluoroquinolones are recommended for adults with <a href="https://www.mdedge.com/oncologypractice/article/174314/patient-survivor-care/asco-updates-guidance-prophylaxis-adults" rel="noopener nofollow" target="_blank">cancer-related immunosuppression</a>. Also today, statins are not preventative in the elderly <a href="https://www.mdedge.com/internalmedicinenews/article/174148/diabetes/statins-arent-preventive-elderly-unless-they-have" rel="noopener nofollow" target="_blank">unless they have diabetes</a>, children born from ART have <a href="https://www.mdedge.com/internalmedicinenews/article/174165/cardiology/children-born-art-increased-risk-developing-arterial" rel="noopener nofollow" target="_blank">risk for arterial hypertension</a>, and Supreme Court nominee Judge <a href="https://www.mdedge.com/internalmedicinenews/article/174168/health-policy/scotus-kavanaugh-suggests-precedent-will-govern" rel="noopener nofollow" target="_blank">Kavanaugh testifies on Roe v. Wade</a>.

New guidelines on prophylaxis for cancer-related immunosuppression

Dr. Joseph Murray of the Mayo Clinic points out that you might know as much about celiac as you think (http://bit.ly/2preFr4). Also today, a novel agent shows unprecedented efficacy in psoriasis (http://bit.ly/2MLLE2I), IgA vasculitis may be more common in adults than you think (http://bit.ly/2DeXTFC), and one-step gestational diabetes screening doesn’t improve outcomes (http://bit.ly/2xy7VLM).

Dr. Joseph Murray of the Mayo Clinic points out that you might know as much about celiac as you think (<a href="http://bit.ly/2preFr4" rel="nofollow" target="_blank">http://bit.ly/2preFr4</a>). Also today, a novel agent shows unprecedented efficacy in psoriasis (<a href="http://bit.ly/2MLLE2I" rel="nofollow" target="_blank">http://bit.ly/2MLLE2I</a>), IgA vasculitis may be more common in adults than you think (<a href="http://bit.ly/2DeXTFC" rel="nofollow" target="_blank">http://bit.ly/2DeXTFC</a>), and one-step gestational diabetes screening doesn’t improve outcomes (<a href="http://bit.ly/2xy7VLM" rel="nofollow" target="_blank">http://bit.ly/2xy7VLM</a>).

What you should know about celiac disease 

Tai chi tempers  the risk of falls in older adults.  Rosacea’s global reach may be greater than expected. How an  MRI at prostate cancer diagnosis shapes disease management. And new guidelines debut for diagnosing and treating  mild traumatic brain injury in children.

Tai chi tempers <a href="https://www.mdedge.com/internalmedicinenews/article/174381/preventive-care/tai-chi-tempers-risk-falls-older-adults" rel="nofollow" target="_blank"> the risk of falls</a> in older adults. <a href="https://www.mdedge.com/internalmedicinenews/article/174403/rosacea/global-incidence-rosacea-estimated-be-over-5" rel="nofollow" target="_blank"> Rosacea’s global reach</a> may be greater than expected. How an <a href="https://www.mdedge.com/internalmedicinenews/article/174183/genitourinary-cancer/mri-doubles-rate-observation-low-risk" rel="nofollow" target="_blank"> MRI at prostate cancer diagnosis</a> shapes disease management. And new guidelines debut for diagnosing and treating <a href="https://www.mdedge.com/pediatricnews/article/174308/neurosurgery-trauma/cdc-releases-guidelines-pediatric-mtbi" rel="nofollow" target="_blank"> mild traumatic brain injury</a> in children.

Can tai chi tame seniors' fall risk?

Today, we’re bringing you a special episode featuring exclusive coverage from the annual meeting of the American Academy of Dermatology in Washington. 1. Food allergies and atopic dermatitis: What is the evidence? https://bit.ly/2CayGcp 2. Many common dermatologic drugs can be safely used during pregnancy. https://bit.ly/2HmZLfY 3. 31-GEP test predicts likelihood of metastasis for cutaneous melanoma. https://bit.ly/2NO3dkK 4. Bermekimab reduces lesions, cuts pain in patients with hidradenitis suppurativa. https://bit.ly/2H6NuNe Contact us: podcasts@mdedge.com

Today, we’re bringing you a special episode featuring exclusive coverage from the annual meeting of the American Academy of Dermatology in Washington. 1. Food allergies and atopic dermatitis: What is the evidence? <a href="https://bit.ly/2CayGcp" rel="nofollow" target="_blank">https://bit.ly/2CayGcp</a> 2. Many common dermatologic drugs can be safely used during pregnancy. <a href="https://bit.ly/2HmZLfY" rel="nofollow" target="_blank">https://bit.ly/2HmZLfY</a> 3. 31-GEP test predicts likelihood of metastasis for cutaneous melanoma. <a href="https://bit.ly/2NO3dkK" rel="nofollow" target="_blank">https://bit.ly/2NO3dkK</a> 4. Bermekimab reduces lesions, cuts pain in patients with hidradenitis suppurativa. <a href="https://bit.ly/2H6NuNe" rel="nofollow" target="_blank">https://bit.ly/2H6NuNe</a> Contact us: <a href="mailto:podcasts@mdedge.com">podcasts@mdedge.com</a>

AAD 2019 meeting wrap-up

Physician burnout may  jeopardize patient care. The FDA cracks down on companies selling an increasingly popular, unproven  alternative to opioids.  Multiday seizure cycles in epilepsy may be quite common. And  new stroke guidelines raise the bar on mechanical thrombectomy procedures.

Physician burnout may <a href="https://www.mdedge.com/internalmedicinenews/article/174693/lifestyle/burnout-may-jeopardize-patient-care" rel="nofollow" target="_blank"> jeopardize patient care</a>. The FDA cracks down on companies selling an increasingly popular, unproven <a href="https://www.mdedge.com/internalmedicinenews/article/174674/addiction-medicine/fda-warns-kratom-vendors-about-unproven" rel="nofollow" target="_blank"> alternative to opioids</a>. <a href="https://www.mdedge.com/internalmedicinenews/article/174715/epilepsy-seizures/multiday-seizure-cycles-may-be-very-common" rel="nofollow" target="_blank"> Multiday seizure cycles</a> in epilepsy may be quite common. And <a href="https://www.mdedge.com/internalmedicinenews/article/174660/stroke/new-stroke-intervention-guidelines-stress-volume" rel="nofollow" target="_blank"> new stroke guidelines</a> raise the bar on mechanical thrombectomy procedures.

Physician burnout singes patient safety

Contact us: podcasts@mdedge  Automated office BP readings best routine measures  https://www.mdedge.com/internalmedicinenews/article/193804/hypertension/automated-office-bp-readings-best-routine-measures   Positive FIT test should prompt colonoscopy  https://www.mdedge.com/internalmedicinenews/article/193798/gastroenterology/positive-fit-test-should-prompt-colonoscopy  Mild aerobic exercise speeds sports concussion recovery  https://www.mdedge.com/internalmedicinenews/article/193748/injuries/mild-aerobic-exercise-speeds-sports-concussion-recovery   Phase 3 studies of antiamyloid Alzheimer’s drug crenezumab stopped  https://www.mdedge.com/psychiatry/article/193578/alzheimers-cognition/phase-3-studies-antiamyloid-alzheimers-drug

Contact us: <a href="mailto:podcasts@mdedge">podcasts@mdedge</a> Automated office BP readings best routine measures <a href="https://www.mdedge.com/internalmedicinenews/article/193804/hypertension/automated-office-bp-readings-best-routine-measures" rel="nofollow" target="_blank"> https://www.mdedge.com/internalmedicinenews/article/193804/hypertension/automated-office-bp-readings-best-routine-measures</a> Positive FIT test should prompt colonoscopy <a href="https://www.mdedge.com/internalmedicinenews/article/193798/gastroenterology/positive-fit-test-should-prompt-colonoscopy" rel="nofollow" target="_blank"> https://www.mdedge.com/internalmedicinenews/article/193798/gastroenterology/positive-fit-test-should-prompt-colonoscopy</a> Mild aerobic exercise speeds sports concussion recovery <a href="https://www.mdedge.com/internalmedicinenews/article/193748/injuries/mild-aerobic-exercise-speeds-sports-concussion-recovery" rel="nofollow" target="_blank"> https://www.mdedge.com/internalmedicinenews/article/193748/injuries/mild-aerobic-exercise-speeds-sports-concussion-recovery</a> Phase 3 studies of antiamyloid Alzheimer’s drug crenezumab stopped <a href="https://www.mdedge.com/psychiatry/article/193578/alzheimers-cognition/phase-3-studies-antiamyloid-alzheimers-drug" rel="nofollow" target="_blank"> https://www.mdedge.com/psychiatry/article/193578/alzheimers-cognition/phase-3-studies-antiamyloid-alzheimers-drug</a>

Time to switch to automated BP readings?

More than half of patients who were tested for prescription drug compliance last year misused their medications (http://bit.ly/2xpqou1). Also today, obesity prevalence is now at least 35% in 7 states(http://bit.ly/2NLI3WW), the FDA has a new plan to combat antibiotic resistance (http://bit.ly/2MCBykL), and what will come of all the comments about the new E/M payment proposals (http://bit.ly/2xryMZM).

More than half of patients who were tested for prescription drug compliance last year misused their medications (<a href="http://bit.ly/2xpqou1" rel="nofollow" target="_blank">http://bit.ly/2xpqou1</a>). Also today, obesity prevalence is now at least 35% in 7 states(<a href="http://bit.ly/2NLI3WW" rel="nofollow" target="_blank">http://bit.ly/2NLI3WW</a>), the FDA has a new plan to combat antibiotic resistance (<a href="http://bit.ly/2MCBykL" rel="nofollow" target="_blank">http://bit.ly/2MCBykL</a>), and what will come of all the comments about the new E/M payment proposals (<a href="http://bit.ly/2xryMZM" rel="nofollow" target="_blank">http://bit.ly/2xryMZM</a>).

Urine drugs screens show improper medication use

The best podcast episodes of the most interesting stories and things. From skyping someone while they're in space, to tracking down and meeting a telephone scammer in person, to the story of a Galapagos. These episodes will keep you and all your friends entertained and captivated for hours. Learn something new in every episode! Add episodes you're interested into your queue below!

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