Shervin Takyar's guest appearances

Shervin Takyar

Finding Genius Podcast

J Scott

Bill Barhydt

Whitney Johnson

Alex Mashinsky

Ross Ulbricht

Lyn Ulbricht

Jameson Lopp

Marco Peereboom

Megan Ramos

Danny Flood

Abel James

Nir Eyal

Perry Marshall

Scott Young

Ben Goertzel

OwlTail

What allows a cancer cell to proliferate and metastasize? Is cancer a product of evolutionary selection? How do the leading hypotheses in cancer research apply specifically to lung cancer? Tune in for the answer, and discover:  Whether the pathway that allows an injured cell to survive could be the same or similar pathway for cell proliferation and the development of cancer Which two factors are universally recognized as risks for lung cancer, and under what circumstances non-smokers might get lung cancer How cell-to-cell signaling between different cells plays a role in the development of cancer  Shervin Takyar is an associate professor at Yale School of Medicine and practicing pulmonologist who joins the show to discuss his experience with cancer, both in research and in the clinic. His work is focused primarily on endothelium, which is an important part of the tumor microenvironment, and also on what happens before cancer develops, rather than what to do once it has.   What factors predispose a person to develop cancer? And which individuals are likely to develop recurrence or resistance to cancer therapies? Takyar answers a number of compelling questions, and in the process, explains what he believes to be the common denominator of all cancers, and how cancer might be viewed as the product of cycles of evolutionary selection.  He also discusses how the seed-and-soil theory applies to lung cancer, cell-to-cell signaling, where primary lung tumors tend to spread and why, ongoing research looking at advanced lung tumor samples, field cancerization, what makes a tumor successful, whether there are epigenetic markers that can tell which patients have higher tolerance for tumor cells, and more.

What allows a cancer cell to proliferate and metastasize? Is cancer a product of evolutionary selection? How do the leading hypotheses in cancer research apply specifically to lung cancer? Tune in for the answer, and discover: <ul> <li>Whether the pathway that allows an injured cell to survive could be the same or similar pathway for cell proliferation and the development of cancer</li> <li>Which two factors are universally recognized as risks for lung cancer, and under what circumstances non-smokers might get lung cancer</li> <li>How cell-to-cell signaling between different cells plays a role in the development of cancer</li> </ul> Shervin Takyar is an associate professor at Yale School of Medicine and practicing pulmonologist who joins the show to discuss his experience with cancer, both in research and in the clinic. His work is focused primarily on endothelium, which is an important part of the tumor microenvironment, and also on what happens before cancer develops, rather than what to do once it has.  What factors predispose a person to develop cancer? And which individuals are likely to develop recurrence or resistance to cancer therapies? Takyar answers a number of compelling questions, and in the process, explains what he believes to be the common denominator of all cancers, and how cancer might be viewed as the product of cycles of evolutionary selection. He also discusses how the seed-and-soil theory applies to lung cancer, cell-to-cell signaling, where primary lung tumors tend to spread and why, ongoing research looking at advanced lung tumor samples, field cancerization, what makes a tumor successful, whether there are epigenetic markers that can tell which patients have higher tolerance for tumor cells, and more.

Cancer: It Takes a Village—Insights from Shervin Takyar, MD, PhD

Another in the Finding Genius Podcast series on viruses, this captivating conversation with Yale University's Dr. Takyar explores interesting avenues of the  virus-host relationship, offering listeners a glimpse into a top researcher's understandings of viral characteristics and behavior.  Listeners will hear  How his answer to the inevitable question, "are viruses living" provides a new spin, Why a recent study shows that viruses do message each other as translated through cellular machinery, and What his own research may show regarding a virus's ability to affect surrounding cells in such a way to increase the potential for tumor growth by creating a niche.  Seyedtaghi “Shervin” Takyar, MD, PhD, is a Yale Medicine pulmonologist and an associate professor of Pulmonary, Critical Care, and Sleep Medicine. His work on disease research his given him an interesting perspective on  virus-cell interaction and Richard brings him into this continuing look at viral behaviors. They begin by addressing if viruses are living or nonliving and this gives Dr. Takyar a chance to provide a rich answer in which he says, on the one hand, they are akin to a program in a computer if a computer were consider "life."  On the other hand, he adds, nature doesn't have rigid lines, and he would say viruses are at the very least a footprint of life. He explains each of these analogies in more depth and ends his answer with, "it is more interesting to find their place in life," rather than label them as one or the other. The rest of the podcast examines this place. The origin and evolution of viruses follows the pattern of life: virus evolution over time just means they've found those places that fit best. He explains various behavior with similar language. For example, a virus incubation period depends on their environment. They may not express parts of their genome until the right time comes. The right time inside the cell is dictated by a lot of actors—like aging, for example—the increased mortality in older folks with SARS CoV-2 is because those states are codes for the virus: certain parts of the process that it needs to grow are available and this triggers replication.  He shares a brand new behavior confirmed by researchers next, that viruses use the factory inside cells to talk to each other. Scientists have shown that bacteriophages use the translation machinery inside the bacteria to translate their message to other viral particles. Dr. Takyar shares more of his thoughts with listeners on topics from quasi-species to speculations on viral epigenetics.  For more about Dr. Takyar and his research, start with his lab website: medicine.yale.edu/lab/takyar.   Available on Apple Podcasts: apple.co/2Os0myK 

Another in the Finding Genius Podcast series on viruses, this captivating conversation with Yale University's Dr. Takyar explores interesting avenues of the <a href="https://www.findinggeniuspodcast.com/podcasts/islands-in-a-sea-of-viruses-with-guenther-witzany/" rel="nofollow" target="_blank"> virus-host relationship</a>, offering listeners a glimpse into a top researcher's understandings of viral characteristics and behavior. Listeners will hear <ul> <li>How his answer to the inevitable question, "<a href="https://www.findinggeniuspodcast.com/podcasts/the-most-perfect-parasite-exploring-viruses-with-dr-richard-white-iii/" rel="nofollow" target="_blank">are viruses living</a>" provides a new spin,</li> <li>Why a recent study shows that viruses do message each other as translated through cellular machinery, and</li> <li>What his own research may show regarding a virus's ability to affect surrounding cells in such a way to increase the potential for tumor growth by creating a niche.</li> </ul> Seyedtaghi “Shervin” Takyar, MD, PhD, is a Yale Medicine pulmonologist and an associate professor of Pulmonary, Critical Care, and Sleep Medicine. His work on disease research his given him an interesting perspective on <a href="https://www.findinggeniuspodcast.com/podcasts/its-mutual-viruses-and-immune-system-adaptations-with-nils-g-walter/" rel="nofollow" target="_blank"> virus-cell interaction</a> and Richard brings him into this continuing look at viral behaviors. They begin by addressing if viruses are living or nonliving and this gives Dr. Takyar a chance to provide a rich answer in which he says, on the one hand, they are akin to a program in a computer if a computer were consider "life." On the other hand, he adds, nature doesn't have rigid lines, and he would say viruses are at the very least a footprint of life. He explains each of these analogies in more depth and ends his answer with, "it is more interesting to find their place in life," rather than label them as one or the other. The rest of the podcast examines this place. The origin and evolution of viruses follows the pattern of life: virus evolution over time just means they've found those places that fit best. He explains various behavior with similar language. For example, a virus incubation period depends on their environment. They may not express parts of their genome until the right time comes. The right time inside the cell is dictated by a lot of actors—like aging, for example—the increased mortality in older folks with SARS CoV-2 is because those states are codes for the virus: certain parts of the process that it needs to grow are available and this triggers replication. He shares a brand new behavior confirmed by researchers next, that viruses use the factory inside cells to talk to each other. Scientists have shown that bacteriophages use the translation machinery inside the bacteria to translate their message to other viral particles. Dr. Takyar shares more of his thoughts with listeners on topics from quasi-species to speculations on viral epigenetics.  For more about Dr. Takyar and his research, start with his lab website: <a href="https://medicine.yale.edu/lab/takyar/" rel="nofollow" target="_blank">medicine.yale.edu/lab/takyar</a>. Available on Apple Podcasts: <a href="https://podcasts.apple.com/us/podcast/id1169016854" rel="nofollow" target="_blank">apple.co/2Os0myK</a>

Viruses in Every Step of Life: Virus-Host Cell Interaction with Shervin Takyar

Shervin Takyar, MD, PhD, is an associate professor at Yale School of Medicine who joins the show today to discuss  microRNA (miRNA). Tune in to learn the following:  What role  microRNA play in cell-to-cell communication How the identification of a particular  microRNA has shed light on the allergic response in asthma, and how to decrease that response How  microRNA are able to control multiple genes, and why this could potentially have life-saving clinical applications  Dr. Takyar holds a medical degree, as well as a PhD in both microbiology and molecular biology. He discusses the discovery of  microRNA over 10 years ago, and the subsequent discoveries about their role in the body and gene expression. His research is focused on the interaction between  microRNA and endothelium. His most recent work began years ago when he noticed that a vascular growth factor (VEGF) was high in patients with asthma. Up until that point, most of the research about asthma was focused on lung epithelium or immune cells; Dr. Takyar wanted to investigate whether this vascular growth factor also affects the  microRNA in endothelial cells. Over the past 12 years, that’s been his primary focus. He has been able to show a correlation between VEGF and one particular  microRNA in endothelial cells—specifically in the expression of the Mpl gene, which controls the adhesion of eosinophils (a type of white blood cell present in the asthmatic response). He has shown that when VEGF increases, the specific  microRNA decreases, and the Mpl gene is expressed. The relationship between the microRNA and Mpl gene makes sense, since microRNA is known to play an inhibitory role in gene expression. By changing this one microRNA in the endothelium of an animal model, the asthma response decreased significantly. This explanation leads Dr. Takyar to discuss the potential of  microRNA as a tool for inhibiting or modulating groups of genes, rather than just one gene. This would confer a huge advantage to the treatment of certain ailments such as lung cancer, where it is known that targeting a single gene does not often produce the desired result. In addition to explaining just why it is that single-gene targets don’t work well, Dr. Takyar discusses a number of interesting topics, including the role of  microRNA in cell-to-cell communication, how genes are matched with certain  microRNA, how  microRNA is able to control many genes as opposed to just one, and the biogenesis of  microRNA. Learn more at https://medicine.yale.edu/profile/seyedtaghi_takyar/.

Shervin Takyar, MD, PhD, is an associate professor at Yale School of Medicine who joins the show today to discuss <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> (miRNA). Tune in to learn the following: <ul> <li>What role <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> play in cell-to-cell communication</li> <li>How the identification of a particular <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> has shed light on the allergic response in asthma, and how to decrease that response</li> <li>How <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> are able to control multiple genes, and why this could potentially have life-saving clinical applications</li> </ul> Dr. Takyar holds a medical degree, as well as a PhD in both microbiology and molecular biology. He discusses the discovery of <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> over 10 years ago, and the subsequent discoveries about their role in the body and gene expression. His research is focused on the interaction between <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> and endothelium. His most recent work began years ago when he noticed that a vascular growth factor (VEGF) was high in patients with asthma. Up until that point, most of the research about asthma was focused on lung epithelium or immune cells; Dr. Takyar wanted to investigate whether this vascular growth factor also affects the <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> in endothelial cells. Over the past 12 years, that’s been his primary focus. He has been able to show a correlation between VEGF and one particular <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> in endothelial cells—specifically in the expression of the Mpl gene, which controls the adhesion of eosinophils (a type of white blood cell present in the asthmatic response). He has shown that when VEGF increases, the specific <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> decreases, and the Mpl gene is expressed. The relationship between the microRNA and Mpl gene makes sense, since microRNA is known to play an inhibitory role in gene expression. By changing this one microRNA in the endothelium of an animal model, the asthma response decreased significantly. This explanation leads Dr. Takyar to discuss the potential of <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> as a tool for inhibiting or modulating groups of genes, rather than just one gene. This would confer a huge advantage to the treatment of certain ailments such as lung cancer, where it is known that targeting a single gene does not often produce the desired result. In addition to explaining just why it is that single-gene targets don’t work well, Dr. Takyar discusses a number of interesting topics, including the role of <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> in cell-to-cell communication, how genes are matched with certain <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a>, how <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a> is able to control many genes as opposed to just one, and the biogenesis of <a href="https://www.findinggeniuspodcast.com/podcasts/gene-silencing-through-rna-interference-phillip-zamore-phd-university-of-massachusetts-medical-school/" rel="nofollow" target="_blank"> microRNA</a>. Learn more at <a href="https://medicine.yale.edu/profile/seyedtaghi_takyar/" rel="noopener nofollow" target="_blank">https://medicine.yale.edu/profile/seyedtaghi_takyar/</a>.