Bárbara Bitarello's guest appearances

Bárbara Bitarello

the bioinformatics chat

David Kelley

Irineo Cabreros

Romain Lopez

Gabriel Misrachi

Hassan Samee

Kristina Grigaityte

Jacob Schreiber

Simeon Carstens

Trevor Pesout

HoJoon Lee

Seung Woo Cho

Kaushik Panda

Keith Slotkin

Fernando Portela

Chang Xu

OwlTail

Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS)to predict the phenotype based on the genotype. However, the predictionaccuracy suffers when GWAS from one population are used to calculate PRS withina different population, which is a problem because the majority of the GWASare done on cohorts of European ancestry. In this episode, Bárbara Bitarello helps usunderstand how PRS work and why they don’t transfer well across populations. Links:  Polygenic Scores for Height in Admixed Populations (Bárbara D. Bitarello, Iain Mathieson) What is ancestry? (Iain Mathieson, Aylwyn Scally)  If you enjoyed this episode, please consider supporting the podcast on Patreon!

Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS) to predict the phenotype based on the genotype. However, the prediction accuracy suffers when GWAS from one population are used to calculate PRS within a different population, which is a problem because the majority of the GWAS are done on cohorts of European ancestry. In this episode, <a href="https://bbitarello.github.io/" rel="nofollow" target="_blank">Bárbara Bitarello</a> helps us understand how PRS work and why they don’t transfer well across populations. Links: <ul> <li><a href="https://www.g3journal.org/content/10/11/4027" rel="nofollow" target="_blank">Polygenic Scores for Height in Admixed Populations</a> (Bárbara D. Bitarello, Iain Mathieson)</li> <li><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008624" rel="nofollow" target="_blank">What is ancestry?</a> (Iain Mathieson, Aylwyn Scally)</li> </ul> If you enjoyed this episode, please consider supporting the podcast on <a href="https://www.patreon.com/bioinfochat" rel="nofollow" target="_blank">Patreon</a>!

#56 Polygenic risk scores in admixed populations with Bárbara Bitarello