Dan Passeri's guest appearances

Dan Passeri

Empowered Patient Podcast

Business Of Biotech

Amit Kumar

James McArthur

Glenn Mattes

Anixa Biosciences

Hamid Khoja

Purnanand Sarma

Edith Perez

Ian Walters

Seth Lederman

Dietrich Stephan

Amolyt Pharma

Jeff Stein

Alexis Peyroles

Jeff Wolf

Brian Culley

OwlTail

 CUE Biopharma CEO Dan Passeri, J.D. joins us for a discussion on the development of the company's Immuno-STAT platform for the selective targeting and alteration of T cells. Passeri shares the rationale behind his belief in the company's immunotherapeutic approach, and how the CUE-100 series of candidates in its pipeline are being developed to address the scourge of HPV-related head, neck, and other cancers expected in pre-HPV vaccine populations. Subscribe to the NEW #BusinessofBiotech newsletter at bioprocessonline.com/bob for more real, honest, transparent interactions with the leaders of emerging biotech. It's a once-per-month dose of insight and intel that you'll actually look forward to receiving! Check it out at bioprocessonline.com/bob!

<a href="https://www.cuebiopharma.com/" rel="nofollow" target="_blank"> CUE Biopharma</a> CEO Dan Passeri, J.D. joins us for a discussion on the development of the company's Immuno-STAT platform for the selective targeting and alteration of T cells. Passeri shares the rationale behind his belief in the company's immunotherapeutic approach, and how the CUE-100 series of candidates in its pipeline are being developed to address the scourge of HPV-related head, neck, and other cancers expected in pre-HPV vaccine populations. Subscribe to the NEW #BusinessofBiotech newsletter at <a href="https://www9.bioprocessonline.com/business-of-biotech-nl-sign-up/" rel="nofollow" target="_blank">bioprocessonline.com/bob</a> for more real, honest, transparent interactions with the leaders of emerging biotech. It's a once-per-month dose of insight and intel that you'll actually look forward to receiving! Check it out at <a href="https://www9.bioprocessonline.com/business-of-biotech-nl-sign-up/" rel="nofollow" target="_blank">bioprocessonline.com/bob</a>!

Filling A Vaccine Void with Cue Biopharma's Dan Passeri, J.D.

Dan Passeri, CEO, Cue Biopharma discusses their proprietary Immuno-STAT(TM) platform.  Cue Biopharma is engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body to transform the treatment of cancer and autoimmune diseases.  The platform is designed to harness the body's intrinsic immune system response without the need for ex vivo manipulation.  Cue is currently conducting a Phase 1 study in HPV16-driven head and neck cancer and partnering with Merck to develop treatments for autoimmune diseases. #immunooncology #HNSCC #TCells @CueBiopharma CueBiopharma.com Download the entire transcript here Page 1 of Transcript Karen Jagoda: Welcome to the empoweredpatientpodcast.com show. I'm Karen Jagoda, and my guest today is Dan Passeri. He's the CEO of Cue Biopharma. That's cuebiopharma.com. And I recently talked with Anish Suri, who is the Chief Scientific Officer at Cue, and I thought it was such an interesting story that I thought it was also a good idea to get the CEO of the company on the show to give us a little bit of an update and perhaps a little bit more in the way of details. So welcome to the show today, Dan. Dan Passeri: Thanks, Karen. Appreciate it. Karen Jagoda: So let's just talk a little bit about where Cue fits into the landscape of immuno-oncology companies. Dan Passeri: Sure. Immuno-oncology is obviously a very broad, encompassing category, and what it really covers is any approach that is meant to stimulate the immune system in some manner, that is meant to have clinical activity against cancer. And there's a myriad of approaches, but ultimately, no matter what approach is being taken, the objective is to stimulate the effective components of the immune system that can identify and attack cancer. Dan Passeri: What we do is actually quite distinctive in that the majority of approaches have tried to stimulate T-cells in various ways by taking them out of the body, for instance. And we've all heard of all these various cell therapy approaches, CAR T being the best publicized and characterized. And that's where you're taking T-cells out of the patient, you're genetically altering them to have a particular receptor that recognizes cancer, and infusing them back in. Dan Passeri: There are also cell therapy approaches where they take the cells out and use particular proteins that are represented on cancer, and then those T-cells will recognize that protein, and they use something called IL-2, Interleukin-2. It's an approved drug called proleukin, and they'll stimulate the T-cells, and then they infuse them back into the body. Dan Passeri: What we're doing is quite a different approach, and we believe it's a transformative approach in that we are using a biologic engineering category to stimulate T-cells directly in the patient's body. So it basically removes the need for having to extract T-cells out of the patient and the cumbersome manipulations, and we believe what we'll have is a potential breakthrough in the space where we can use our biologic to engage the desired T-cells. Now, that is only those T-cells that will recognize the protein on the cancer, activate those T-cells, and make many copies of them so that they then will identify the tumor cells, attack them, and destroy them. So that's the broad overview of what we're doing.

Dan Passeri, CEO, Cue Biopharma discusses their proprietary Immuno-STAT(TM) platform.  Cue Biopharma is engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body to transform the treatment of cancer and autoimmune diseases.  The platform is designed to harness the body's intrinsic immune system response without the need for ex vivo manipulation.  Cue is currently conducting a Phase 1 study in HPV16-driven head and neck cancer and partnering with Merck to develop treatments for autoimmune diseases. #immunooncology #HNSCC #TCells @CueBiopharma <a href="http://cuebiopharma.com" rel="noopener nofollow" target="_blank">CueBiopharma.com</a> <a href="http://cuebiopharma.com" rel="noopener nofollow" target="_blank"></a><a href="http://empoweredpatientradio.com/injectable-biologics-modulate-targeted-t-cells-in-treatment-for-cancer-and-autoimmune-diseases-with-dan-passeri-cue-biopharma-transcript" rel="noopener nofollow" target="_blank">Download the entire transcript here</a> Page 1 of Transcript Karen Jagoda: Welcome to the <a href="http://empoweredpatientpodcast.com" rel="nofollow" target="_blank">empoweredpatientpodcast.com</a> show. I'm Karen Jagoda, and my guest today is Dan Passeri. He's the CEO of Cue Biopharma. That's <a href="http://cuebiopharma.com" rel="nofollow" target="_blank">cuebiopharma.com</a>. And I recently talked with Anish Suri, who is the Chief Scientific Officer at Cue, and I thought it was such an interesting story that I thought it was also a good idea to get the CEO of the company on the show to give us a little bit of an update and perhaps a little bit more in the way of details. So welcome to the show today, Dan. Dan Passeri: Thanks, Karen. Appreciate it. Karen Jagoda: So let's just talk a little bit about where Cue fits into the landscape of immuno-oncology companies. Dan Passeri: Sure. Immuno-oncology is obviously a very broad, encompassing category, and what it really covers is any approach that is meant to stimulate the immune system in some manner, that is meant to have clinical activity against cancer. And there's a myriad of approaches, but ultimately, no matter what approach is being taken, the objective is to stimulate the effective components of the immune system that can identify and attack cancer. Dan Passeri: What we do is actually quite distinctive in that the majority of approaches have tried to stimulate T-cells in various ways by taking them out of the body, for instance. And we've all heard of all these various cell therapy approaches, CAR T being the best publicized and characterized. And that's where you're taking T-cells out of the patient, you're genetically altering them to have a particular receptor that recognizes cancer, and infusing them back in. Dan Passeri: There are also cell therapy approaches where they take the cells out and use particular proteins that are represented on cancer, and then those T-cells will recognize that protein, and they use something called IL-2, Interleukin-2. It's an approved drug called proleukin, and they'll stimulate the T-cells, and then they infuse them back into the body. Dan Passeri: What we're doing is quite a different approach, and we believe it's a transformative approach in that we are using a biologic engineering category to stimulate T-cells directly in the patient's body. So it basically removes the need for having to extract T-cells out of the patient and the cumbersome manipulations, and we believe what we'll have is a potential breakthrough in the space where we can use our biologic to engage the desired T-cells. Now, that is only those T-cells that will recognize the protein on the cancer, activate those T-cells, and make many copies of them so that they then will identify the tumor cells, attack them, and destroy them. So that's the broad overview of what we're doing.

Injectable Biologics Modulate Targeted T Cells in Treatment for Cancer and Autoimmune Diseases with Dan Passeri Cue Biopharma