Saverio Gentile's guest appearances

Saverio Gentile

Finding Genius Podcast

J Scott

Bill Barhydt

Whitney Johnson

Alex Mashinsky

Ross Ulbricht

Lyn Ulbricht

Jameson Lopp

Marco Peereboom

Megan Ramos

Danny Flood

Abel James

Nir Eyal

Perry Marshall

Scott Young

Ben Goertzel

OwlTail

What makes new discoveries about ion channels in relation to cancer? With recent developments and techniques, revolutionary therapeutic methods may be on the horizon. Listen up to learn:  How an ion channel functions Why voltage-gated ion channels are crucial Why some cells proliferate but don't die  Saverio Gentile, an assistant professor in the Department of Medicine at the University of Illinois at Chicago, shares his work researching ion channels in cancer cells. Cancer has been one of the most mysterious and complex to treat conditions present in recent history. While the current treatments have severe side effects and other negative implications, ion channels may offer new opportunities. Ion channels are highly selective proteins that play a significant role in the function of cells. By changing the cell's charge, the various functions and metabolism can be manipulated, allowing for the development of new therapeutic techniques to treat cancer. For more information, email sgentile@uic.edu. Episode also available on Apple Podcast: http://apple.co/30PvU9C

What makes new discoveries about ion channels in relation to cancer? With recent developments and techniques, revolutionary therapeutic methods may be on the horizon. Listen up to learn: <ul> <li>How an ion channel functions</li> <li>Why voltage-gated ion channels are crucial</li> <li>Why some cells proliferate but don't die</li> </ul> Saverio Gentile, an assistant professor in the Department of Medicine at the University of Illinois at Chicago, shares his work researching ion channels in cancer cells. Cancer has been one of the most mysterious and complex to treat conditions present in recent history. While the current treatments have severe side effects and other negative implications, ion channels may offer new opportunities. Ion channels are highly selective proteins that play a significant role in the function of cells. By changing the cell's charge, the various functions and metabolism can be manipulated, allowing for the development of new therapeutic techniques to treat cancer. For more information, email <a href="mailto:sgentile@uic.edu">sgentile@uic.edu</a>. Episode also available on Apple Podcast: <a href="http://apple.co/30PvU9C" rel="noopener nofollow" target="_blank">http://apple.co/30PvU9C</a>

Ion Channels in Cancer Cells and the Significant Potential To Develop Anticancer Therapeutics with Saverio Gentile

Manipulating ion channels may save lives. Researcher Saverio Gentile explains how. He tells listeners about exciting research on biochemical pathways in cancer cells in the human body. He and colleagues are looking at tumor cells versus normal cells regarding an understudied cell mechanism called voltage-gated ion channels.  Listen and learn  Why a key characteristic of cancer cells—proliferation—may easily be inhibited through this research; How channels work in normal cells to regulate highly-sensitive gradients for ions like sodium, calcium, chloride, and potassium; What's significant about how these channels appear to evolve and work in cancer cells; and How one study has shown a reduction of tumor growth by manipulating these channels with a common drug.  Saverio Gentile, PhD, is a research assistant professor with the College of Medicine at Chicago Medicine with the University of Illinois and is a member of the Translational Oncology Program.  He takes listeners on a deep dive in the latest on cancer treatment utilizing an understudied cellular mechanism as it relates to  cancer causes: voltage-gated ion channels. As he shares  facts about cancer cells, he describes these channels as interspersed on cell membranes and in cellular organs. They've been historically studied in terms of cardio myocyte function and the neuron—cancer cells are shifting front and center in Saverio Gentile's work. These channels work throughout the body to maintain the appropriate gradient of ions. He adds, "the other wonderful thing about this class of proteins is that they don't really work alone . . . like a concert, basically they work together." Through research, they are finding out how to change the "action potential" of some of these channels in cancer cells. He gets specific with one project that manipulates the potassium channel in ovarian and breast cancers to "push it in a corner," and then hits it with another drug that kills the cancer cell.  He describes other fascinating ways altering these channels may lead to effective therapies and discusses how students and other researchers can participate in the conversation around this work. Listen in for more hopeful news about cancer treatments.  Episode also available on Apple Podcasts: apple.co/30PvU9C

Manipulating ion channels may save lives. Researcher Saverio Gentile explains how. He tells listeners about exciting research on biochemical pathways in cancer cells in the human body. He and colleagues are looking at tumor cells versus normal cells regarding an understudied cell mechanism called voltage-gated ion channels. Listen and learn <ul> <li>Why a key characteristic of cancer cells—proliferation—may easily be inhibited through this research;</li> <li>How channels work in normal cells to regulate highly-sensitive gradients for ions like sodium, calcium, chloride, and potassium;</li> <li>What's significant about how these channels appear to evolve and work in cancer cells; and</li> <li>How one study has shown a reduction of tumor growth by manipulating these channels with a common drug.</li> </ul> Saverio Gentile, PhD, is a research assistant professor with the College of Medicine at Chicago Medicine with the University of Illinois and is a member of the Translational Oncology Program. He takes listeners on a deep dive in the latest on cancer treatment utilizing an understudied cellular mechanism as it relates to <a href="https://www.findinggeniuspodcast.com/podcasts/cancer-causation-mutagenic-potential-and-metastasis-understanding-cancer-with-james-shapiro/" rel="nofollow" target="_blank"> cancer causes</a>: voltage-gated ion channels. As he shares <a href="https://www.findinggeniuspodcast.com/podcasts/an-in-depth-examination-of-cancer-cells-and-cell-metabolism-impact-factors-with-matthew-g-vander-heiden/" rel="nofollow" target="_blank"> facts about cancer cells</a>, he describes these channels as interspersed on cell membranes and in cellular organs. They've been historically studied in terms of cardio myocyte function and the neuron—cancer cells are shifting front and center in Saverio Gentile's work. These channels work throughout the body to maintain the appropriate gradient of ions. He adds, "the other wonderful thing about this class of proteins is that they don't really work alone . . . like a concert, basically they work together." Through research, they are finding out how to change the "action potential" of some of these channels in cancer cells. He gets specific with one project that manipulates the potassium channel in ovarian and breast cancers to "push it in a corner," and then hits it with another drug that kills the cancer cell. He describes other fascinating ways altering these channels may lead to effective therapies and discusses how students and other researchers can participate in the conversation around this work. Listen in for more hopeful news about cancer treatments. Episode also available on Apple Podcasts: <a href="https://podcasts.apple.com/us/podcast/id1169016854" rel="nofollow" target="_blank">apple.co/30PvU9C</a>

Disrupting Cancer: Altering Cellular Ion Channels to Inhibit Cancer with Saverio Gentile