Michael Rosbash's guest appearances

Michael Rosbash

HHMI's Holiday Lectures Video Extras

iBiology: Subtitled versions

iBiology Science Stories

Freeman Hrabowski

David Baker

Chris Field

Jennifer Doudna

George Shultz

James Watson

Michael Bishop

Robert Ramirez

Dan Rather

Manu Prakash

Neil Shubin

Steven Chu

Elizabeth Blackburn

Erling Norrby

Jeffrey Friedman

OwlTail

Michael Rosbash tells the story of how a collaboration with friend Jeff Hall led to the discovery of the genetic mechanisms that regulate circadian rhythms. Circadian rhythms are the physiological and behavioral changes, such as sleep and wakefulness, which occur in response to a 24-hour cycle of light and darkness. Using Drosophila as a model, Rosbash and Hall cloned the circadian timekeeping gene called period, which they later demonstrated blocks its own transcription through an oscillating negative feedback loop. http://www.ibiology.org/ibiomagazine/michael-rosbash-understanding-circadian-rhythms.htmlSpeaker Biography: Michael Rosbash is Professor of Biology at Brandeis University and Investigator of the Howard Hughes Medical Institute. Rosbash uses genetics to understand the underlying mechanisms of circadian rhythms. In 1984, Rosbash, along with collaborator Jeff Hall, cloned the period gene in Drosophila, which led them to discover the transcriptional negative feedback loop of circadian clocks several years later. Since that time, Rosbash and Hall have identified several other important circadian genes and their functions. More recently, Rosbash's studies have focused on understanding how neuronal function contributes to circadian rhythmicity. For his seminal discoveries, Rosbash was elected to the National Academy of Sciences in 2003. Rosbash graduated with a BS in Chemistry from Caltech in 1965, and then spent a year at the Institut de Biologie Physico-Chimique in Paris on a Fullbright Scholarship. He earned his PhD in Biophysics from the Massachusetts Institute of Technology in 1970. Rosbash joined the faculty at Brandeis University in 1974 after a three-year postdoctoral fellowship at the University of Edinburgh.

Michael Rosbash tells the story of how a collaboration with friend Jeff Hall led to the discovery of the genetic mechanisms that regulate circadian rhythms. Circadian rhythms are the physiological and behavioral changes, such as sleep and wakefulness, which occur in response to a 24-hour cycle of light and darkness. Using Drosophila as a model, Rosbash and Hall cloned the circadian timekeeping gene called period, which they later demonstrated blocks its own transcription through an oscillating negative feedback loop. <a href="http://www.ibiology.org/ibiomagazine/michael-rosbash-understanding-circadian-rhythms.html" rel="nofollow" target="_blank">http://www.ibiology.org/ibiomagazine/michael-rosbash-understanding-circadian-rhythms.html</a> Speaker Biography: Michael Rosbash is Professor of Biology at Brandeis University and Investigator of the Howard Hughes Medical Institute. Rosbash uses genetics to understand the underlying mechanisms of circadian rhythms. In 1984, Rosbash, along with collaborator Jeff Hall, cloned the period gene in Drosophila, which led them to discover the transcriptional negative feedback loop of circadian clocks several years later. Since that time, Rosbash and Hall have identified several other important circadian genes and their functions. More recently, Rosbash's studies have focused on understanding how neuronal function contributes to circadian rhythmicity. For his seminal discoveries, Rosbash was elected to the National Academy of Sciences in 2003. Rosbash graduated with a BS in Chemistry from Caltech in 1965, and then spent a year at the Institut de Biologie Physico-Chimique in Paris on a Fullbright Scholarship. He earned his PhD in Biophysics from the Massachusetts Institute of Technology in 1970. Rosbash joined the faculty at Brandeis University in 1974 after a three-year postdoctoral fellowship at the University of Edinburgh.

Michael Rosbash: Understanding Circadian Rhythms