John Gilleard's guest appearances

John Gilleard

Finding Genius Podcast

Two Brad For You

CAHSS Podcast Series - Animal Health Insights

Bill Barhydt

Whitney Johnson

Alex Mashinsky

Ross Ulbricht

Lyn Ulbricht

Jameson Lopp

Marco Peereboom

Megan Ramos

Danny Flood

Abel James

Nir Eyal

Perry Marshall

Scott Young

Ben Goertzel

Steven Kotler

OwlTail

Our veterinary patients deal with the effects of “worms” in a number of ways – we frequently see animals who suffer from gastrointestinal illness, weight loss, blood loss, and occasionally kidney, cardiac, muscular or neurologic diseases that all may relate to parasitic infections. If you’re a pet parent or animal producer – your eyes may glaze over a bit when your vet discusses the health risks associated with parasites – but these risks are significant. Many parasites have zoonotic potential – they can be shared between animals and humans – and this is part of why veterinarians continue to discuss these creatures with our clients – we want to protect animal health AND the health of humans who care for and interact with animals. The parasite risks in a specific region constantly change as parasites migrate (along for the ride in an infected animal) around the province, country, continent, or around the world. In many species, including dogs, there is evidence that some parasites are developing resistance to certain types of deworming medications. One of these parasites is the canine hookworm – known as Ancylostoma caninum. Dr. John Gilleard from the University of Calgary has been involved in investigations into the emergence and diagnosis of these drug-resistant canine hookworms over the past few years. In addition to working as a Professor of Parasitology and the Associate Dean of Research at the faculty of Veterinary Medicine in Calgary, his research focusses on drug-resistant parasites and ways to investigate the emergence and spread of these in animal populations including cattle, other ruminants, and dogs. Links of Interest: Persistent or Suspected Resistant Hookworm Infections, Clinician's Brief Multiple drug resistance in hookworms infecting greyhound dogs in the USA Pablo D. Jimenez Castro, Abhinaya Venkatesan, Elizabeth Redman, Rebecca Chen, Abigail Malatesta, Hannah Huff, Daniel A. Zuluaga Salazar, Russell Avramenko, John S. Gilleard, Ray M. Kaplan, Multiple drug resistance in hookworms infecting greyhound dogs in the USA, International Journal for Parasitology: Drugs and Drug Resistance, Volume 17, 2021, Pages 107-117, ISSN 2211-3207, https://doi.org/10.1016/j.ijpddr.2021.08.005  Multiple Drug Resistance in the canine hookworm Ancylostoma caninum: an emerging threat? Jimenez Castro, P.D., Howell, S.B., Schaefer, J.J. et al. Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?. Parasites Vectors 12, 576 (2019). https://doi.org/10.1186/s13071-019-3828-6 Information about Dr. Gilleard's laboratory at the University of Calgary and his research  Note: A. caninum photo credit: Dr Pablo Jimenez-Castro and Dr Ray Kaplan

Our veterinary patients deal with the effects of “worms” in a number of ways – we frequently see animals who suffer from gastrointestinal illness, weight loss, blood loss, and occasionally kidney, cardiac, muscular or neurologic diseases that all may relate to parasitic infections. If you’re a pet parent or animal producer – your eyes may glaze over a bit when your vet discusses the health risks associated with parasites – but these risks are significant. Many parasites have zoonotic potential – they can be shared between animals and humans – and this is part of why veterinarians continue to discuss these creatures with our clients – we want to protect animal health AND the health of humans who care for and interact with animals. The parasite risks in a specific region constantly change as parasites migrate (along for the ride in an infected animal) around the province, country, continent, or around the world. In many species, including dogs, there is evidence that some parasites are developing resistance to certain types of deworming medications. One of these parasites is the canine hookworm – known as Ancylostoma caninum. Dr. John Gilleard from the University of Calgary has been involved in investigations into the emergence and diagnosis of these drug-resistant canine hookworms over the past few years. In addition to working as a Professor of Parasitology and the Associate Dean of Research at the faculty of Veterinary Medicine in Calgary, his research focusses on drug-resistant parasites and ways to investigate the emergence and spread of these in animal populations including cattle, other ruminants, and dogs. Links of Interest: <ul><li><a href="https://www.cliniciansbrief.com/article/persistent-or-suspected-resistant-hookworm-infections" rel="nofollow" target="_blank">Persistent or Suspected Resistant Hookworm Infections, Clinician's Brief</a></li> <li><a href="https://www.sciencedirect.com/science/article/pii/S2211320721000415" rel="nofollow" target="_blank">Multiple drug resistance in hookworms infecting greyhound dogs in the USA</a> Pablo D. Jimenez Castro, Abhinaya Venkatesan, Elizabeth Redman, Rebecca Chen, Abigail Malatesta, Hannah Huff, Daniel A. Zuluaga Salazar, Russell Avramenko, John S. Gilleard, Ray M. Kaplan, Multiple drug resistance in hookworms infecting greyhound dogs in the USA, International Journal for Parasitology: Drugs and Drug Resistance, Volume 17, 2021, Pages 107-117, ISSN 2211-3207, <a href="https://doi.org/10.1016/j.ijpddr.2021.08.005" rel="nofollow" target="_blank">https://doi.org/10.1016/j.ijpddr.2021.08.005</a> </li> <li><a href="https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3828-6" rel="nofollow" target="_blank">Multiple Drug Resistance in the canine hookworm Ancylostoma caninum: an emerging threat?</a> Jimenez Castro, P.D., Howell, S.B., Schaefer, J.J. et al. Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?. Parasites Vectors 12, 576 (2019). <a href="https://doi.org/10.1186/s13071-019-3828-6" rel="nofollow" target="_blank">https://doi.org/10.1186/s13071-019-3828-6</a></li> <li>Information about <a href="https://vet.ucalgary.ca/labs/jsgilleard/home" rel="nofollow" target="_blank">Dr. Gilleard's laborator</a>y at the University of Calgary and <a href="https://pubmed.ncbi.nlm.nih.gov/?term=gilleard+j" rel="nofollow" target="_blank">his research </a></li> <li>Note: A. caninum photo credit: Dr Pablo Jimenez-Castro and Dr Ray Kaplan</li></ul>

Recognizing Resistant Hookworms with Dr. John Gilleard. Animal Health Insights. Ep. 16, June 12, 2022

Professor of parasitology at Calgary University, John Gilleard, joins the show to discuss his work and research on  parasites and how they become resistant to drugs.  In this episode, you will learn:  How Haemonchus contortus can sense and respond to changes in the climate surrounding its host, and how transmission of Haemonchus contortus is dependent in part upon the environment of the host What types of drugs have been developed to treat parasitic infection with Haemonchus contortus and what effect they have on the parasite What it means to take a genetic approach rather than a pharmacological approach to the problem of antiparasitic drug resistance  As a model for studying antiparasitic  drug resistance, Gilleard uses Haemonchus contortus, a sheep parasite known as the “king” of drug resistance. He discusses what makes this such a good model for studying various parasites, and details its life cycle, how transmission occurs, what triggers inhibited development of the parasite, what types of drugs have been developed and how Haemonchus contortus becomes resistant to them, whether there is a tradeoff for the parasite to becoming resistant to an antiparasitic drug, recent research on understanding the genetics of C. elegans, the value that could be gained from taking a wider approach to the study of antiparasitic drug resistance (e.g. metabolomics, proteomics), the challenges posed by the genetic variability of worms, and what’s on the horizon in terms of further research in the field. Tune in and learn more at https://vet.ucalgary.ca/contact-us/john-gilleard.   Available on Apple Podcasts: apple.co/2Os0myK

Professor of parasitology at Calgary University, John Gilleard, joins the show to discuss his work and research on <a href="https://www.findinggeniuspodcast.com/podcasts/the-molecular-language-of-parasites-dr-timothy-geary-explains-parasite-ecology/" rel="nofollow" target="_blank"> parasites</a> and how they become resistant to drugs. In this episode, you will learn: <ul> <li>How Haemonchus contortus can sense and respond to changes in the climate surrounding its host, and how transmission of Haemonchus contortus is dependent in part upon the environment of the host</li> <li>What types of drugs have been developed to treat parasitic infection with Haemonchus contortus and what effect they have on the parasite</li> <li>What it means to take a genetic approach rather than a pharmacological approach to the problem of antiparasitic drug resistance</li> </ul> As a model for studying antiparasitic <a href="https://www.findinggeniuspodcast.com/podcasts/opening-a-parasitic-drug-resistant-can-of-worms-ray-kaplan-dvm-phd-department-of-infectious-diseases-university-of-georgia/" rel="nofollow" target="_blank"> drug resistance</a>, Gilleard uses Haemonchus contortus, a sheep parasite known as the “king” of drug resistance. He discusses what makes this such a good model for studying various parasites, and details its life cycle, how transmission occurs, what triggers inhibited development of the parasite, what types of drugs have been developed and how Haemonchus contortus becomes resistant to them, whether there is a tradeoff for the parasite to becoming resistant to an antiparasitic drug, recent research on understanding the genetics of C. elegans, the value that could be gained from taking a wider approach to the study of antiparasitic drug resistance (e.g. metabolomics, proteomics), the challenges posed by the genetic variability of worms, and what’s on the horizon in terms of further research in the field. Tune in and learn more at <a href="https://vet.ucalgary.ca/contact-us/john-gilleard" rel="nofollow" target="_blank">https://vet.ucalgary.ca/contact-us/john-gilleard</a>. Available on Apple Podcasts: <a href="https://podcasts.apple.com/us/podcast/id1169016854" rel="nofollow" target="_blank">apple.co/2Os0myK</a>

Studying the Parasitic King of Drug Resistance with John Gilleard 

The second installment in the TBFY In Conversation series features Dr. John Gilleard. John was the co-supervisor of Brad (aka Flash) PhD thesis, he is a veterinarian,professor and researcher of parasitology. John gives some reluctant career advice, a refreshing take on Twitter from an academics standpoint, why he engages in scientific outreach, the value of grad students and a bit about his researchand why animal health, environmental health and human health are all connected; the so called One Health approach.Featuring Hot Plate and The Heist pt.II from The Freak Motif

The second installment in the TBFY In Conversation series features Dr. John Gilleard. John was the co-supervisor of Brad (aka Flash) PhD thesis, he is a veterinarian, professor and researcher of parasitology. John gives some reluctant career advice, a refreshing take on Twitter from an academics standpoint, why he engages in scientific outreach, the value of grad students and a bit about his research and why animal health, environmental health and human health are all connected; the so called One Health approach. Featuring Hot Plate and The Heist pt.II from The Freak Motif

TBFY In Conversation 2-Dr. John Gilleard