Arthur Horwich's guest appearances

Arthur Horwich

Yale University

iBiology Science Stories

Gloria Steinem

Aaron Copland

Freeman Hrabowski

David Baker

Chris Field

Jennifer Doudna

George Shultz

James Watson

Michael Bishop

Robert Ramirez

Dan Rather

Gary Hart

Ezra Laderman

Herbert Yu

Jim Lehrer

OwlTail

About this talkHorwich explains that his lab was studying the import and folding of mitochondrial proteins in yeast mutants when he, and his collaborator Ulrich Hartl, discovered Hsp 60, a mitochondrial matrix protein required for proper folding of imported proteins. Hsp60 was found to have homology with proteins from bacteria and plants leading to the discovery of the molecular chaperonin protein family and its role in protein folding. About the speakerArt Horwich is the Sterling Professor of Genetics and Professor of Pediatrics at Yale School of Medicine and a Howard Hughes Medical Institute Investigator.  Using genetics, biochemistry and biophysics, his lab studies the mechanism of action of chaperonins and, more recently, the neurodegenerative diseases resulting from protein misfolding.  Horwich has received the Lasker Award and The Shaw Prize, amongst other awards, and he is a member of the National Academy of Sciences.

About this talk<br>Horwich explains that his lab was studying the import and folding of mitochondrial proteins in yeast mutants when he, and his collaborator Ulrich Hartl, discovered Hsp 60, a mitochondrial matrix protein required for proper folding of imported proteins. Hsp60 was found to have homology with proteins from bacteria and plants leading to the discovery of the molecular chaperonin protein family and its role in protein folding.<br> <br>About the speaker<br>Art Horwich is the Sterling Professor of Genetics and Professor of Pediatrics at Yale School of Medicine and a Howard Hughes Medical Institute Investigator.  Using genetics, biochemistry and biophysics, his lab studies the mechanism of action of chaperonins and, more recently, the neurodegenerative diseases resulting from protein misfolding.  Horwich has received the Lasker Award and The Shaw Prize, amongst other awards, and he is a member of the National Academy of Sciences.

Arthur Horwich: Discovery of chaperonin-assisted protein folding

Arthur Horwich talks about his research on the protein folding machinery in cells and its potential to cure neurodegenerative and other diseases.

Arthur Horwich: Protein Folding