Laura-Isobel McCall's guest appearances

Laura-Isobel McCall

Finding Genius Podcast

FutureTech Podcast

Laura Potterat

Marc Guell

Paul Turner

Jan Vijg

Eleftherios Mylonakis

Cory Kidd

Charles C.J

Helius Medical Technologies

Patrick McKeown

Michael G. Surette

Katelyn Parsons

John Tucker

Jake Kushner

Erik Gunther

Kim Kush

OwlTail

When you listen to this discussion with Dr. McCall, you will hear about:   The use of liquid chromatography and mass spectrometry to ascertain and pinpoint disease microbes' location in internal organs. How effective rehabilitation for the host lies in this metabolomics testing rather than in destroying pathogens. How the creation of compounds centered on these locations can battle the effects of these pathogens.   Laura-Isobel McCall, Assistant Professor at the University of Oklahoma, specializes in chemical cartography of host-microbe interactions. The McCall Lab, run by Dr. McCall, uses the application of analytical chemistry as chemical cartography by locating pathogens in the internal organs of mice. Dr. McCall notes that understanding location leads to understanding function, and the McCall Lab discerns how pathogens, the microbiome, and the host interact. This helps them assimilate drugs with the ability to modulate the host's metabolism. By means of metabolomics testing and chemical cartography, the McCall Lab is developing compounds to offset the effects of parasites. Dr. McCall has made a concerted effort to center their work on neglected deadly diseases such as trypanosoma cruzi, a tropical parasite that can be found in the United States. Dr. McCall describes how chemical cartography with 3D mapping and metabolomics testing helps them comprehend the workings of particular pathogens. In addition, these studies reveal how key timing can be in halting the detrimental result of the parasitic attacks. In addition, the lab is manufacturing compounds that provide nutrients for the host based on the cartography findings, enabling the host to survive the effects of the parasite. They've found this is more effective than drugs designed to kill the parasite. The lab hopes to apply this work to additional pathogens and diseases that are location-driven while continuing to cultivate and strengthen the effects of the compounds. For more information, see the McCall Lab page at http://mccall-lab.oucreate.com/ and find them on twitter as @LabMccall.

When you listen to this discussion with Dr. McCall, you will hear about: <ul> <li>The use of liquid chromatography and mass spectrometry to ascertain and pinpoint disease microbes' location in internal organs.</li> <li>How effective rehabilitation for the host lies in this metabolomics testing rather than in destroying pathogens.</li> <li>How the creation of compounds centered on these locations can battle the effects of these pathogens.</li> </ul> Laura-Isobel McCall, Assistant Professor at the University of Oklahoma, specializes in chemical cartography of host-microbe interactions. The <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">McCall Lab</a>, run by Dr. McCall, uses the application of analytical chemistry as chemical cartography by locating pathogens in the internal organs of mice. Dr. McCall notes that understanding location leads to understanding function, and the <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">McCall Lab</a> discerns how pathogens, the microbiome, and the host interact. This helps them assimilate drugs with the ability to modulate the host's metabolism. By means of metabolomics testing and chemical cartography, the <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">McCall Lab</a> is developing compounds to offset the effects of parasites. Dr. McCall has made a concerted effort to center their work on neglected deadly diseases such as trypanosoma cruzi, a tropical parasite that can be found in the United States. Dr. McCall describes how chemical cartography with 3D mapping and metabolomics testing helps them comprehend the workings of particular pathogens. In addition, these studies reveal how key timing can be in halting the detrimental result of the parasitic attacks. In addition, the lab is manufacturing compounds that provide nutrients for the host based on the cartography findings, enabling the host to survive the effects of the parasite. They've found this is more effective than drugs designed to kill the parasite. The lab hopes to apply this work to additional pathogens and diseases that are location-driven while continuing to cultivate and strengthen the effects of the compounds. For more information, see the McCall Lab page at <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">http://mccall-lab.oucreate.com/</a> and find them on twitter as <a href="https://mobile.twitter.com/LabMccall" rel="nofollow" target="_blank">@LabMccall</a>.

Cartography for Microbes: Dr. Laura-Isobel McCall's Application of Analytical Chemistry to Map Disease

This podcast describes a cutting-edge application of analytical chemistry. When you listen, you will learn:   How Dr. McCall's lab uses liquid chromatography and mass spectrometry together to identify and locate pathogen microbes in bodily organs. How identifying their location leads to creating compounds that help the body fight their effects. Why this new pathogen management is centered on metabolomics testing rather than killing the microbes.   Laura-Isobel McCall, Assistant Professor at the University of Oklahoma, specializes in chemical cartography of host-microbe interactions. She runs the McCall Lab, where they practice the application of analytical chemistry to map disease-causing microbes in mammalian organ systems. The McCall Lab explores the interaction between pathogens, the microbiome, and the host to develop drugs that are capable of metabolism modulation. Through metabolomics testing and chemical cartography, Dr. McCall's lab is working on compounds to counter the effects of pathogens such as parasites. Much of their work focuses on neglected diseases, often potentially deadly, such as trypanosoma cruzi, which is present in the United States. Dr. McCall explains how locating and mapping microbes with 3D technology and metabolomics testing opens up an understanding of how these pathogens function. This has led to identifying how important timing is in treating against the effects of such pathogens: the extent of tissue damage and the eventual dormant stage of a parasite are factors of time, for example. Furthermore, developing compounds to bolster how the host deals with the energy demand of the pathogen is more effective than simply targeting the pathogen. Future work of the lab includes applying these techniques to other types of pathogens, improving the compounds to help patients, and connecting this work to other location-centered diseases. For more information, see the McCall Lab page at http://mccall-lab.oucreate.com/ and find them on twitter as @LabMccall.

This podcast describes a cutting-edge application of analytical chemistry. When you listen, you will learn: <ul> <li>How Dr. McCall's lab uses liquid chromatography and mass spectrometry together to identify and locate pathogen microbes in bodily organs.</li> <li>How identifying their location leads to creating compounds that help the body fight their effects.</li> <li>Why this new pathogen management is centered on metabolomics testing rather than killing the microbes.</li> </ul> Laura-Isobel McCall, Assistant Professor at the University of Oklahoma, specializes in chemical cartography of host-microbe interactions. She runs the <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">McCall Lab</a>, where they practice the application of analytical chemistry to map disease-causing microbes in mammalian organ systems. The <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">McCall Lab</a> explores the interaction between pathogens, the microbiome, and the host to develop drugs that are capable of metabolism modulation. Through metabolomics testing and chemical cartography, Dr. McCall's lab is working on compounds to counter the effects of pathogens such as parasites. Much of their work focuses on neglected diseases, often potentially deadly, such as trypanosoma cruzi, which is present in the United States. Dr. McCall explains how locating and mapping microbes with 3D technology and metabolomics testing opens up an understanding of how these pathogens function. This has led to identifying how important timing is in treating against the effects of such pathogens: the extent of tissue damage and the eventual dormant stage of a parasite are factors of time, for example. Furthermore, developing compounds to bolster how the host deals with the energy demand of the pathogen is more effective than simply targeting the pathogen. Future work of the lab includes applying these techniques to other types of pathogens, improving the compounds to help patients, and connecting this work to other location-centered diseases. For more information, see the McCall Lab page at <a href="http://mccall-lab.oucreate.com/" rel="nofollow" target="_blank">http://mccall-lab.oucreate.com/</a> and find them on twitter as <a href="https://mobile.twitter.com/LabMccall" rel="nofollow" target="_blank">@LabMccall</a>.

Mapping Microbes: How Dr. Laura-Isobel McCall Uses Chemical Cartography to Fight Disease