Jesse Bloom's guest appearances

Jesse Bloom

Badass Spiritual Warriors

Meet the Microbiologist

In the Bubble with Andy Slavitt

Follow the Science

Peter Hotez

Alex Gibney

Dan Pfeiffer

Shannon Watts

Jessica Green

Adam Conover

Tim Kaine

Bernie Sanders

Andrew Yang

Pete Buttigieg

Amy Klobuchar

Nicholas Bagley

Rob Knight

Scott Galloway

John Doerr

OwlTail

Andy tries to get a glimpse into SARS-CoV-2's future with Fred Hutchinson molecular biologist Jesse Bloom. Jesse is studying the ways the virus could continue to evolve and he gives us a sense of what may be on the horizon and how our immunity could hold up to those changes. Plus, they go back to the basics and talk about how and why this virus is evolving so much faster than other known viruses.   Keep up with Andy on Twitter @ASlavitt and Instagram @andyslavitt.    Follow Jesse on Twitter @jbloom_lab.    Joining Lemonada Premium is a great way to support our show and get bonus content. Subscribe today at bit.ly/lemonadapremium.    Support the show by checking out our sponsors!    Click this link for a list of current sponsors and discount codes for this show and all Lemonada shows: https://lemonadamedia.com/sponsors/  Throughout the pandemic, CVS Health has been there, bringing quality, affordable health care closer to home—so it’s never out of reach for anyone. Because at CVS Health, healthier happens together. Learn more at cvshealth.com.    Check out these resources from today’s episode:     Read more about California’s SMARTER Plan: https://www.gov.ca.gov/2022/02/17/governor-newsom-unveils-smarter-plan-charting-californias-path-forward-on-nation-leading-pandemic-response/ Learn more about the Bloom Lab’s work: https://research.fredhutch.org/bloom/en.html Read this preprint about the Bloom Lab’s antibody-escape calculator: https://www.biorxiv.org/content/10.1101/2021.12.04.471236v1 Find a COVID-19 vaccine site near you: https://www.vaccines.gov/  Order Andy’s book, Preventable: The Inside Story of How Leadership Failures, Politics, and Selfishness Doomed the U.S. Coronavirus Response: https://us.macmillan.com/books/9781250770165     Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia.    For additional resources, information, and a transcript of the episode, visit lemonadamedia.com/show/inthebubble.See omnystudio.com/listener for privacy information.

Andy tries to get a glimpse into SARS-CoV-2's future with Fred Hutchinson molecular biologist Jesse Bloom. Jesse is studying the ways the virus could continue to evolve and he gives us a sense of what may be on the horizon and how our immunity could hold up to those changes. Plus, they go back to the basics and talk about how and why this virus is evolving so much faster than other known viruses. Keep up with Andy on Twitter @ASlavitt and Instagram @andyslavitt.  Follow Jesse on Twitter @jbloom_lab.  Joining Lemonada Premium is a great way to support our show and get bonus content. Subscribe today at <a href="http://bit.ly/lemonadapremium" rel="nofollow" target="_blank">bit.ly/lemonadapremium</a>.  Support the show by checking out our sponsors! <ul> <li>Click this link for a list of current sponsors and discount codes for this show and all Lemonada shows: <a href="https://lemonadamedia.com/sponsors/" rel="nofollow" target="_blank">https://lemonadamedia.com/sponsors/</a> </li> <li>Throughout the pandemic, CVS Health has been there, bringing quality, affordable health care closer to home—so it’s never out of reach for anyone. Because at CVS Health, healthier happens together. Learn more at <a href="http://cvshealth.com/" rel="nofollow" target="_blank">cvshealth.com</a>.</li> </ul> Check out these resources from today’s episode:  <ul> <li>Read more about California’s SMARTER Plan: <a href="https://www.gov.ca.gov/2022/02/17/governor-newsom-unveils-smarter-plan-charting-californias-path-forward-on-nation-leading-pandemic-response/" rel="nofollow" target="_blank">https://www.gov.ca.gov/2022/02/17/governor-newsom-unveils-smarter-plan-charting-californias-path-forward-on-nation-leading-pandemic-response/</a></li> <li>Learn more about the Bloom Lab’s work: <a href="https://research.fredhutch.org/bloom/en.html" rel="nofollow" target="_blank">https://research.fredhutch.org/bloom/en.html</a></li> <li>Read this preprint about the Bloom Lab’s antibody-escape calculator: <a href="https://www.biorxiv.org/content/10.1101/2021.12.04.471236v1" rel="nofollow" target="_blank">https://www.biorxiv.org/content/10.1101/2021.12.04.471236v1</a></li> <li>Find a COVID-19 vaccine site near you: <a href="https://www.vaccines.gov/" rel="nofollow" target="_blank">https://www.vaccines.gov/</a> </li> <li>Order Andy’s book, Preventable: The Inside Story of How Leadership Failures, Politics, and Selfishness Doomed the U.S. Coronavirus Response: <a href="https://us.macmillan.com/books/9781250770165" rel="nofollow" target="_blank">https://us.macmillan.com/books/9781250770165</a> </li> </ul> Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia.  For additional resources, information, and a transcript of the episode, visit <a href="https://lemonadamedia.com/show/inthebubble/" rel="nofollow" target="_blank">lemonadamedia.com/show/inthebubble</a>.See <a href="https://omnystudio.com/listener" rel="nofollow" target="_blank">omnystudio.com/listener</a> for privacy information.

How Is SARS-CoV-2 Going to Evolve, and What Does It Mean for Our Future? (with Jesse Bloom)

Influenza is famous for its ability to mutate and evolve but are mutations always the virus’ friend? Jesse Bloom discusses his work on influenza escape from serum through mutation and how mutations affect influenza virus function and transmission. Subscribe (free) on  Apple Podcasts,  Google Podcasts,  Android,  RSS, or by email. Also available on the ASM Podcast Network app. Julie’s Biggest Takeaways Influenza is famous for its ability to mutate and evolve through two major mechanisms:  Antigenic drift occurs when a few mutations accumulate in the influenza genome and lead to seasonal changes. Antigenic shift occurs when two influenza strains recombine their genomes to form one previously unknown in human populations.  Avian influenza has caused thousands of zoonotic cases, in which the virus is transmitted from birds to people. This causes serious disease but the virus doesn’t easily pass from person-to-person, limiting how many people are affected. When a zoonotic case becomes easily transmissible between people, as is suspected occurred in the 1918 influenza pandemic, the outcome can be very serious for many, many people. During antigenic drift, the virus accumulates mutations randomly throughout its genome. Mutations in the hemagglutinin (HA) glycoprotein gene are the mutations most likely to affect the ability of antibodies to attach and block HA during viral infection of a new host cell. The circulating human H3N2 influenza A virus accumulates approximately 3-4 mutations annually within its HA gene, representing a 0.5-1% change. On average, it takes 5-7 years of these mutations accumulating until a viral strain can reinfect a previously infected person. The changes in the influenza sequence are responsible for waning immunity against the annually circulating strain. This was demonstrated when a flu strain from the 1950s was inadvertently reintroduced in the 1970s; older people who had previously been infected were protected against this exact same strain. Influenza viruses can escape from sera, which contains many different antibodies, similar to how they can escape from a single monoclonal antibody: through mutations in major antibody binding sites. However, the mutations that allow escape from one person’s serum are different from the mutations that allow escape from another person’s serum. This means the strains that escape one person’s immune system may only be able to infect those with similar immunity.   Links for This Episode  MTM Listener Survey, only takes 3 minutes. Thanks! Jesse Bloom’s lab website Guns Germs and Steel by Jared Diamond Lee J.M. et al. Mapping Person-to-Person Variation in Viral Mutations that Escape Polyclonal Serum Targeting Influenza Hemagglutinin.eLife. August 2019. Xue K.S. et al. Cooperating H3N2 Influenza Virus Variants are not Detectable in Primary Clinical Samples.mSphere. January 2018. Francis Arnold at ASM Microbe:Innovation by Evolution: Bringing New Chemistry to Life  Let us know what you thought about this episode by tweeting at us @ASMicrobiology or leaving a comment on facebook.com/asmfan.

Influenza is famous for its ability to mutate and evolve but are mutations always the virus’ friend? Jesse Bloom discusses his work on influenza escape from serum through mutation and how mutations affect influenza virus function and transmission. Subscribe (free) on <a href="https://itunes.apple.com/podcast/meet-the-scientist/id289419806?mt=2&amp;ls=1" rel="nofollow" target="_blank"> Apple Podcasts</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL21lZXR0aGVzY2llbnRpc3QubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vcnNz" rel="nofollow" target="_blank"> Google Podcasts</a>, <a href="http://www.subscribeonandroid.com/meetthescientist.microbeworld.libsynpro.com/rss" rel="nofollow" target="_blank"> Android</a>, <a href="http://meetthescientist.microbeworld.libsynpro.com/rss" rel="nofollow" target="_blank"> RSS</a>, or by <a href="http://eepurl.com/c4MKHb" rel="nofollow" target="_blank">email</a>. Also available on the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" rel="nofollow" target="_blank">ASM Podcast Network app</a>. Julie’s Biggest Takeaways Influenza is famous for its ability to mutate and evolve through two major mechanisms: <ul> <li>Antigenic drift occurs when a few mutations accumulate in the influenza genome and lead to seasonal changes.</li> <li>Antigenic shift occurs when two influenza strains recombine their genomes to form one previously unknown in human populations.</li> </ul> Avian influenza has caused thousands of zoonotic cases, in which the virus is transmitted from birds to people. This causes serious disease but the virus doesn’t easily pass from person-to-person, limiting how many people are affected. When a zoonotic case becomes easily transmissible between people, as is suspected occurred in the 1918 influenza pandemic, the outcome can be very serious for many, many people. During antigenic drift, the virus accumulates mutations randomly throughout its genome. Mutations in the hemagglutinin (HA) glycoprotein gene are the mutations most likely to affect the ability of antibodies to attach and block HA during viral infection of a new host cell. The circulating human H3N2 influenza A virus accumulates approximately 3-4 mutations annually within its HA gene, representing a 0.5-1% change. On average, it takes 5-7 years of these mutations accumulating until a viral strain can reinfect a previously infected person. The changes in the influenza sequence are responsible for waning immunity against the annually circulating strain. This was demonstrated when a flu strain from the 1950s was inadvertently reintroduced in the 1970s; older people who had previously been infected were protected against this exact same strain. Influenza viruses can escape from sera, which contains many different antibodies, similar to how they can escape from a single monoclonal antibody: through mutations in major antibody binding sites. However, the mutations that allow escape from one person’s serum are different from the mutations that allow escape from another person’s serum. This means the strains that escape one person’s immune system may only be able to infect those with similar immunity.   Links for This Episode <ul> <li><a href="https://asm.org/mtmpoll/" rel="nofollow" target="_blank">MTM Listener Survey</a>, only takes 3 minutes. Thanks!</li> <li><a href="https://research.fhcrc.org/bloom/en.html" rel="nofollow" target="_blank">Jesse Bloom’s lab website</a></li> <li><a href="https://en.wikipedia.org/wiki/Guns,_Germs,_and_Steel" rel="nofollow" target="_blank">Guns Germs and Steel by Jared Diamond</a></li> <li>Lee J.M. et al. <a href="https://elifesciences.org/articles/49324" rel="nofollow" target="_blank">Mapping Person-to-Person Variation in Viral Mutations that Escape Polyclonal Serum Targeting Influenza Hemagglutinin.</a>eLife. August 2019.</li> <li>Xue K.S. et al. <a href="https://msphere.asm.org/content/3/1/e00552-17" rel="nofollow" target="_blank">Cooperating H3N2 Influenza Virus Variants are not Detectable in Primary Clinical Samples.</a>mSphere. January 2018.</li> <li><a href="https://www.youtube.com/watch?v=W-VlegtO7K8&amp;t=5s" rel="nofollow" target="_blank">Francis Arnold at ASM Microbe:</a>Innovation by Evolution: Bringing New Chemistry to Life</li> </ul> Let us know what you thought about this episode by tweeting at us <a href="http://twitter.com/ASMicrobiology" rel="nofollow" target="_blank">@ASMicrobiology</a> or leaving a comment on <a href="http://facebook.com/asmfan" rel="nofollow" target="_blank">facebook.com/asmfan</a>.

117: Influenza Virus Evolution with Jesse Bloom

Honor

I sat down with Jesse Bloom to chat about honor. A great word- carrying great meaning. Do you think about honor in your life? How do you live with honor? Let's talk about it. Check out The 5 Simple Shifts to Finally Overcome Anxiety at https://get.janelleklander.com/badasswarriors/ www.janelleklander.com

I sat down with Jesse Bloom to chat about honor. A great word- carrying great meaning. Do you think about honor in your life? How do you live with honor? Let's talk about it. Check out The 5 Simple Shifts to Finally Overcome Anxiety at <a href="https://get.janelleklander.com/badasswarriors/" rel="nofollow" target="_blank">https://get.janelleklander.com/badasswarriors/</a> <a href="http://www.janelleklander.com" rel="nofollow" target="_blank">www.janelleklander.com</a>

009 Let's Talk About Honor with Jesse Bloom