Michaela Reagan's guest appearances

Michaela Reagan

Finding Genius Podcast

FutureTech Podcast

Richard Andrews

Naveed Akbar

Marc Guell

Laura Potterat

Jan Vijg

Paul Turner

Eleftherios Mylonakis

Cory Kidd

Charles C.J

Helius Medical Technologies

Patrick McKeown

Michael G. Surette

Katelyn Parsons

John Tucker

Jake Kushner

OwlTail

Up to 75% of the cells in bone marrow are fat cells (adipocytes), which interact very closely with multiple myeloma tumor cells. In addition, as the concentration of bone marrow cells increases with age and obesity, so too does the incidence of multiple myeloma. Why, then, are these cells and this interaction so understudied? What remains to be discovered about the underlying mechanism of multiple myeloma and how might it lead to better ways of managing and treating it? These are the questions being asked and investigated by Michaela Reagan, PhD and her team at the Maine Medical Center Research Institute. She explains the biochemical and physiological processes involved with the development of multiple myeloma, including the pre-metastatic niche and something referred to as the chemokine gradient, the connection between cancer and osteoporosis, how combination therapies can be used to determine why drug therapies are effective for some and not for others, epigenetic changes in tumors, and ultimate goals of her ongoing research. Tune in for the full conversation and learn more by visiting mmcri.org and clicking on Dr. Reagan in the faculty list. 

Up to 75% of the cells in bone marrow are fat cells (adipocytes), which interact very closely with multiple myeloma tumor cells. In addition, as the concentration of bone marrow cells increases with age and obesity, so too does the incidence of multiple myeloma. Why, then, are these cells and this interaction so understudied? What remains to be discovered about the underlying mechanism of multiple myeloma and how might it lead to better ways of managing and treating it? These are the questions being asked and investigated by Michaela Reagan, PhD and her team at the Maine Medical Center Research Institute. She explains the biochemical and physiological processes involved with the development of multiple myeloma, including the pre-metastatic niche and something referred to as the chemokine gradient, the connection between cancer and osteoporosis, how combination therapies can be used to determine why drug therapies are effective for some and not for others, epigenetic changes in tumors, and ultimate goals of her ongoing research. Tune in for the full conversation and learn more by visiting <a href="http://mmcri.org/" rel="nofollow" target="_blank">mmcri.org</a> and clicking on Dr. Reagan in the faculty list.

Exploring the Connection Between Fat Cells in Your Bone Marrow and Your Risk of Developing Multiple Myeloma—Michaela Reagan—Maine Medical Center Research Institute  

Quite a bit is known about bone-building cells (osteoblasts) and bone-resorbing cells (osteoclasts), but not much is known about bone marrow fat cells—aside from the fact that bone marrow becomes packed with them as we age or become obese. We also know that there is a correlation between the incidence of multiple myeloma (a type of blood cancer that affects the bone marrow) and age, and multiple myeloma and obesity. This naturally poses the question, how might bone marrow fat cells be connected to or aid in the development of the tumor cells seen in multiple myeloma? This is precisely what Michaela Reagan, PhD and her team at the Maine Medical Center Research Institute are investigating. She joins the podcast today to discuss a variety of interesting topics, including the details of this research, the process of multiple myeloma, how tumor and non-tumor cells enter the bloodstream from the bone, the parallels between bone cancer and osteoporosis, epigenetic changes in tumors, and where her research is headed. Press play for all the details and learn more by visiting mmcri.org and clicking on Dr. Reagan in the faculty list.

Quite a bit is known about bone-building cells (osteoblasts) and bone-resorbing cells (osteoclasts), but not much is known about bone marrow fat cells—aside from the fact that bone marrow becomes packed with them as we age or become obese. We also know that there is a correlation between the incidence of multiple myeloma (a type of blood cancer that affects the bone marrow) and age, and multiple myeloma and obesity. This naturally poses the question, how might bone marrow fat cells be connected to or aid in the development of the tumor cells seen in multiple myeloma? This is precisely what Michaela Reagan, PhD and her team at the Maine Medical Center Research Institute are investigating. She joins the podcast today to discuss a variety of interesting topics, including the details of this research, the process of multiple myeloma, how tumor and non-tumor cells enter the bloodstream from the bone, the parallels between bone cancer and osteoporosis, epigenetic changes in tumors, and where her research is headed. Press play for all the details and learn more by visiting <a href="http://mmcri.org/" rel="nofollow" target="_blank">mmcri.org</a> and clicking on Dr. Reagan in the faculty list.

Cancer and Bone Marrow Fat Cells New Research on the Mechanism and Treatment of Multiple Myeloma—Michaela Reagan—Maine Medical Center Research Institute