Wendy Bickmore's guest appearances

Wendy Bickmore

Epigenetics Podcast

The Lonely Pipette : helping scientists do better science

The Genomics Lab

Brad Richardson

Joe Fernandez

David Jones

Monica Dus

Peter Ellis

Patrick Martin

Karmella Haynes

Erez Lieberman Aiden

Michelle Taylor

Jess Chadwick

Noe Gonzalez

Shelley Berger

Emily Bernstein

Gary Karpen

Susan Gasser

OwlTail

Remote

This week we are honoured to host Professor Wendy Bickmore, the Director of the MRC Human Genetics unit at the University of Edinburgh. Wendys research laboratory focuses on trying to better understand the 3D organisation of the genome, and how this controls how the genome functions during normal development. They are further interested in how this may be perturbed into disease. Wendy talks to us about some of her recent work which has been extremely important for better understanding enhancer function and also, some of the challenges and questions which remain to be answered in the field. She also provides some great insight into the experiments and methods ongoing in her lab now.   Find Wendy on twitter here : https://twitter.com/wendy_bickmore Find out more about Wendys laboratory here: https://www.ed.ac.uk/mrc-human-genetics-unit/research/bickmore-group

This week we are honoured to host Professor Wendy Bickmore, the Director of the MRC Human Genetics unit at the University of Edinburgh. Wendys research laboratory focuses on trying to better understand the 3D organisation of the genome, and how this controls how the genome functions during normal development. They are further interested in how this may be perturbed into disease. Wendy talks to us about some of her recent work which has been extremely important for better understanding enhancer function and also, some of the challenges and questions which remain to be answered in the field. She also provides some great insight into the experiments and methods ongoing in her lab now.  Find Wendy on twitter here : <a href="https://twitter.com/wendy_bickmore" rel="nofollow" target="_blank">https://twitter.com/wendy_bickmore</a> Find out more about Wendys laboratory here: <a href="https://www.ed.ac.uk/mrc-human-genetics-unit/research/bickmore-group" rel="nofollow" target="_blank">https://www.ed.ac.uk/mrc-human-genetics-unit/research/bickmore-group</a>

Remote control of gene expression: enhancers and the 4D genome with Professor Wendy Bickmore

In recent years it has become more and more evident, that genome folding and chromatin packaging into the nucleus plays a pivotal role in the regulation of gene expression. In this Episode of our Podcast our host Dr. Stefan Dillinger spoke with Professor Wendy Bickmore about her work on the spatial organization of the human genome. Prof. Bickmore and her team mainly use visual methods like fluorescence in situ hybridisation (FISH) to study the organization of chromosomes in human and murine cells and how they contribute to transcriptional regulation and how this organization changes during ageing, development or disease. References  Charlene Boumendil, Priya Hari, … Wendy A. Bickmore (2019) Nuclear pore density controls heterochromatin reorganization during senescence (Genes &amp; Development) DOI: 10.1101/gad.321117.118  Charlene Lemaître, Wendy A. Bickmore (2015) Chromatin at the nuclear periphery and the regulation of genome functions (Histochemistry and Cell Biology) DOI: 10.1007/s00418-015-1346-y  James Fraser, Iain Williamson, … Josée Dostie (2015) An Overview of Genome Organization and How We Got There: from FISH to Hi-C (Microbiology and Molecular Biology Reviews) DOI: 10.1128/MMBR.00006-15  Emmanuelle Deniaud, Wendy A Bickmore (2009) Transcription and the nuclear periphery: edge of darkness? (Current Opinion in Genetics &amp; Development) DOI: 10.1016/j.gde.2009.01.005  Nicola L. Mahy, Paul E. Perry, … Wendy A. Bickmore (2002) Spatial organization of active and inactive genes and noncoding DNA within chromosome territories (The Journal of Cell Biology) DOI: 10.1083/jcb.200111071  Contact https://twitter.com/activemotif  https://twitter.com/epigenetics_pod  https://www.linkedin.com/company-beta/35651/  https://www.facebook.com/ActiveMotifInc/  https://activemotif.com/blog  eurotech@activemotif.com

In recent years it has become more and more evident, that genome folding and chromatin packaging into the nucleus plays a pivotal role in the regulation of gene expression. In this Episode of our Podcast our host Dr. Stefan Dillinger spoke with Professor Wendy Bickmore about her work on the spatial organization of the human genome. Prof. Bickmore and her team mainly use visual methods like fluorescence in situ hybridisation (FISH) to study the organization of chromosomes in human and murine cells and how they contribute to transcriptional regulation and how this organization changes during ageing, development or disease. References <ul><li>Charlene Boumendil, Priya Hari, … Wendy A. Bickmore (2019) <a href="http://genesdev.cshlp.org/content/33/3-4/144" rel="nofollow" target="_blank">Nuclear pore density controls heterochromatin reorganization during senescence</a> (Genes &amp; Development) DOI: <a href="http://dx.doi.org/10.1101/gad.321117.118" rel="nofollow" target="_blank">10.1101/gad.321117.118</a> </li> <li>Charlene Lemaître, Wendy A. Bickmore (2015) <a href="https://doi.org/10.1007/s00418-015-1346-y" rel="nofollow" target="_blank">Chromatin at the nuclear periphery and the regulation of genome functions</a> (Histochemistry and Cell Biology) DOI: <a href="http://dx.doi.org/10.1007/s00418-015-1346-y" rel="nofollow" target="_blank">10.1007/s00418-015-1346-y</a> </li> <li>James Fraser, Iain Williamson, … Josée Dostie (2015) <a href="https://mmbr.asm.org/content/79/3/347" rel="nofollow" target="_blank">An Overview of Genome Organization and How We Got There: from FISH to Hi-C</a> (Microbiology and Molecular Biology Reviews) DOI: <a href="http://dx.doi.org/10.1128/MMBR.00006-15" rel="nofollow" target="_blank">10.1128/MMBR.00006-15</a> </li> <li>Emmanuelle Deniaud, Wendy A Bickmore (2009) <a href="http://www.sciencedirect.com/science/article/pii/S0959437X09000240" rel="nofollow" target="_blank">Transcription and the nuclear periphery: edge of darkness?</a> (Current Opinion in Genetics &amp; Development) DOI: <a href="http://dx.doi.org/10.1016/j.gde.2009.01.005" rel="nofollow" target="_blank">10.1016/j.gde.2009.01.005</a> </li> <li>Nicola L. Mahy, Paul E. Perry, … Wendy A. Bickmore (2002) <a href="http://www.jcb.org/lookup/doi/10.1083/jcb.200111071" rel="nofollow" target="_blank">Spatial organization of active and inactive genes and noncoding DNA within chromosome territories</a> (The Journal of Cell Biology) DOI: <a href="http://dx.doi.org/10.1083/jcb.200111071" rel="nofollow" target="_blank">10.1083/jcb.200111071</a></li> </ul> Contact <ul><li><a href="https://twitter.com/activemotif" rel="nofollow" target="_blank">https://twitter.com/activemotif </a></li> <li><a href="https://twitter.com/epigenetics_pod" rel="nofollow" target="_blank">https://twitter.com/epigenetics_pod </a></li> <li><a href="https://www.linkedin.com/company-beta/35651/" rel="nofollow" target="_blank">https://www.linkedin.com/company-beta/35651/ </a></li> <li><a href="https://www.facebook.com/ActiveMotifInc/" rel="nofollow" target="_blank">https://www.facebook.com/ActiveMotifInc/ </a></li> <li><a href="https://activemotif.com/blog" rel="nofollow" target="_blank">https://activemotif.com/blog </a></li> <li>eurotech@activemotif.com</li></ul>

Spatial Organization of the Human Genome (Wendy Bickmore)