Evangelos Kiskinis's guest appearances

Evangelos Kiskinis

The Stem Cell Podcast

Personalized Medicine Podcast

Nicole Quinn

Chris Smith

David Piper

Michael Levin

Austin Smith

Robert Mays

Kiki Sanford

Bernie Siegel

Greg Smith

Aubrey de Grey

Kaytlyn Gerbin

Chuck Murry

Sarthak Sinha

Andrew Cohen

Camilla Forsberg

OwlTail

On this episode we take a look at the role induced Pluripotent Stem Cells (iPSCs) are playing in drug discovery and development for neurodegenerative diseases. Our host Oleksandr sat down with Professor Evangelos Kiskinis, who is leading his own research group at the Northwestern University in Chicago. Evangelos and his team are leading the way on the development of novel cell-based models for ALS, epilepsy and other types of neurological conditions.Check out this episode to learn more about:◦ Evangelos’s career story and what got him excited in stem cell research◦ Challenges in modeling neurodegenerative diseases in a dish◦ iPSC based models for inherited vs sporadic diseases◦ Transitioning promising in vitro discoveries into clinical trials◦ iPSC based cell replacement therapies for Parkinsons and Alzheimers disease◦ The future of iPSC based models in drug discovery◦ Evangelos’s advice to young scientists pursuing academic career◦ Get in touch with Evangelos:◦ LinkedIn: Evangelos Kiskinis ◦ Web: http://evangeloskiskinislab.org/index.htmlMake sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com

On this episode we take a look at the role induced Pluripotent Stem Cells (iPSCs) are playing in drug discovery and development for neurodegenerative diseases. Our host Oleksandr sat down with Professor Evangelos Kiskinis, who is leading his own research group at the Northwestern University in Chicago. Evangelos and his team are leading the way on the development of novel cell-based models for ALS, epilepsy and other types of neurological conditions. Check out this episode to learn more about: ◦ Evangelos’s career story and what got him excited in stem cell research ◦ Challenges in modeling neurodegenerative diseases in a dish ◦ iPSC based models for inherited vs sporadic diseases ◦ Transitioning promising in vitro discoveries into clinical trials ◦ iPSC based cell replacement therapies for Parkinsons and Alzheimers disease ◦ The future of iPSC based models in drug discovery ◦ Evangelos’s advice to young scientists pursuing academic career ◦ Get in touch with Evangelos: ◦ LinkedIn: Evangelos Kiskinis ◦ Web: <a href="http://evangeloskiskinislab.org/index.html" rel="noopener nofollow" target="_blank">http://evangeloskiskinislab.org/index.html</a> Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at <a href="http://pmedcast.com" rel="nofollow" target="_blank">pmedcast.com</a>

Ep#030: Using iPSCs to Discover New Therapies for Neurodegenerative Disorders with Professor Evangelos Kiskinis

Guest:Evangelos Kiskinis, PhD is an Assistant Professor in Neurology at Northwestern University.  His lab focuses on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of diseases such as ALS.Featured Resource: Madeline Lancaster on Brain Organoids: Modeling Human Brain Development in a Dish WebinarResources and LinksHow Norovirus Invades - While investigating the cell tropism for murine norovirus, scientists discovered that a rare cell type, tuft cells, carrying the CD300lf receptor were the virus’s specific target.Viruses that Clean Up Bacteria- Viruses can be engineered to carry magnetic nanoparticles and modified DNA, transforming them into nanobots that detect bacteria in water or food.Cancers Should Be Treated by Type Not Location - Cancer should not be treated based on where it is first found in the body, but depending on the type of tumor, scientists have said.California Ordered to Add Cancer Warning to Coffee, but the Science Doesn't Hold Up - Storm clouds are brewing in California’s coffee cups. Companies across the state will have to add a cancer-warning label to coffee, a judge ruled, because the drink contains a chemical called acrylamide.Thrombopoietin is Required for Bone Marrow Stem Cell Maintenance- Investigators found that hematopoietic stem cells (HSCs) were markedly reduced in hepatocyte-specific thrombopoietin-deficient mice. These results indicate that systemic factors, in addition to the local niche, are a critical extrinsic component for HSC maintenance.Researchers Optimize Lung Stem Cell Engineering Process- The Center for Regenerative Medicine’s pioneering research using induced pluripotent stem cells, which self-renew indefinitely as undifferentiated cells that become specific adult cell types, has helped create an inexhaustible source of disease- or patient-specific stem cells.An In Vivo Model of Functional and Vascularized Human Brain Organoids- Scientists developed more sophisticated organoid models to help provide new insights into a range of neurological and psychological disorders.iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation - The authors showed that ground squirrel iPSCs offer a unique platform for bringing cold-adaptive strategies from hibernators to humans in clinical applications.Photo Reference: Courtesy of  Evangelos Kiskinis#footable_5807  {    font-family: inherit;    font-size: 14px;    }#footable_parent_5807 thead{    display: none;}#footable_parent_5807 a.nt_edit_link{    display: none;}#footable_parent_5807 td{    border-color: #fff;}#footable_parent_5807 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5808  {    font-family: inherit;    font-size: 14px;    }thead{    display: none;}#footable_parent_5808 a.nt_edit_link{    display: none;}#footable_parent_5808 td{    border-color: #fff;}#footable_parent_5808 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}                                                                        #footable_5807  {    font-family: inherit;    font-size: 14px;    }#footable_parent_5807 thead{    display: none;}#footable_parent_5807 a.nt_edit_link{    display: none;}#footable_parent_5807 td{    border-color: #fff;}#footable_parent_5807 img{    margin-top: 0px;}.semantic_ui .ui.table{  border: 0px solid !important;  }.semantic_ui .ui.table td {    padding: 0em;}

Guest: Evangelos Kiskinis, PhD is an Assistant Professor in Neurology at Northwestern University.  His lab focuses on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of diseases such as ALS. Featured Resource: Madeline Lancaster on Brain Organoids: Modeling Human Brain Development in a Dish Webinar Resources and Links How Norovirus Invades - While investigating the cell tropism for murine norovirus, scientists discovered that a rare cell type, tuft cells, carrying the CD300lf receptor were the virus’s specific target. Viruses that Clean Up Bacteria- Viruses can be engineered to carry magnetic nanoparticles and modified DNA, transforming them into nanobots that detect bacteria in water or food. Cancers Should Be Treated by Type Not Location - Cancer should not be treated based on where it is first found in the body, but depending on the type of tumor, scientists have said. California Ordered to Add Cancer Warning to Coffee, but the Science Doesn't Hold Up - Storm clouds are brewing in California’s coffee cups. Companies across the state will have to add a cancer-warning label to coffee, a judge ruled, because the drink contains a chemical called acrylamide. Thrombopoietin is Required for Bone Marrow Stem Cell Maintenance- Investigators found that hematopoietic stem cells (HSCs) were markedly reduced in hepatocyte-specific thrombopoietin-deficient mice. These results indicate that systemic factors, in addition to the local niche, are a critical extrinsic component for HSC maintenance. Researchers Optimize Lung Stem Cell Engineering Process- The Center for Regenerative Medicine’s pioneering research using induced pluripotent stem cells, which self-renew indefinitely as undifferentiated cells that become specific adult cell types, has helped create an inexhaustible source of disease- or patient-specific stem cells. An In Vivo Model of Functional and Vascularized Human Brain Organoids- Scientists developed more sophisticated organoid models to help provide new insights into a range of neurological and psychological disorders. iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation - The authors showed that ground squirrel iPSCs offer a unique platform for bringing cold-adaptive strategies from hibernators to humans in clinical applications. Photo Reference: Courtesy of  Evangelos Kiskinis #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; }

Ep. 115: “Motor Neurons” Featuring Evangelos Kiskinis

Christy Allen

Guest:In this episode we discuss topics ranging from a chemical in vegetables that can destroy cancer stem cells, chewing gum to prevent signing a song over and over, the first report of germ line gene editing in human embryo, neuronal hyperactivity and neutral stem cells, and the discovery of a new pluripotent stem cell. The second half of the show comes live from The Next-Gen Stem Cell Conference in Saratoga NY, where we interview four scientists about their work and conference experience.Resources and LinksCould High Blood Sugar Be a Cause of Alzheimer's Disease? – Scientists suspect one of the drivers that causes the complex brain changes that lead to Alzheimer’s disease is the accumulation of plaques of a faulty protein called beta-amyloid and that too much sugar in the blood can speed up the production of this protein.Activin A Directs Striatal Projection Neuron Differentiation of Human Pluripotent Stem Cells – Activin A induces lateral ganglionic eminence (LGE) characteristics in nascent neural progenitors derived from human embryonic stem cells and induced pluripotent stem cells in a sonic hedgehog-independent manner.Take a Deep Breath: Patients Find Relief through 3D Printing – A patient suffering from the rare condition, tracheobronchomalacia was treated with the use of 3D printing to construct a splint that would support the weakened trachea.Relaxed DNA May Contribute to Aging – Analysis from scientists suggests that loosely wrapped DNA underlies the accelerated physical decline of Werner syndrome and promotes aging in the rest of the population.U of M Institute Discovers How Aspirin Fights Cancer – Researchers discovered that aspirin might exert its chemopreventive activity against colorectal cancer, at least partially, by normalizing the expression of epidermal growth factor receptor in gastrointestinal precancerous lesions.Bat-Winged Dinosaur Discovery Poses Flight Puzzle – This article describes the fossilized remains of a small, feathered dinosaur, unearthed in eastern China, that probably sported bat-like wing membranes and might have been able to glide or fly short distances.Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution – Researchers describe a way to transform A and B blood into a type that, like O, could be universally donated by using enzymes to remove certain sugars in the blood.The Search for Satiety Neurons and How to Short Circuit Hunger – A team of researchers has found that a melanoncortin 4 receptor-regulated (MC4R) circuit serves as the neural link that inhibits and controls eating by promoting fullness and removing the almost painful sensation of grating hunger.Finding the Body Clock's Molecular Reset Button – Researchers at McGill and Concordia universities in Montreal, report that the body's clock is reset during the process known as phosphorylation, when a phosphate combines with a key protein in the brain.Chew Gum to Get Rid of That Song in Your Head: Study – This article reveals that chewing gum could be the best way to get rid of the annoying songs that play in our heads which some call as earworms, according to a team of researchers at the University of Reading in the U.K.Chinese Researchers Have Genetically Modified a Human Embryo—and Many Scientists Think They’ve Gone Too Far – This article discusses the research conducted by a team of scientists in China on altering the DNA of human embryos which many scientists contend that newly developed genetic-engineering methods need to be studied further in animals before running the risk of unpredictable human mutations and scarier developments in human evolution.Scientists Stumble Across Unknown Stem-Cell Type – According to this article, a newly discovered type of stem cell could help provide a model for early human development — and, eventually, allow human organs to be grown in large animals such as pigs or cows for research or therapeutic purposes.

Guest: In this episode we discuss topics ranging from a chemical in vegetables that can destroy cancer stem cells, chewing gum to prevent signing a song over and over, the first report of germ line gene editing in human embryo, neuronal hyperactivity and neutral stem cells, and the discovery of a new pluripotent stem cell. The second half of the show comes live from The Next-Gen Stem Cell Conference in Saratoga NY, where we interview four scientists about their work and conference experience. Resources and Links Could High Blood Sugar Be a Cause of Alzheimer's Disease? – Scientists suspect one of the drivers that causes the complex brain changes that lead to Alzheimer’s disease is the accumulation of plaques of a faulty protein called beta-amyloid and that too much sugar in the blood can speed up the production of this protein. Activin A Directs Striatal Projection Neuron Differentiation of Human Pluripotent Stem Cells – Activin A induces lateral ganglionic eminence (LGE) characteristics in nascent neural progenitors derived from human embryonic stem cells and induced pluripotent stem cells in a sonic hedgehog-independent manner. Take a Deep Breath: Patients Find Relief through 3D Printing – A patient suffering from the rare condition, tracheobronchomalacia was treated with the use of 3D printing to construct a splint that would support the weakened trachea. Relaxed DNA May Contribute to Aging – Analysis from scientists suggests that loosely wrapped DNA underlies the accelerated physical decline of Werner syndrome and promotes aging in the rest of the population. U of M Institute Discovers How Aspirin Fights Cancer – Researchers discovered that aspirin might exert its chemopreventive activity against colorectal cancer, at least partially, by normalizing the expression of epidermal growth factor receptor in gastrointestinal precancerous lesions. Bat-Winged Dinosaur Discovery Poses Flight Puzzle – This article describes the fossilized remains of a small, feathered dinosaur, unearthed in eastern China, that probably sported bat-like wing membranes and might have been able to glide or fly short distances. Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution – Researchers describe a way to transform A and B blood into a type that, like O, could be universally donated by using enzymes to remove certain sugars in the blood. The Search for Satiety Neurons and How to Short Circuit Hunger – A team of researchers has found that a melanoncortin 4 receptor-regulated (MC4R) circuit serves as the neural link that inhibits and controls eating by promoting fullness and removing the almost painful sensation of grating hunger. Finding the Body Clock's Molecular Reset Button – Researchers at McGill and Concordia universities in Montreal, report that the body's clock is reset during the process known as phosphorylation, when a phosphate combines with a key protein in the brain. Chew Gum to Get Rid of That Song in Your Head: Study – This article reveals that chewing gum could be the best way to get rid of the annoying songs that play in our heads which some call as earworms, according to a team of researchers at the University of Reading in the U.K. Chinese Researchers Have Genetically Modified a Human Embryo—and Many Scientists Think They’ve Gone Too Far – This article discusses the research conducted by a team of scientists in China on altering the DNA of human embryos which many scientists contend that newly developed genetic-engineering methods need to be studied further in animals before running the risk of unpredictable human mutations and scarier developments in human evolution. Scientists Stumble Across Unknown Stem-Cell Type – According to this article, a newly discovered type of stem cell could help provide a model for early human development — and, eventually, allow human organs to be grown in large animals such as pigs or cows for research or therapeutic purposes.

Ep. 44: “Saratoga Stem Cell” Featuring Greg Smith, Christy Allen, Samantha Morris and Evangelos Kiskinis