Gene Duplications's guest appearances

Gene Duplications

CARTA - Center for Academic Research and Training in Anthropogeny (Audio)

CARTA - Center for Academic Research and Training in Anthropogeny (Video)

PaperPlayer biorxiv developmental biology

David Perlmutter

Rob Knight

Tim Weaver

Richard Wrangham

Helen Fisher

Robert Kelly

Daniel Dennett

Baba Brinkman

Martin Rees

Simon Baron-Cohen

Nicholas Humphrey

Bruce Miller

Peter Ungar

Katie Hinde

Homo Naledi

OwlTail

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.19.210658v1?rss=1Authors: Cole, A. G., Kaul, S., Jahnel, S. M., Steger, J., Zimmermann, B., Reischl, R., Richards, G. S., Rentzsch, F., Steinmetz, P., Technau, U.Abstract: The evolutionary mechanisms underlying the emergence of new cell types are still unclear. Here, we address the origin and diversification of muscle cells in the diploblastic sea anemone Nematostella vectensis. We discern two fast and two slow-contracting muscle cell populations in Nematostella differing by extensive sets of paralogous genes. The regulatory gene set of the slow cnidarian muscles and the bilaterian cardiac muscle are remarkably similar. By contrast, the two fast muscles differ substantially from each other, while driving the same set of paralogous structural protein genes. Our data suggest that extensive gene duplications and co-option of individual effector modules may have played an important role in cell type diversification during metazoan evolution.One Sentence SummaryThe study of the simple sea anemone suggests a molecular mechanism for cell type evolution and morphological complexity.Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: <a href="http://biorxiv.org/cgi/content/short/2020.07.19.210658v1?rss=1" rel="nofollow" target="_blank">http://biorxiv.org/cgi/content/short/2020.07.19.210658v1?rss=1</a> Authors: Cole, A. G., Kaul, S., Jahnel, S. M., Steger, J., Zimmermann, B., Reischl, R., Richards, G. S., Rentzsch, F., Steinmetz, P., Technau, U. Abstract: The evolutionary mechanisms underlying the emergence of new cell types are still unclear. Here, we address the origin and diversification of muscle cells in the diploblastic sea anemone Nematostella vectensis. We discern two fast and two slow-contracting muscle cell populations in Nematostella differing by extensive sets of paralogous genes. The regulatory gene set of the slow cnidarian muscles and the bilaterian cardiac muscle are remarkably similar. By contrast, the two fast muscles differ substantially from each other, while driving the same set of paralogous structural protein genes. Our data suggest that extensive gene duplications and co-option of individual effector modules may have played an important role in cell type diversification during metazoan evolution. One Sentence SummaryThe study of the simple sea anemone suggests a molecular mechanism for cell type evolution and morphological complexity. Copy rights belong to original authors. Visit the link for more info

Muscle cell type diversification driven by extensive gene duplications

Carta

Evolution of Human Duplications: Genomic Instability and New Genes (Evan Eichler); Human Accelerated Regions in the Genome (Katherine S. Pollard) Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21956]

CARTA: The Genetics of Humanness: Gene Duplications and Deletions and Accelerated Regions in the Human Genome