Stephanie Culler's guest appearances

Stephanie Culler

Angel Invest Boston

Empowered Patient Podcast

Dog Cancer Answers

David Solomon

Matt Murphy

Robin Smith

Thomas Cowan

Greg Miller

Travis Mickle

Justin Miller

Sean Tucker

Matt Wilson

Chris Young

Jim Martin

Robin Zander

Andrew Newberg

Mike Rea

Tom Cowan

OwlTail

The loss of two grandmothers to cancer propelled the daughter of an entrepreneurial family, Stephanie Culler, to a Ph.D. at Caltech and eventually to founding Persephone Microbiome. The VC-funded startup seeks to use gut bacteria to increase the success of cancer therapies. Persephone is also launching a probiotic for infants. Fascinating chat with a brilliant and articulate scientific founder. Highlights:   ·       Sal Daher Introduces Stephanie Culler, Ph.D. Co-Founder of Persephone Microbiome  ·       Persephone’s Business Model Is to Partner with Big Pharma to Develop Products Based on Its Platform  ·       A Probiotic for Babies and Infants Is Coming in Early 2024  ·       Results from the Largest Study in the US of Infant Gut Microbiome Were Unsettling  ·       Causes of Insufficiencies in the Gut Biome of Babies  ·       “Upwards of 80% of cells of our immune system is in our gut.”  ·       “...if you have a good microbiome, you're much more likely to respond to treatment.”  ·       “We are wet lab and in silico.”  ·       How Persephone Got Funded  ·       The Importance of Enrolling Populations Previously Under-represented in Studies  ·       The Promise of Population-Scale Data Sets  ·       Scanning Large Patient Populations Unencumbered by Animal Studies  ·       Why You Should Help This Podcast Get Found  ·       Stephanie Culler, Ph.D.’s Entrepreneurial Journey  ·       Entrepreneurial Family that Lost Two Grandmothers to Cancer  ·       Sal’s Appreciation of Articulate Chemical Engineers Like Stephanie  ·       Stephanie’s Experience at Y Combinator  ·       How Stephanie Culler Connected with Leen Kawas  ·       Stephanie’s Parting Thoughts on Biotech Winter Topics: biotech, robotics / AI, venture funding, discovering entrepreneurship 

The loss of two grandmothers to cancer propelled the daughter of an entrepreneurial family, Stephanie Culler, to a Ph.D. at Caltech and eventually to founding Persephone Microbiome. The VC-funded startup seeks to use gut bacteria to increase the success of cancer therapies. Persephone is also launching a probiotic for infants. Fascinating chat with a brilliant and articulate scientific founder. Highlights: <ul> <li> ·       Sal Daher Introduces Stephanie Culler, Ph.D. Co-Founder of Persephone Microbiome</li> <li> ·       Persephone’s Business Model Is to Partner with Big Pharma to Develop Products Based on Its Platform</li> <li> ·       A Probiotic for Babies and Infants Is Coming in Early 2024</li> <li> ·       Results from the Largest Study in the US of Infant Gut Microbiome Were Unsettling</li> <li> ·       Causes of Insufficiencies in the Gut Biome of Babies</li> <li> ·       “Upwards of 80% of cells of our immune system is in our gut.”</li> <li> ·       “...if you have a good microbiome, you're much more likely to respond to treatment.”</li> <li> ·       “We are wet lab and in silico.”</li> <li> ·       How Persephone Got Funded</li> <li> ·       The Importance of Enrolling Populations Previously Under-represented in Studies</li> <li> ·       The Promise of Population-Scale Data Sets</li> <li> ·       Scanning Large Patient Populations Unencumbered by Animal Studies</li> <li> ·       Why You Should Help This Podcast Get Found</li> <li> ·       Stephanie Culler, Ph.D.’s Entrepreneurial Journey</li> <li> ·       Entrepreneurial Family that Lost Two Grandmothers to Cancer</li> <li> ·       Sal’s Appreciation of Articulate Chemical Engineers Like Stephanie</li> <li> ·       Stephanie’s Experience at Y Combinator</li> <li> ·       How Stephanie Culler Connected with Leen Kawas</li> <li> ·       Stephanie’s Parting Thoughts on Biotech Winter</li> <li>Topics: biotech, robotics / AI, venture funding, discovering entrepreneurship</li> </ul>

Stephanie Culler PhD - Cancer & the Gut Biome - Co-founder of VC-Backed Persephone Microbiome

Dr. Stephanie Culler and the rest of her team have been studying differences in the gut microbiome of healthy people and people with cancer to find biomarkers that can detect or predict cancer development. After all, the gut plays a key role in the immune systemSo where do dogs come in? Dogs and humans share 60-80% of their gut microbiome with humans! Because of this combined with dogs’ shorter lifespans, it is much easier and more efficient to study and develop therapeutics for the microbiome in dogs first. So Dr. Culler expanded their research to include both healthy dogs and dogs with cancer. Both humans and dogs will benefit from this research. But she still needs poop samples from more dogs with cancer!Links Mentioned in Today’s Show:Persephone BiosciencesPoop for the Cure (contact them to donate dog poop!)Designing microbiome therapeutics to help cure cancer TEDx talkAbout Today’s Guest, Dr. Stephanie Culler: Stephanie Culler, Ph.D., is the co-founder and CEO of Persephone Biosciences, a business taking a novel approach to improving the efficacy of current cancer therapies and vaccines, leveraging the systemic impact of the gut microbiome on the human immune system. Persephone’s technology platform is based on collecting and analyzing gut microbiota samples from thousands of healthy and diseased patients, then using machine learning in conjunction with systems biology tools to understand the impact of gut microbes on patient prognosis. The results are used to design novel immunotherapies and companion diagnostics for diseases of unmet needs. Dr. Culler is a graduate of the prestigious Y Combinator accelerator and has spoken at TEDx San Diego. Prior to establishing Persephone Biosciences, she was a senior scientist at Genomatica, where she developed and applied synthetic biology tools toward the engineering of microorganisms as biocatalysts for the commercial production of sustainable chemicals. She received her Ph.D. in Chemical Engineering from the California Institute of Technology under the mentorship of Prof. Christina Smolke and has over sixteen publications and patents on synthetic biology and microbial based technologies.Other Links:If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&amp;A episode, call our Listener Line at 808-868-3200.Dog Cancer News is a free weekly newsletter that contains useful information designed to help your dog with cancer. To sign up, please visit DogCancerNews.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Stephanie Culler and the rest of her team have been studying differences in the gut microbiome of healthy people and people with cancer to find biomarkers that can detect or predict cancer development. After all, the gut plays a key role in the immune systemSo where do dogs come in? Dogs and humans share 60-80% of their gut microbiome with humans! Because of this combined with dogs’ shorter lifespans, it is much easier and more efficient to study and develop therapeutics for the microbiome in dogs first. So Dr. Culler expanded their research to include both healthy dogs and dogs with cancer. Both humans and dogs will benefit from this research. But she still needs poop samples from more dogs with cancer!Links Mentioned in Today’s Show:<a href="https://www.persephonebiosciences.com/" rel="nofollow" target="_blank">Persephone Biosciences</a><a href="https://www.persephonebiosciences.com/poop-for-the-cure-us/" rel="nofollow" target="_blank">Poop for the Cure</a> (contact them to donate dog poop!)<a href="https://www.ted.com/talks/stephanie_culler_designing_microbiome_therapeutics_to_help_cure_cancer" rel="nofollow" target="_blank">Designing microbiome therapeutics to help cure cancer</a> TEDx talkAbout Today’s Guest, Dr. Stephanie Culler: Stephanie Culler, Ph.D., is the co-founder and CEO of Persephone Biosciences, a business taking a novel approach to improving the efficacy of current cancer therapies and vaccines, leveraging the systemic impact of the gut microbiome on the human immune system. Persephone’s technology platform is based on collecting and analyzing gut microbiota samples from thousands of healthy and diseased patients, then using machine learning in conjunction with systems biology tools to understand the impact of gut microbes on patient prognosis. The results are used to design novel immunotherapies and companion diagnostics for diseases of unmet needs. Dr. Culler is a graduate of the prestigious Y Combinator accelerator and has spoken at TEDx San Diego. Prior to establishing Persephone Biosciences, she was a senior scientist at Genomatica, where she developed and applied synthetic biology tools toward the engineering of microorganisms as biocatalysts for the commercial production of sustainable chemicals. She received her Ph.D. in Chemical Engineering from the California Institute of Technology under the mentorship of Prof. Christina Smolke and has over sixteen publications and patents on synthetic biology and microbial based technologies.Other Links:If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&amp;A episode, call our Listener Line at 808-868-3200.Dog Cancer News is a free weekly newsletter that contains useful information designed to help your dog with cancer. To sign up, please visit <a href="https://dogcancernews.com/" rel="nofollow" target="_blank">DogCancerNews.com</a> Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices" rel="nofollow" target="_blank">megaphone.fm/adchoices</a>

Poop for the Cure: Your Dog’s Gut Bacteria and Cancer | Dr. Stephanie Culler #159

Stephanie Culler PhD, Co-Founder and CEO, Persephone Biosciences describes how the microbiome, the microbes that exist in our GI tract, impacts our overall health and specifically the immune system. Their goal is to leverage the impact of a healthy microbiome to improve the effectiveness of drugs and vaccines. By creating the VOICES study, Persephone is looking at a representative population to look at the connection between the microbiome and clearance of viral infections as well as vaccine efficacy to better understand how the microbiome is impacting a patient's response to the COVID-19 vaccines.  @persephonebio #GutMicrobiome #Microbiome #COVID19 #vaccine PersephoneBiosciences.com Download the transcript here

Stephanie Culler PhD, Co-Founder and CEO, Persephone Biosciences describes how the microbiome, the microbes that exist in our GI tract, impacts our overall health and specifically the immune system. Their goal is to leverage the impact of a healthy microbiome to improve the effectiveness of drugs and vaccines. By creating the VOICES study, Persephone is looking at a representative population to look at the connection between the microbiome and clearance of viral infections as well as vaccine efficacy to better understand how the microbiome is impacting a patient's response to the COVID-19 vaccines.  @persephonebio #GutMicrobiome #Microbiome #COVID19 #vaccine <a href="http://persephonebiosciences.com" rel="noopener nofollow" target="_blank">PersephoneBiosciences.com</a> <a href="http://empoweredpatientradio.com/developing-microbiome-therapeutics-to-improve-efficacy-of-drugs-and-vaccines-with-stephanie-culler-persephone-biosciences-transcript" rel="noopener nofollow" target="_blank">Download the transcript here</a>

Developing Microbiome Therapeutics to Improve Efficacy of Drugs and Vaccines with Stephanie Culler Persephone Biosciences