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Psychedelic Ibogaine

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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.25.172304v1?rss=1Authors: Gonzalez, J., Cavelli, M., Castro-Zaballa, S., Mondino, A., Tort, A. B., Rubido, N., Carrera, I., Torterolo, P.Abstract: Ibogaine is a psychedelic alkaloid that has attracted scientific interest because of its important antiaddictive properties evidenced in observational studies in humans, and in models for substance-use-disorders in rodents. Its subjective effect has been described as intense vivid dream-like experiences occurring while awake; hence, ibogaine is often referred to as an oneirogenic psychedelic. While this unique dream-like profile has been hypothesized to aid the antiaddictive effects in the past, the electrophysiological signatures of the ibogaine psychedelic state remain unknown. In our previous work, we showed in rats that ibogaine administration promotes a waking state with abnormal motor behavior, accompanied by a decrease in NREM and REM sleep. Here, we performed an in-depth analysis of the intracranial electroencephalogram during "ibogaine wakefulness". Ibogaine induced gamma oscillations with larger power than control levels but less coherent and less complex; i.e., this state shows clear REM sleep traits within the gamma frequency band. Thus, our results provide novel biological evidence for the association between the psychedelic state and REM sleep, and an empirical basis for the oneirogenic conjecture of ibogaine.Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: <a href="http://biorxiv.org/cgi/content/short/2020.06.25.172304v1?rss=1" rel="nofollow" target="_blank">http://biorxiv.org/cgi/content/short/2020.06.25.172304v1?rss=1</a> Authors: Gonzalez, J., Cavelli, M., Castro-Zaballa, S., Mondino, A., Tort, A. B., Rubido, N., Carrera, I., Torterolo, P. Abstract: Ibogaine is a psychedelic alkaloid that has attracted scientific interest because of its important antiaddictive properties evidenced in observational studies in humans, and in models for substance-use-disorders in rodents. Its subjective effect has been described as intense vivid dream-like experiences occurring while awake; hence, ibogaine is often referred to as an oneirogenic psychedelic. While this unique dream-like profile has been hypothesized to aid the antiaddictive effects in the past, the electrophysiological signatures of the ibogaine psychedelic state remain unknown. In our previous work, we showed in rats that ibogaine administration promotes a waking state with abnormal motor behavior, accompanied by a decrease in NREM and REM sleep. Here, we performed an in-depth analysis of the intracranial electroencephalogram during "ibogaine wakefulness". Ibogaine induced gamma oscillations with larger power than control levels but less coherent and less complex; i.e., this state shows clear REM sleep traits within the gamma frequency band. Thus, our results provide novel biological evidence for the association between the psychedelic state and REM sleep, and an empirical basis for the oneirogenic conjecture of ibogaine. Copy rights belong to original authors. Visit the link for more info

Gamma band alterations and REM-like traits underpin the acute effect of the atypical psychedelic ibogaine

Rocky Caravelli

Rocky Caravelli talks about his recovery from 25 years of methamphetamine and heroin addition and a bipolar diagnosis through treatment with Ibogaine, a visionary plant medicine from indigenous people in West Africa, and his work helping many others heal.  Rocky is director of Ibogaine treatment center Awaken In The Dream house in San Francisco de Nayarit, Mexico. http://www.awakeninginthedream.comThe post Rocky Caravelli: Treating Addiction with Psychedelic Ibogaine first appeared on Madness Radio.

Rocky Caravelli talks about his recovery from 25 years of methamphetamine and heroin addition and a bipolar diagnosis through treatment with Ibogaine, a visionary plant medicine from indigenous people in West Africa, and his work helping many others heal. Rocky is director of Ibogaine treatment center Awaken In The Dream house in San Francisco de Nayarit, Mexico. <a href="http://www.awakeninginthedream.com/" rel="nofollow" target="_blank">http://www.awakeninginthedream.com</a>The post <a href="https://www.madnessradio.net/madness-radio-2007-06-20-rocky-caravelli-ibogaine-psychedelic-addction-treatment/" rel="nofollow" target="_blank">Rocky Caravelli: Treating Addiction with Psychedelic Ibogaine</a> first appeared on <a href="https://www.madnessradio.net" rel="nofollow" target="_blank">Madness Radio</a>.

Rocky Caravelli: Treating Addiction with Psychedelic Ibogaine