David Pamies's guest appearances

David Pamies

Finding Genius Podcast

FutureTech Podcast

Laura Potterat

Marc Guell

Paul Turner

Jan Vijg

Eleftherios Mylonakis

Cory Kidd

Charles C.J

Helius Medical Technologies

Patrick McKeown

Michael G. Surette

Katelyn Parsons

John Tucker

Jake Kushner

Erik Gunther

Kim Kush

OwlTail

Animal models predominate the field of drug testing and discovery, despite a growing body of evidence suggesting that such models are often poor predictors of human reactions. As a postdoctoral researcher at the University of Lausanne in Switzerland, Dr. David Pamies is working on something which might help to address these shortcomings: a human-induced pluripotent stem cell-derived 3D platform, and the development of a brain organoid—an in vitro model representing the human brain. He and his team are using the model to predict the toxicity of many different chemicals that we encounter on a daily basis. In addition to providing a cheaper and more efficient way of studying this than the industry standard of mouse models, this model is allowing Dr. Pamies to study the effectiveness of pharmaceuticals such as temozolomide in glioblastoma, a type of brain cancer also referred to as glioblastoma multiforme (GBM). He explains how they transplant and incorporate glioblastoma tumors from humans into the model, what they’ve learned so far in doing so, and the current issues they’re working on. He also discusses the nature of his most recent research and where it’s headed in the future. Tune in to hear the full conversation.

Animal models predominate the field of drug testing and discovery, despite a growing body of evidence suggesting that such models are often poor predictors of human reactions. As a postdoctoral researcher at the University of Lausanne in Switzerland, Dr. David Pamies is working on something which might help to address these shortcomings: a human-induced pluripotent stem cell-derived 3D platform, and the development of a brain organoid—an in vitro model representing the human brain. He and his team are using the model to predict the toxicity of many different chemicals that we encounter on a daily basis. In addition to providing a cheaper and more efficient way of studying this than the industry standard of mouse models, this model is allowing Dr. Pamies to study the effectiveness of pharmaceuticals such as temozolomide in glioblastoma, a type of <a href="https://www.futuretechhealth.com/podcasts/curing-resistant-ovarian-cancer-mice-jay-shepard-aravive/" rel="nofollow" target="_blank">brain cancer</a> also referred to as glioblastoma multiforme (GBM). He explains how they transplant and incorporate glioblastoma tumors from humans into the model, what they’ve learned so far in doing so, and the current issues they’re working on. He also discusses the nature of his most recent research and where it’s headed in the future. Tune in to hear the full conversation.

Organoid-Based Research of Environmental Toxins and Glioblastoma Tumors—David Pamies, PhD—University of Lausanne, Switzerland

It used to be a thing of science fiction…growing human organs in test tubes and observing their behavior as we manipulate their environment. For David Pamies, postdoctoral researcher at the University of Lausanne, Switzerland, this is daily life, although it may not always be ordinary. On today’s episode, he discusses how he’s using a brain organoid—an organ grown from human-induced pluripotent stem cells—to learn more about the toxins we come into contact with on a daily basis. He explains why and how this model is superior to far more commonly-used mouse models, and how it’s also fueling research on drug treatment for an aggressive type of brain cancer known as glioblastoma multiforme (GBM). Such research includes testing the effectiveness of temozolomide, a commonly used chemotherapy drug. Dr. Pamies dives into the science behind it all and provides a compelling glimpse into the exciting and growing world of organoid-based research. Press play for all the details.

It used to be a thing of science fiction…growing human organs in test tubes and observing their behavior as we manipulate their environment. For David Pamies, postdoctoral researcher at the University of Lausanne, Switzerland, this is daily life, although it may not always be ordinary. On today’s episode, he discusses how he’s using a brain organoid—an organ grown from human-induced pluripotent stem cells—to learn more about the toxins we come into contact with on a daily basis. He explains why and how this model is superior to far more commonly-used mouse models, and how it’s also fueling research on drug treatment for an aggressive type of <a href="https://www.futuretechpodcast.com/podcasts/cancer-causation-dr-anthony-b-miller-professor-emeritus-dalla-lana-school-of-public-health-university-of-toronto-taking-a-closer-look-at-cancer-and-its-causes/" rel="nofollow" target="_blank">brain cancer</a> known as glioblastoma multiforme (GBM). Such research includes testing the effectiveness of temozolomide, a commonly used chemotherapy drug. Dr. Pamies dives into the science behind it all and provides a compelling glimpse into the exciting and growing world of organoid-based research. Press play for all the details.

A Faster, Cheaper, Mouse-Free Model for Studying the Effects of Environmental Toxins on the Human Brain—David Pamies, PhD—University of Lausanne, Switzerland