Rudy Leibel's guest appearances

Rudy Leibel

The Peter Attia Drive

Sam Harris

Tim Ferriss

Annie Duke

Peter Attia

David Epstein

Robert Sapolsky

Ethan Weiss

Lori Gottlieb

Kristin Neff

BJ Miller

Sebastian Junger

Dave Feldman

Jason Fung

James Clear

Tom Bilyeu

OwlTail

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism. We discuss:  Rudy’s background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15]; Finding the first evidence of leptin by studying obese mice [23:30]; Zucker rats, and the push/pull theories of obesity [34:45]; A breakthrough in obesity research, and closing in on leptin [45:45]; Understanding leptin in humans [1:03:30]; What Prader–Willi syndrome teaches us about body weight regulation [1:09:45]; Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter’s self-experiments [1:18:00]; How is appetite being regulated? [1:29:45]; Are there epigenetic consequences of being obese? [1:37:00]; What makes low-carb diets so effective at obesity reduction? [1:46:15]; What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15]; Rudy’s dream study of the FTO gene [1:57:15]; What the hell does insulin resistance actually mean? [2:08:30]; and More.    Learn more at www.PeterAttiaMD.com  Connect with Peter on   Facebook |   Twitter |   Instagram.

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism. We discuss: <ul> <li>Rudy’s background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15];</li> <li>Finding the first evidence of leptin by studying obese mice [23:30];</li> <li>Zucker rats, and the push/pull theories of obesity [34:45];</li> <li>A breakthrough in obesity research, and closing in on leptin [45:45];</li> <li>Understanding leptin in humans [1:03:30];</li> <li>What Prader–Willi syndrome teaches us about body weight regulation [1:09:45];</li> <li>Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter’s self-experiments [1:18:00];</li> <li>How is appetite being regulated? [1:29:45];</li> <li>Are there epigenetic consequences of being obese? [1:37:00];</li> <li>What makes low-carb diets so effective at obesity reduction? [1:46:15];</li> <li>What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15];</li> <li>Rudy’s dream study of the FTO gene [1:57:15];</li> <li>What the hell does insulin resistance actually mean? [2:08:30]; and</li> <li>More.</li> </ul> Learn more at <a href="http://www.peterattiamd.com/" rel="nofollow" target="_blank">www.PeterAttiaMD.com</a> Connect with Peter on <a> Facebook</a> | <a> Twitter</a> | <a> Instagram</a>.

#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin