Hamish King's guest appearances

Hamish King

the bioinformatics chat

The Genomics Lab

David Kelley

Brad Richardson

Peter Ellis

Irineo Cabreros

Romain Lopez

Gabriel Misrachi

Hassan Samee

Kristina Grigaityte

Jacob Schreiber

Simeon Carstens

Trevor Pesout

HoJoon Lee

Seung Woo Cho

Kaushik Panda

Keith Slotkin

OwlTail

In todays episode, I speak to Dr Hamish King, a Sir Henry Wellcome Fellow affiliated with the Blizard Institute at Queen Mary University of London. Hamish is interested in how errors in gene regulation lead to changes in the behaviour and function of B cells, an important cell type in our immune system that makes antibodies to fight and remember infections. Hamish talks about how he uses wet lab and bioinformatic techniques to answer these questions. Dr King is also due to become a laboratory head at WEHI in early 2022, where his lab will focus on answering a range of questions including:  How immune-specific chromatin-based mechanisms regulate gene expression Whether autoimmune-associated genetic risk loci disrupt regulatory function of enhancers If disease-specific epigenomic networks exist in autoimmunity  We talk also in the episode, about Hamish's recent paper which is accessible here, you can also find Hamish on twitter here where he is happy to be contacted further about his research and upcoming vacancies in his brand new lab. 

In todays episode, I speak to Dr Hamish King, a Sir Henry Wellcome Fellow affiliated with the Blizard Institute at Queen Mary University of London. Hamish is interested in how errors in gene regulation lead to changes in the behaviour and function of B cells, an important cell type in our immune system that makes antibodies to fight and remember infections. Hamish talks about how he uses wet lab and bioinformatic techniques to answer these questions. Dr King is also due to become a laboratory head at WEHI in early 2022, where his lab will focus on answering a range of questions including: <ol> <li>How immune-specific chromatin-based mechanisms regulate gene expression</li> <li>Whether autoimmune-associated genetic risk loci disrupt regulatory function of enhancers</li> <li>If disease-specific epigenomic networks exist in autoimmunity</li> </ol> We talk also in the episode, about Hamish's recent paper which is accessible <a href="https://www.biorxiv.org/content/10.1101/2021.03.16.435578v1" rel="nofollow" target="_blank">here</a>, you can also find Hamish on twitter <a href="https://twitter.com/hamish_king" rel="nofollow" target="_blank">here</a> where he is happy to be contacted further about his research and upcoming vacancies in his brand new lab.

The immune system: B cells and Epigenetics with Dr Hamish King

In this episode, we learn about B cell maturation and class switching fromHamish King. Hamish recently published apaper on this subject in Science Immunology, where he and his coauthorsanalyzed gene expression and antibody repertoire data from human tonsils.In the episode Hamish talks about some of the interesting B cell states heuncovered and shares his thoughts on questions such as «When does a B celldecide to class-switch?» and «Why is the antibody isotype correlated with itsaffinity?» Links:  Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics(Hamish W. King, Nara Orban, John C. Riches, Andrew J. Clear, Gary Warnes, Sarah A. Teichmann, Louisa K. James) (paywalled by Science Immunology) Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation(the preprint of the above Science Immunology paper) www.tonsilimmune.org: An immune cell atlas of the human tonsil and B cell maturation  If you enjoyed this episode, please consider supporting the podcast on Patreon!

In this episode, we learn about B cell maturation and class switching from <a href="https://twitter.com/hamish_king" rel="nofollow" target="_blank">Hamish King</a>. Hamish recently published a <a href="https://immunology.sciencemag.org/content/6/56/eabe6291" rel="nofollow" target="_blank">paper</a> on this subject in Science Immunology, where he and his coauthors analyzed gene expression and antibody repertoire data from human tonsils. In the episode Hamish talks about some of the interesting B cell states he uncovered and shares his thoughts on questions such as «When does a B cell decide to class-switch?» and «Why is the antibody isotype correlated with its affinity?» Links: <ul> <li><a href="https://immunology.sciencemag.org/content/6/56/eabe6291" rel="nofollow" target="_blank">Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics</a> (Hamish W. King, Nara Orban, John C. Riches, Andrew J. Clear, Gary Warnes, Sarah A. Teichmann, Louisa K. James) (paywalled by Science Immunology)</li> <li><a href="https://www.biorxiv.org/content/10.1101/2020.04.28.054775v2" rel="nofollow" target="_blank">Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation</a> (the preprint of the above Science Immunology paper)</li> <li><a href="https://www.tonsilimmune.org/" rel="nofollow" target="_blank">www.tonsilimmune.org: An immune cell atlas of the human tonsil and B cell maturation</a></li> </ul> If you enjoyed this episode, please consider supporting the podcast on <a href="https://www.patreon.com/bioinfochat" rel="nofollow" target="_blank">Patreon</a>!

#58 B cell maturation and class switching with Hamish King