Moshe Arditi's guest appearances

Moshe Arditi

This Week in Virology

Kristian Andersen

Peter Hotez

Michael Mina

Janet Smith

Chris Sullivan

Greg Zuckerman

Paul Offit

Fred Murphy

Laurie Garrett

David Oshinsky

David Fajgenbaum

Adam Kucharski

Ginger Campbell

David Brenner

Janet Iwasa

OwlTail

Ivet Bahar

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MIS-C in US children (NEJM) Superantigen in spike and T cell skewing in MIS-C (PNAS) MIS-C mimics  toxic shock syndrome (J Allergy Clin Immunol) Antibody against bacterial superantigen  blocks SARS-CoV-2 entry (Structure) Autoimmune signature of MIS-C in children (J Clin Invest) HLA1 associated T cell expansion in MIS-C (J Clin Invest) Passing of Bill Wold (one, two) Letters read on TWiV 815 Timestamps by Jolene. Thanks!  Weekly Picks Dickson –  Mel Brooks Kathy –  Dickson’s art show at Fordham Rich – Saildrone captures footage from inside Hurricane Sam Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman Listener Picks Kathryn – Project Drawdown and the book Charles – Arrowsmith by Sinclair Lewis Intro music is by Ronald Jenkees  Send your virology questions and comments to twiv@microbe.tv

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" rel="nofollow" target="_blank">Vincent Racaniello</a>, <a href="http://www.trichinella.org/" rel="nofollow" target="_blank">Dickson Despommier</a>, <a href="http://mgm.ufl.edu/profile/condit-rich/" rel="nofollow" target="_blank">Rich Condi</a><a href="http://enterovirus.net/" rel="nofollow" target="_blank">t</a> and <a href="https://sites.google.com/a/umich.edu/spindler-lab/" rel="nofollow" target="_blank">Kathy Spindler</a> Guests: <a href="https://www.cedars-sinai.edu/research/labs/arditi.html" rel="nofollow" target="_blank">Moshe Arditi</a> and <a href="https://www.ccbb.pitt.edu/Faculty/bahar/" rel="nofollow" target="_blank">Ivet Behar</a> Subscribe (free): <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" rel="nofollow" target="_blank">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D" rel="nofollow" target="_blank">Google Podcasts</a>, <a href="http://twiv.microbeworld.libsynpro.com/twiv" rel="nofollow" target="_blank">RSS</a>, <a href="http://eepurl.com/Gcw59" rel="nofollow" target="_blank">email</a> Become a <a href="https://www.microbe.tv/contribute" rel="nofollow" target="_blank">patron</a> of TWiV! Links for this episode <ul> <li>MIS-C in <a href="https://pubmed.ncbi.nlm.nih.gov/33085853/" rel="nofollow" target="_blank">US children</a> (NEJM)</li> <li><a href="https://www.pnas.org/content/117/41/25254.long" rel="nofollow" target="_blank">Superantigen in spike</a> and T cell skewing in MIS-C (PNAS)</li> <li>MIS-C mimics <a href="https://www.jacionline.org/article/S0091-6749(20)31414-7/fulltext" rel="nofollow" target="_blank"> toxic shock syndrome</a> (J Allergy Clin Immunol)</li> <li>Antibody against bacterial superantigen <a href="https://www.cell.com/structure/fulltext/S0969-2126(21)00121-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0969212621001210%3Fshowall%3Dtrue" rel="nofollow" target="_blank"> blocks SARS-CoV-2 entry</a> (Structure)</li> <li><a href="https://www.jci.org/articles/view/151520" rel="nofollow" target="_blank">Autoimmune signature</a> of MIS-C in children (J Clin Invest)</li> <li><a href="https://www.jci.org/articles/view/146614" rel="nofollow" target="_blank">HLA1 associated</a> T cell expansion in MIS-C (J Clin Invest)</li> <li>Passing of Bill Wold (<a href="https://www.buchholzmortuary.com/obituaries/William-Wold/#!/Obituary" rel="nofollow" target="_blank">one</a>, <a href="https://journals.asm.org/doi/epdf/10.1128/JVI.01184-21" rel="nofollow" target="_blank">two</a>)</li> <li><a href="https://www.microbe.tv/twiv/twiv-815-letters/" rel="nofollow" target="_blank">Letters read</a> on TWiV 815</li> <li>Timestamps by <a href="http://www.twitter.com/jrrmicro" rel="nofollow" target="_blank">Jolene</a>. Thanks!</li> </ul> Weekly Picks Dickson –  <a href="https://www.youtube.com/watch?v=XTujWe175Ts" rel="nofollow" target="_blank">Mel Brooks</a> Kathy – <a href="https://fordhamuniversitygalleries.com/artwork/4949788-Dickson-Despommier.html" rel="nofollow" target="_blank"> Dickson’s art show at Fordham</a> Rich – <a href="https://www.youtube.com/watch?v=cGFry-u66cQ" rel="nofollow" target="_blank">Saildrone captures footage from inside Hurricane Sam</a> Vincent – <a href="https://amzn.to/3Fv6U9h" rel="nofollow" target="_blank">A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman</a> Listener Picks Kathryn – <a href="https://www.drawdown.org/solutions/table-of-solutions" rel="nofollow" target="_blank">Project Drawdown</a> and <a href="https://www.drawdown.org/the-book" rel="nofollow" target="_blank">the book</a> Charles – <a href="https://amzn.to/3BrU35x" rel="nofollow" target="_blank">Arrowsmith by Sinclair Lewis</a> Intro music is by <a href="http://www.ronaldjenkees.com/" rel="nofollow" target="_blank">Ronald Jenkees</a> Send your virology questions and comments to twiv@microbe.tv

TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar