Claudia Keller Valsecchi's guest appearances

Claudia Keller Valsecchi

Epigenetics Podcast

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In this episode of the Epigenetics Podcast, we caught up with Claudia Keller Valsecchi from the Institute for Molecular Biology in Mainz to talk about her work on gene dosage alterations in evolution and ageing. Claudia Keller-Valsecchi's team focuses on understanding the fundamental mechanisms of how cellular function in eukaryotes is influenced by gene copy number variation. Recent findings indicate that precise MSL2-mediated gene dosage is highly relevant for organismal development. Since 2020 Claudia Keller-Valsecchi runs her own lab at the IMB in Mainz, Germany, where she tries to understand from a molecular mechanistic point of view how gene dosage compensation works, with projects in mosquitoes and in Artemia franciscanagene, as well as dosage regulation in the mammalian system regarding development and disease.   References  Keller, C., Adaixo, R., Stunnenberg, R., Woolcock, K. J., Hiller, S., &amp; Bühler, M. (2012). HP1Swi6 Mediates the Recognition and Destruction of Heterochromatic RNA Transcripts. Molecular Cell, 47(2), 215–227. https://doi.org/10.1016/j.molcel.2012.05.009   Valsecchi, C.I.K., Basilicata, M.F., Georgiev, P. et al. RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, 137–142 (2021). https://doi.org/10.1038/s41586-020-2935-z   Keller Valsecchi, C. I., Marois, E., Basilicata, M. F., Georgiev, P., &amp; Akhtar, A. (2021). Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life Science Alliance, 4(9), e202000996. https://doi.org/10.26508/lsa.202000996     Related Episodes  Epigenetics and X-Inactivation (Edith Heard)   Dosage Compensation in Drosophila (Asifa Akhtar)      Contact  Epigenetics Podcast on Twitter   Epigenetics Podcast on Instagram   Epigenetics Podcast on Mastodon   Active Motif on Twitter   Active Motif on LinkedIn   Email: podcast@activemotif.com   

In this episode of the Epigenetics Podcast, we caught up with Claudia Keller Valsecchi from the Institute for Molecular Biology in Mainz to talk about her work on gene dosage alterations in evolution and ageing. Claudia Keller-Valsecchi's team focuses on understanding the fundamental mechanisms of how cellular function in eukaryotes is influenced by gene copy number variation. Recent findings indicate that precise MSL2-mediated gene dosage is highly relevant for organismal development. Since 2020 Claudia Keller-Valsecchi runs her own lab at the IMB in Mainz, Germany, where she tries to understand from a molecular mechanistic point of view how gene dosage compensation works, with projects in mosquitoes and in Artemia franciscanagene, as well as dosage regulation in the mammalian system regarding development and disease. References <ul><li> Keller, C., Adaixo, R., Stunnenberg, R., Woolcock, K. J., Hiller, S., &amp; Bühler, M. (2012). HP1Swi6 Mediates the Recognition and Destruction of Heterochromatic RNA Transcripts. Molecular Cell, 47(2), 215–227. <a href="https://doi.org/10.1016/j.molcel.2012.05.009" rel="nofollow" target="_blank">https://doi.org/10.1016/j.molcel.2012.05.009</a> </li> <li> Valsecchi, C.I.K., Basilicata, M.F., Georgiev, P. et al. RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, 137–142 (2021). <a href="https://doi.org/10.1038/s41586-020-2935-z" rel="nofollow" target="_blank">https://doi.org/10.1038/s41586-020-2935-z</a> </li> <li> Keller Valsecchi, C. I., Marois, E., Basilicata, M. F., Georgiev, P., &amp; Akhtar, A. (2021). Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life Science Alliance, 4(9), e202000996. <a href="https://doi.org/10.26508/lsa.202000996" rel="nofollow" target="_blank">https://doi.org/10.26508/lsa.202000996</a> </li> </ul> Related Episodes <ul><li> <a href="https://www.activemotif.com/podcasts#edith-heard" rel="nofollow" target="_blank">Epigenetics and X-Inactivation (Edith Heard)</a> </li> <li> <a href="https://www.activemotif.com/podcasts#asifa-akhtar" rel="nofollow" target="_blank">Dosage Compensation in Drosophila (Asifa Akhtar)</a> </li> </ul> <ul><li> Contact <ul><li> <a href="https://twitter.com/epigenetics_pod" rel="nofollow" target="_blank">Epigenetics Podcast on Twitter</a> </li> <li> <a href="https://www.instagram.com/epigenetics_pod/" rel="nofollow" target="_blank">Epigenetics Podcast on Instagram</a> </li> <li> <a href="https://podcasts.social/@epigenetics_pod" rel="nofollow" target="_blank">Epigenetics Podcast on Mastodon</a> </li> <li> <a href="https://twitter.com/activemotif" rel="nofollow" target="_blank">Active Motif on Twitter</a> </li> <li> <a href="https://www.linkedin.com/company-beta/35651/" rel="nofollow" target="_blank">Active Motif on LinkedIn</a> </li> <li> Email: <a href="mailto:podcast@activemotif.com">podcast@activemotif.com</a> </li> </ul> </li></ul>