Microscopy methods today are enabling researchers to see small details within cells, previously undetectable by light microscopy. Chief Editor Barbara Cheifet speaks with Drs. Ed Boyden and Johann Danzl about the technological advances and challenges in the fields of super resolution and expansion microscopy. Hosted on Acast. See acast.com/privacy for more information.

Microscopy methods today are enabling researchers to see small details within cells, previously undetectable by light microscopy. Chief Editor Barbara Cheifet speaks with Drs. Ed Boyden and Johann Danzl about the technological advances and challenges in the fields of super resolution and expansion microscopy. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Super Resolution and Expansion Microscopy Roundtable: Boyden and Danzl

Single-cell metabolomics is focused on detecting, understanding, and interpreting metabolites and lipids at single-cell resolution. Theodore Alexandrov and Anne Le discuss recent technical advances in the field with Chief Editor Barbara Cheifet. Hosted on Acast. See acast.com/privacy for more information.

Single-cell metabolomics is focused on detecting, understanding, and interpreting metabolites and lipids at single-cell resolution. Theodore Alexandrov and Anne Le discuss recent technical advances in the field with Chief Editor Barbara Cheifet. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Single-cell metabolomics Roundtable: Alexandrov and Le

Chief Editor Barbara Cheifet speaks with Drs. Michael Fischbach and Sarkis Mazmanian about recent work uncovering functional roles for our microbiomes and what is needed to bring microbiome therapies to the clinic.  Hosted on Acast. See acast.com/privacy for more information.

Chief Editor Barbara Cheifet speaks with Drs. Michael Fischbach and Sarkis Mazmanian about recent work uncovering functional roles for our microbiomes and what is needed to bring microbiome therapies to the clinic.  Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Microbiome Roundtable: Fischbach and Mazmanian

Jayme Locke and Megan Sykes discuss advances in xenotransplantation with Chief Editor Barbara Cheifet, including details of the recent transplants of pig heart and kidney into braindead patients, as well as the questions researchers and clinicians are asking next.  Hosted on Acast. See acast.com/privacy for more information.

Jayme Locke and Megan Sykes discuss advances in xenotransplantation with Chief Editor Barbara Cheifet, including details of the recent transplants of pig heart and kidney into braindead patients, as well as the questions researchers and clinicians are asking next.  Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Xenotransplantation Roundtable: Locke and Sykes

Human Cell Atlas

Aviv Regev and Sarah Teichmann talk with Senior Editor Barbara Cheifet about the development and exciting recent progress of the Human Cell Atlas project. Hosted on Acast. See acast.com/privacy for more information.

Aviv Regev and Sarah Teichmann talk with Senior Editor Barbara Cheifet about the development and exciting recent progress of the Human Cell Atlas project. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Human Cell Atlas Roundtable: Regev and Teichmann

Senior Editor Markus Elsner has a discussion with Ray Deshaies and Carolyn Bertozzi about PROTACs, small molecules that have the potential to treat previously-undruggable targets in clinical applications. Hosted on Acast. See acast.com/privacy for more information.

Senior Editor Markus Elsner has a discussion with Ray Deshaies and Carolyn Bertozzi about PROTACs, small molecules that have the potential to treat previously-undruggable targets in clinical applications. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

PROTACs Roundtable: Bertozzi and Deshaies

Ana Pombo and Jennifer Phillips-Cremins talk with senior editor Barbara Cheifet about how new methods to look at the 3D genome are providing insights into the links between genome structure and cellular function. Hosted on Acast. See acast.com/privacy for more information.

Ana Pombo and Jennifer Phillips-Cremins talk with senior editor Barbara Cheifet about how new methods to look at the 3D genome are providing insights into the links between genome structure and cellular function. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

3D Genome Roundtable: Pombo and Phillips-Cremins

Kimberly Stegmaier and John Doench speak with senior editor Markus Elsner about the history and latest developments in the field of CRISPR screening.   Hosted on Acast. See acast.com/privacy for more information.

Kimberly Stegmaier and John Doench speak with senior editor Markus Elsner about the history and latest developments in the field of CRISPR screening.  Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

CRISPR Screening Roundtable: Stegmaier and Doench

Kathryn Whitehead and Robert Langer talk with Senior Editor Markus Elsner about drug delivery methods and their applications within a wide range of therapeutic modalities.  Hosted on Acast. See acast.com/privacy for more information.

Kathryn Whitehead and Robert Langer talk with Senior Editor Markus Elsner about drug delivery methods and their applications within a wide range of therapeutic modalities.  Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Drug Delivery Roundtable: Whitehead and Langer

Katherine High and Donald Kohn speak with senior editor Markus Elsner about the latest developments in gene therapy Hosted on Acast. See acast.com/privacy for more information.

Katherine High and Donald Kohn speak with senior editor Markus Elsner about the latest developments in gene therapy Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Gene Therapy Roundtable: High and Kohn

Nature Biotechnology's Forum podcast explores biotech's latest scientific publications, found in Nature Biotechnology and elsewhere, through discussions with today's leading researchers. Hosted on Acast. See acast.com/privacy for more information.

Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue Hosted on Acast. See acast.com/privacy for more information.

Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Hope Lies in Dreams Chapter 1

Karl Deisseroth and Viviana Gradinaru speak with senior editor Markus Elsner about the current state of optogenetics and how it can be used to better understand and treat human disease.  Hosted on Acast. See acast.com/privacy for more information.

Karl Deisseroth and Viviana Gradinaru speak with senior editor Markus Elsner about the current state of optogenetics and how it can be used to better understand and treat human disease.  Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Optogenetics Roundtable: Deisseroth and Gradinaru

Lillian Siu and Elaine Mardis speak with senior editor Markus Elsner about the current state of precision cancer medicine and what progress the future might hold. Hosted on Acast. See acast.com/privacy for more information.

Lillian Siu and Elaine Mardis speak with senior editor Markus Elsner about the current state of precision cancer medicine and what progress the future might hold. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Precision Oncology Roundtable: Siu and Mardis

Nature Biotechnology’s Irene Jarchum speaks with Michel Sadelain about off-the-shelf CAR-T cells, and discusses a recent paper from Maksim Mamonkin’s group describing a clever strategy to mitigate CAR-T cell rejection. The paper was published in Nature Biotechnology and can be read here. Hosted on Acast. See acast.com/privacy for more information.

Nature Biotechnology’s Irene Jarchum speaks with Michel Sadelain about off-the-shelf CAR-T cells, and discusses a recent paper from Maksim Mamonkin’s group describing a clever strategy to mitigate CAR-T cell rejection. The paper was published in Nature Biotechnology and can be read <a href="https://www.nature.com/articles/s41587-020-0601-5" rel="noopener noreferrer nofollow" target="_blank">here</a>. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

The T cell wars

David Liu and Jennifer Doudna talk with our Senior Editor Markus Elsner about the state of the genome editing field and what challenges remain, especially as various therapies are now entering the clinic. This episode is part of Nature Biotechnology’s Focus issue on CRISPR tools and therapies. Hosted on Acast. See acast.com/privacy for more information.

David Liu and Jennifer Doudna talk with our Senior Editor Markus Elsner about the state of the genome editing field and what challenges remain, especially as various therapies are now entering the clinic. This episode is part of Nature Biotechnology’s Focus issue on CRISPR tools and therapies. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

CRISPR Roundtable: Liu and Doudna

A recent Nature Biotechnology paper from Tony Atala and colleagues at Wake Forest describes the use of bioengineered scaffolds to repair substantial injuries to rabbit uteri, supporting pregnancies and live births. Senior Editor Irene Jarchum discusses this work with Mats Brännström and Mats Hellström, both from Gothenburg University in Sweden. You can read the paper here.  Hosted on Acast. See acast.com/privacy for more information.

A recent Nature Biotechnology paper from Tony Atala and colleagues at Wake Forest describes the use of bioengineered scaffolds to repair substantial injuries to rabbit uteri, supporting pregnancies and live births. Senior Editor Irene Jarchum discusses this work with Mats Brännström and Mats Hellström, both from Gothenburg University in Sweden. You can read the paper <a href="https://www.nature.com/articles/s41587-020-0547-7" rel="noopener noreferrer nofollow" target="_blank">here</a>.  Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Bioengineered scaffolds repair the uterus in rabbits

David Shapiro Ilan talks to Senior Editor Susan Jones about a paper in the May issue where Ricardo Machado and colleagues describe how bacterial symbionts of nematodes are evolved to help these worms kill a devastating crop pest: Western Corn Rootworm. The paper can be read here. Hosted on Acast. See acast.com/privacy for more information.

David Shapiro Ilan talks to Senior Editor Susan Jones about a paper in the May issue where Ricardo Machado and colleagues describe how bacterial symbionts of nematodes are evolved to help these worms kill a devastating crop pest: Western Corn Rootworm. The paper can be <a href="https://www.nature.com/articles/s41587-020-0419-1" rel="noopener noreferrer nofollow" target="_blank">read here</a>. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Worms and gut microbes team up to kill corn pest

Senior Editor Markus Elsner talks to Alex Marson of UCSF about the significance of a Science paper describing the phase 1 clinical trial of CRISPR-engineered T cells. The work was carried out by Carl June and Edward Stadtmauer from UPenn. Read the paper here. Hosted on Acast. See acast.com/privacy for more information.

Senior Editor Markus Elsner talks to Alex Marson of UCSF about the significance of a Science paper describing the phase 1 clinical trial of CRISPR-engineered T cells. The work was carried out by Carl June and Edward Stadtmauer from UPenn. Read the paper <a href="https://science.sciencemag.org/content/367/6481/eaba7365" rel="noopener noreferrer nofollow" target="_blank">here</a>. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

First human trial of engineered T cells

Senior editor Irene Jarchum talks to Cliona Rooney about a recent paper in which Mark Cobbold and colleagues describe an antibody-mediated strategy to re-target virus-specific T cells against tumors. The paper was published in Nature Biotechnology; it can be read here. Hosted on Acast. See acast.com/privacy for more information.

Senior editor Irene Jarchum talks to Cliona Rooney about a recent paper in which Mark Cobbold and colleagues describe an antibody-mediated strategy to re-target virus-specific T cells against tumors. The paper was published in Nature Biotechnology; it can be read <a href="https://www.nature.com/articles/s41587-019-0404-8" rel="noopener noreferrer nofollow" target="_blank">here</a>. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Repurposing viral immunity to fight cancer

Brady Huggett talks with Zemin Zhang about a recent Nature Biotechnology paper detailing the use of spatial transcriptomics in providing new insights into tumor architecture. The work was done by Itai Yanai and co-authors, and the paper can be read here.   Hosted on Acast. See acast.com/privacy for more information.

Brady Huggett talks with Zemin Zhang about a recent Nature Biotechnology paper detailing the use of spatial transcriptomics in providing new insights into tumor architecture. The work was done by Itai Yanai and co-authors, and the paper can be read <a href="https://www.nature.com/articles/s41587-019-0392-8" rel="noopener noreferrer nofollow" target="_blank">here</a>.   Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Molecular mapping of tumor heterogeneity

An interesting idea for giving context to new biotech research. I enjoyed the first episode.

Interesting Idea

Nature Biotechnology's Forum podcast explores biotech's latest scientific publications, found in Nature Biotechnology and elsewhere, through discussions with today's leading researchers. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Forum

Senior Editor Irene Jarchum talks to Stefan Schneeberger about the significance of a recent Nature Biotechnology paper describing a sophisticated perfusion machine to keep human livers alive for a week. The work was carried out by Pierre-Alain Clavien and colleagues from ETH Zurich. Read the paper here. Hosted on Acast. See acast.com/privacy for more information.

Senior Editor Irene Jarchum talks to Stefan Schneeberger about the significance of a recent Nature Biotechnology paper describing a sophisticated perfusion machine to keep human livers alive for a week. The work was carried out by Pierre-Alain Clavien and colleagues from ETH Zurich. Read the paper <a href="https://www.nature.com/articles/s41587-019-0374-x" rel="noopener noreferrer nofollow" target="_blank">here</a>. Hosted on Acast. See <a href="https://acast.com/privacy" rel="noopener noreferrer nofollow" target="_blank">acast.com/privacy</a> for more information.

Supercooling extends human liver storage

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